L M Stuart

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome
    W K Eddie Ip
    Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 205:169-81. 2008
  2. pmc Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function
    Anna Sokolovska
    Developmental Immunology and Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 14:543-53. 2013
  3. pmc RhoGTPases--NODes for effector-triggered immunity in animals
    Lynda M Stuart
    Developmental Immunology and Center for Computational and Integrative Biology, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Cell Res 23:980-1. 2013
  4. ncbi Effector-triggered versus pattern-triggered immunity: how animals sense pathogens
    Lynda M Stuart
    Developmental Immunology CCIB, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Rev Immunol 13:199-206. 2013
  5. ncbi Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotype
    Lynda M Stuart
    Laboratory of Developmental Immunology, Harvard Department of Pediatrics, Massachusetts General Hospital, Boston, MA 02114, USA
    J Immunol 174:3220-6. 2005
  6. doi Phagocytosis and comparative innate immunity: learning on the fly
    Lynda M Stuart
    Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02144, USA
    Nat Rev Immunol 8:131-41. 2008
  7. ncbi Collectins: opsonins for apoptotic cells and regulators of inflammation
    Lynda M Stuart
    Laboratory of Developmental Immunology, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Curr Dir Autoimmun 9:143-61. 2006
  8. ncbi A systems biology analysis of the Drosophila phagosome
    L M Stuart
    Laboratory of Developmental Immunology, Massachusetts General Hospital Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nature 445:95-101. 2007
  9. pmc CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer
    Cameron R Stewart
    Lipid Metabolism Unit, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 11:155-61. 2010
  10. pmc Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain
    Lynda M Stuart
    Laboratory of Developmental Immunology, Department of Pediatrics, Harvard Medical School, Boston, MA 02114, USA
    J Cell Biol 170:477-85. 2005

