Affiliation: Massachusetts General Hospital
Takahashi K. Mannose-binding lectin and the balance between immune protection and complication. Expert Rev Anti Infect Ther. 2011;9:1179-90 pubmed publisher
..Beginning from these observations, this review focuses on the interaction of innate immunity and other homeostatic systems, the derangement of which may lead to complications in infection and other inflammatory states. ..
Chang W, White M, Moyo P, McClear S, Thiel S, Hartshorn K, et al
. Lack of the pattern recognition molecule mannose-binding lectin increases susceptibility to influenza A virus infection. BMC Immunol. 2010;11:64 pubmed publisher
..MBL plays a key role in clearing IAV and maintaining lung homeostasis. In addition, our findings also suggest that MBL deficiency maybe a risk factor in IAV infection and MBL may be a useful adjunctive therapy for IAV infection. ..
Takahashi K, Shi L, Gowda L, Ezekowitz R. Relative roles of complement factor 3 and mannose-binding lectin in host defense against infection. Infect Immun. 2005;73:8188-93 pubmed
..018 versus wild-type mice). These results confirm an essential function for complement in host resistance against S. aureus infection but also identify an MBL-dependent mechanism that is C3 independent. ..
Takahashi K. Lessons learned from murine models of mannose-binding lectin deficiency. Biochem Soc Trans. 2008;36:1487-90 pubmed publisher
..In addition to confirming findings from human clinical research, these model studies have uncovered unexpected roles of MBL and evidence of its interaction with other molecules of the innate immune system. ..
Takahashi K, Chang W, Takahashi M, Pavlov V, Ishida Y, La Bonte L, et al
. Mannose-binding lectin and its associated proteases (MASPs) mediate coagulation and its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation. Immunobiology. 2011;216:96-102 pubmed publisher
..Infected MBL null mice also develop liver injury. These findings suggest that MBL deficiency may manifest into DIC and organ failure during infectious diseases. ..
Takahashi K, Saha D, Shattino I, Pavlov V, Stahl G, Finnegan P, et al
. Complement 3 is involved with ventilator-induced lung injury. Int Immunopharmacol. 2011;11:2138-43 pubmed publisher
..We propose that C3 is involved with VILI and inhibition of complement activation may be a potential therapeutic strategy. ..
Takahashi K, Kurokawa K, Moyo P, Jung D, An J, Chigweshe L, et al
. Intradermal immunization with wall teichoic acid (WTA) elicits and augments an anti-WTA IgG response that protects mice from methicillin-resistant Staphylococcus aureus infection independent of mannose-binding lectin status. PLoS ONE. 2013;8:e69739 pubmed publisher