Guillermo J Tearney

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Identifying intestinal metaplasia at the squamocolumnar junction by using optical coherence tomography
    John A Evans
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Gastrointest Endosc 65:50-6. 2007
  2. pmc Comprehensive esophageal microscopy by using optical frequency-domain imaging (with video)
    Benjamin J Vakoc
    Wellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard MIT Division of Health Sciences and Technology, Boston, Massachusetts, USA
    Gastrointest Endosc 65:898-905. 2007
  3. pmc Tethered capsule endomicroscopy enables less invasive imaging of gastrointestinal tract microstructure
    Michalina J Gora
    Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 19:238-40. 2013
  4. doi request reprint Consensus standards for acquisition, measurement, and reporting of intravascular optical coherence tomography studies: a report from the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation
    Guillermo J Tearney
    The Massachusetts General Hospital and the Wellman Center for Photomedicine, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 59:1058-72. 2012
  5. pmc Optical coherence tomography to identify intramucosal carcinoma and high-grade dysplasia in Barrett's esophagus
    John A Evans
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Clin Gastroenterol Hepatol 4:38-43. 2006
  6. pmc Optical coherence tomography for imaging the vulnerable plaque
    Guillermo J Tearney
    Wellman Center for Photomedicine, Department of Pathology, Massachusetts General Hospital, 50 Blossom Street, BAR703, Boston, Massachusetts 02114, USA
    J Biomed Opt 11:021002. 2006
  7. pmc Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging
    Guillermo J Tearney
    Wellman Center for Photomedicine, Massachusetts General Hospital, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02114, USA
    JACC Cardiovasc Imaging 1:752-61. 2008
  8. pmc Image-guided biopsy in the esophagus through comprehensive optical frequency domain imaging and laser marking: a study in living swine
    Melissa J Suter
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Gastrointest Endosc 71:346-53. 2010
  9. ncbi request reprint Diagnostic accuracy of optical coherence tomography and integrated backscatter intravascular ultrasound images for tissue characterization of human coronary plaques
    Masanori Kawasaki
    Wellman Laboratories of Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 48:81-8. 2006
  10. pmc Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging
    Melissa J Suter
    Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital Boston, Massachusetts 02114, USA
    Gastrointest Endosc 68:745-53. 2008

Detail Information

Publications73

  1. pmc Identifying intestinal metaplasia at the squamocolumnar junction by using optical coherence tomography
    John A Evans
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Gastrointest Endosc 65:50-6. 2007
    ..The accuracy of OCT for differentiating tissue types at the squamocolumnar junction (SCJ) has not been established...
  2. pmc Comprehensive esophageal microscopy by using optical frequency-domain imaging (with video)
    Benjamin J Vakoc
    Wellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard MIT Division of Health Sciences and Technology, Boston, Massachusetts, USA
    Gastrointest Endosc 65:898-905. 2007
    ..However, the relatively slow image-acquisition rate of the present OCT systems inhibits wide-field imaging and limits the clinical utility of OCT for diagnostic imaging in patients with Barrett's esophagus...
  3. pmc Tethered capsule endomicroscopy enables less invasive imaging of gastrointestinal tract microstructure
    Michalina J Gora
    Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 19:238-40. 2013
    ....
  4. doi request reprint Consensus standards for acquisition, measurement, and reporting of intravascular optical coherence tomography studies: a report from the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation
    Guillermo J Tearney
    The Massachusetts General Hospital and the Wellman Center for Photomedicine, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 59:1058-72. 2012
    ....
  5. pmc Optical coherence tomography to identify intramucosal carcinoma and high-grade dysplasia in Barrett's esophagus
    John A Evans
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Clin Gastroenterol Hepatol 4:38-43. 2006
    ..The purpose of this study was to establish OCT image characteristics of IMC and HGD in Barrett's esophagus...
  6. pmc Optical coherence tomography for imaging the vulnerable plaque
    Guillermo J Tearney
    Wellman Center for Photomedicine, Department of Pathology, Massachusetts General Hospital, 50 Blossom Street, BAR703, Boston, Massachusetts 02114, USA
    J Biomed Opt 11:021002. 2006
    ....