Research Grants

Collaborators

Detail Information

Publications19

  1. pmc Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome
    W K Eddie Ip
    Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 205:169-81. 2008
    ..Furthermore, we demonstrate that this cooperation occurs within the phagosome, emphasizing the importance of engulfment in providing the appropriate cellular environment to facilitate the synergy between these defense pathways...
  2. pmc Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function
    Anna Sokolovska
    Developmental Immunology and Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 14:543-53. 2013
    ..These data provide insight into a mechanism by which innate immune signals can modify cellular defenses and establish a new function for the NLRP3 inflammasome and caspase-1 in host defense...
  3. pmc RhoGTPases--NODes for effector-triggered immunity in animals
    Lynda M Stuart
    Developmental Immunology and Center for Computational and Integrative Biology, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Cell Res 23:980-1. 2013
    ..Interestingly, their findings reveal striking similarities with previous observations made in flies and plants, establishing the evolutionary conservation of this detection system in the innate immune arsenal in many taxa...
  4. ncbi Effector-triggered versus pattern-triggered immunity: how animals sense pathogens
    Lynda M Stuart
    Developmental Immunology CCIB, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Rev Immunol 13:199-206. 2013
    ..Such 'effector-triggered immunity' was previously demonstrated mainly in plants, but recent data confirm that animals can also use this strategy...
  5. ncbi Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotype
    Lynda M Stuart
    Laboratory of Developmental Immunology, Harvard Department of Pediatrics, Massachusetts General Hospital, Boston, MA 02114, USA
    J Immunol 174:3220-6. 2005
    ..Moreover, it demonstrates that failure of apoptotic cell clearance can be dissociated from autoimmunity...
  6. doi Phagocytosis and comparative innate immunity: learning on the fly
    Lynda M Stuart
    Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02144, USA
    Nat Rev Immunol 8:131-41. 2008
    ..As we discuss in this Review, over the past two decades important insights into phagocytosis have been gleaned from studies in the model organism Drosophila melanogaster...
  7. ncbi Collectins: opsonins for apoptotic cells and regulators of inflammation
    Lynda M Stuart
    Laboratory of Developmental Immunology, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Curr Dir Autoimmun 9:143-61. 2006
    ..Here will discuss our current understanding of the process of collectin recognition of dying and damaged cells and its implications for autoimmune and inflammatory diseases...
  8. ncbi A systems biology analysis of the Drosophila phagosome
    L M Stuart
    Laboratory of Developmental Immunology, Massachusetts General Hospital Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nature 445:95-101. 2007
    ....
  9. pmc CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer
    Cameron R Stewart
    Lipid Metabolism Unit, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 11:155-61. 2010
    ....
  10. pmc Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain
    Lynda M Stuart
    Laboratory of Developmental Immunology, Department of Pediatrics, Harvard Medical School, Boston, MA 02114, USA
    J Cell Biol 170:477-85. 2005
    ..aureus in vivo resulting in profound bacteraemia. Thus, response to S. aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain, which initiates TLR2/6 signaling...
  11. pmc Identification of Drosophila Yin and PEPT2 as evolutionarily conserved phagosome-associated muramyl dipeptide transporters
    Guillaume M Charriere
    Developmental Immunology, Massachusetts General Hospital Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA
    J Biol Chem 285:20147-54. 2010
    ....
  12. ncbi Phagocytosis: elegant complexity
    Lynda M Stuart
    Laboratory of Developmental Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Immunity 22:539-50. 2005
    ..We also indicate an important role for genetically tractable model organisms in defining key components of this evolutionarily conserved process...
  13. pmc Deficiency of mannose-binding lectin greatly increases antibody response in a mouse model of vaccination
    Hilde Kari Guttormsen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Clin Immunol 130:264-71. 2009
    ..B1 cells were expanded in peritonium but not in spleen of MBL null mice. The mechanisms of heightened IgG response in MBL null mice were related to C3, and share the same pathway with IgM...
  14. pmc Phagocytosis and phagosome acidification are required for pathogen processing and MyD88-dependent responses to Staphylococcus aureus
    W K Eddie Ip
    Developmental Immunology and Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02144, USA
    J Immunol 184:7071-81. 2010
    ..aureus...
  15. ncbi CD36 signals to the actin cytoskeleton and regulates microglial migration via a p130Cas complex
    Lynda M Stuart
    Developmental Immunology Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    J Biol Chem 282:27392-401. 2007
    ..Together, these data are the first to identify the signaling cascade that directly links CD36 to the actin cytoskeleton and, thus, implicates it in diverse processes such as cellular migration, adhesion, and phagocytosis...
  16. ncbi Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila
    Christine Kocks
    Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cell 123:335-46. 2005
    ..Our results suggest that Eater is a major phagocytic receptor for a broad range of bacterial pathogens in Drosophila and provide a powerful model to address the role of phagocytosis in vivo...
  17. ncbi Requirements for apoptotic cell contact in regulation of macrophage responses
    Mark Lucas
    Medical Research Council University of Edinburgh Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Immunol 177:4047-54. 2006
    ..We conclude that the profound suppression of LPS-driven TNF-alpha release by macrophage populations requires hitherto obscure contact-dependent licensing of macrophage responsiveness to TGF-beta by apoptotic cells...
  18. ncbi Inhibitory effects of apoptotic cell ingestion upon endotoxin-driven myeloid dendritic cell maturation
    Lynda M Stuart
    Medical Research Council Center for Inflammation Research, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    J Immunol 168:1627-35. 2002
    ....
  19. ncbi Apoptotic cells and innate immune stimuli combine to regulate macrophage cytokine secretion
    Mark Lucas
    University of Edinburgh MRC Center for Inflammation Research, University of Edinburgh, College of Medicine and Veterinary Medicine, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    J Immunol 171:2610-5. 2003
    ....

Research Grants4

  1. The role of the phagosome in innate immune sensing
    Lynda Stuart; Fiscal Year: 2010
    ..Moreover, this process of phagocytosis is essential for our host defense to be fully activated. We propose to study the role phagocytosis in sensing of bacterial invasion and induction of our normal immune defense. ..
  2. The role of the phagosome in innate immune sensing
    Lynda Stuart; Fiscal Year: 2009
    ..Moreover, this process of phagocytosis is essential for our host defense to be fully activated. We propose to study the role phagocytosis in sensing of bacterial invasion and induction of our normal immune defense. ..
  3. The role of the phagosome in innate immune sensing
    Lynda Stuart; Fiscal Year: 2010
    ..Moreover, this process of phagocytosis is essential for our host defense to be fully activated. We propose to study the role phagocytosis in sensing of bacterial invasion and induction of our normal immune defense. ..