Research Topics
| Guillermo J TearneySummaryAffiliation: Massachusetts General Hospital Country: USA Publications
| Collaborators
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Detail Information
Publications
Identifying intestinal metaplasia at the squamocolumnar junction by using optical coherence tomographyJohn A Evans
Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
Gastrointest Endosc 65:50-6. 2007..The accuracy of OCT for differentiating tissue types at the squamocolumnar junction (SCJ) has not been established...- Comprehensive esophageal microscopy by using optical frequency-domain imaging (with video)Benjamin J Vakoc
Wellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard MIT Division of Health Sciences and Technology, Boston, Massachusetts, USA
Gastrointest Endosc 65:898-905. 2007..However, the relatively slow image-acquisition rate of the present OCT systems inhibits wide-field imaging and limits the clinical utility of OCT for diagnostic imaging in patients with Barrett's esophagus... 
Consensus standards for acquisition, measurement, and reporting of intravascular optical coherence tomography studies: a report from the International Working Group for Intravascular Optical Coherence Tomography Standardization and ValidationGuillermo J Tearney
The Massachusetts General Hospital and the Wellman Center for Photomedicine, Boston, Massachusetts 02114, USA
J Am Coll Cardiol 59:1058-72. 2012....- Optical coherence tomography to identify intramucosal carcinoma and high-grade dysplasia in Barrett's esophagusJohn A Evans
Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
Clin Gastroenterol Hepatol 4:38-43. 2006..The purpose of this study was to establish OCT image characteristics of IMC and HGD in Barrett's esophagus... - Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imagingGuillermo J Tearney
Wellman Center for Photomedicine, Massachusetts General Hospital, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02114, USA
JACC Cardiovasc Imaging 1:752-61. 2008..We present the first clinical experience with intracoronary optical frequency domain imaging (OFDI) in human patients... - Optical coherence tomography for imaging the vulnerable plaqueGuillermo J Tearney
Wellman Center for Photomedicine, Department of Pathology, Massachusetts General Hospital, 50 Blossom Street, BAR703, Boston, Massachusetts 02114, USA
J Biomed Opt 11:021002. 2006.... - Image-guided biopsy in the esophagus through comprehensive optical frequency domain imaging and laser marking: a study in living swineMelissa J Suter
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA
Gastrointest Endosc 71:346-53. 2010..When deployed through a balloon-centering catheter, OFDI can automatically image the entire distal esophagus (6.0 cm length) in approximately 2 minutes... 
Diagnostic accuracy of optical coherence tomography and integrated backscatter intravascular ultrasound images for tissue characterization of human coronary plaquesMasanori Kawasaki
Wellman Laboratories of Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
J Am Coll Cardiol 48:81-8. 2006....- Comprehensive microscopy of the esophagus in human patients with optical frequency domain imagingMelissa J Suter
Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital Boston, Massachusetts 02114, USA
Gastrointest Endosc 68:745-53. 2008..The clinical utility of OCT has been limited, however, by its inability to acquire images over large areas... - Reflectance confocal microscopy for the diagnosis of eosinophilic esophagitis: a pilot study conducted on biopsy specimensHongki Yoo
Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Gastrointest Endosc 74:992-1000. 2011..Reflectance confocal microscopy (RCM) is an endomicroscopy technology that is capable of obtaining high-resolution, optically sectioned images of esophageal mucosa without the administration of exogenous contrast... - Quantification of macrophage content in atherosclerotic plaques by optical coherence tomographyGuillermo J Tearney
Wellman Laboratories of Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
Circulation 107:113-9. 2003..The aim of this study was to investigate the use of OCT for identifying macrophages in fibrous caps... - In vivo association between positive coronary artery remodelling and coronary plaque characteristics assessed by intravascular optical coherence tomographyOwen Christopher Raffel
Cardiology Division, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, GRB 800, Boston, MA 02114, USA