  7. pmc Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging
    Guillermo J Tearney
    Wellman Center for Photomedicine, Massachusetts General Hospital, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02114, USA
    JACC Cardiovasc Imaging 1:752-61. 2008
    ..We present the first clinical experience with intracoronary optical frequency domain imaging (OFDI) in human patients...
  8. pmc Image-guided biopsy in the esophagus through comprehensive optical frequency domain imaging and laser marking: a study in living swine
    Melissa J Suter
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Gastrointest Endosc 71:346-53. 2010
    ..When deployed through a balloon-centering catheter, OFDI can automatically image the entire distal esophagus (6.0 cm length) in approximately 2 minutes...
  9. ncbi request reprint Diagnostic accuracy of optical coherence tomography and integrated backscatter intravascular ultrasound images for tissue characterization of human coronary plaques
    Masanori Kawasaki
    Wellman Laboratories of Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 48:81-8. 2006
    ....
  10. pmc Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging
    Melissa J Suter
    Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital Boston, Massachusetts 02114, USA
    Gastrointest Endosc 68:745-53. 2008
    ..The clinical utility of OCT has been limited, however, by its inability to acquire images over large areas...
  11. pmc Reflectance confocal microscopy for the diagnosis of eosinophilic esophagitis: a pilot study conducted on biopsy specimens
    Hongki Yoo
    Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Gastrointest Endosc 74:992-1000. 2011
    ..Reflectance confocal microscopy (RCM) is an endomicroscopy technology that is capable of obtaining high-resolution, optically sectioned images of esophageal mucosa without the administration of exogenous contrast...
  12. ncbi request reprint Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography
    Guillermo J Tearney
    Wellman Laboratories of Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Circulation 107:113-9. 2003
    ..The aim of this study was to investigate the use of OCT for identifying macrophages in fibrous caps...
  13. pmc In vivo association between positive coronary artery remodelling and coronary plaque characteristics assessed by intravascular optical coherence tomography
    Owen Christopher Raffel
    Cardiology Division, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, GRB 800, Boston, MA 02114, USA
    Eur Heart J 29:1721-8. 2008
    ..OCT is a unique imaging modality capable of characterizing these important morphological features of vulnerable plaque...
  14. pmc Comprehensive imaging of gastroesophageal biopsy samples by spectrally encoded confocal microscopy
    DongKyun Kang
    Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Gastrointest Endosc 71:35-43. 2010
    ....
  15. ncbi request reprint Focal and multi-focal plaque macrophage distributions in patients with acute and stable presentations of coronary artery disease
    Briain D Macneill
    Cardiology Division, Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 44:972-9. 2004
    ..This study was designed to utilize optical coherence tomography (OCT) images of coronary atherosclerotic plaque macrophages to investigate the relationship between macrophage distributions and clinical syndrome...
  16. pmc In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography
    Ik Kyung Jang
    Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Circulation 111:1551-5. 2005
    ..Optical coherence tomography (OCT) is a high-resolution ( approximately 10 microm), catheter-based imaging modality capable of investigating detailed coronary plaque morphology in vivo...
  17. pmc Comprehensive volumetric optical microscopy in vivo
    Seok H Yun
    Wellman Center for Photomedicine, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nat Med 12:1429-33. 2006
    ..Our pilot study results suggest that this technology may be a useful clinical tool for comprehensive diagnostic imaging for epithelial disease and for evaluating coronary pathology and iatrogenic effects...
  18. pmc Compensation of motion artifacts in intracoronary optical frequency domain imaging and optical coherence tomography
    Jinyong Ha
    Harvard Medical School, Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom St, BAR 701, Boston, MA 02114, USA
    Int J Cardiovasc Imaging 28:1299-304. 2012
    ....
