AHMED A TAWAKOL

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc HIF-1α and PFKFB3 Mediate a Tight Relationship Between Proinflammatory Activation and Anerobic Metabolism in Atherosclerotic Macrophages
    Ahmed Tawakol
    From the Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston A T, P S, H E, M M Cardiology Division, Weill Cornell Medical College, New York Presbyterian Hospital, NY P S Instituto de Investigaciones Biomédicas Alberto Sols CSIC UAM, Madrid, Spain M M, M P S, P G T, M F V, P M S, L B Centro de Investigación en Red en Enfermedades Hepáticas y Digestivas CIBERHED, Instituto de Salud Carlos III, Madrid, Spain M M, M P S, P G T, M F V, P M S, L B Hospital General Universitario Gregorio Marañón, Madrid, Spain M M, A T Division of Cardiovascular Medicine, University of Cambridge, Cambridge, United Kingdom J H F R Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY J N, Z A F Centro Nacional de Investigaciones Cardiovasculares, Melchor Fernandez Almagro, Madrid, Spain J A E The Salk Institute for Biological Studies, La Jolla
    Arterioscler Thromb Vasc Biol 35:1463-71. 2015
  2. doi request reprint Intensification of statin therapy results in a rapid reduction in atherosclerotic inflammation: results of a multicenter fluorodeoxyglucose-positron emission tomography/computed tomography feasibility study
    Ahmed Tawakol
    Cardiology Division, Massachusetts General Hospital, Boston, MA, USA
    J Am Coll Cardiol 62:909-17. 2013
  3. ncbi request reprint In vivo 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients
    Ahmed Tawakol
    Department of Medicine Cardiac Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 48:1818-24. 2006
  4. ncbi request reprint Noninvasive in vivo measurement of vascular inflammation with F-18 fluorodeoxyglucose positron emission tomography
    Ahmed Tawakol
    Department of Medicine Cardiac Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    J Nucl Cardiol 12:294-301. 2005
  5. pmc High-dose folic acid acutely improves coronary vasodilator function in patients with coronary artery disease
    Ahmed Tawakol
    Department of Medicine Cardiac Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 45:1580-4. 2005
  6. ncbi request reprint Homocysteine impairs coronary microvascular dilator function in humans
    Ahmed Tawakol
    Departments of Medicine Cardiac Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 40:1051-58. 2002
  7. doi request reprint Imaging atherosclerotic plaque inflammation by fluorodeoxyglucose with positron emission tomography: ready for prime time?
    James H F Rudd
    Division of Cardiovascular Medicine, University of Cambridge, Cambridge, England
    J Am Coll Cardiol 55:2527-35. 2010
  8. ncbi request reprint Effects of sildenafil on myocardial blood flow in humans with ischemic heart disease
    Ahmed Tawakol
    Department of Medicine Cardiac Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Coron Artery Dis 16:443-9. 2005
  9. pmc Photosensitizer delivery to vulnerable atherosclerotic plaque: comparison of macrophage-targeted conjugate versus free chlorin(e6)
    Ahmed Tawakol
    Massachusetts General Hospital, Cardiac Unit, Department of Medicine, and Harvard Medical School, Boston, Massachusetts, USA
    J Biomed Opt 11:021008. 2006
  10. ncbi request reprint Heterogeneity of myocardial blood flow and metabolism: review of physiologic principles and implications for radionuclide imaging of the heart
    Henry Gewirtz
    Department of Medicine, Cardiac Unit, Massachusetts General Hospital, Boston 02114, USA
    J Nucl Cardiol 9:534-41. 2002