Eur Heart J 29:1721-8. 2008..OCT is a unique imaging modality capable of characterizing these important morphological features of vulnerable plaque... - Comprehensive imaging of gastroesophageal biopsy samples by spectrally encoded confocal microscopyDongKyun Kang
Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Gastrointest Endosc 71:35-43. 2010.... - Comprehensive volumetric optical microscopy in vivoSeok H Yun
Wellman Center for Photomedicine, 55 Fruit Street, Boston, Massachusetts 02114, USA
Nat Med 12:1429-33. 2006..Our pilot study results suggest that this technology may be a useful clinical tool for comprehensive diagnostic imaging for epithelial disease and for evaluating coronary pathology and iatrogenic effects... - In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomographyIk Kyung Jang
Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Circulation 111:1551-5. 2005..Optical coherence tomography (OCT) is a high-resolution ( approximately 10 microm), catheter-based imaging modality capable of investigating detailed coronary plaque morphology in vivo... - Focal and multi-focal plaque macrophage distributions in patients with acute and stable presentations of coronary artery diseaseBriain D Macneill
Cardiology Division, Harvard Medical School, Boston, Massachusetts, USA
J Am Coll Cardiol 44:972-9. 2004..By providing a means of detecting increases in plaque macrophage content before an acute event, this technique may aid in determining prognosis and guiding preventive therapy... - Compensation of motion artifacts in intracoronary optical frequency domain imaging and optical coherence tomographyJinyong Ha
Harvard Medical School, Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom St, BAR 701, Boston, MA 02114, USA
Int J Cardiovasc Imaging 28:1299-304. 2012.... - Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomographySeemantini K Nadkarni
Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA
J Am Coll Cardiol 49:1474-81. 2007..The purpose of this study was to investigate the measurement of collagen and smooth muscle cell (SMC) content in atherosclerotic plaques using polarization-sensitive optical coherence tomography (PSOCT)... - Relationship between a systemic inflammatory marker, plaque inflammation, and plaque characteristics determined by intravascular optical coherence tomographyO Christopher Raffel
Cardiology Division, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Arterioscler Thromb Vasc Biol 27:1820-7. 2007.... - In vivo characterisation of coronary plaques with conventional grey-scale intravascular ultrasound: correlation with optical coherence tomographyAdrian F Low
Cardiology Division, Massachusetts General Hospital, Boston, MA, USA
EuroIntervention 4:626-32. 2009..The aim of this study was to evaluate the ability of conventional grey-scale IVUS in identifying in vivo coronary plaque characteristics, in particular lipid content as a marker of the vulnerable plaque, when compared to OCT... - Performance of reduced bit-depth acquisition for optical frequency domain imagingBRIAN D GOLDBERG
Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom St, Boston, MA 02114, USA
Opt Express 17:16957-68. 2009..Images of a human coronary artery acquired in vivo at 8-bit depth are presented and compared with images at higher bit-depth acquisition... - Physiological homology between Drosophila melanogaster and vertebrate cardiovascular systemsMichael A Choma
Children s Hospital Boston, Boston, MA 02115, USA
Dis Model Mech 4:411-20. 2011..Our results demonstrate physiological homology and support the use of D. melanogaster as an animal model of complex cardiovascular disease... - Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imagingTeresa C Chen
Department of Ophthalmology, Harvard Medical School, Boston, Mass, USA
Arch Ophthalmol 123:1715-20. 2005..To introduce a new ophthalmic optical coherence tomography technology that allows unprecedented simultaneous ultra-high speed and ultra-high resolution... - Intravascular optical imaging technology for investigating the coronary arteryMelissa J Suter
Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
JACC Cardiovasc Imaging 4:1022-39. 2011..Given the wealth of information that these techniques can provide, optical imaging modalities are poised to play an increasingly significant role in the evaluation of the coronary artery in the future... - Comparison of coronary plaque characteristics between diabetic and non-diabetic subjects: An in vivo optical coherence tomography studyStanley Chia
Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street GRB 800, Boston, MA, United States
Diabetes Res Clin Pract 81:155-60. 2008..Using OCT imaging, we compared in vivo plaque characteristics between diabetic and non-diabetic subjects... - Automated algorithm for differentiation of human breast tissue using low coherence interferometry for fine needle aspiration biopsy guidanceBRIAN D GOLDBERG
Massachusetts General Hospital, Wellman Center for Photomedicine, 40 Blossom Street, Boston, Massachusetts 02114, USA
J Biomed Opt 13:014014. 2008..1% (89.7 to 99.9) sensitivity and 82.4% (65.5 to 93.2) specificity where the numbers in parentheses represent the 95% confidence intervals. These results suggest that LCI can be used to determine tissue type and guide FNAB of the breast... - Speckle reduction in optical coherence tomography images using digital filteringAydogan Ozcan
Harvard Medical School, Massachusetts General Hospital, Boston 02114, USA
J Opt Soc Am A Opt Image Sci Vis 24:1901-10. 2007..Our results suggest that by using these digital filters, the number of individual angles required to attain a certain level of speckle reduction can be decreased... - Optical coherence tomography as a tool for percutaneous coronary interventionsLarry J Diaz-Sandoval
Cardiology Division and Cardiovascular Clinical Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Catheter Cardiovasc Interv 65:492-6. 2005..This is the first report of the use of OCT to identify in vivo human intracoronary pathology after PCI... - Measurement of fibrous cap thickness in atherosclerotic plaques by spatiotemporal analysis of laser speckle imagesSeemantini K Nadkarni
Massachusetts General Hospital, Harvard Medical School, Wellman Center for Photomedicine, Boston, Massachusetts 02114, USA
J Biomed Opt 11:021006. 2006..4). These results demonstrate that spatio-temporal LSI may allow the estimation of fibrous cap thickness in NCFAs, which is an important predictor of plaque stability... - Evaluation of optical reflectance techniques for imaging of alveolar structureCarolin I Unglert
Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, 40 Parkman Street, RSL 160, Boston, Massachusetts 02114, USA
J Biomed Opt 17:071303. 2012..Spatial and temporal resolution, imaging depth, and suitability for in vivo probe development were compared to highlight the merits and limitations of each technology for studying respiratory physiology at the alveolar level... - Characterization of human atherosclerosis by optical coherence tomographyHiroshi Yabushita
Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
Circulation 106:1640-5. 2002..These results represent an important step in validating this new intravascular imaging modality and will provide a basis for the interpretation of intracoronary OCT images obtained from patients... - Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivoHongki Yoo
Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA
Nat Med 17:1680-4. 2011.... - Spectrally-encoded color imagingDongKyun Kang
Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Opt Express 17:15239-47. 2009..The color SEE system showed qualitatively and quantitatively similar color imaging performance to that of a conventional digital camera... - Multimodality optical imaging of embryonic heart microstructureRonit Yelin
Massachusetts General Hospital, Harvard Medical School and the Wellman Center for Photomedicine, 55 Fruit Street, BAR 703, Boston, Massachusetts 02114, USA
J Biomed Opt 12:064021. 2007..Microstructural abnormalities associated with high levels of ethanol exposure are observed, including compromised heart looping and loss of ventricular trabecular mass... - Fourier fluorescence spectrometer for excitation emission matrix measurementLeilei Peng
Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 55 Fruit Street, BAR 708, Massachusetts 02114, USA
Opt Express 16:10493-500. 2008..The system provides a wide spectral range, adjustable spectral resolution, and fast EEM acquisition speed, which allows EEM's to be acquired in 40 seconds at a spectral resolution of 81-cm-1... - Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasoundIk Kyung Jang
Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Am Coll Cardiol 39:604-9. 2002..The aim of this study was to evaluate the feasibility and the ability of intravascular optical coherence tomography (OCT) to visualize the components of coronary plaques in living patients... - Laser speckle imaging of atherosclerotic plaques through optical fiber bundlesSeemantini K Nadkarni
