Kenneth Tanabe

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Mouse model of carbon tetrachloride induced liver fibrosis: Histopathological changes and expression of CD133 and epidermal growth factor
    Tsutomu Fujii
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, USA
    BMC Gastroenterol 10:79. 2010
  2. ncbi request reprint Radiofrequency ablation: the experts weigh in
    Kenneth K Tanabe
    Department of Surgery, Harvard Medical School, Boston, Massachusetts, USA
    Cancer 100:641-50. 2004
  3. doi request reprint Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis
    Kenneth K Tanabe
    Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 2696, USA
    JAMA 299:53-60. 2008
  4. doi request reprint The past 60 years in liver surgery
    Kenneth K Tanabe
    Division of Surgical Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts, USA
    Cancer 113:1888-96. 2008
  5. ncbi request reprint Biology of desmoplastic melanoma: a case-control comparison with other melanomas
    Daan P Livestro
    Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Oncol 23:6739-46. 2005
  6. ncbi request reprint Melanoma in the young: differences and similarities with adult melanoma: a case-matched controlled analysis
    Daan P Livestro
    Division of Surgical Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Cancer 110:614-24. 2007
  7. doi request reprint Surgical management of melanoma
    Jennifer A Wargo
    Department of Surgery, Harvard Medical School, Boston, MA, USA
    Hematol Oncol Clin North Am 23:565-81, x. 2009
  8. pmc A functional epidermal growth factor (EGF) polymorphism, EGF serum levels, and esophageal adenocarcinoma risk and outcome
    Michael Lanuti
    Division of Thoracic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Clin Cancer Res 14:3216-22. 2008
  9. ncbi request reprint Adult primary retroperitoneal teratoma
    Sam S Yoon
    Department of Surgery, Division of Surgical Oncology, Massachusetts General Hospital, Boston 02114, USA
    Surgery 137:663-4. 2005
  10. ncbi request reprint Profile of plasma angiogenic factors before and after hepatectomy for colorectal cancer liver metastases
    Sam S Yoon
    Department of Surgery, Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Yawkey 7B 7926, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Ann Surg Oncol 13:353-62. 2006

Research Grants

  1. Targeting diffuse liver metastases with Herpes virus
    Kenneth Tanabe; Fiscal Year: 2009
  2. Phase I clinical trial of viral oncolysis of liver tumo*
    Kenneth Tanabe; Fiscal Year: 2007
  3. TRAINING PROGRAM IN CANCER BIOLOGY
    Kenneth Tanabe; Fiscal Year: 2007
  4. Targeting diffuse liver metastases with Herpes virus
    Kenneth Tanabe; Fiscal Year: 2007
  5. TARGETTING DIFFUSE LIVER METASTASES WITH HERPES VIRUS
    Kenneth Tanabe; Fiscal Year: 2002
  6. Targeting diffuse liver metastases with Herpes virus
    Kenneth K Tanabe; Fiscal Year: 2010

Detail Information

Publications45

  1. pmc Mouse model of carbon tetrachloride induced liver fibrosis: Histopathological changes and expression of CD133 and epidermal growth factor
    Tsutomu Fujii
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, USA
    BMC Gastroenterol 10:79. 2010
    ..The carbon tetrachloride (CCl4)-induced mouse model has been historically relied upon to study liver injury and regeneration. We exposed mice to CCl4 to assess whether EGF and CD133+ HSCs are up-regulated in chronically injured liver...
  2. ncbi request reprint Radiofrequency ablation: the experts weigh in
    Kenneth K Tanabe
    Department of Surgery, Harvard Medical School, Boston, Massachusetts, USA
    Cancer 100:641-50. 2004
  3. doi request reprint Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis
    Kenneth K Tanabe
    Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 2696, USA
    JAMA 299:53-60. 2008
    ..Overexpression of epidermal growth factor (EGF) in the liver induces transformation to hepatocellular carcinoma in animal models. Polymorphisms in the EGF gene modulate EGF levels...
