Research Topics
| Subra SureshSummaryAffiliation: Massachusetts Institute of Technology Country: USA Publications
| Collaborators
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Detail Information
Publications
Nanomedicine: elastic clues in cancer detectionSubra Suresh
Nat Nanotechnol 2:748-9. 2007- Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malariaS Suresh
Department of Materials Science and Engineering, and Division of Bioengineering, Massachusetts Institute of Technology, Cambridge, MA 02139 4307, USA
Acta Biomater 1:15-30. 2005..Some general perspectives on connections among structure, single-cell mechanical properties and biological responses associated with pathogenic processes are also provided in the context of the two diseases considered in this work... 
Biomechanics and biophysics of cancer cellsSubra Suresh
Department of Materials Science and Engineering, Division of Biological Engineering, and Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139 4307, USA
Acta Biomater 3:413-38. 2007....- Metabolic remodeling of the human red blood cell membraneYongkeun Park
G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 107:1289-94. 2010.... - Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cellsYongkeun Park
Massachusetts Institute of Technology, G R Harrison Spectroscopy Laboratory, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
J Biomed Opt 15:020506. 2010..Progressive changes to the biophysical properties of the Pf-RBC membrane are captured from dynamic light scattering... - Pf155/RESA protein influences the dynamic microcirculatory behavior of ring-stage Plasmodium falciparum infected red blood cellsMonica Diez-Silva
Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Sci Rep 2:614. 2012.... - A microfabricated deformability-based flow cytometer with application to malariaHansen Bow
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 36 841, Cambridge, MA 02139, USA
Lab Chip 11:1065-73. 2011..These methods collectively provide a systematic approach to characterize the biomechanical properties of cells in a high-throughput manner... - Combined simulation and experimental study of large deformation of red blood cells in microfluidic systemsDavid J Quinn
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
Ann Biomed Eng 39:1041-50. 2011..In particular, we identify a cross-sectional area threshold below which the RBC membrane properties begin to dominate its flow behavior at room temperature; at physiological temperatures this effect is less profound... - Biomechanics of single cortical neuronsKristin B Bernick
Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 4307, USA
Acta Biomater 7:1210-9. 2011..The simulated cell response was calibrated to the experimental measurements under the selected test conditions, providing a novel single cell model that could form the basis for further refinements... - Protection mechanisms of the iron-plated armor of a deep-sea hydrothermal vent gastropodHaimin Yao
Department of Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 107:987-92. 2010..The structure-property-performance relationships described are expected to be of technological interest for a variety of civilian and defense applications... - Nanoscale heterogeneity promotes energy dissipation in boneKuangshin Tai
Department of Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Nat Mater 6:454-62. 2007..The fundamental concepts discovered here are applicable to a broad class of biological materials and may serve as a design consideration for biologically inspired materials technologies... - Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparumYongkeun Park
G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 105:13730-5. 2008..These findings offer potential, and sufficiently general, avenues for identifying, through cell membrane dynamics, pathological states that cause or accompany human diseases... 
Dynamic mechanical response of brain tissue in indentation in vivo, in situ and in vitroThibault P Prevost
Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Acta Biomater 7:4090-101. 2011....- Measuring single-cell densityWilliam H Grover
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 108:10992-6. 2011..These demonstrations suggest that the ability to measure single-cell density will provide valuable insights into cell state for a wide range of biological processes... - Biomechanics of brain tissueThibault P Prevost
Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, 02139, USA
Acta Biomater 7:83-95. 2011..01-3000 s⁻¹), thereby providing a valuable tool for simulations of dynamic transients (impact, blast/shock wave propagation) leading to traumatic brain injury... - Cytoskeletal dynamics of human erythrocyteJu Li
Department of Materials Science and Engineering, Ohio State University, Columbus, OH 43210, USA
Proc Natl Acad Sci U S A 104:4937-42. 2007..These phenomena may have implication for RBC membrane loss and shape change in the context of hereditary hemolytic disorders such as spherocytosis and elliptocytosis... - Effect of plasmodial RESA protein on deformability of human red blood cells harboring Plasmodium falciparumJ P Mills
Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 104:9213-7. 2007..We also show that the effect of RESA on deformability is more pronounced at febrile temperature, which ring-stage parasite-harboring RBCs can be exposed to during a malaria attack, than at normal body temperature... - Spectrin-level modeling of the cytoskeleton and optical tweezers stretching of the erythrocyteJ Li
Department of Materials Science and Engineering, Ohio State University, Columbus, Ohio, USA
Biophys J 88:3707-19. 2005..We have devised and implemented a liquefied network structure evolution algorithm that relaxes shear stress everywhere in the network and generates cytoskeleton structures that mimic experimental observations... - Viscoelasticity of the human red blood cellMarina Puig-de-Morales-Marinkovic
Program in Molecular and Integrative Physiological Sciences MIPS Dept of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
Am J Physiol Cell Physiol 293:C597-605. 2007.... - Crystal deformation: colloid model for atomsSubra Suresh
Nat Mater 5:253-4. 2006