  19. ncbi request reprint Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging
    Teresa C Chen
    Department of Ophthalmology, Harvard Medical School, Boston, Mass, USA
    Arch Ophthalmol 123:1715-20. 2005
    ..To introduce a new ophthalmic optical coherence tomography technology that allows unprecedented simultaneous ultra-high speed and ultra-high resolution...
  20. pmc In vivo characterisation of coronary plaques with conventional grey-scale intravascular ultrasound: correlation with optical coherence tomography
    Adrian F Low
    Cardiology Division, Massachusetts General Hospital, Boston, MA, USA
    EuroIntervention 4:626-32. 2009
    ..The aim of this study was to evaluate the ability of conventional grey-scale IVUS in identifying in vivo coronary plaque characteristics, in particular lipid content as a marker of the vulnerable plaque, when compared to OCT...
  21. pmc Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography
    Seemantini K Nadkarni
    Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA
    J Am Coll Cardiol 49:1474-81. 2007
    ..The purpose of this study was to investigate the measurement of collagen and smooth muscle cell (SMC) content in atherosclerotic plaques using polarization-sensitive optical coherence tomography (PSOCT)...
  22. pmc Intravascular optical imaging technology for investigating the coronary artery
    Melissa J Suter
    Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    JACC Cardiovasc Imaging 4:1022-39. 2011
    ..Given the wealth of information that these techniques can provide, optical imaging modalities are poised to play an increasingly significant role in the evaluation of the coronary artery in the future...
  23. pmc Performance of reduced bit-depth acquisition for optical frequency domain imaging
    BRIAN D GOLDBERG
    Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom St, Boston, MA 02114, USA
    Opt Express 17:16957-68. 2009
    ..Images of a human coronary artery acquired in vivo at 8-bit depth are presented and compared with images at higher bit-depth acquisition...
  24. pmc Physiological homology between Drosophila melanogaster and vertebrate cardiovascular systems
    Michael A Choma
    Children s Hospital Boston, Boston, MA 02115, USA
    Dis Model Mech 4:411-20. 2011
    ..Our results demonstrate physiological homology and support the use of D. melanogaster as an animal model of complex cardiovascular disease...
  25. doi request reprint Histogram analysis of lipid-core plaques in coronary computed tomographic angiography: ex vivo validation against histology
    Christopher L Schlett
    Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Invest Radiol 48:646-53. 2013
    ..We sought to determine whether the quantitative histogram analysis improves accuracy of the detection of lipid-core plaque (LCP) in ex vivo hearts by validation against histological analysis...
  26. pmc Relationship between a systemic inflammatory marker, plaque inflammation, and plaque characteristics determined by intravascular optical coherence tomography
    O Christopher Raffel
    Cardiology Division, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Arterioscler Thromb Vasc Biol 27:1820-7. 2007
    ....
  27. pmc Validation of two-dimensional and three-dimensional measurements of subpleural alveolar size parameters by optical coherence tomography
    Carolin I Unglert
    Harvard Medical School and Massachusetts General Hospital, Wellman Center for Photomedicine, 40 Parkman Street, RSL 160, Boston, Massachusetts 02114, USA
    J Biomed Opt 17:126015. 2012
    ..These methods and results should enable the quantification of alveolar sizes from OCT images in vivo...
  28. ncbi request reprint Optical coherence tomography as a tool for percutaneous coronary interventions
    Larry J Diaz-Sandoval
    Cardiology Division and Cardiovascular Clinical Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Catheter Cardiovasc Interv 65:492-6. 2005
    ..This is the first report of the use of OCT to identify in vivo human intracoronary pathology after PCI...
  29. doi request reprint Automated algorithm for differentiation of human breast tissue using low coherence interferometry for fine needle aspiration biopsy guidance
    BRIAN D GOLDBERG
    Massachusetts General Hospital, Wellman Center for Photomedicine, 40 Blossom Street, Boston, Massachusetts 02114, USA
    J Biomed Opt 13:014014. 2008
    ..1% (89.7 to 99.9) sensitivity and 82.4% (65.5 to 93.2) specificity where the numbers in parentheses represent the 95% confidence intervals. These results suggest that LCI can be used to determine tissue type and guide FNAB of the breast...
