Research Topics
| E M StoffelSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Lynch Syndrome/Hereditary Non-polyposis Colorectal Cancer (HNPCC)E M Stoffel
Division of Gastroenterology, Brigham and Women s Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Minerva Gastroenterol Dietol 56:45-53. 2010..Colonoscopy at frequent intervals has been shown to be effective in reducing morbidity and mortality from Lynch-associated colorectal cancer...
Prevalence and predictors of appropriate colorectal cancer surveillance in Lynch syndromeElena M Stoffel
Division of Gastroenterology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Am J Gastroenterol 105:1851-60. 2010..Lynch syndrome (LS) is a hereditary cancer syndrome that conveys a high risk of colorectal cancer (CRC). Guidelines recommend colonoscopy every 1 to 2 years. There is limited information about screening compliance in this high-risk group...- Chromoendoscopy detects more adenomas than colonoscopy using intensive inspection without dye sprayingElena M Stoffel
Division of Gastroenterology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Cancer Prev Res (Phila) 1:507-13. 2008..Chromoendoscopy detected more polyps missed by standard colonoscopy than did intensive inspection. The clinical significance of these small missed lesions warrants further study... - Missed adenomas during colonoscopic surveillance in individuals with Lynch Syndrome (hereditary nonpolyposis colorectal cancer)Elena M Stoffel
Division of Gastroenterology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Cancer Prev Res (Phila) 1:470-5. 2008..We evaluated the adenoma miss rate of conventional colonoscopy in patients with Lynch syndrome, and compared the sensitivity of chromoendoscopy versus intensive inspection for detecting polyps missed by conventional colonoscopy... - Sharing genetic test results in Lynch syndrome: communication with close and distant relativesElena M Stoffel
Division of Gastroenterology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Clin Gastroenterol Hepatol 6:333-8. 2008..Clinical genetic testing can help direct cancer screening for members of Lynch syndrome families; however, there is limited information about family communication of genetic test results... 
Phenotype comparison of MLH1 and MSH2 mutation carriers in a cohort of 1,914 individuals undergoing clinical genetic testing in the United StatesFay Kastrinos
Division of Gastroenterology, Brigham and Women s Hospital, Boston, Massachusetts, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 17:2044-51. 2008..We examined the phenotypic differences between MLH1 and MSH2 gene mutation carriers and whether mutation type (point versus large rearrangement) affected phenotypic expression...- Prediction of MLH1 and MSH2 mutations in Lynch syndromeJudith Balmana
Population Sciences Division, Dana Farber Cancer Institute, and Division of Gastroenterology, Boston, Mass 02115, USA
JAMA 296:1469-78. 2006..Lynch syndrome is caused primarily by mutations in the mismatch repair genes MLH1 and MSH2... - Colorectal cancer risk perception on the basis of genetic test results in individuals at risk for Lynch syndromeShilpa Grover
Division of Gastroenterology, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
J Clin Oncol 27:3981-6. 2009..This study examines colorectal cancer (CRC) risk perception in individuals tested for MMR mutations and identifies the factors associated with an appropriate interpretation of their cancer risk... - Development and validation of a colon cancer risk assessment tool for patients undergoing colonoscopyFay Kastrinos
Division of Gastroenterology, Brigham and Women s Hospital, Boston, Massachusetts, USA
Am J Gastroenterol 104:1508-18. 2009..Our aim was to develop a simple, preprocedural risk assessment tool to identify who may be at highest risk for CRC... - Attitudes toward prenatal genetic testing in patients with familial adenomatous polyposisFay Kastrinos
Division of Gastroenterology, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
Am J Gastroenterol 102:1284-90. 2007..If a mutation is identified, prenatal testing can reveal whether an embryo or fetus is affected. We conducted a pilot study to assess FAP patients' attitudes toward prenatal testing... - Risk of pancreatic cancer in families with Lynch syndromeFay Kastrinos
Department of Internal Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
JAMA 302:1790-5. 2009..A number of extracolonic tumors have been associated with the disorder, including pancreatic cancer; however, the risk of pancreatic cancer in Lynch syndrome is uncertain and not quantified... - Physician assessment of family cancer history and referral for genetic evaluation in colorectal cancer patientsShilpa Grover
Population Sciences Division, Dana-Farber Cancer Institute, Boston, MA 02114, USA
Clin Gastroenterol Hepatol 2:813-9. 2004..Familial cancer risk remains largely unrecognized and referral rates for genetic evaluation for CRC syndromes are low... - Adenomas in young patients: what is the optimal evaluation?Elena M Stoffel
Am J Gastroenterol 100:1150-3. 2005....
Research Grants
- Genetic Testing and Cancer Screening in Hereditary Cancer SyndromesElena Stoffel; Fiscal Year: 2007..Identification of factors which impact cancer screening behaviors and cancer risk stratification will lead to improvements in clinical care for all patients at risk for CRC. ..