James R Stone

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Basal and hydrogen peroxide stimulated sites of phosphorylation in heterogeneous nuclear ribonucleoprotein C1/C2
    James R Stone
    Department of Pathology, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biochemistry 42:1301-8. 2003
  2. ncbi request reprint Intimal hyperplasia in the distal ulnar artery; Influence of gender and implications for the hypothenar hammer syndrome
    James R Stone
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Warren 501B, 55 Fruit Street, Boston, MA 02114, USA
    Cardiovasc Pathol 13:20-5. 2004
  3. ncbi request reprint An assessment of proposed mechanisms for sensing hydrogen peroxide in mammalian systems
    James R Stone
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Arch Biochem Biophys 422:119-24. 2004
  4. doi request reprint IgG4-related systemic disease accounts for a significant proportion of thoracic lymphoplasmacytic aortitis cases
    John H Stone
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Arthritis Care Res (Hoboken) 62:316-22. 2010
  5. ncbi request reprint The role of hydrogen peroxide in endothelial proliferative responses
    James R Stone
    Department of Pathology, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Endothelium 9:231-8. 2002
  6. ncbi request reprint Hydrogen peroxide: a signaling messenger
    James R Stone
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Antioxid Redox Signal 8:243-70. 2006
  7. doi request reprint Recommendations for processing cardiovascular surgical pathology specimens: a consensus statement from the Standards and Definitions Committee of the Society for Cardiovascular Pathology and the Association for European Cardiovascular Pathology
    James R Stone
    Massachusetts General Hospital, Boston, MA 02114, USA
    Cardiovasc Pathol 21:2-16. 2012
  8. doi request reprint Aortitis, periaortitis, and retroperitoneal fibrosis, as manifestations of IgG4-related systemic disease
    James R Stone
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin Rheumatol 23:88-94. 2011
  9. pmc Neuregulin-1 attenuated doxorubicin-induced decrease in cardiac troponins
    Yun Bian
    Cardiovascular Research, Caritas St Elizabeth s Medical Center, 736 Cambridge St CBR3, Boston, MA 02135, USA
    Am J Physiol Heart Circ Physiol 297:H1974-83. 2009
  10. ncbi request reprint Protein kinase CK1alpha regulates mRNA binding by heterogeneous nuclear ribonucleoprotein C in response to physiologic levels of hydrogen peroxide
    Taj Kattapuram
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 280:15340-7. 2005

Detail Information

Publications59

  1. ncbi request reprint Basal and hydrogen peroxide stimulated sites of phosphorylation in heterogeneous nuclear ribonucleoprotein C1/C2
    James R Stone
    Department of Pathology, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biochemistry 42:1301-8. 2003
    ....
  2. ncbi request reprint Intimal hyperplasia in the distal ulnar artery; Influence of gender and implications for the hypothenar hammer syndrome
    James R Stone
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Warren 501B, 55 Fruit Street, Boston, MA 02114, USA
    Cardiovasc Pathol 13:20-5. 2004
    ..Since the trauma-inducing activities associated with the HHS are common, the histopathology of this arterial segment in our autopsy population was evaluated...
  3. ncbi request reprint An assessment of proposed mechanisms for sensing hydrogen peroxide in mammalian systems
    James R Stone
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Arch Biochem Biophys 422:119-24. 2004
    ....
  4. doi request reprint IgG4-related systemic disease accounts for a significant proportion of thoracic lymphoplasmacytic aortitis cases
    John H Stone
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Arthritis Care Res (Hoboken) 62:316-22. 2010
    ..We aimed to determine the percentage of noninfectious thoracic aortitis cases that are associated with IgG4-related systemic disease and to establish pathologic criteria for identifying involvement of the thoracic aorta by this disorder...
  5. ncbi request reprint The role of hydrogen peroxide in endothelial proliferative responses
    James R Stone
    Department of Pathology, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Endothelium 9:231-8. 2002
    ..Recently a functional proteomics approach has been utilized to identify proteins responsive to low concentrations of H2O2 in human endothelial cells...