  30. pmc Speckle reduction in optical coherence tomography images using digital filtering
    Aydogan Ozcan
    Harvard Medical School, Massachusetts General Hospital, Boston 02114, USA
    J Opt Soc Am A Opt Image Sci Vis 24:1901-10. 2007
    ..Our results suggest that by using these digital filters, the number of individual angles required to attain a certain level of speckle reduction can be decreased...
  31. pmc Measurement of fibrous cap thickness in atherosclerotic plaques by spatiotemporal analysis of laser speckle images
    Seemantini K Nadkarni
    Massachusetts General Hospital, Harvard Medical School, Wellman Center for Photomedicine, Boston, Massachusetts 02114, USA
    J Biomed Opt 11:021006. 2006
    ..4). These results demonstrate that spatio-temporal LSI may allow the estimation of fibrous cap thickness in NCFAs, which is an important predictor of plaque stability...
  32. pmc Fourier-domain optical coherence tomography: recent advances toward clinical utility
    Brett E Bouma
    Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Harvard MIT Division of Health Sciences and Technology, Boston, MA 02114, USA
    Curr Opin Biotechnol 20:111-8. 2009
    ....
  33. pmc Comparison of coronary plaque characteristics between diabetic and non-diabetic subjects: An in vivo optical coherence tomography study
    Stanley Chia
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street GRB 800, Boston, MA, United States
    Diabetes Res Clin Pract 81:155-60. 2008
    ..Using OCT imaging, we compared in vivo plaque characteristics between diabetic and non-diabetic subjects...
  34. doi request reprint Evaluation of optical reflectance techniques for imaging of alveolar structure
    Carolin I Unglert
    Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, 40 Parkman Street, RSL 160, Boston, Massachusetts 02114, USA
    J Biomed Opt 17:071303. 2012
    ..Spatial and temporal resolution, imaging depth, and suitability for in vivo probe development were compared to highlight the merits and limitations of each technology for studying respiratory physiology at the alveolar level...
  35. ncbi request reprint Characterization of human atherosclerosis by optical coherence tomography
    Hiroshi Yabushita
    Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Circulation 106:1640-5. 2002
    ..The aim of this study was to establish objective OCT image criteria for atherosclerotic plaque characterization in vitro...
  36. pmc Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo
    Hongki Yoo
    Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Med 17:1680-4. 2011
    ....
  37. pmc Laser speckle imaging of atherosclerotic plaques through optical fiber bundles
    Seemantini K Nadkarni
    Harvard Medical Schooland Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Biomed Opt 13:054016. 2008
    ..Our results show that leached fiber bundles may reliably transmit laser speckle images in the presence of cardiac motion, providing a viable option to conduct intracoronary LSI...
  38. ncbi request reprint Fourier fluorescence spectrometer for excitation emission matrix measurement
    Leilei Peng
    Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 55 Fruit Street, BAR 708, Massachusetts 02114, USA
    Opt Express 16:10493-500. 2008
    ..The system provides a wide spectral range, adjustable spectral resolution, and fast EEM acquisition speed, which allows EEM's to be acquired in 40 seconds at a spectral resolution of 81-cm-1...
  39. ncbi request reprint Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound
    Ik Kyung Jang
    Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 39:604-9. 2002
    ..The aim of this study was to evaluate the feasibility and the ability of intravascular optical coherence tomography (OCT) to visualize the components of coronary plaques in living patients...
  40. pmc Spectrally-encoded color imaging
    DongKyun Kang
    Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Opt Express 17:15239-47. 2009
    ..The color SEE system showed qualitatively and quantitatively similar color imaging performance to that of a conventional digital camera...
  41. pmc Multimodality optical imaging of embryonic heart microstructure
    Ronit Yelin
    Massachusetts General Hospital, Harvard Medical School and the Wellman Center for Photomedicine, 55 Fruit Street, BAR 703, Boston, Massachusetts 02114, USA
    J Biomed Opt 12:064021. 2007
    ..Microstructural abnormalities associated with high levels of ethanol exposure are observed, including compromised heart looping and loss of ventricular trabecular mass...