Harvard Medical Schooland Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Biomed Opt 13:054016. 2008..Our results show that leached fiber bundles may reliably transmit laser speckle images in the presence of cardiac motion, providing a viable option to conduct intracoronary LSI... - Distribution of inflammation within carotid atherosclerotic plaques with high-risk morphological features: a comparison between positron emission tomography activity, plaque morphology, and histopathologyAmparo L Figueroa
Cardiac MR PET CT Program, Department of Radiology and Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114 2750, USA
Circ Cardiovasc Imaging 5:69-77. 2012..Although plaque inflammation is also associated with atherothrombosis, the relationship between inflammation and number of HRM is not well understood... - Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imagingBenjamin J Vakoc
Wellman Center for Photomedicine, Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA
Nat Med 15:1219-23. 2009.... - Real-time FPGA processing for high-speed optical frequency domain imagingAdrien E Desjardins
Harvard Biophysics Program, Boston, MA 02115, USA
IEEE Trans Med Imaging 28:1468-72. 2009..When implemented in FPGAs, the algorithm allowed for real-time processing of interferograms acquired with a high-speed OFDI system at 54 kHz and a sampling rate of 100 MS/s... - Fourier-domain optical coherence tomography: recent advances toward clinical utilityBrett E Bouma
Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Harvard MIT Division of Health Sciences and Technology, Boston, MA 02114, USA
Curr Opin Biotechnol 20:111-8. 2009.... - Real-time microscopic visualization of tissue response to laser thermal therapyBenjamin J Vakoc
Harvard Medical School and Massachusetts General Hospital, Wellman Center for Photomedicine, 55 Fruit Street, BAR 703, Boston, Massachusetts 02114, USA
J Biomed Opt 12:020501. 2007..Using porcine esophageal specimens ex vivo, we demonstrate that the extent and evolution of laser thermal damage can be assessed in real time... - Intravascular optical coherence tomography: cellular imagingBriain D Macneill
Cardiology Division, Massachusetts General Hospital, Boston, MA 02114, USA
J Nucl Cardiol 12:460-5. 2005..Superimposed on this inflammatory background, local increases in macrophage content, particularly at the cap surface and at areas at high risk for rupture, further promote the instability of individual lesions... - Optical microscopy of the pediatric vocal foldCaroline Boudoux
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA
Arch Otolaryngol Head Neck Surg 135:53-64. 2009..To compare and contrast 4 optical imaging techniques for evaluating the developing microstructure of the pediatric vocal fold and to identify the optimal strategy for in vivo imaging... - In-vivo comparison of coronary plaque characteristics using optical coherence tomography in women vs. men with acute coronary syndromeStanley Chia
Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Coron Artery Dis 18:423-7. 2007..Intravascular optical coherence tomography (OCT) is a high-resolution imaging technique capable of in-vivo plaque characterization. The aim of this study was to compare culprit plaque characteristics in women and men presenting with ACS... - Association of statin therapy with reduced coronary plaque rupture: an optical coherence tomography studyStanley Chia
Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Coron Artery Dis 19:237-42. 2008..We aimed to demonstrate the potential utility of OCT in evaluating coronary plaques in patients with or without statin therapy... - Backscattering spectroscopic contrast with angle-resolved optical coherence tomographyAdrien E Desjardins
Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston 02114, USA
Opt Lett 32:3158-60. 2007..High levels of speckle noise reduction achieved by angular compounding increased the spatial resolution at which backscattering spectra could be accurately differentiated... - >400 kHz repetition rate wavelength-swept laser and application to high-speed optical frequency domain imagingWang Yuhl Oh
Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, BAR 704, Boston, Massachusetts 02114, USA
Opt Lett 35:2919-21. 2010..Optical frequency domain imaging of the human skin in vivo is presented using this laser, and the system shows sensitivity of higher than 98 dB with single-side ranging depth of 1.7 mm over 4 dB sensitivity roll-off... - Characterization of atherosclerotic plaques by laser speckle imagingSeemantini K Nadkarni
