Research Topics
| M O SweeneySummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Detail Information
Publications
Novel cause of spurious mode switching in dual-chamber pacemakers: atrioventricular desynchronization arrhythmiaMichael O Sweeney
Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Cardiovasc Electrophysiol 13:616-9. 2002..This report describes a novel cause of spurious mode switching, AV desynchronization arrhythmia. Clinical manifestations, recognition, and management are discussed...
The nature of the gameMichael O Sweeney
J Cardiovasc Electrophysiol 16:483-5. 2005
Wide rightMichael O Sweeney
Heart Rhythm 2:616-8. 2005
Multicenter, prospective, randomized safety and efficacy study of a new atrial-based managed ventricular pacing mode (MVP) in dual chamber ICDsMichael O Sweeney
Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Cardiovasc Electrophysiol 16:811-7. 2005..We hypothesized that a new managed ventricular pacing mode (MVP) would safely provide AAI/R pacing with ventricular monitoring and DDD/R during AV block (AVB) and reduce Cum%VP compared to DDD/R...
A new paradigm for physiologic ventricular pacingMichael O Sweeney
Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Am Coll Cardiol 47:282-8. 2006..Awareness of the problem of desynchronization should also lead to more regular monitoring of cardiac pump function and mechanical asynchrony in any patient with ventricular pacing...
Response to the Center for Medicare & Medicaid Services coverage with evidence development request for primary prevention implantable cardioverter-defibrillators: data from the OMNI studyMichael O Sweeney
Cardiac Pacing and Heart Failure Device Therapies, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
Heart Rhythm 9:1058-66. 2012....
Prospective randomized comparison of 50%/50% versus 65%/65% tilt biphasic waveform on defibrillation in humansM O Sweeney
Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
Pacing Clin Electrophysiol 24:60-5. 2001....
Reduced ejection fraction, sudden cardiac death, and heart failure death in the mode selection trial (MOST): implications for device selection in elderly patients with sinus node diseaseMichael O Sweeney
Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Cardiovasc Electrophysiol 19:1160-6. 2008..Sudden Cardiac Death in Elderly Pacemaker Patients...
Severe atrioventricular decoupling, uncoupling, and ventriculoatrial coupling during enhanced atrial pacing: incidence, mechanisms, and implications for minimizing right ventricular pacing in ICD patientsMichael O Sweeney
Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Cardiovasc Electrophysiol 19:1175-80. 2008..AV Decoupling During Enhanced AAIR Pacing...
Randomized pilot study of a new atrial-based minimal ventricular pacing mode in dual-chamber implantable cardioverter-defibrillatorsMichael O Sweeney
Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Heart Rhythm 1:160-7. 2004....
Association of prolonged QRS duration with death in a clinical trial of pacemaker therapy for sinus node dysfunctionMichael O Sweeney
Cardiac Arrhythmia Service, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
Circulation 111:2418-23. 2005..The relationship of baseline QRSd to death and heart failure hospitalization in patients with sinus node dysfunction who require pacemaker therapy is unknown...
Minimizing ventricular pacing to reduce atrial fibrillation in sinus-node diseaseMichael O Sweeney
Cardiac Arrhythmia Service, Brigham and Women s Hospital, Boston, MA 02115, USA
N Engl J Med 357:1000-8. 2007....
Appropriate and inappropriate ventricular therapies, quality of life, and mortality among primary and secondary prevention implantable cardioverter defibrillator patients: results from the Pacing Fast VT REduces Shock ThErapies (PainFREE Rx II) trialMichael O Sweeney
Cardiac Arrhythmia Service, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
Circulation 111:2898-905. 2005....
Bradycardia pacing-induced short-long-short sequences at the onset of ventricular tachyarrhythmias: a possible mechanism of proarrhythmia?Michael O Sweeney
Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Am Coll Cardiol 50:614-22. 2007..The purpose of this study was to characterize interactions between normal pacing system operation and the initiating sequence of ventricular tachycardia (VT)/ventricular fibrillation (VF)...