  4. doi request reprint The past 60 years in liver surgery
    Kenneth K Tanabe
    Division of Surgical Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts, USA
    Cancer 113:1888-96. 2008
    ..However, no matter now astounding these past achievements may be, it is clear that the future holds even greater promise...
  5. ncbi request reprint Biology of desmoplastic melanoma: a case-control comparison with other melanomas
    Daan P Livestro
    Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Oncol 23:6739-46. 2005
    ..Consequently, comparisons with other forms of melanoma have been strongly biased by differences in Breslow stage. This is the first case-matched control study comparing DM with other forms of melanoma...
  6. ncbi request reprint Melanoma in the young: differences and similarities with adult melanoma: a case-matched controlled analysis
    Daan P Livestro
    Division of Surgical Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Cancer 110:614-24. 2007
    ..In this study, the use of an adult control group that was matched for tumor thickness adjusted for this bias and allowed for a comparison of the biology of pediatric melanoma and adult melanoma...
  7. doi request reprint Surgical management of melanoma
    Jennifer A Wargo
    Department of Surgery, Harvard Medical School, Boston, MA, USA
    Hematol Oncol Clin North Am 23:565-81, x. 2009
    ....
  8. pmc A functional epidermal growth factor (EGF) polymorphism, EGF serum levels, and esophageal adenocarcinoma risk and outcome
    Michael Lanuti
    Division of Thoracic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Clin Cancer Res 14:3216-22. 2008
    ..We hypothesized that the EGF A61G homozygous variant genotype (GG) is (a) both a risk and poor prognostic factor for EAC and (b) associated with higher EGF serum levels in individuals with gastroesophageal reflux disease (GERD)...
  9. ncbi request reprint Adult primary retroperitoneal teratoma
    Sam S Yoon
    Department of Surgery, Division of Surgical Oncology, Massachusetts General Hospital, Boston 02114, USA
    Surgery 137:663-4. 2005
  10. ncbi request reprint Profile of plasma angiogenic factors before and after hepatectomy for colorectal cancer liver metastases
    Sam S Yoon
    Department of Surgery, Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Yawkey 7B 7926, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Ann Surg Oncol 13:353-62. 2006
    ..Circulating angiogenic factors in patients with colorectal cancer liver metastases may promote tumor growth and contribute to liver regeneration after partial hepatectomy...
  11. ncbi request reprint Intraoperative US in patients undergoing surgery for liver neoplasms: comparison with MR imaging
    Dushyant V Sahani
    Department of Radiology, Massachusetts General Hospital, White 270, 55 Fruit St, Boston, MA 02114, USA
    Radiology 232:810-4. 2004
    ..To retrospectively compare intraoperative ultrasonography (US) and preoperative magnetic resonance (MR) imaging with contrast material enhancement for the depiction of liver lesions in patients undergoing hepatic resection...
  12. ncbi request reprint Is completion lymphadenectomy after a positive sentinel lymph node biopsy for cutaneous melanoma always necessary?
    Nahel Elias
    Departments of Surgery, Dermatology, and Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Arch Surg 139:400-4; discussion 404-5. 2004
    ..We hypothesized that patients with negative lymph nodes included in the initial SLN specimen have low risk of metastases in the residual draining basin and may not require CLND...
  13. ncbi request reprint Introduction to cancer gene therapy
    James C Cusack
    Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Cox Building, Room 626, 100 Blossom Street, Boston, MA 02114, USA
    Surg Oncol Clin N Am 11:497-519, v. 2002
    ..This, in turn, has led to the development of more complex therapies that frequently draw upon multiple disciplines in an effort to optimize treatment response...
  14. ncbi request reprint Using multidetector CT for preoperative vascular evaluation of liver neoplasms: technique and results
    Dushyant Sahani
    Department of Radiology, Division of Abdominal Imaging and Intervention, Massachusetts General Hospital, Ellison 234 E, 55 Fruit St, Boston, MA 02114, USA
    AJR Am J Roentgenol 179:53-9. 2002
    ..The purpose of our study was to evaluate the performance of CT angiography using multidetector CT (MDCT) for preoperative vascular evaluation in candidates who were scheduled for liver neoplasm resection...
