Research Topics
Species | Kenneth TanabeSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
Mouse model of carbon tetrachloride induced liver fibrosis: Histopathological changes and expression of CD133 and epidermal growth factorTsutomu Fujii
Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, USA
BMC Gastroenterol 10:79. 2010..The carbon tetrachloride (CCl4)-induced mouse model has been historically relied upon to study liver injury and regeneration. We exposed mice to CCl4 to assess whether EGF and CD133+ HSCs are up-regulated in chronically injured liver...
Radiofrequency ablation: the experts weigh inKenneth K Tanabe
Department of Surgery, Harvard Medical School, Boston, Massachusetts, USA
Cancer 100:641-50. 2004
Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosisKenneth K Tanabe
Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 2696, USA
JAMA 299:53-60. 2008..Overexpression of epidermal growth factor (EGF) in the liver induces transformation to hepatocellular carcinoma in animal models. Polymorphisms in the EGF gene modulate EGF levels...- The past 60 years in liver surgeryKenneth K Tanabe
Division of Surgical Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts, USA
Cancer 113:1888-96. 2008..However, no matter now astounding these past achievements may be, it is clear that the future holds even greater promise... - Biology of desmoplastic melanoma: a case-control comparison with other melanomasDaan P Livestro
Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
J Clin Oncol 23:6739-46. 2005..Importantly, patients with DM have survival rates similar to patients with other melanomas of similar thickness... - Melanoma in the young: differences and similarities with adult melanoma: a case-matched controlled analysisDaan P Livestro
Division of Surgical Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Cancer 110:614-24. 2007..In this study, the use of an adult control group that was matched for tumor thickness adjusted for this bias and allowed for a comparison of the biology of pediatric melanoma and adult melanoma... - Surgical management of melanomaJennifer A Wargo
Department of Surgery, Harvard Medical School, Boston, MA, USA
Hematol Oncol Clin North Am 23:565-81, x. 2009.... - A functional epidermal growth factor (EGF) polymorphism, EGF serum levels, and esophageal adenocarcinoma risk and outcomeMichael Lanuti
Division of Thoracic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Clin Cancer Res 14:3216-22. 2008..We hypothesized that the EGF A61G homozygous variant genotype (GG) is (a) both a risk and poor prognostic factor for EAC and (b) associated with higher EGF serum levels in individuals with gastroesophageal reflux disease (GERD)... - Adult primary retroperitoneal teratomaSam S Yoon
Department of Surgery, Division of Surgical Oncology, Massachusetts General Hospital, Boston 02114, USA
Surgery 137:663-4. 2005 - Profile of plasma angiogenic factors before and after hepatectomy for colorectal cancer liver metastasesSam S Yoon
Department of Surgery, Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Yawkey 7B 7926, 55 Fruit Street, Boston, Massachusetts 02114, USA
Ann Surg Oncol 13:353-62. 2006..Circulating angiogenic factors in patients with colorectal cancer liver metastases may promote tumor growth and contribute to liver regeneration after partial hepatectomy... - Intraoperative US in patients undergoing surgery for liver neoplasms: comparison with MR imagingDushyant V Sahani
Department of Radiology, Massachusetts General Hospital, White 270, 55 Fruit St, Boston, MA 02114, USA
Radiology 232:810-4. 2004..To retrospectively compare intraoperative ultrasonography (US) and preoperative magnetic resonance (MR) imaging with contrast material enhancement for the depiction of liver lesions in patients undergoing hepatic resection... - Is completion lymphadenectomy after a positive sentinel lymph node biopsy for cutaneous melanoma always necessary?Nahel Elias
Departments of Surgery, Dermatology, and Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Arch Surg 139:400-4; discussion 404-5. 2004..We hypothesized that patients with negative lymph nodes included in the initial SLN specimen have low risk of metastases in the residual draining basin and may not require CLND... - Introduction to cancer gene therapyJames C Cusack
Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Cox Building, Room 626, 100 Blossom Street, Boston, MA 02114, USA
Surg Oncol Clin N Am 11:497-519, v. 2002..This, in turn, has led to the development of more complex therapies that frequently draw upon multiple disciplines in an effort to optimize treatment response... - Using multidetector CT for preoperative vascular evaluation of liver neoplasms: technique and resultsDushyant Sahani
Department of Radiology, Division of Abdominal Imaging and Intervention, Massachusetts General Hospital, Ellison 234-E, 55 Fruit St, Boston, MA 02114, USA
AJR Am J Roentgenol 179:53-9. 2002..CONCLUSION: Multidetector CT provides valuable preoperative information about hepatic vascular architecture and can be used as a noninvasive alternative to catheter angiography before oncologic liver surgery... - Liver-directed surgery for metastatic squamous cell carcinoma to the liver: results of a multi-center analysisTimothy M Pawlik
Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA
Ann Surg Oncol 14:2807-16. 2007..The role of hepatic resection for metastatic squamous cell carcinoma (SCC) remains unknown. The current study evaluates the role of hepatic resection in patients with metastatic SCC to the liver... - Case records of the Massachusetts General Hospital. Case 23-2005. A 57-year-old man with a mass in the liverKenneth K Tanabe
Department of Surgical Oncology, Massachusetts General Hospital, USA
N Engl J Med 353:401-10. 2005 - Viral oncolysisJames M Donahue
Massachusetts General Hospital, Harvard Medical School, Cox 626, 100 Blossom Street, Boston, MA 02114-2696, USA
Surg Oncol Clin N Am 11:661-80. 2002..In addition, using similar genetic modification strategies, these viruses have demonstrated antineoplastic effects in humans similar to those seen in preclinical animal models... - Lymphoscintigraphy and sentinel node biopsy accurately stage melanoma in patients presenting after wide local excisionHeather L Evans
Department of Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Ann Surg Oncol 10:416-25. 2003..Patients have traditionally been considered candidates for sentinel node biopsy (SNBx) only at the time of wide local excision (WLE). We hypothesized that patients with prior WLE may also be staged accurately with SNBx... - Epithelial-to-mesenchymal transition and integrin-linked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cellsBryan C Fuchs
Division of Surgical Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Cancer Res 68:2391-9. 2008..These data suggest that EMT predicts HCC sensitivity to EGFR-targeted therapies and that ILK is a novel target to overcome HCC resistance to EGFR inhibition... - New techniques of liver surgeryKenneth K Tanabe
Massachusetts General Hospital, Boston, MA 02114, USA
Semin Oncol 33:S39-41. 2006..Continued study of and experience with novel surgical techniques and treatment strategies will continue to improve outcomes in liver resection for metastatic colorectal cancer... - Molecular and functional analysis of glutamine uptake in human hepatoma and liver-derived cellsBarrie P Bode
Surgical Oncology Research Laboratories, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Physiol Gastrointest Liver Physiol 283:G1062-73. 2002.... - Cost-effectiveness of hepatic metastasectomy in patients with metastatic colorectal carcinoma: a state-transition Monte Carlo decision analysisG Scott Gazelle
Institute for Technology Assessment, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Zero Emerson Place, Suite 2H, Boston, MA 02114, USA
Ann Surg 237:544-55. 2003.... - The impact of primary tumor size, lymph node status, and other prognostic factors on the risk of cancer deathL Leon Chen
Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA
Cancer 115:5071-83. 2009..There is currently no method for integrating tumor size, lymph node status, and other prognostic information from a patient into a single risk of death estimate... - Morbidity and mortality after liver resection: results of the patient safety in surgery studySophia Virani
Harvard Medical School, Boston, MA, USA