  42. ncbi request reprint Intravascular optical coherence tomography: cellular imaging
    Briain D Macneill
    Cardiology Division, Massachusetts General Hospital, Boston, MA 02114, USA
    J Nucl Cardiol 12:460-5. 2005
    ..Superimposed on this inflammatory background, local increases in macrophage content, particularly at the cap surface and at areas at high risk for rupture, further promote the instability of individual lesions...
  43. pmc Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging
    Benjamin J Vakoc
    Wellman Center for Photomedicine, Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Med 15:1219-23. 2009
    ....
  44. pmc Real-time FPGA processing for high-speed optical frequency domain imaging
    Adrien E Desjardins
    Harvard Biophysics Program, Boston, MA 02115, USA
    IEEE Trans Med Imaging 28:1468-72. 2009
    ..When implemented in FPGAs, the algorithm allowed for real-time processing of interferograms acquired with a high-speed OFDI system at 54 kHz and a sampling rate of 100 MS/s...
  45. ncbi request reprint Real-time microscopic visualization of tissue response to laser thermal therapy
    Benjamin J Vakoc
    Harvard Medical School and Massachusetts General Hospital, Wellman Center for Photomedicine, 55 Fruit Street, BAR 703, Boston, Massachusetts 02114, USA
    J Biomed Opt 12:020501. 2007
    ..Using porcine esophageal specimens ex vivo, we demonstrate that the extent and evolution of laser thermal damage can be assessed in real time...
  46. doi request reprint Optical microscopy of the pediatric vocal fold
    Caroline Boudoux
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA
    Arch Otolaryngol Head Neck Surg 135:53-64. 2009
    ..To compare and contrast 4 optical imaging techniques for evaluating the developing microstructure of the pediatric vocal fold and to identify the optimal strategy for in vivo imaging...
  47. pmc Backscattering spectroscopic contrast with angle-resolved optical coherence tomography
    Adrien E Desjardins
    Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston 02114, USA
    Opt Lett 32:3158-60. 2007
    ..High levels of speckle noise reduction achieved by angular compounding increased the spatial resolution at which backscattering spectra could be accurately differentiated...
  48. ncbi request reprint In-vivo comparison of coronary plaque characteristics using optical coherence tomography in women vs. men with acute coronary syndrome
    Stanley Chia
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Coron Artery Dis 18:423-7. 2007
    ..Intravascular optical coherence tomography (OCT) is a high-resolution imaging technique capable of in-vivo plaque characterization. The aim of this study was to compare culprit plaque characteristics in women and men presenting with ACS...
  49. doi request reprint Distribution of inflammation within carotid atherosclerotic plaques with high-risk morphological features: a comparison between positron emission tomography activity, plaque morphology, and histopathology
    Amparo L Figueroa
    Cardiac MR PET CT Program, Department of Radiology and Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114 2750, USA
    Circ Cardiovasc Imaging 5:69-77. 2012
    ..Although plaque inflammation is also associated with atherothrombosis, the relationship between inflammation and number of HRM is not well understood...
  50. pmc Association of statin therapy with reduced coronary plaque rupture: an optical coherence tomography study
    Stanley Chia
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Coron Artery Dis 19:237-42. 2008
    ..We aimed to demonstrate the potential utility of OCT in evaluating coronary plaques in patients with or without statin therapy...
  51. pmc Characterization of atherosclerotic plaques by laser speckle imaging
    Seemantini K Nadkarni
    Department of Dermatology, Harvard Medical School, Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom St, BAR 718, Boston, MA 02114, USA
    Circulation 112:885-92. 2005
    ..In this article, we describe a new optical technique, laser speckle imaging (LSI), that measures an index of plaque viscoelasticity. We evaluate the potential of LSI for characterizing atherosclerotic plaque...