  6. ncbi request reprint Hydrogen peroxide: a signaling messenger
    James R Stone
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Antioxid Redox Signal 8:243-70. 2006
    ..Application of physiologic levels of H2O2 to mammalian cells has been shown to stimulate biological responses and to activate specific biochemical pathways in these cells...
  7. doi request reprint Recommendations for processing cardiovascular surgical pathology specimens: a consensus statement from the Standards and Definitions Committee of the Society for Cardiovascular Pathology and the Association for European Cardiovascular Pathology
    James R Stone
    Massachusetts General Hospital, Boston, MA 02114, USA
    Cardiovasc Pathol 21:2-16. 2012
    ..This report is presented to aid pathologists, pathology assistants, and clinicians in maximizing the diagnostic utility of cardiovascular surgical pathology specimens for enhanced patient care...
  8. doi request reprint Aortitis, periaortitis, and retroperitoneal fibrosis, as manifestations of IgG4-related systemic disease
    James R Stone
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin Rheumatol 23:88-94. 2011
    ..This review will focus on IgG4-related systemic disease as a cause of thoracic aortitis, inflammatory abdominal aortic aneurysm or periaortitis, and retroperitoneal fibrosis...
  9. pmc Neuregulin-1 attenuated doxorubicin-induced decrease in cardiac troponins
    Yun Bian
    Cardiovascular Research, Caritas St Elizabeth s Medical Center, 736 Cambridge St CBR3, Boston, MA 02135, USA
    Am J Physiol Heart Circ Physiol 297:H1974-83. 2009
    ..NRG1 maintains cardiac troponins by the erbB2-PI3K pathway, which may lessen Dox-induced cardiac dysfunction...
  10. ncbi request reprint Protein kinase CK1alpha regulates mRNA binding by heterogeneous nuclear ribonucleoprotein C in response to physiologic levels of hydrogen peroxide
    Taj Kattapuram
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 280:15340-7. 2005
    ..In contrast, hnRNP-C1 that was also modified at the CK1alpha phosphorylation sites exhibited a 14-500-fold decrease in binding affinity, demonstrating that CK1alpha-mediated phosphorylation modulates the mRNA binding ability of hnRNP-C...
  11. pmc Caveolin-1 ablation reduces the adverse cardiovascular effects of N-omega-nitro-L-arginine methyl ester and angiotensin II
    Luminita H Pojoga
    Brigham and Women s Hospital Harvard Medical School, Department of Endocrinology, Diabetes, and Hypertension, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    Endocrinology 151:1236-46. 2010
    ..WT mice, consistent with decreased MR signaling in the cav-1 KO. Thus, we conclude that the L-NAME/AngII-induced biventricular damage is mediated by a mechanism partially dependent on cav-1 and signaling via MR/ALDO...
  12. ncbi request reprint Molecular profiling of the role of the NF-kappaB family of transcription factors during alloimmunity
    Patricia W Finn
    Pulmonary Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Leukoc Biol 72:1054-62. 2002
    ....
  13. ncbi request reprint Analysis of robust innate immune response after transplantation in the absence of adaptive immunity
    Hongzhen He
    Laboratory of Molecular Immunology, Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Transplantation 73:853-61. 2002
    ..During transplantation, innate immunity may be stimulated by multiple factors, including ischemia, reperfusion, sterile injury, systemic stress, and cell death...
  14. pmc Risk factors for atherosclerosis and the development of preatherosclerotic intimal hyperplasia
    Stephanie M Cizek
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Cardiovasc Pathol 16:344-50. 2007
    ..To gain insight into the etiology of preatherosclerotic intimal hyperplasia, we correlated traditional risk factors for atherosclerosis with the intimal hyperplasia in an atherosclerosis-resistant vessel, the internal thoracic artery...
  15. pmc Estradiol increases angiotensin II type 1 receptor in hearts of ovariectomized rats
    Vincent Ricchiuti
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Endocrinol 200:75-84. 2009
    ..In summary, E(2) treatment increased cardiac expression of AT(1)R as well as the expression of pro-inflammatory and prothrombotic factors...