  15. ncbi request reprint Liver-directed surgery for metastatic squamous cell carcinoma to the liver: results of a multi-center analysis
    Timothy M Pawlik
    Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Ann Surg Oncol 14:2807-16. 2007
    ..The role of hepatic resection for metastatic squamous cell carcinoma (SCC) remains unknown. The current study evaluates the role of hepatic resection in patients with metastatic SCC to the liver...
  16. ncbi request reprint Case records of the Massachusetts General Hospital. Case 23-2005. A 57-year-old man with a mass in the liver
    Kenneth K Tanabe
    Department of Surgical Oncology, Massachusetts General Hospital, USA
    N Engl J Med 353:401-10. 2005
  17. ncbi request reprint Viral oncolysis
    James M Donahue
    Massachusetts General Hospital, Harvard Medical School, Cox 626, 100 Blossom Street, Boston, MA 02114 2696, USA
    Surg Oncol Clin N Am 11:661-80. 2002
    ..In addition, using similar genetic modification strategies, these viruses have demonstrated antineoplastic effects in humans similar to those seen in preclinical animal models...
  18. ncbi request reprint Lymphoscintigraphy and sentinel node biopsy accurately stage melanoma in patients presenting after wide local excision
    Heather L Evans
    Department of Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Ann Surg Oncol 10:416-25. 2003
    ..Patients have traditionally been considered candidates for sentinel node biopsy (SNBx) only at the time of wide local excision (WLE). We hypothesized that patients with prior WLE may also be staged accurately with SNBx...
  19. doi request reprint Epithelial-to-mesenchymal transition and integrin-linked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cells
    Bryan C Fuchs
    Division of Surgical Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Cancer Res 68:2391-9. 2008
    ..These data suggest that EMT predicts HCC sensitivity to EGFR-targeted therapies and that ILK is a novel target to overcome HCC resistance to EGFR inhibition...
  20. ncbi request reprint New techniques of liver surgery
    Kenneth K Tanabe
    Massachusetts General Hospital, Boston, MA 02114, USA
    Semin Oncol 33:S39-41. 2006
    ..Continued study of and experience with novel surgical techniques and treatment strategies will continue to improve outcomes in liver resection for metastatic colorectal cancer...
  21. ncbi request reprint Molecular and functional analysis of glutamine uptake in human hepatoma and liver-derived cells
    Barrie P Bode
    Surgical Oncology Research Laboratories, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Physiol Gastrointest Liver Physiol 283:G1062-73. 2002
    ....
  22. pmc Cost-effectiveness of hepatic metastasectomy in patients with metastatic colorectal carcinoma: a state-transition Monte Carlo decision analysis
    G Scott Gazelle
    Institute for Technology Assessment, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Zero Emerson Place, Suite 2H, Boston, MA 02114, USA
    Ann Surg 237:544-55. 2003
    ....
  23. doi request reprint The impact of primary tumor size, lymph node status, and other prognostic factors on the risk of cancer death
    L Leon Chen
    Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA
    Cancer 115:5071-83. 2009
    ..There is currently no method for integrating tumor size, lymph node status, and other prognostic information from a patient into a single risk of death estimate...
  24. ncbi request reprint Morbidity and mortality after liver resection: results of the patient safety in surgery study
    Sophia Virani
    Harvard Medical School, Boston, MA, USA
    J Am Coll Surg 204:1284-92. 2007
    ....
  25. ncbi request reprint Vaccination with irradiated, autologous melanoma cells engineered to secrete granulocyte-macrophage colony-stimulating factor by adenoviral-mediated gene transfer augments antitumor immunity in patients with metastatic melanoma
    Robert Soiffer
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    J Clin Oncol 21:3343-50. 2003
    ..We conducted a phase I clinical trial testing the biologic activity of vaccination with irradiated, autologous melanoma cells engineered to secrete GM-CSF by adenoviral-mediated gene transfer...
