Research Topics
Genomes and Genes
| James R StoneSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
An assessment of proposed mechanisms for sensing hydrogen peroxide in mammalian systemsJames R Stone
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Arch Biochem Biophys 422:119-24. 2004....
Aortitis, periaortitis, and retroperitoneal fibrosis, as manifestations of IgG4-related systemic diseaseJames R Stone
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Curr Opin Rheumatol 23:88-94. 2011..This review will focus on IgG4-related systemic disease as a cause of thoracic aortitis, inflammatory abdominal aortic aneurysm or periaortitis, and retroperitoneal fibrosis...- Intimal hyperplasia in the distal ulnar artery; Influence of gender and implications for the hypothenar hammer syndromeJames R Stone
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Warren 501B, 55 Fruit Street, Boston, MA 02114, USA
Cardiovasc Pathol 13:20-5. 2004..Since the trauma-inducing activities associated with the HHS are common, the histopathology of this arterial segment in our autopsy population was evaluated... - Hydrogen peroxide: a signaling messengerJames R Stone
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Antioxid Redox Signal 8:243-70. 2006..Application of physiologic levels of H2O2 to mammalian cells has been shown to stimulate biological responses and to activate specific biochemical pathways in these cells... - IgG4-related systemic disease accounts for a significant proportion of thoracic lymphoplasmacytic aortitis casesJohn H Stone
Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Arthritis Care Res (Hoboken) 62:316-22. 2010..We aimed to determine the percentage of noninfectious thoracic aortitis cases that are associated with IgG4-related systemic disease and to establish pathologic criteria for identifying involvement of the thoracic aorta by this disorder... - The role of hydrogen peroxide in endothelial proliferative responsesJames R Stone
Department of Pathology, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Endothelium 9:231-8. 2002..Recently a functional proteomics approach has been utilized to identify proteins responsive to low concentrations of H2O2 in human endothelial cells... - Basal and hydrogen peroxide stimulated sites of phosphorylation in heterogeneous nuclear ribonucleoprotein C1/C2James R Stone
Department of Pathology, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Biochemistry 42:1301-8. 2003.... - Recommendations for processing cardiovascular surgical pathology specimens: a consensus statement from the Standards and Definitions Committee of the Society for Cardiovascular Pathology and the Association for European Cardiovascular PathologyJames R Stone
Massachusetts General Hospital, Boston, MA 02114, USA
Cardiovasc Pathol 21:2-16. 2012..This report is presented to aid pathologists, pathology assistants, and clinicians in maximizing the diagnostic utility of cardiovascular surgical pathology specimens for enhanced patient care... 
Neuregulin-1 attenuated doxorubicin-induced decrease in cardiac troponinsYun Bian
Cardiovascular Research, Caritas St Elizabeth s Medical Center, 736 Cambridge St CBR3, Boston, MA 02135, USA
Am J Physiol Heart Circ Physiol 297:H1974-83. 2009..NRG1 maintains cardiac troponins by the erbB2-PI3K pathway, which may lessen Dox-induced cardiac dysfunction...- Molecular profiling of the role of the NF-kappaB family of transcription factors during alloimmunityPatricia W Finn
Pulmonary Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Leukoc Biol 72:1054-62. 2002.... - Protein kinase CK1alpha regulates mRNA binding by heterogeneous nuclear ribonucleoprotein C in response to physiologic levels of hydrogen peroxideTaj Kattapuram
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Biol Chem 280:15340-7. 2005..In contrast, hnRNP-C1 that was also modified at the CK1alpha phosphorylation sites exhibited a 14-500-fold decrease in binding affinity, demonstrating that CK1alpha-mediated phosphorylation modulates the mRNA binding ability of hnRNP-C... - Caveolin-1 ablation reduces the adverse cardiovascular effects of N-omega-nitro-L-arginine methyl ester and angiotensin IILuminita H Pojoga
Brigham and Women s Hospital Harvard Medical School, Department of Endocrinology, Diabetes, and Hypertension, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
Endocrinology 151:1236-46. 2010..WT mice, consistent with decreased MR signaling in the cav-1 KO. Thus, we conclude that the L-NAME/AngII-induced biventricular damage is mediated by a mechanism partially dependent on cav-1 and signaling via MR/ALDO... - Estradiol increases angiotensin II type 1 receptor in hearts of ovariectomized ratsVincent Ricchiuti
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Endocrinol 200:75-84. 2009..In summary, E(2) treatment increased cardiac expression of AT(1)R as well as the expression of pro-inflammatory and prothrombotic factors... - Mammalian SCAN domain dimer is a domain-swapped homolog of the HIV capsid C-terminal domainDmitri Ivanov