Research Grants

Collaborators

Detail Information

Publications18

  1. pmc HIF-1α and PFKFB3 Mediate a Tight Relationship Between Proinflammatory Activation and Anerobic Metabolism in Atherosclerotic Macrophages
    Ahmed Tawakol
    From the Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston A T, P S, H E, M M Cardiology Division, Weill Cornell Medical College, New York Presbyterian Hospital, NY P S Instituto de Investigaciones Biomédicas Alberto Sols CSIC UAM, Madrid, Spain M M, M P S, P G T, M F V, P M S, L B Centro de Investigación en Red en Enfermedades Hepáticas y Digestivas CIBERHED, Instituto de Salud Carlos III, Madrid, Spain M M, M P S, P G T, M F V, P M S, L B Hospital General Universitario Gregorio Marañón, Madrid, Spain M M, A T Division of Cardiovascular Medicine, University of Cambridge, Cambridge, United Kingdom J H F R Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY J N, Z A F Centro Nacional de Investigaciones Cardiovasculares, Melchor Fernandez Almagro, Madrid, Spain J A E The Salk Institute for Biological Studies, La Jolla
    Arterioscler Thromb Vasc Biol 35:1463-71. 2015
    ....
  2. doi request reprint Intensification of statin therapy results in a rapid reduction in atherosclerotic inflammation: results of a multicenter fluorodeoxyglucose-positron emission tomography/computed tomography feasibility study
    Ahmed Tawakol
    Cardiology Division, Massachusetts General Hospital, Boston, MA, USA
    J Am Coll Cardiol 62:909-17. 2013
    ..The study sought to test whether high-dose statin treatment would result in greater reductions in plaque inflammation than low-dose statins, using fluorodeoxyglucose-positron emission tomography/computed tomographic imaging (FDG-PET/CT)...
  3. ncbi request reprint In vivo 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients
    Ahmed Tawakol
    Department of Medicine Cardiac Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 48:1818-24. 2006
    ..Given the importance of inflammation in atherosclerosis, we sought to determine if atherosclerotic plaque inflammation could be measured noninvasively in humans using positron emission tomography (PET)...
  4. ncbi request reprint Noninvasive in vivo measurement of vascular inflammation with F-18 fluorodeoxyglucose positron emission tomography
    Ahmed Tawakol
    Department of Medicine Cardiac Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    J Nucl Cardiol 12:294-301. 2005
    ..The aim of this study was to test the hypothesis that vascular inflammation can be measured noninvasively by use of positron emission tomography (PET) with FDG...
  5. pmc High-dose folic acid acutely improves coronary vasodilator function in patients with coronary artery disease
    Ahmed Tawakol
    Department of Medicine Cardiac Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 45:1580-4. 2005
    ..We investigated the acute effect of orally administered high-dose folic acid on coronary dilator function in humans...
  6. ncbi request reprint Homocysteine impairs coronary microvascular dilator function in humans
    Ahmed Tawakol
    Departments of Medicine Cardiac Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 40:1051-58. 2002
    ..We sought to use positron emission tomography (PET) to test the hypothesis that hyperhomocysteinemia adversely effects coronary microvascular dilator function...
  7. doi request reprint Imaging atherosclerotic plaque inflammation by fluorodeoxyglucose with positron emission tomography: ready for prime time?
    James H F Rudd
    Division of Cardiovascular Medicine, University of Cambridge, Cambridge, England
    J Am Coll Cardiol 55:2527-35. 2010
    ..This review sets out the background and current and potential future applications of this emerging biomarker of cardiovascular risk, along with its limitations...
  8. ncbi request reprint Effects of sildenafil on myocardial blood flow in humans with ischemic heart disease
    Ahmed Tawakol
    Department of Medicine Cardiac Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Coron Artery Dis 16:443-9. 2005
    ..We tested the hypothesis that sildenafil increases myocardial dilator reserve in humans with ischemic heart disease...
  9. pmc Photosensitizer delivery to vulnerable atherosclerotic plaque: comparison of macrophage-targeted conjugate versus free chlorin(e6)