  26. ncbi request reprint Viral oncolysis by herpes simplex virus and other viruses
    Darshini Kuruppu
    Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Cancer Biol Ther 4:524-31. 2005
    ..Positron emission tomography (PET) can be used for this purpose. This review focuses on commonly used oncolytic viruses, their selection for oncolytic therapy, the design of HSV-1 viral mutants, and monitoring their replication by PET...
  27. ncbi request reprint Viral oncolysis for malignant liver tumors
    John T Mullen
    Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Ann Surg Oncol 10:596-605. 2003
    ..We also describe results from our laboratory research program, which is focused on developing effective, liver tumor-specific Herpes simplex virus 1 mutants...
  28. ncbi request reprint Viral oncolysis
    John T Mullen
    Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114 2696, USA
    Oncologist 7:106-19. 2002
    ..Special attention is focused on the unique biology of each of these viruses as well as the status of several of these mutants in clinical trials...
  29. ncbi request reprint Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgene
    Timothy M Pawlik
    Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston 02114 2696, USA
    Cancer 95:1171-81. 2002
    ..rRp450 is a novel replication-conditional HSV-1 mutant that expresses both the endogenous herpes viral thymidine kinase gene and the rat p450 CYP2B1 transgene; p450 bioactivates such cancer prodrugs as cyclophosphamide...
  30. ncbi request reprint Mammographic screening: patterns of use and estimated impact on breast carcinoma survival
    Karen Blanchard
    Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Cancer 101:495-507. 2004
    ..In the current report, the authors describe patterns of screening use among women who were examined at a large screening and diagnostic service and estimate the added mortality associated with missed screening mammograms...
  31. ncbi request reprint Liver resection in veterans affairs and selected university medical centers: results of the patient safety in surgery study
    Robert T Lancaster
    Department of Surgery, Codman Center for Clinical Effectiveness in Surgery, Massachusetts General Hospital, Boston, MA 02114
    J Am Coll Surg 204:1242-51. 2007
    ..A series of National Surgical Quality Improvement Program articles evaluate the effect of hospital type (VA versus university hospitals) on procedure-specific outcomes. This article focuses on liver resections...
  32. ncbi request reprint Selectivity of an oncolytic herpes simplex virus for cells expressing the DF3/MUC1 antigen
    Hideki Kasuya
    Division of Surgical Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 64:2561-7. 2004
    ..DF3gamma34.5 was effective against carcinoma xenografts in nude mice. Regulation of gamma(1)34.5 by the DF3/MUC1 promoter is a promising strategy for development of HSV-1 mutants for viral oncolysis...
  33. ncbi request reprint The effect of tumor size and lymph node status on breast carcinoma lethality
    James S Michaelson
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer 98:2133-43. 2003
    ....
  34. ncbi request reprint Cholangiocarcinoma in association with Thorotrast exposure
    Andrew X Zhu
    Division of Hematology Oncology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    J Hepatobiliary Pancreat Surg 11:430-3. 2004
    ..Radiology, treatment, pathologic findings, and relevant literature are discussed...
  35. doi request reprint Why cancer at the primary site and in the lymph nodes contributes to the risk of cancer death
    James S Michaelson
    Department of Pathology, Massachusetts General Hospital, Boston, Massachusett, USA
    Cancer 115:5084-94. 2009
    ....
  36. ncbi request reprint Oncolysis by viral replication and inhibition of angiogenesis by a replication-conditional herpes simplex virus that expresses mouse endostatin
    John T Mullen
    Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer 101:869-77. 2004
    ..However, complete tumor regression was rarely observed...
  37. doi request reprint How cancer at the primary site and in the lymph nodes contributes to the risk of cancer death
    James S Michaelson
    Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Cancer 115:5095-107. 2009
    ....
  38. ncbi request reprint HSV-1 viral oncolysis and molecular imaging with PET
    Darshini Kuruppu
    Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Curr Cancer Drug Targets 7:175-80. 2007
    ..We review viral oncolysis, focusing on HSV-1 viral oncolysis and therapeutic monitoring by PET...