  52. pmc Imaging the subcellular structure of human coronary atherosclerosis using micro-optical coherence tomography
    Linbo Liu
    Harvard Medical School, Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Med 17:1010-4. 2011
    ....
  53. pmc >400 kHz repetition rate wavelength-swept laser and application to high-speed optical frequency domain imaging
    Wang Yuhl Oh
    Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, BAR 704, Boston, Massachusetts 02114, USA
    Opt Lett 35:2919-21. 2010
    ..Optical frequency domain imaging of the human skin in vivo is presented using this laser, and the system shows sensitivity of higher than 98 dB with single-side ranging depth of 1.7 mm over 4 dB sensitivity roll-off...
  54. ncbi request reprint In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography
    Nader Nassif
    Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, BAR 724, Boston, Massachusetts 02114, USA
    Opt Lett 29:480-2. 2004
    ..In vivo images of the human retina are presented, demonstrating the ability to acquire high-quality structural images with an axial resolution of 6 microm at ultrahigh speed and with an ocular exposure level of less than 600 microW...
  55. doi request reprint Quantitative FRET measurement by high-speed fluorescence excitation and emission spectrometer
    Jing Yuan
    Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Opt Express 18:18839-51. 2010
    ..The system can be utilized to enable real-time biochemistry reaction studies...
  56. pmc Evaluation of collagen in atherosclerotic plaques: the use of two coherent laser-based imaging methods
    Seemantini K Nadkarni
    Harvard Medical School, Massachusetts General Hospital and Wellman Center for Photomedicine, Boston, MA 02114, USA
    Lasers Med Sci 24:439-45. 2009
    ..In this article we review recent developments in these techniques and potential challenges in translating these methods into intra-arterial use in patients...
  57. pmc Intravascular laser speckle imaging catheter for the mechanical evaluation of the arterial wall
    Zeinab Hajjarian
    Massachusetts General Hospital, Wellman Center for Photomedicine, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biomed Opt 16:026005. 2011
    ..Distinct differences in arterial time constants are identified at normal aortic and stented sites in vivo with intravascular LSI...
  58. doi request reprint Challenges on the frontier of intracoronary imaging: atherosclerotic plaque macrophage measurement by optical coherence tomography
    Atsushi Tanaka
    Harvard Medical School, Massachusetts General Hospital, Wellman Center for Photomedicine, Boston, Massachusetts 02114, USA
    J Biomed Opt 15:011104. 2010
    ..Because of its high resolution, OCT may also be used to identify macrophages in vivo. In this paper we review recent developments in OCT for measuring macrophages in atherosclerotic plaques...
  59. pmc Miniature swept source for point of care optical frequency domain imaging
    BRIAN D GOLDBERG
    Harvard Medical School and the Wellman Center for Photomedicine, Massachusetts General Hospital, 50 BlossomSt, Boston, MA 02114, USA
    Opt Express 17:3619-29. 2009
    ..4 kHz A-line rate when utilizing forward and backward sweeps. The entire laser system is approximately the size of a deck of cards and can operate on battery power for at least one hour...
  60. ncbi request reprint Spectral- and frequency-encoded fluorescence imaging
    Jason T Motz
    Harvard Medical School and the Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Opt Lett 30:2760-2. 2005
    ..This method is applicable for developing submillimeter diameter endoscopes. The principles of the technique are validated by imaging indocyanine green fluorescence in microfluidic channels...
  61. ncbi request reprint Technology Insight: optical coherence tomography--current status and future development
    Adrian F Low
    Cardiology Division at the Massachusetts General Hospital, Boston, MA 02114, USA
    Nat Clin Pract Cardiovasc Med 3:154-62; quiz 172. 2006
    ..Here, we discuss results from clinical studies which indicate that optical coherence tomography is a promising imaging technique for improved characterization of the coronary atherosclerotic plaque...