Department of Dermatology, Harvard Medical School, Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom St, BAR 718, Boston, MA 02114, USA
Circulation 112:885-92. 2005..In this article, we describe a new optical technique, laser speckle imaging (LSI), that measures an index of plaque viscoelasticity. We evaluate the potential of LSI for characterizing atherosclerotic plaque... - In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomographyNader Nassif
Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, BAR 724, Boston, Massachusetts 02114, USA
Opt Lett 29:480-2. 2004..In vivo images of the human retina are presented, demonstrating the ability to acquire high-quality structural images with an axial resolution of 6 microm at ultrahigh speed and with an ocular exposure level of less than 600 microW... - Imaging the subcellular structure of human coronary atherosclerosis using micro-optical coherence tomographyLinbo Liu
Harvard Medical School, Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA
Nat Med 17:1010-4. 2011.... - Intravascular laser speckle imaging catheter for the mechanical evaluation of the arterial wallZeinab Hajjarian
Massachusetts General Hospital, Wellman Center for Photomedicine, Harvard Medical School, Boston, Massachusetts 02114, USA
J Biomed Opt 16:026005. 2011..Distinct differences in arterial time constants are identified at normal aortic and stented sites in vivo with intravascular LSI... - Spectral- and frequency-encoded fluorescence imagingJason T Motz
Harvard Medical School and the Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Opt Lett 30:2760-2. 2005..This method is applicable for developing submillimeter diameter endoscopes. The principles of the technique are validated by imaging indocyanine green fluorescence in microfluidic channels... - Quantitative FRET measurement by high-speed fluorescence excitation and emission spectrometerJing Yuan
Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
Opt Express 18:18839-51. 2010..The system can be utilized to enable real-time biochemistry reaction studies... - Miniature swept source for point of care optical frequency domain imagingBRIAN D GOLDBERG
Harvard Medical School and the Wellman Center for Photomedicine, Massachusetts General Hospital, 50 BlossomSt, Boston, MA 02114, USA
Opt Express 17:3619-29. 2009..4 kHz A-line rate when utilizing forward and backward sweeps. The entire laser system is approximately the size of a deck of cards and can operate on battery power for at least one hour... - Technology Insight: optical coherence tomography--current status and future developmentAdrian F Low
Cardiology Division at the Massachusetts General Hospital, Boston, MA 02114, USA
Nat Clin Pract Cardiovasc Med 3:154-62; quiz 172. 2006..Here, we discuss results from clinical studies which indicate that optical coherence tomography is a promising imaging technique for improved characterization of the coronary atherosclerotic plaque... - Evaluation of collagen in atherosclerotic plaques: the use of two coherent laser-based imaging methodsSeemantini K Nadkarni
Harvard Medical School, Massachusetts General Hospital and Wellman Center for Photomedicine, Boston, MA 02114, USA
Lasers Med Sci 24:439-45. 2009..In this article we review recent developments in these techniques and potential challenges in translating these methods into intra-arterial use in patients... - Statistical properties of phase-decorrelation in phase-resolved Doppler optical coherence tomographyBenjamin J Vakoc
Wellman Center, for Photomedicine, Massachusetts General Hospital and Harvard Medical, School, Boston, MA 02114, USA
IEEE Trans Med Imaging 28:814-21. 2009..Expressions for the noise distribution and the noise variance as a function of relevant imaging system parameters are given, and the implications of these results on both system and algorithm design are discussed... - Challenges on the frontier of intracoronary imaging: atherosclerotic plaque macrophage measurement by optical coherence tomographyAtsushi Tanaka
Harvard Medical School, Massachusetts General Hospital, Wellman Center for Photomedicine, Boston, Massachusetts 02114, USA
J Biomed Opt 15:011104. 2010..Because of its high resolution, OCT may also be used to identify macrophages in vivo. In this paper we review recent developments in OCT for measuring macrophages in atherosclerotic plaques... - Volumetric optical frequency domain imaging of pulmonary pathology with precise correlation to histopathologyLida P Hariri
Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
Chest 143:64-74. 2013..Bronchoscopic OFDI has been evaluated in vivo, but a lack of correlated histopathology has limited the ability to develop accurate image interpretation criteria... - Tethered capsule endomicroscopy enables less invasive imaging of gastrointestinal tract microstructureMichalina J Gora
Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Nat Med 19:238-40. 2013.... - Validation of two-dimensional and three-dimensional measurements of subpleural alveolar size parameters by optical coherence tomographyCarolin I Unglert
Harvard Medical School and Massachusetts General Hospital, Wellman Center for Photomedicine, 40 Parkman Street, RSL 160, Boston, Massachusetts 02114, USA
J Biomed Opt 17:126015. 2012..These methods and results should enable the quantification of alveolar sizes from OCT images in vivo... - Injury depth control from combined wavelength and power tuning in scanned beam laser thermal therapyMartin Villiger
Harvard Medical School and Massachusetts General Hospital, Wellman Center for Photomedicine, Boston, Massachusetts 02114, USA
J Biomed Opt 16:118001. 2011..The combination of two or three discrete wavelengths combined at variable ratios provides similar control, and may provide an improved strategy for the treatment of endothelial lesions... - Heart wall velocimetry and exogenous contrast-based cardiac flow imaging in Drosophila melanogaster using Doppler optical coherence tomographyMichael A Choma
Children s Hospital Boston, and Harvard Medical School, Department of Pediatrics, Boston, Massachusetts 02115, USA
J Biomed Opt 15:056020. 2010..The results presented here open up new possibilities for functional cardiovascular phenotyping of normal and mutant D. melanogaster... - Differential near-field scanning optical microscopyAydogan Ozcan
Wellman Center for Photomedicine, Harvard Medical School, Boston, Massachusetts 02114, USA
Nano Lett 6:2609-16. 2006..Principles of DNSOM can also be extended to other aperture/detector geometries such as triangles and parallelograms... - Optical coherence tomography of the biliary tree during ERCPJohn M Poneros
Gastrointestinal Unit, Wellman Laboratories of Photomedicine, Harvard Medical School, Boston, Massachusetts, USA
Gastrointest Endosc 55:84-8. 2002..There were no OCT-related complications. CONCLUSIONS: High-resolution OCT imaging of the biliary tree is feasible and may provide useful diagnostic information during ERCP... - Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young childrenDavid K Meyerholz
Department of Pathology, University of Iowa, Iowa City, 52242, USA
Am J Respir Crit Care Med 182:1251-61. 2010..Although airway abnormalities are common in patients with cystic fibrosis (CF), it is unknown whether they are all secondary to postnatal infection and inflammation, which characterize the disease... - Arterial wall imaging: evaluation with 16-section multidetector CT in blood vessel phantoms and ex vivo coronary arteriesMaros Ferencik
Department of Radiology, Wellman Laboratories of Photomedicine, Boston, MA 02114, USA
Radiology 240:708-16. 2006..001). CONCLUSION: Determination of composition of individual plaques from attenuation values can be more challenging because of overlapping values for different tissue types... - Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomographyJohannes F de Boer
Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, BAR 724, Boston, Massachusetts 02114, USA
Opt Lett 28:2067-9. 2003..A significant SNR gain of several hundredfold is found for acquisition in the spectral domain. The SNR benefit is demonstrated experimentally in a hybrid time-domain-spectral-domain OCT system... - Conformational change in coronary artery structure assessed by optical coherence tomography in patients with vasospastic anginaAtsushi Tanaka
Harvard Medical School, 50 Blossom Street, Boston, Massachusetts 02114, USA
J Am Coll Cardiol 58:1608-13. 2011..The aim of this study was to investigate the conformational change of arterial structure in the vasospastic lesion with optical coherence tomography... - Mechanical analysis of atherosclerotic plaques based on optical coherence tomographyAlexandra H Chau
Department of Mechanical Engineering and Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Ann Biomed Eng 32:1494-503. 2004..Our results indicate that vascular structure and composition determined by OCT provides an adequate basis for investigating the biomechanical factors relevant to atherosclerosis and acute myocardial infarction...