  39. ncbi request reprint Advances in the treatment of liver tumors
    Steven A Curley
    The University of Texas M D Anderson Cancer Center, Houston, USA
    Curr Probl Surg 39:449-571. 2002
  40. ncbi request reprint Palliative liver resections
    Kenneth K Tanabe
    J Surg Oncol 80:69-71. 2002
  41. ncbi request reprint The outcome of surgical resection versus assignment to the liver transplant waiting list for hepatocellular carcinoma
    Jean Pierre E N Pierie
    Department of Gastro intestinal Surgery, Medical Center, Leeuwarden, Henri Dunantweg Z, 8934 AD Leeuwarden, The Netherlands
    Ann Surg Oncol 12:552-60. 2005
    ..Optimal management of patients with hepatocellular carcinoma (HCC) is controversial. This study was conducted to evaluate the outcome of tumor resection versus assignment to a liver transplant waiting list (WL) in patients with HCC...
  42. ncbi request reprint Melanoma
    Alan N Houghton
    J Natl Compr Canc Netw 4:666-84. 2006
  43. ncbi request reprint Restoration of CD44S in non-small cell lung cancer cells enhanced their susceptibility to the macrophage cytotoxicity
    Kazuhisa Takahashi
    Department of Respiratory Medicine, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Lung Cancer 41:145-53. 2003
    ..These findings suggest that CD44S down-regulation in NSCLC cells may confer a protective advantage of allowing escape from tumoricidal effector cells including activated macrophages of the host...
  44. ncbi request reprint Interaction between CD44 and hyaluronate induces chemoresistance in non-small cell lung cancer cell
    Rina Ohashi
    Department of Respiratory Medicine, Juntendo University, School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Cancer Lett 252:225-34. 2007
    ..These results suggest that the interaction between CD44s and HA play a pivotal role in acquired resistance to CDDP in NSCLC and MRP2 could be involved in this potential mechanism...
  45. ncbi request reprint Endostatin gene transfer in murine lung carcinoma cells induces vascular endothelial growth factor secretion resulting in up-regulation of in vivo tumorigenecity
    Ri Cui
    Department of Respiratory Medicine, Juntendo University, School of Medicine, 2 1 1 Hongo Bunkyo ku, Tokyo 113 8421, Japan
    Cancer Lett 232:262-71. 2006
    ..More attention should be paid for ED gene therapy into lung cancer cells since it may influence other proteins secretion, which upregulates angiogenesis...

Research Grants10

  1. Targeting diffuse liver metastases with Herpes virus
    Kenneth Tanabe; Fiscal Year: 2009
    ..We will also use [19F] magnetic resonance spectroscopy (MRS) to image cytosine deaminase transgene function. We are in position to directly translate observations from these experiments into clinical trials. ..
  2. Phase I clinical trial of viral oncolysis of liver tumo*
    Kenneth Tanabe; Fiscal Year: 2007
    ..Data from this trial are a necessary first step to determine whether further clinical study of this novel and promising therapy is warranted. These data will also provide insight into rRp450 mechanism of action. ..
  3. TRAINING PROGRAM IN CANCER BIOLOGY
    Kenneth Tanabe; Fiscal Year: 2007
    ..Relevance to Public Health: This project helps to train young physicians for a future career in clinical research and to enhance their knowledge and expertise in the treatment of cancer. ..
  4. Targeting diffuse liver metastases with Herpes virus
    Kenneth Tanabe; Fiscal Year: 2007
    ..We will also use [19F] magnetic resonance spectroscopy (MRS) to image cytosine deaminase transgene function. We are in position to directly translate observations from these experiments into clinical trials. ..
  5. TARGETTING DIFFUSE LIVER METASTASES WITH HERPES VIRUS
    Kenneth Tanabe; Fiscal Year: 2002
    ..We will subsequently examine the effect of individual components of the immune system on viral spread and anti-tumor efficacy. In concert, these studieds will provide a basis for development of clinical trials with HSV. ..
  6. Targeting diffuse liver metastases with Herpes virus
    Kenneth K Tanabe; Fiscal Year: 2010
    ..We will also use [19F] magnetic resonance spectroscopy (MRS) to image cytosine deaminase transgene function. We are in position to directly translate observations from these experiments into clinical trials. ..