Heart failure during cardiac pacingMichael O Sweeney
Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Circulation 113:2082-8. 2006..The adverse effects of ventricular desynchronization may explain the association of RVA pacing with an increased risk of heart failure hospitalization (HFH) in clinical trials...
Clustering of sudden death and aborted cardiac arrest associated with a family grief reactionMichael O Sweeney
Harvard Medical School, Boston, MA 02115, USA
Heart Rhythm 4:952-5. 2007
Minimizing right ventricular pacing: a new paradigm for cardiac pacing in sinus node dysfunctionMichael O Sweeney
Harvard Medical School, Boston, MA, USA
Am Heart J 153:34-43. 2007
Antitachycardia pacing for ventricular tachycardia using implantable cardioverter defibrillators:Michael O Sweeney
CRM Research, Cardiac Arrhythmia Service, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Pacing Clin Electrophysiol 27:1292-305. 2004
The Managed Ventricular pacing versus VVI 40 Pacing (MVP) Trial: clinical background, rationale, design, and implementationMichael O Sweeney
Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Cardiovasc Electrophysiol 17:1295-8. 2006..Right ventricular apical (RVA) pacing has been implicated in worsening heart failure and death. The optimal pacemaker mode for bradycardia support while minimizing unnecessary and potentially harmful RVA pacing has not been determined...
Adverse effect of ventricular pacing on heart failure and atrial fibrillation among patients with normal baseline QRS duration in a clinical trial of pacemaker therapy for sinus node dysfunctionMichael O Sweeney
Cardiac Arrhythmia Service, Brigham and Women s Hospital and Harvard Medical School, 75 Francis St, Boston, Mass 02115, USA
Circulation 107:2932-7. 2003..The effect of pacing-induced ventricular desynchronization in patients with normal baseline QRSd is unknown...
Atrial pacing or ventricular backup-only pacing in implantable cardioverter-defibrillator patientsMichael O Sweeney
Cardiac Pacing and Heart Failure Device Therapies, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Heart Rhythm 7:1552-60. 2010..The need for pacing support in typical ICD patients is unknown...
Exploding implantable cardioverter defibrillatorM O Sweeney
Cardiac Arrhythmia Service, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Cardiovasc Electrophysiol 12:1422-4. 2001..Device analysis confirmed a shorted transistor in the high-voltage output circuit. Unsuspected physical contact between high-voltage electrodes of opposite polarity within the pocket can cause catastrophic ICD system failure...
Implantable cardioverter defibrillators in heart failureM O Sweeney
Cardiac Arrhythmia Service, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Cardiol Clin 19:653-67. 2001..Future devices will incorporate features that have the potential to reduce atrial arrhythmias, improve ventricular function, monitor hemodynamics, and prevent sudden arrhythmic death...
Differences in effects of electrical therapy type for ventricular arrhythmias on mortality in implantable cardioverter-defibrillator patientsMichael O Sweeney
Cardiac Arrhythmia Service, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Heart Rhythm 7:353-60. 2010..It is unknown whether this is due to the ventricular arrhythmia (VA) or shocks and whether antitachycardia pacing (ATP) termination can reduce this risk...
Analysis of ventricular activation using surface electrocardiography to predict left ventricular reverse volumetric remodeling during cardiac resynchronization therapyMichael O Sweeney
Brigham and Women s Hospital, Boston, MA 02115, USA
Circulation 121:626-34. 2010..We hypothesized that reverse remodeling is predicted by the left bundle branch block ventricular activation sequence, the paced activation sequence, and interactions between these 2 conditions...
Prospective randomized study of mode switching in a clinical trial of pacemaker therapy for sinus node dysfunctionMichael O Sweeney
Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Cardiovasc Electrophysiol 15:153-60. 2004..Mode switching (MS) reduces RVP, but its clinical benefit in patients with SND is unknown...