  16. ncbi request reprint Mammalian SCAN domain dimer is a domain-swapped homolog of the HIV capsid C-terminal domain
    Dmitri Ivanov
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Mol Cell 17:137-43. 2005
    ..In the SCAN-like dimer, the MHR contributes the major part of the large intertwined dimer interface explaining its functional significance...
  17. pmc Analysis of differential immune responses induced by innate and adaptive immunity following transplantation
    Hongzhen He
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Immunology 109:185-96. 2003
    ....
  18. pmc Protein kinase CK1alphaLS promotes vascular cell proliferation and intimal hyperplasia
    Mikhail P Panchenko
    Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Pathol 177:1562-72. 2010
    ..Our results indicate that the nuclear form of CK1alpha in humans, CK1alphaLS, plays a critical role in vascular cell proliferation, cellular activation, and hydrogen peroxide-mediated mitogenic signal transduction...
  19. pmc Up-regulation of a hydrogen peroxide-responsive pre-mRNA binding protein in atherosclerosis and intimal hyperplasia
    Mikhail P Panchenko
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Cardiovasc Pathol 18:167-72. 2009
    ..The expression of hnRNP-C in human arteries has not previously been assessed...
  20. pmc Regulation of protein kinase CK1alphaLS by dephosphorylation in response to hydrogen peroxide
    Shahinaz Bedri
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Simches Research Building, Boston, MA 02114, USA
    Arch Biochem Biophys 466:242-9. 2007
    ..These observations indicate that CK1alphaLS and hnRNP-C represent conserved components of a vertebrate-specific H(2)O(2)-responsive nuclear signaling pathway...
  21. doi request reprint Dense IgG4 plasma cell infiltrates associated with chronic infectious aortitis: implications for the diagnosis of IgG4-related disease
    Zakir Siddiquee
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston MA, 02114, USA
    Cardiovasc Pathol 21:470-5. 2012
    ..Chronic infectious aortitis can also display lymphoplasmacytic infiltrates, but the degree of IgG4 expression in these cases has not been specifically evaluated...
  22. pmc Direct tissue evaluation via immunofluorescence: in the diagnosis of hereditary transthyretin cardiac amyloidosis
    Michael G Fradley
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Tex Heart Inst J 39:71-5. 2012
    ..This case highlights the importance-in the diagnostic algorithm of cardiac amyloidosis-of direct evaluation of the tissue with immunofluorescence and of genetic testing...
  23. ncbi request reprint Case records of the Massachusetts General Hospital. Case 37-2007. A 47-year-old man with left ventricular dysfunction after heart transplantation
    Marc J Semigran
    Cardiology Division, Massachusetts General Hospital, USA
    N Engl J Med 357:2286-97. 2007
  24. pmc Myeloperoxidase-rich Ly-6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in mice
    Filip K Swirski
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 120:2627-34. 2010
    ..Thus, MPO imaging represents a potential alternative to the current invasive clinical standard by which transplants are monitored...
  25. ncbi request reprint Rapid phosphorylation of heterogeneous nuclear ribonucleoprotein C1/C2 in response to physiologic levels of hydrogen peroxide in human endothelial cells
    James R Stone
    Department of Pathology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:15621-8. 2002
    ..The effects were observed with as little as 1 microm H(2)O(2) and were maximal with 5-8 microm H(2)O(2). The H(2)O(2)-stimulated phosphorylation was inhibited by catalase, but not by the transcriptional inhibitor actinomycin D...
  26. ncbi request reprint The SCAN domain defines a large family of zinc finger transcription factors
    Tara L Sander
    Department of Pathology, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Gene 310:29-38. 2003
    ..Collectively, these studies define a large family of vertebrate-specific transcriptional regulators that may have rapidly expanded during recent evolution...
  27. ncbi request reprint Case records of the Massachusetts General Hospital. Case 36-2007. A 31-year-old woman with rash, fever, and hypotension
    Marc S Sabatine
    Cardiovascular Division, Brigham and Women s Hospital, Boston, USA
    N Engl J Med 357:2167-78. 2007
  28. ncbi request reprint Case records of the Massachusetts General Hospital. Case 28-2007. A 68-year-old man with syncope
    James L Januzzi
    Coronary Care Unit, Massachusetts General Hospital, USA
    N Engl J Med 357:1137-45. 2007
  29. ncbi request reprint Classification of amyloid deposits in diagnostic cardiac specimens by immunofluorescence
    A Bernard Collins
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Cardiovasc Pathol 18:205-16. 2009
    ..Immunofluorescence staining on fresh frozen tissue is generally considered superior to immunoperoxidase staining for subtyping amyloid; however, this technique has not previously been reported in a series of cardiac specimens...