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
Mol Cell 17:137-43. 2005..In the SCAN-like dimer, the MHR contributes the major part of the large intertwined dimer interface explaining its functional significance... - Risk factors for atherosclerosis and the development of preatherosclerotic intimal hyperplasiaStephanie M Cizek
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Cardiovasc Pathol 16:344-50. 2007..To gain insight into the etiology of preatherosclerotic intimal hyperplasia, we correlated traditional risk factors for atherosclerosis with the intimal hyperplasia in an atherosclerosis-resistant vessel, the internal thoracic artery... - Analysis of robust innate immune response after transplantation in the absence of adaptive immunityHongzhen He
Laboratory of Molecular Immunology, Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Transplantation 73:853-61. 2002..CONCLUSIONS: Our study demonstrated a robust innate immune response that is independent of adaptive immunity and natural killer cell responses... - Analysis of differential immune responses induced by innate and adaptive immunity following transplantationHongzhen He
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Immunology 109:185-96. 2003.... - Regulation of protein kinase CK1alphaLS by dephosphorylation in response to hydrogen peroxideShahinaz Bedri
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Simches Research Building, Boston, MA 02114, USA
Arch Biochem Biophys 466:242-9. 2007..These observations indicate that CK1alphaLS and hnRNP-C represent conserved components of a vertebrate-specific H(2)O(2)-responsive nuclear signaling pathway... - Up-regulation of a hydrogen peroxide-responsive pre-mRNA binding protein in atherosclerosis and intimal hyperplasiaMikhail P Panchenko
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Cardiovasc Pathol 18:167-72. 2009..The expression of hnRNP-C in human arteries has not previously been assessed... - Protein kinase CK1alphaLS promotes vascular cell proliferation and intimal hyperplasiaMikhail P Panchenko
Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Pathol 177:1562-72. 2010..Our results indicate that the nuclear form of CK1alpha in humans, CK1alphaLS, plays a critical role in vascular cell proliferation, cellular activation, and hydrogen peroxide-mediated mitogenic signal transduction... - Direct tissue evaluation via immunofluorescence: in the diagnosis of hereditary transthyretin cardiac amyloidosisMichael G Fradley
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Tex Heart Inst J 39:71-5. 2012..This case highlights the importance-in the diagnostic algorithm of cardiac amyloidosis-of direct evaluation of the tissue with immunofluorescence and of genetic testing... - Rapid phosphorylation of heterogeneous nuclear ribonucleoprotein C1/C2 in response to physiologic levels of hydrogen peroxide in human endothelial cellsJames R Stone
Department of Pathology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 277:15621-8. 2002..The effects were observed with as little as 1 microm H(2)O(2) and were maximal with 5-8 microm H(2)O(2). The H(2)O(2)-stimulated phosphorylation was inhibited by catalase, but not by the transcriptional inhibitor actinomycin D... - Case records of the Massachusetts General Hospital. Case 37-2007. A 47-year-old man with left ventricular dysfunction after heart transplantationMarc J Semigran
Cardiology Division, Massachusetts General Hospital, USA
N Engl J Med 357:2286-97. 2007 - Myeloperoxidase-rich Ly-6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in miceFilip K Swirski
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
J Clin Invest 120:2627-34. 2010..Thus, MPO imaging represents a potential alternative to the current invasive clinical standard by which transplants are monitored... - Case records of the Massachusetts General Hospital. Case 36-2007. A 31-year-old woman with rash, fever, and hypotensionMarc S Sabatine
Cardiovascular Division, Brigham and Women's Hospital, Boston, USA
N Engl J Med 357:2167-78. 2007 - The SCAN domain defines a large family of zinc finger transcription factorsTara L Sander
Department of Pathology, Children's Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Gene 310:29-38. 2003..Collectively, these studies define a large family of vertebrate-specific transcriptional regulators that may have rapidly expanded during recent evolution... - Case records of the Massachusetts General Hospital. Case 28-2007. A 68-year-old man with syncopeJames L Januzzi
Coronary Care Unit, Massachusetts General Hospital, USA
N Engl J Med 357:1137-45. 2007 - Classification of amyloid deposits in diagnostic cardiac specimens by immunofluorescenceA Bernard Collins