Provoked and spontaneous high-frequency, low-amplitude, respirophasic noise transients in patients with implantable cardioverter defibrillatorsM O Sweeney
Cardiac Arrhythmia Service, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Cardiovasc Electrophysiol 12:402-10. 2001..The incidence of OS and its relationship to clinical variables and ICD system design are unknown...
Upgrade of permanent pacemakers and single chamber implantable cardioverter defibrillators to pectoral dual chamber implantable cardioverter defibrillators: indications, surgical approach, and long-term clinical resultsMichael O Sweeney
Cardiac Arrhythmia Service, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachussetts, USA
Pacing Clin Electrophysiol 25:1715-23. 2002..Preexisting transvenous leads can be successfully incorporated into new DDDR ICDs, simplifying the surgical procedure, minimizing transvenous hardware, and eliminating the possibility of hazardous pacemaker-ICD interactions...
Recalls and safety alerts involving pacemakers and implantable cardioverter-defibrillator generatorsW H Maisel
Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
JAMA 286:793-9. 2001..Despite increasingly frequent device implantation, pacemaker and ICD recalls and safety alerts (advisories) remain poorly characterized...
Single site left ventricular pacing for cardiac resynchronizationWilliam G Stevenson
Cardiovascular Division, Department of Internal Medicine, Brigham and Women's Hospital, 75 Francis St, Boston, Mass 02115, USA
Circulation 109:1694-6. 2004
Patient-specific computational analysis of transvenous defibrillation: a comparison to clinical metrics in humansDaniel Mocanu
Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
Ann Biomed Eng 32:775-83. 2004..However, inspection of the weak potential gradient field in all nine patients revealed a relationship between the degree of dispersion of the weak field and the clinical DFT, which may help identify high DFT patients...
Socio-economic analysis of cardiac resynchronization therapyMichael E Field
Cardiac Arrhythmia Service, Brigham and Women's Hospital, Boston, MA, 02115, USA
J Interv Card Electrophysiol 17:225-36. 2006....
Management of arrhythmias in heart failureWilliam G Stevenson
Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA
Cardiol Rev 10:8-14. 2002..Ongoing trials will provide further guidance for arrhythmia management...
Cardiology patient page. Cardiac resynchronization therapy: a patient's guideJulie B Shea
Brigham and Women's Hospital and Harvard Medical School, Boston, Mass 02115, USA
Circulation 108:e64-6. 2003
A comparison of biventricular and conventional transvenous defibrillation: a computational study using patient derived modelsDaniel Mocanu
Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA
Pacing Clin Electrophysiol 27:586-93. 2004..05) with the DFT decreasing in some patients and increasing in others. These results suggest that patient-specific computational models may be able to identify those patients who would most benefit from a biventricular configuration...
ACC/AHA/HRS 2008 guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: executive summaryAndrew E Epstein
Heart Rhythm 5:934-55. 2008
ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 GuidelineAndrew E Epstein
J Am Coll Cardiol 51:e1-62. 2008
"The world is not black and white. More like black and gray"Michael O Sweeney
J Cardiovasc Electrophysiol 19:28-31. 2008
Impact of rate-modulated pacing on quality of life and exercise capacity--evidence from the Advanced Elements of Pacing Randomized Controlled Trial (ADEPT)Gervasio A Lamas
Division of Cardiology, Mount Sinai Medical Center, Miami Beach, Florida 33140, USA
Heart Rhythm 4:1125-32. 2007..Ninety-nine percent of pacemakers implanted in the United States include an option for rate modulation...
In a footnote, at leastMichael O Sweeney
Heart Rhythm 3:1207-9. 2006
Ventricular pacing or dual-chamber pacing for sinus-node dysfunctionGervasio A Lamas
Division of Cardiology, Mount Sinai Medical Center, and the University of Miami School of Medicine, Miami Beach, Fla, USA
N Engl J Med 346:1854-62. 2002..However, it is unknown which type of pacing results in the better outcome...