  30. ncbi request reprint Imaging findings of pericardial metastasis on chest computed tomography
    Priyanka Prakash
    Division of Thoracic Radiology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Comput Assist Tomogr 34:554-8. 2010
    ..To assess imaging features of pericardial metastases on chest computed tomography (CT) scanning...
  31. ncbi request reprint IgG4-related systemic disease and lymphoplasmacytic aortitis
    John H Stone
    rhumatology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Arthritis Rheum 60:3139-45. 2009
    ..Treatment of the aortitis may prevent progression of the IgG4-related systemic disease to involvement of other organs. IgG4-related systemic disease should be considered in all patients with aortitis judged to be of unknown etiology...
  32. pmc Whole-slide imaging digital pathology as a platform for teleconsultation: a pilot study using paired subspecialist correlations
    David C Wilbur
    Department of Pathology, James Homer Wright Pathology Laboratories, Massachusetts General Hospital, and the Department of Pathology, Harvard Medical School, Boston, MA 02114, USA
    Arch Pathol Lab Med 133:1949-53. 2009
    ..Before implementation, technical issues, pathologist adaptability, and morphologic pitfalls must be well characterized...
  33. doi request reprint Altered vascular activation due to deficiency of the NADPH oxidase component p22phox
    He Wang
    Center for Systems Biology, Massachusetts General Hospital and Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Cardiovasc Pathol 23:35-42. 2014
    ..The p22(phox) subunit is necessary for the activity of NADPH oxidase complexes utilizing Nox1, Nox2, Nox3, and Nox4 catalytic subunits...
  34. ncbi request reprint Consensus statement on the pathology of IgG4-related disease
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Mod Pathol 25:1181-92. 2012
    ..As the spectrum of this disease continues to expand, we advocate the use of strict criteria for accepting newly proposed entities or sites as components of the IgG4-related disease spectrum...
  35. ncbi request reprint Aldosterone and not plasminogen activator inhibitor-1 is a critical mediator of early angiotensin II/NG-nitro-L-arginine methyl ester-induced myocardial injury
    Eveline M Oestreicher
    Division of Endocrinology, Hypertension and Diabetes, Department of Medicine, Brigham and Women s Hospital, 221 Longwood Ave, Boston, Mass 02115, USA
    Circulation 108:2517-23. 2003
    ....
  36. ncbi request reprint Case records of the Massachusetts General Hospital. Case 15-2005. An 80-year-old man with shortness of breath, edema, and proteinuria
    Laura M Dember
    Renal Section, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, USA
    N Engl J Med 352:2111-9. 2005
  37. doi request reprint Tongue necrosis and systemic vascular amyloidosis
    James R Lin
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Hum Pathol 42:734-7. 2011
    ..To our knowledge, this is the first report of ischemic tongue necrosis resulting from vascular amyloidosis...
  38. pmc Analysis of intimal proteoglycans in atherosclerosis-prone and atherosclerosis-resistant human arteries by mass spectrometry
    Paul Talusan
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Mol Cell Proteomics 4:1350-7. 2005
    ..The enhanced deposition of lumican in the intima of an atherosclerosis prone artery has important implications for the pathogenesis of atherosclerosis...
  39. ncbi request reprint Case records of the Massachusetts General Hospital. Case 3-2007. A 3-year-old boy with recurrent episodes of respiratory insufficiency
    Debra Boyer
    Division of Respiratory Diseases, Children s Hospital, Harvard Medical School, Boston, USA
    N Engl J Med 356:398-407. 2007
  40. ncbi request reprint Case records of the Massachusetts General Hospital. Case 34-2006. A 72-year-old woman with nausea followed by hypotension and respiratory failure
    Paula A Johnson
    Division of Women s Health, Brigham and Women s Hospital, Massachusetts General Hospital, Boston, USA
    N Engl J Med 355:2022-31. 2006
  41. pmc The SCAN domain of ZNF174 is a dimer
    James R Stone
    Department of Pathology, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:5448-52. 2002
    ....
