B R Stockwell

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Chemical genetics: ligand-based discovery of gene function
    B R Stockwell
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Rev Genet 1:116-25. 2000
  2. ncbi request reprint Frontiers in chemical genetics
    B R Stockwell
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, MA 02142, USA
    Trends Biotechnol 18:449-55. 2000
  3. ncbi request reprint Chemical genetic screening approaches to neurobiology
    Brent R Stockwell
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Neuron 36:559-62. 2002
  4. pmc Detecting spatial patterns in biological array experiments
    David E Root
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142 1479, USA
    J Biomol Screen 8:393-8. 2003
  5. pmc Exploring biology with small organic molecules
    Brent R Stockwell
    Department of Biological Sciences, Columbia University, 614 Fairchild Center, MC 2406, New York, New York 10027, USA
    Nature 432:846-54. 2004
  6. ncbi request reprint Advances in chemical genetics
    Inese Smukste
    Department of Biological Sciences and Department of Chemistry, Columbia University, Fairchild Center, New York, New York 10027, USA
    Annu Rev Genomics Hum Genet 6:261-86. 2005
  7. ncbi request reprint Biologically active molecules that reduce polyglutamine aggregation and toxicity
    Urvee A Desai
    Department of Neurology and Cellular and Molecular Pharmacology, San Francisco, CA 94143 2280, USA
    Hum Mol Genet 15:2114-24. 2006
  8. pmc Chemical genetic approaches to probing cell death
    Nidhi M Gangadhar
    Department of Biological Sciences, 614 Fairchild Center, New York, NY 10027, USA
    Curr Opin Chem Biol 11:83-7. 2007
  9. ncbi request reprint Selective inhibitors of death in mutant huntingtin cells
    Hemant Varma
    Department of Biological Sciences, Columbia University, Fairchild Center, MC 2406, 1212 Amsterdam Avenue, New York, New York 10027, USA
    Nat Chem Biol 3:99-100. 2007

Collaborators

  • Hemant Varma
  • Nidhi M Gangadhar
  • Urvee A Desai
  • Inese Smukste
  • David E Root
  • Elena Cattaneo
  • C Todd DeMarco
  • Anne C Hart
  • Donald C Lo
  • Cindy Voisine
  • Aye Aye K Ma
  • Judit Pallos
  • J Lawrence Marsh
  • Marc I Diamond
  • Leslie Michels Thompson
  • Brian P Kelley

Detail Information

Publications9

  1. pmc Chemical genetics: ligand-based discovery of gene function
    B R Stockwell
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Rev Genet 1:116-25. 2000
    ..The growing sophistication of this approach raises the possibility of its application to any biological process...
  2. ncbi request reprint Frontiers in chemical genetics
    B R Stockwell
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, MA 02142, USA
    Trends Biotechnol 18:449-55. 2000
    ....
  3. ncbi request reprint Chemical genetic screening approaches to neurobiology
    Brent R Stockwell
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Neuron 36:559-62. 2002
    ..This powerful set of tools will enable the molecular dissection of complex processes that occur within the nervous system...
  4. pmc Detecting spatial patterns in biological array experiments
    David E Root
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142 1479, USA
    J Biomol Screen 8:393-8. 2003
    ..In addition, the authors employ a statistical test to allow for automatic detection of such errors. Software tools for using this approach are provided...
  5. pmc Exploring biology with small organic molecules
    Brent R Stockwell
    Department of Biological Sciences, Columbia University, 614 Fairchild Center, MC 2406, New York, New York 10027, USA
    Nature 432:846-54. 2004
    ..The mapping of biological-activity space using small molecules is akin to mapping the stars--uncharted territory is explored using a system of coordinates that describes where each new feature lies...
  6. ncbi request reprint Advances in chemical genetics
    Inese Smukste
    Department of Biological Sciences and Department of Chemistry, Columbia University, Fairchild Center, New York, New York 10027, USA
    Annu Rev Genomics Hum Genet 6:261-86. 2005
    ..Several technologies have converged, raising the hope that it may be possible to systematically apply chemical probes to biological processes...
  7. ncbi request reprint Biologically active molecules that reduce polyglutamine aggregation and toxicity
    Urvee A Desai
    Department of Neurology and Cellular and Molecular Pharmacology, San Francisco, CA 94143 2280, USA
    Hum Mol Genet 15:2114-24. 2006
    ..The high predictive value of the primary screen suggests that the FRET-based screening assay may be useful for further primary and secondary screens for genes or small molecules that inhibit polyglutamine protein aggregation...
  8. pmc Chemical genetic approaches to probing cell death
    Nidhi M Gangadhar
    Department of Biological Sciences, 614 Fairchild Center, New York, NY 10027, USA
    Curr Opin Chem Biol 11:83-7. 2007
    ..Recent advances include the discovery of novel small molecules regulating cell death pathways -- necrostatin and erastin -- as well as the elucidation of the mechanism of death induced in cancer cells by the cytotoxic agent Apratoxin A...
  9. ncbi request reprint Selective inhibitors of death in mutant huntingtin cells
    Hemant Varma
    Department of Biological Sciences, Columbia University, Fairchild Center, MC 2406, 1212 Amsterdam Avenue, New York, New York 10027, USA
    Nat Chem Biol 3:99-100. 2007
    ..Four compounds were active in diverse HD models, which suggests a role for cell death in HD; these compounds are mechanistic probes and potential drug leads for HD...