J Am Coll Surg 204:1284-92. 2007.... - Vaccination with irradiated, autologous melanoma cells engineered to secrete granulocyte-macrophage colony-stimulating factor by adenoviral-mediated gene transfer augments antitumor immunity in patients with metastatic melanomaRobert Soiffer
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
J Clin Oncol 21:3343-50. 2003..CONCLUSION: Vaccination with irradiated, autologous melanoma cells engineered to secrete GM-CSF by adenoviral-mediated gene transfer augments antitumor immunity in patients with metastatic melanoma... - Viral oncolysis by herpes simplex virus and other virusesDarshini Kuruppu
Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Cancer Biol Ther 4:524-31. 2005..Positron emission tomography (PET) can be used for this purpose. This review focuses on commonly used oncolytic viruses, their selection for oncolytic therapy, the design of HSV-1 viral mutants, and monitoring their replication by PET... - Viral oncolysis for malignant liver tumorsJohn T Mullen
Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Ann Surg Oncol 10:596-605. 2003..We also describe results from our laboratory research program, which is focused on developing effective, liver tumor-specific Herpes simplex virus 1 mutants... - Viral oncolysisJohn T Mullen
Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114-2696, USA
Oncologist 7:106-19. 2002..Special attention is focused on the unique biology of each of these viruses as well as the status of several of these mutants in clinical trials... - Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgeneTimothy M Pawlik
Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston 02114-2696, USA
Cancer 95:1171-81. 2002..Oncolysis induced by HSV-1 replication combined with cyclophosphamide prodrug activation warrants further investigation as a potential therapy for colon carcinoma liver metastases... - Mammographic screening: patterns of use and estimated impact on breast carcinoma survivalKaren Blanchard
Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Cancer 101:495-507. 2004..Improvements in the promptness with which women return to screening appear to have the potential to lead to considerable reductions in breast carcinoma death... - Liver resection in veterans affairs and selected university medical centers: results of the patient safety in surgery studyRobert T Lancaster
Department of Surgery, Codman Center for Clinical Effectiveness in Surgery, Massachusetts General Hospital, Boston, MA 02114
J Am Coll Surg 204:1242-51. 2007..A series of National Surgical Quality Improvement Program articles evaluate the effect of hospital type (VA versus university hospitals) on procedure-specific outcomes. This article focuses on liver resections... - Selectivity of an oncolytic herpes simplex virus for cells expressing the DF3/MUC1 antigenHideki Kasuya
Division of Surgical Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Cancer Res 64:2561-7. 2004..DF3gamma34.5 was effective against carcinoma xenografts in nude mice. Regulation of gamma(1)34.5 by the DF3/MUC1 promoter is a promising strategy for development of HSV-1 mutants for viral oncolysis... - The effect of tumor size and lymph node status on breast carcinoma lethalityJames S Michaelson
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Cancer 98:2133-43. 2003.... - Cholangiocarcinoma in association with Thorotrast exposureAndrew X Zhu
Division of Hematology Oncology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
J Hepatobiliary Pancreat Surg 11:430-3. 2004..Radiology, treatment, pathologic findings, and relevant literature are discussed... - Why cancer at the primary site and in the lymph nodes contributes to the risk of cancer deathJames S Michaelson
Department of Pathology, Massachusetts General Hospital, Boston, Massachusett, USA
Cancer 115:5084-94. 2009.... - Oncolysis by viral replication and inhibition of angiogenesis by a replication-conditional herpes simplex virus that expresses mouse endostatinJohn T Mullen
Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Cancer 101:869-77. 2004..CONCLUSIONS: The oncolytic HSV-1 mutant HSV-Endo provided a two-pronged therapy; namely, inhibition of angiogenesis and direct tumor cell destruction by viral replication... - How cancer at the primary site and in the lymph nodes contributes to the risk of cancer deathJames S Michaelson
Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA
Cancer 115:5095-107. 2009.... - HSV-1 viral oncolysis and molecular imaging with PETDarshini Kuruppu
Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Curr Cancer Drug Targets 7:175-80. 2007..We review viral oncolysis, focusing on HSV-1 viral oncolysis and therapeutic monitoring by PET... - Advances in the treatment of liver tumorsSteven A Curley
The University of Texas M.D. Anderson Cancer Center, Houston, USA
Curr Probl Surg 39:449-571. 2002 - Palliative liver resectionsKenneth K Tanabe
J Surg Oncol 80:69-71. 2002 - The outcome of surgical resection versus assignment to the liver transplant waiting list for hepatocellular carcinomaJean-Pierre E N Pierie
Department of Gastro-Intestinal Surgery, Medical Center, Leeuwarden, Henri Dunantweg Z, 8934 AD Leeuwarden, The Netherlands
Ann Surg Oncol 12:552-60. 2005..Survival after resection in a group of patients with advanced tumors is worse than that after transplantation; however, shortages of donor livers presently preclude transplantation in this population of patients... - MelanomaAlan N Houghton
J Natl Compr Canc Netw 4:666-84. 2006 - Restoration of CD44S in non-small cell lung cancer cells enhanced their susceptibility to the macrophage cytotoxicityKazuhisa Takahashi
Department of Respiratory Medicine, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
Lung Cancer 41:145-53. 2003..These findings suggest that CD44S down-regulation in NSCLC cells may confer a protective advantage of allowing escape from tumoricidal effector cells including activated macrophages of the host... - Interaction between CD44 and hyaluronate induces chemoresistance in non-small cell lung cancer cellRina Ohashi
Department of Respiratory Medicine, Juntendo University, School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
Cancer Lett 252:225-34. 2007..These results suggest that the interaction between CD44s and HA play a pivotal role in acquired resistance to CDDP in NSCLC and MRP2 could be involved in this potential mechanism... - Endostatin gene transfer in murine lung carcinoma cells induces vascular endothelial growth factor secretion resulting in up-regulation of in vivo tumorigenecityRi Cui
Department of Respiratory Medicine, Juntendo University, School of Medicine, 2-1-1 Hongo; Bunkyo-Ku, Tokyo 113-8421, Japan
Cancer Lett 232:262-71. 2006..More attention should be paid for ED gene therapy into lung cancer cells since it may influence other proteins secretion, which upregulates angiogenesis...
Research Grants
- Targeting diffuse liver metastases with Herpes virusKenneth Tanabe; Fiscal Year: 2009..We will also use [19F] magnetic resonance spectroscopy (MRS) to image cytosine deaminase transgene function. We are in position to directly translate observations from these experiments into clinical trials. ..
- Phase I clinical trial of viral oncolysis of liver tumo*Kenneth Tanabe; Fiscal Year: 2007..Data from this trial are a necessary first step to determine whether further clinical study of this novel and promising therapy is warranted. These data will also provide insight into rRp450 mechanism of action. ..
- TRAINING PROGRAM IN CANCER BIOLOGYKenneth Tanabe; Fiscal Year: 2007..Relevance to Public Health: This project helps to train young physicians for a future career in clinical research and to enhance their knowledge and expertise in the treatment of cancer. ..
- Targeting diffuse liver metastases with Herpes virusKenneth Tanabe; Fiscal Year: 2007..We will also use [19F] magnetic resonance spectroscopy (MRS) to image cytosine deaminase transgene function. We are in position to directly translate observations from these experiments into clinical trials. ..
- TARGETTING DIFFUSE LIVER METASTASES WITH HERPES VIRUSKenneth Tanabe; Fiscal Year: 2002..We will subsequently examine the effect of individual components of the immune system on viral spread and anti-tumor efficacy. In concert, these studieds will provide a basis for development of clinical trials with HSV. ..
- Targeting diffuse liver metastases with Herpes virusKenneth K Tanabe; Fiscal Year: 2010..We will also use [19F] magnetic resonance spectroscopy (MRS) to image cytosine deaminase transgene function. We are in position to directly translate observations from these experiments into clinical trials. ..