    Ahmed Tawakol
    Massachusetts General Hospital, Cardiac Unit, Department of Medicine, and Harvard Medical School, Boston, Massachusetts, USA
    J Biomed Opt 11:021008. 2006
    ..The liver, spleen, lung, and gall bladder have the highest uptake in nontarget organs. Macrophage-targeted photosensitizer conjugates may have applications in both detecting and treating inflamed vulnerable plaque...
  10. ncbi request reprint Heterogeneity of myocardial blood flow and metabolism: review of physiologic principles and implications for radionuclide imaging of the heart
    Henry Gewirtz
    Department of Medicine, Cardiac Unit, Massachusetts General Hospital, Boston 02114, USA
    J Nucl Cardiol 9:534-41. 2002
  11. doi request reprint Feasibility of FDG imaging of the coronary arteries: comparison between acute coronary syndrome and stable angina
    Ian S Rogers
    Cardiac MR PET CT Program, Division of Cardiology and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    JACC Cardiovasc Imaging 3:388-97. 2010
    ....
  12. ncbi request reprint Direct effect of ethanol on human vascular function
    Ahmed Tawakol
    Cardiac Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Physiol Heart Circ Physiol 286:H2468-73. 2004
    ..None of these effects appear to be mediated by an increase in nitric oxide bioavailability, thus disputing findings from preclinical models...
  13. ncbi request reprint Myocardial blood flow and oxygen consumption in patients with Friedreich's ataxia prior to the onset of cardiomyopathy
    Shawn A Gregory
    Departments of Medicine Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Coron Artery Dis 18:15-22. 2007
    ....
  14. ncbi request reprint Myocardial flow regulation in people with mitochondrial myopathy, encephalopathy, lactic acidosis, stroke-like episodes/myoclonic epilepsy and ragged red fibers and other mitochondrial syndromes
    Ahmed Tawakol
    Cardiac Unit, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Coron Artery Dis 14:197-205. 2003
    ..This study tests the hypothesis that elevated levels of rest myocardial blood flow (MBF), indicative of inefficient aerobic metabolism, will be present in some patients with mitochondrial disorders but structurally normal hearts...
  15. pmc Intravascular detection of inflamed atherosclerotic plaques using a fluorescent photosensitizer targeted to the scavenger receptor
    Ahmed Tawakol
    Department of Medicine Cardiac Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Photochem Photobiol Sci 7:33-9. 2008
    ..83, p < 0.001) and an inverse correlation between MA-ce6 uptake and smooth muscle cell staining (R = -0.74, p < 0.001). MA-ce6 may function as a molecular imaging agent to detect and/or photodynamically treat inflamed plaques...
  16. doi request reprint Association between cardiovascular risk profiles and the presence and extent of different types of coronary atherosclerotic plaque as detected by multidetector computed tomography
    Fabian Bamberg
    Cardiac MR PET CT Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Arterioscler Thromb Vasc Biol 28:568-74. 2008
    ..To assess the association between cardiovascular risk factors and extent of noncalcified- (NCAP), mixed- (MCAP), and calcified coronary atherosclerotic plaque (CAP)...
  17. ncbi request reprint New opportunities for identification and reduction of coronary risk: treatment of vulnerable patients, arteries, and plaques
    James E Muller
    Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 47:C2-6. 2006
    ..If vulnerable plaques and patients can be successfully identified and treated, there will be immense clinical benefits, accompanied by cost savings...
  18. ncbi request reprint Sildenafil improves exercise capacity and quality of life in patients with systolic heart failure and secondary pulmonary hypertension
    Gregory D Lewis
    Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Circulation 116:1555-62. 2007
    ..We tested the hypothesis that sildenafil, an effective therapy for pulmonary arterial hypertension, would lower pulmonary vascular resistance and improve exercise capacity in patients with HF complicated by PH...

Research Grants1

  1. LOWERING HOMOCYSTEINE TO REDUCE MYOCARDIAL ISCHEMIA
    Ahmed Tawakol; Fiscal Year: 2006
    ....