  42. ncbi request reprint Giant cell arteritis causing symmetric bilateral posterior circulation infarcts
    Devin D Mackay
    From the Departments of Neurology and Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA
    J Clin Rheumatol 19:393-6. 2013
    ..Her unusual symptomatic, laboratory, and imaging presentation highlights the importance of considering GCA in the differential diagnosis of unusual bilateral stroke syndromes, where early treatment decreases morbid outcomes. ..
  43. ncbi request reprint Extracellular traps in lipid-rich lesions of carotid atherosclerotic plaques: implications for lipoprotein retention and lesion progression
    Rahmi Oklu
    Department of Imaging, Division of Vascular Imaging and Intervention, Massachusetts General Hospital, 290 Gray Bigelow, 55 Fruit Street, Boston, MA 02114 Harvard Medical School, Boston, Massachusetts Electronic address
    J Vasc Interv Radiol 25:631-4. 2014
    ..To investigate the presence and location of extracellular traps (ETs) in atherosclerotic plaques and to determine whether they are spatially associated with inflammatory cells and the lipid core...
  44. pmc Myocardial infarction accelerates atherosclerosis
    Partha Dutta
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 487:325-9. 2012
    ..The progenitors then seeded the spleen, yielding a sustained boost in monocyte production. These observations provide new mechanistic insight into atherogenesis and provide a novel therapeutic opportunity to mitigate disease progression...
  45. ncbi request reprint Case records of the Massachusetts General Hospital. Case 23-2006. A 36-year-old man with numbness in the left [corrected] hand and hypertension
    Othon Iliopoulos
    Cancer Center, Massachusetts General Hospital, USA
    N Engl J Med 355:394-402. 2006
  46. ncbi request reprint Case records of the Massachusetts General Hospital. Case 4-2006. A 79-year-old woman with myalgias, fatigue, and shortness of breath
    Jonathan Kay
    Department of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, USA
    N Engl J Med 354:623-30. 2006
  47. pmc Rapid fatty acid ethyl ester synthesis by porcine myocardium upon ethanol infusion into the left anterior descending coronary artery
    Danita M Yoerger
    Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Pathol 168:1435-42. 2006
    ..These data demonstrate that FAEEs may be mediators of ethanol-induced cardiotoxicity...
  48. doi request reprint Case records of the Massachusetts General Hospital. Case 31-2008. A 39-year-old man with chest pain, arthralgias, and a mediastinal mass
    Peter A Merkel
    Arthritis Center, Boston Medical Center, and the Department of Medicine, Boston University School of Medicine, Boston, USA
    N Engl J Med 359:1603-14. 2008
  49. ncbi request reprint Heterozygous knockout of neuregulin-1 gene in mice exacerbates doxorubicin-induced heart failure
    Fen Fen Liu
    Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Rm SL 221, Boston, MA 02215, USA
    Am J Physiol Heart Circ Physiol 289:H660-6. 2005
    ..This is associated with the depression of activation of the erbB2 receptor as well as Akt, p70S6K, and ERK-1/2 pathways...
  50. pmc Acquired resistance to crizotinib from a mutation in CD74-ROS1
    Mark M Awad
    Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
    N Engl J Med 368:2395-401. 2013
    ..Funded by Pfizer and others; ClinicalTrials.gov number, NCT00585195.)...
  51. doi request reprint New treatment strategies in large-vessel vasculitis
    Sebastian Unizony
    Rheumatology Unit, Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Center for Systems BiologyMassachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Curr Opin Rheumatol 25:3-9. 2013
    ..This review summarizes the available evidence for new treatment strategies in this spectrum of diseases...
  52. ncbi request reprint Prolonged allograft survival in TNF receptor 1-deficient recipients is due to immunoregulatory effects, not to inhibition of direct antigraft cytotoxicity
    Charlotte M McKee
    Laboratory of Molecular Immunology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Immunol 168:483-9. 2002
    ..These findings indicate that in our experimental system TNF-alpha and LTalpha exert profound immunoregulatory effects through TNF-R1...