Prospective randomized multicenter trial of empirical antitachycardia pacing versus shocks for spontaneous rapid ventricular tachycardia in patients with implantable cardioverter-defibrillators: Pacing Fast Ventricular Tachycardia Reduces Shock Therapies Mark S Wathen
Vanderbilt Page Campbell Heart Institute, Vanderbilt University Medical Center, 2220 Pierce, Nashville, TN 37232, USA
Circulation 110:2591-6. 2004..Fast VT (FVT) >200 bpm is often treated by shock because of safety concerns, however. This prospective, randomized, multicenter trial compares the safety and utility of empirical ATP with shocks for FVT in a broad ICD population...
Clinical assessment and management of patients with implanted cardioverter-defibrillators presenting to nonelectrophysiologistsWilliam G Stevenson
Circulation 110:3866-9. 2004....
Treatment crossovers did not affect randomized treatment comparisons in the Mode Selection Trial (MOST)Anne S Hellkamp
Duke Clinical Research Institute, Durham, North Carolina, USA
J Am Coll Cardiol 47:2260-6. 2006..We evaluated the impact of treatment crossovers on study results in the Mode Selection Trial (MOST)...
Atrial high rate episodes detected by pacemaker diagnostics predict death and stroke: report of the Atrial Diagnostics Ancillary Study of the MOde Selection Trial (MOST)Taya V Glotzer
Division of Electrophysiology, Hackensack University Medical Center, Hackensack, NJ, USA
Circulation 107:1614-9. 2003..The purpose of the study was to correlate atrial high rate events (AHREs) detected by pacemaker diagnostics with clinical outcomes...
Heart failure hospitalization is more common in pacemaker patients with sinus node dysfunction and a prolonged paced QRS durationHimanshu H Shukla
University of Missouri Columbia, Columbia, Missouri, USA
Heart Rhythm 2:245-51. 2005..The purpose of this study was to determine whether a prolonged paced QRS duration increases the risk of cardiac dysfunction...
QRS duration does not predict occurrence of ventricular tachyarrhythmias in patients with implanted cardioverter-defibrillatorsAlfred E Buxton
Cardiology Division, Department of Medicine, Brown Medical School, Providence, Rhode Island 02905, USA
J Am Coll Cardiol 46:310-6. 2005..The utility of QRSd to predict VT/VF events in patients with CAD requires further prospective evaluation...
Overcoming the defects of a virtue: dual-chamber versus single-chamber detection enhancements for implantable defibrillator rhythm diagnosis: the detect supraventricular tachycardia studyMichael O Sweeney
Circulation 113:2862-4. 2006
A bridge, but to where?Michael O Sweeney
J Cardiovasc Electrophysiol 14:584-6. 2003
A comparison of the output characteristics of several implantable cardioverter-defibrillatorsApiradee Thammanomai
Department of Biomedical Engineering, Boston University, Massachusetts 02215, USA
Heart Rhythm 3:1053-9. 2006..The reporting of ICD output characteristics should be standardized. Additionally, it is recommended that manufacturers report output characteristics as a function of load over the typical range of patient loads clinically encountered...
Delayed presentation of totally avulsed right superior vena cava after extraction of permanent pacemaker leadMarzia Leacche
Pacing Clin Electrophysiol 27:262-3. 2004..The right SVC was found to be almost completely destroyed with only a thin strip of the lateral wall intact and active bleeding. The probable causative mechanisms and surgical management are discussed...
Rules of evidence: CMS and primary prevention of sudden cardiac death in systolic heart failureMichael O Sweeney
Pacing Clin Electrophysiol 28:81-8. 2005
ACC/AHA/HRS 2008 Guidelines for device-based therapy of cardiac rhythm abnormalitiesAndrew E Epstein
Heart Rhythm 5:e1-62. 2008
ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 GuidelineAndrew E Epstein
Circulation 117:e350-408. 2008
Minimizing right ventricular pacingS Serge Barold
University of South Florida College of Medicine and Tampa General Hospital, USA
Am J Cardiol 95:966-9. 2005
