- Chemical genetics: ligand-based discovery of gene function
B R Stockwell
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nat Rev Genet 1:116-25. 2000
..The growing sophistication of this approach raises the possibility of its application to any biological process...
- Frontiers in chemical genetics
B R Stockwell
Whitehead Institute for Biomedical Research, Nine Cambridge Center, MA 02142, USA
Trends Biotechnol 18:449-55. 2000
- Chemical genetic screening approaches to neurobiology
Brent R Stockwell
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
Neuron 36:559-62. 2002
..This powerful set of tools will enable the molecular dissection of complex processes that occur within the nervous system...
- Detecting spatial patterns in biological array experiments
David E Root
Whitehead Institute for Biomedical Research, Cambridge, MA 02142-1479, USA
J Biomol Screen 8:393-8. 2003
..In addition, the authors employ a statistical test to allow for automatic detection of such errors. Software tools for using this approach are provided...
- Exploring biology with small organic molecules
Brent R Stockwell
Department of Biological Sciences, Columbia University, 614 Fairchild Center, MC 2406, New York, New York 10027, USA
Nature 432:846-54. 2004
..The mapping of biological-activity space using small molecules is akin to mapping the stars--uncharted territory is explored using a system of coordinates that describes where each new feature lies...
- Advances in chemical genetics
Department of Biological Sciences and Department of Chemistry, Columbia University, Fairchild Center, New York, New York 10027, USA
Annu Rev Genomics Hum Genet 6:261-86. 2005
..Several technologies have converged, raising the hope that it may be possible to systematically apply chemical probes to biological processes...
- Biologically active molecules that reduce polyglutamine aggregation and toxicity
Urvee A Desai
Department of Neurology and Cellular and Molecular Pharmacology, San Francisco, CA 94143-2280, USA
Hum Mol Genet 15:2114-24. 2006
..The high predictive value of the primary screen suggests that the FRET-based screening assay may be useful for further primary and secondary screens for genes or small molecules that inhibit polyglutamine protein aggregation...
- Chemical genetic approaches to probing cell death
Nidhi M Gangadhar
Department of Biological Sciences, 614 Fairchild Center, New York, NY 10027, USA
Curr Opin Chem Biol 11:83-7. 2007
..Recent advances include the discovery of novel small molecules regulating cell death pathways -- necrostatin and erastin -- as well as the elucidation of the mechanism of death induced in cancer cells by the cytotoxic agent Apratoxin A...
- Selective inhibitors of death in mutant huntingtin cells
Department of Biological Sciences, Columbia University, Fairchild Center, MC 2406, 1212 Amsterdam Avenue, New York, New York 10027, USA
Nat Chem Biol 3:99-100. 2007
..Four compounds were active in diverse HD models, which suggests a role for cell death in HD; these compounds are mechanistic probes and potential drug leads for HD...