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Cardiovasc Pathol 18:205-16. 2009..Immunofluorescence staining on fresh frozen tissue is generally considered superior to immunoperoxidase staining for subtyping amyloid; however, this technique has not previously been reported in a series of cardiac specimens... - IgG4-related systemic disease and lymphoplasmacytic aortitisJohn H Stone
rhumatology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
Arthritis Rheum 60:3139-45. 2009..Treatment of the aortitis may prevent progression of the IgG4-related systemic disease to involvement of other organs. IgG4-related systemic disease should be considered in all patients with aortitis judged to be of unknown etiology... - Whole-slide imaging digital pathology as a platform for teleconsultation: a pilot study using paired subspecialist correlationsDavid C Wilbur
Department of Pathology, James Homer Wright Pathology Laboratories, Massachusetts General Hospital, and the Department of Pathology, Harvard Medical School, Boston, MA 02114, USA
Arch Pathol Lab Med 133:1949-53. 2009..Before implementation, technical issues, pathologist adaptability, and morphologic pitfalls must be well characterized... - Consensus statement on the pathology of IgG4-related diseaseVikram Deshpande
Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
Mod Pathol 25:1181-92. 2012..As the spectrum of this disease continues to expand, we advocate the use of strict criteria for accepting newly proposed entities or sites as components of the IgG4-related disease spectrum... - Aldosterone and not plasminogen activator inhibitor-1 is a critical mediator of early angiotensin II/NG-nitro-L-arginine methyl ester-induced myocardial injuryEveline M Oestreicher
Division of Endocrinology, Hypertension and Diabetes, Department of Medicine, Brigham and Women s Hospital, 221 Longwood Ave, Boston, Mass 02115, USA
Circulation 108:2517-23. 2003.... - Tongue necrosis and systemic vascular amyloidosisJames R Lin
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Hum Pathol 42:734-7. 2011..To our knowledge, this is the first report of ischemic tongue necrosis resulting from vascular amyloidosis... - Imaging findings of pericardial metastasis on chest computed tomographyPriyanka Prakash
Division of Thoracic Radiology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Comput Assist Tomogr 34:554-8. 2010..To assess imaging features of pericardial metastases on chest computed tomography (CT) scanning... - Analysis of intimal proteoglycans in atherosclerosis-prone and atherosclerosis-resistant human arteries by mass spectrometryPaul Talusan
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Mol Cell Proteomics 4:1350-7. 2005..The enhanced deposition of lumican in the intima of an atherosclerosis prone artery has important implications for the pathogenesis of atherosclerosis... - The SCAN domain of ZNF174 is a dimerJames R Stone
Department of Pathology, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 277:5448-52. 2002.... - Case records of the Massachusetts General Hospital. Case 15-2005. An 80-year-old man with shortness of breath, edema, and proteinuriaLaura M Dember
Renal Section, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, USA
N Engl J Med 352:2111-9. 2005 - Case records of the Massachusetts General Hospital. Case 34-2006. A 72-year-old woman with nausea followed by hypotension and respiratory failurePaula A Johnson
Division of Women's Health, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, USA
N Engl J Med 355:2022-31. 2006 - Case records of the Massachusetts General Hospital. Case 3-2007. A 3-year-old boy with recurrent episodes of respiratory insufficiencyDebra Boyer
Division of Respiratory Diseases, Children's Hospital, Harvard Medical School, Boston, USA
N Engl J Med 356:398-407. 2007 - Dense IgG4 plasma cell infiltrates associated with chronic infectious aortitis: implications for the diagnosis of IgG4-related diseaseZakir Siddiquee
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston MA, 02114, USA
Cardiovasc Pathol 21:470-5. 2012..Chronic infectious aortitis can also display lymphoplasmacytic infiltrates, but the degree of IgG4 expression in these cases has not been specifically evaluated... - Myocardial infarction accelerates atherosclerosisPartha Dutta
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Nature 487:325-9. 2012..The progenitors then seeded the spleen, yielding a sustained boost in monocyte production. These observations provide new mechanistic insight into atherogenesis and provide a novel therapeutic opportunity to mitigate disease progression... - Case records of the Massachusetts General Hospital. Case 31-2008. A 39-year-old man with chest pain, arthralgias, and a mediastinal massPeter A Merkel
Arthritis Center, Boston Medical Center, and the Department of Medicine, Boston University School of Medicine, Boston, USA
N Engl J Med 359:1603-14. 2008 - Rapid fatty acid ethyl ester synthesis by porcine myocardium upon ethanol infusion into the left anterior descending coronary arteryDanita M Yoerger
Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Pathol 168:1435-42. 2006..These data demonstrate that FAEEs may be mediators of ethanol-induced cardiotoxicity... - Case records of the Massachusetts General Hospital. Case 4-2006. A 79-year-old woman with myalgias, fatigue, and shortness of breathJonathan Kay
Department of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, USA
N Engl J Med 354:623-30. 2006 - Heterozygous knockout of neuregulin-1 gene in mice exacerbates doxorubicin-induced heart failureFen Fen Liu
Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Rm SL 221, Boston, MA 02215, USA
Am J Physiol Heart Circ Physiol 289:H660-6. 2005..This is associated with the depression of activation of the erbB2 receptor as well as Akt, p70S6K, and ERK-1/2 pathways... - Case records of the Massachusetts General Hospital. Case 23-2006. A 36-year-old man with numbness in the left [corrected] hand and hypertensionOthon Iliopoulos
Cancer Center, Massachusetts General Hospital, USA
N Engl J Med 355:394-402. 2006 - New treatment strategies in large-vessel vasculitisSebastian Unizony
Rheumatology Unit, Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Center for Systems BiologyMassachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Curr Opin Rheumatol 25:3-9. 2013..This review summarizes the available evidence for new treatment strategies in this spectrum of diseases... - Case records of the Massachusetts General Hospital. Case 26-2005. A 48-year-old man with sudden loss of consciousness while joggingWilliam D Binder
Emergency Services, Massachusetts General Hospital, USA
N Engl J Med 353:824-32. 2005 - Prolonged allograft survival in TNF receptor 1-deficient recipients is due to immunoregulatory effects, not to inhibition of direct antigraft cytotoxicityCharlotte M McKee
Laboratory of Molecular Immunology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
J Immunol 168:483-9. 2002..These findings indicate that in our experimental system TNF-alpha and LTalpha exert profound immunoregulatory effects through TNF-R1... - External iliac artery endofibrosis in an amateur runner: hemodynamic, angiographic, histopathological evaluation and percutaneous revascularizationAndrew O Maree
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Vasc Med 12:203-6. 2007..The diagnosis was made by a combination of hemodynamic, angiographic and histopathological assessment and percutaneous revascularization was performed using a balloon expandable stent... - Coronary artery perforation by cutting balloon resulting in dissecting subepicardial hematoma and avulsion of the vasculatureVu H Quan
Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Catheter Cardiovasc Interv 64:163-8. 2005..This was complicated by a subepicardial hematoma leading to avulsion of the penetrating arteries and cardiogenic shock. Despite surgical evacuation and percutaneous left ventricular assist-device support, death ensued... - Mutant mouse models reveal the relative roles of E2F1 and E2F3 in vivoJennifer E Cloud
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Mol Cell Biol 22:2663-72. 2002..These data strongly suggest that tumor suppression is a specific property of E2F1 and not E2F3... - A comparison of adenosine A2A agonism and methylprednisolone in attenuating neuronal damage and improving functional outcome after experimental traumatic spinal cord injury in rabbitsDavid O Okonkwo
Department of Neurological Surgery, University of Virginia Health System, Charlottesville 22908 0212, USA
J Neurosurg Spine 4:64-70. 2006..The authors of this study evaluated ATL-146e and methylprednisolone for their ability to preserve neuronal viability and motor function in experimental SCI... - Traumatically induced axotomy adjacent to the soma does not result in acute neuronal deathRichard H Singleton
Departments of Anatomy and Anesthesiology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298, USA
J Neurosci 22:791-802. 2002..Rather, some somata showed evidence of potential reorganization and repair. This study demonstrates a novel somatic response to TAI in the perisomatic domain and also provides insight into the multifaceted pathology associated with TBI... - Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clustersAndrea Ventura
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cell 132:875-86. 2008..These results provide key insights into the physiologic functions of this family of microRNAs and suggest a link between the oncogenic properties of miR-17 approximately 92 and its functions during B lymphopoiesis and lung development...
Research Grants
- Hydrogen Peroxide Sensing by Human Endothelial CellsJames Stone; Fiscal Year: 2006..3) Identify and characterize additional protein modifications stimulated by low concentrations of H202, and use this information to establish signaling pathways for sensing H202 in human endothelial cells. ..