  53. ncbi request reprint Case records of the Massachusetts General Hospital. Case 26-2005. A 48-year-old man with sudden loss of consciousness while jogging
    William D Binder
    Emergency Services, Massachusetts General Hospital, USA
    N Engl J Med 353:824-32. 2005
  54. ncbi request reprint External iliac artery endofibrosis in an amateur runner: hemodynamic, angiographic, histopathological evaluation and percutaneous revascularization
    Andrew O Maree
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Vasc Med 12:203-6. 2007
    ..The diagnosis was made by a combination of hemodynamic, angiographic and histopathological assessment and percutaneous revascularization was performed using a balloon expandable stent...
  55. ncbi request reprint Coronary artery perforation by cutting balloon resulting in dissecting subepicardial hematoma and avulsion of the vasculature
    Vu H Quan
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Catheter Cardiovasc Interv 64:163-8. 2005
    ..This was complicated by a subepicardial hematoma leading to avulsion of the penetrating arteries and cardiogenic shock. Despite surgical evacuation and percutaneous left ventricular assist-device support, death ensued...
  56. pmc Mutant mouse models reveal the relative roles of E2F1 and E2F3 in vivo
    Jennifer E Cloud
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Mol Cell Biol 22:2663-72. 2002
    ..These data strongly suggest that tumor suppression is a specific property of E2F1 and not E2F3...
  57. ncbi request reprint Traumatically induced axotomy adjacent to the soma does not result in acute neuronal death
    Richard H Singleton
    Departments of Anatomy and Anesthesiology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Neurosci 22:791-802. 2002
    ..Rather, some somata showed evidence of potential reorganization and repair. This study demonstrates a novel somatic response to TAI in the perisomatic domain and also provides insight into the multifaceted pathology associated with TBI...
  58. pmc Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters
    Andrea Ventura
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 132:875-86. 2008
    ..These results provide key insights into the physiologic functions of this family of microRNAs and suggest a link between the oncogenic properties of miR-17 approximately 92 and its functions during B lymphopoiesis and lung development...
  59. ncbi request reprint A comparison of adenosine A2A agonism and methylprednisolone in attenuating neuronal damage and improving functional outcome after experimental traumatic spinal cord injury in rabbits
    David O Okonkwo
    Department of Neurological Surgery, University of Virginia Health System, Charlottesville 22908 0212, USA
    J Neurosurg Spine 4:64-70. 2006
    ..The authors of this study evaluated ATL-146e and methylprednisolone for their ability to preserve neuronal viability and motor function in experimental SCI...

Research Grants5

  1. Hydrogen Peroxide Sensing by Human Endothelial Cells
    James Stone; Fiscal Year: 2003
    ..3) Identify and characterize additional protein modifications stimulated by low concentrations of H202, and use this information to establish signaling pathways for sensing H202 in human endothelial cells. ..
  2. Hydrogen Peroxide Sensing by Human Endothelial Cells
    James Stone; Fiscal Year: 2004
    ..3) Identify and characterize additional protein modifications stimulated by low concentrations of H202, and use this information to establish signaling pathways for sensing H202 in human endothelial cells. ..
  3. Hydrogen Peroxide Sensing by Human Endothelial Cells
    James Stone; Fiscal Year: 2003
    ..3) Identify and characterize additional protein modifications stimulated by low concentrations of H202, and use this information to establish signaling pathways for sensing H202 in human endothelial cells. ..
  4. Hydrogen Peroxide Sensing by Human Endothelial Cells
    James Stone; Fiscal Year: 2005
    ..3) Identify and characterize additional protein modifications stimulated by low concentrations of H202, and use this information to establish signaling pathways for sensing H202 in human endothelial cells. ..
  5. Hydrogen Peroxide Sensing by Human Endothelial Cells
    James Stone; Fiscal Year: 2006
    ..3) Identify and characterize additional protein modifications stimulated by low concentrations of H202, and use this information to establish signaling pathways for sensing H202 in human endothelial cells. ..