  62. pmc Statistical properties of phase-decorrelation in phase-resolved Doppler optical coherence tomography
    Benjamin J Vakoc
    Wellman Center, for Photomedicine, Massachusetts General Hospital and Harvard Medical, School, Boston, MA 02114, USA
    IEEE Trans Med Imaging 28:814-21. 2009
    ..Expressions for the noise distribution and the noise variance as a function of relevant imaging system parameters are given, and the implications of these results on both system and algorithm design are discussed...
  63. pmc Volumetric optical frequency domain imaging of pulmonary pathology with precise correlation to histopathology
    Lida P Hariri
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Chest 143:64-74. 2013
    ..Bronchoscopic OFDI has been evaluated in vivo, but a lack of correlated histopathology has limited the ability to develop accurate image interpretation criteria...
  64. pmc Injury depth control from combined wavelength and power tuning in scanned beam laser thermal therapy
    Martin Villiger
    Harvard Medical School and Massachusetts General Hospital, Wellman Center for Photomedicine, Boston, Massachusetts 02114, USA
    J Biomed Opt 16:118001. 2011
    ..The combination of two or three discrete wavelengths combined at variable ratios provides similar control, and may provide an improved strategy for the treatment of endothelial lesions...
  65. ncbi request reprint Optical coherence tomography of the biliary tree during ERCP
    John M Poneros
    Gastrointestinal Unit, Wellman Laboratories of Photomedicine, Harvard Medical School, Boston, Massachusetts, USA
    Gastrointest Endosc 55:84-8. 2002
    ..Optical coherence tomography (OCT) is a high-resolution imaging technique that produces cross-sectional images in vivo. This is a report of the first use of OCT to acquire images of the biliary tree during ERCP...
  66. pmc Heart wall velocimetry and exogenous contrast-based cardiac flow imaging in Drosophila melanogaster using Doppler optical coherence tomography
    Michael A Choma
    Children s Hospital Boston, and Harvard Medical School, Department of Pediatrics, Boston, Massachusetts 02115, USA
    J Biomed Opt 15:056020. 2010
    ..The results presented here open up new possibilities for functional cardiovascular phenotyping of normal and mutant D. melanogaster...
  67. ncbi request reprint Differential near-field scanning optical microscopy
    Aydogan Ozcan
    Wellman Center for Photomedicine, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nano Lett 6:2609-16. 2006
    ..Principles of DNSOM can also be extended to other aperture/detector geometries such as triangles and parallelograms...
  68. ncbi request reprint Arterial wall imaging: evaluation with 16-section multidetector CT in blood vessel phantoms and ex vivo coronary arteries
    Maros Ferencik
    Department of Radiology, Wellman Laboratories of Photomedicine, Boston, MA 02114, USA
    Radiology 240:708-16. 2006
    ....
  69. pmc Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children
    David K Meyerholz
    Department of Pathology, University of Iowa, Iowa City, 52242, USA
    Am J Respir Crit Care Med 182:1251-61. 2010
    ..Although airway abnormalities are common in patients with cystic fibrosis (CF), it is unknown whether they are all secondary to postnatal infection and inflammation, which characterize the disease...
  70. ncbi request reprint Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography
    Johannes F de Boer
    Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, BAR 724, Boston, Massachusetts 02114, USA
    Opt Lett 28:2067-9. 2003
    ..A significant SNR gain of several hundredfold is found for acquisition in the spectral domain. The SNR benefit is demonstrated experimentally in a hybrid time-domain-spectral-domain OCT system...
  71. pmc Conformational change in coronary artery structure assessed by optical coherence tomography in patients with vasospastic angina
    Atsushi Tanaka
    Harvard Medical School, 50 Blossom Street, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 58:1608-13. 2011
    ..The aim of this study was to investigate the conformational change of arterial structure in the vasospastic lesion with optical coherence tomography...
  72. ncbi request reprint Mechanical analysis of atherosclerotic plaques based on optical coherence tomography
    Alexandra H Chau
    Department of Mechanical Engineering and Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Ann Biomed Eng 32:1494-503. 2004
    ..Our results indicate that vascular structure and composition determined by OCT provides an adequate basis for investigating the biomechanical factors relevant to atherosclerosis and acute myocardial infarction...