Research Topics
| E A StewartSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Detail Information
Publications
Clinical outcomes of focused ultrasound surgery for the treatment of uterine fibroidsElizabeth A Stewart
Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Fertil Steril 85:22-9. 2006..To assess outcomes at 6 and 12 months after magnetic resonance-guided focused ultrasound surgery (MRgFUS) for symptomatic uterine leiomyomas...- The genetics of uterine leiomyomata: what clinicians need to knowElizabeth A Stewart
Center for Uterine Fibroids, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Obstet Gynecol 107:917-21. 2006..The current role of family medical history and future implications of genes relevant to leiomyoma biology will be reviewed... - Uterine fibroidsE A Stewart
Center for Uterine Fibroids, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
Lancet 357:293-8. 2001..New research into the basic biology of these neoplasms may add new treatment options for the future as the role of growth factors and genetic mutations in these tumours are better understood... - Gonadotropins and the uterus: is there a gonad-independent pathway?E A Stewart
Center for Uterine Fibroids, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Soc Gynecol Investig 8:319-26. 2001..I will review the evidence regarding gonadotropin action in nongonadal tissues, primarily the uterus. In addition, the data regarding receptors will be reviewed. Finally, the clinical areas informed by this information will be explored... - Predictors of subsequent surgery for uterine leiomyomata after abdominal myomectomyElizabeth A Stewart
Center for Uterine Fibroids and Ob Gyn Epidemiology Center, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Obstet Gynecol 99:426-32. 2002..To study factors associated with an increased risk of subsequent surgery in a cohort of women undergoing abdominal myomectomy... - New concepts in the treatment of uterine leiomyomasE A Stewart
Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Obstet Gynecol 92:624-7. 1998..As we gain understanding of the molecular events that cause benign gynecologic conditions such as leiomyomas, safer and more effective treatments might be found as we enter the 21st century... - Messenger ribonucleic acid for the gonadal luteinizing hormone/human chorionic gonadotropin receptor is not present in human endometriumE A Stewart
Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital and Havard Medical School, Boston, Massachusetts 02115, USA
Fertil Steril 71:368-72. 1999..To determine whether messenger RNA for the gonadal LH/hCG receptor is present in human endometrium with the use of reverse-transcriptase polymerase chain reaction... - Prolactin is an autocrine or paracrine growth factor for human myometrial and leiomyoma cellsR A Nowak
Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
Gynecol Obstet Invest 48:127-32. 1999..To test the hypothesis that prolactin (PRL) acts as a mitogenic growth factor for human leiomyoma and myometrial cells... 
Molecular and cytogenetic characterization of plexiform leiomyomata provide further evidence for genetic heterogeneity underlying uterine fibroidsJennelle C Hodge
Brigham and Women s Hospital, Department of Obstetrics and Gynecology and Reproductive Biology, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Am J Pathol 172:1403-10. 2008..We further suggest that plexiform UL should be classified among tumors with extensive hyalinization rather than with "true" epithelioid smooth muscle neoplasms...- Does the phase of menstrual cycle affect MR-guided focused ultrasound surgery of uterine leiomyomas?Minna J So
Department of Radiology, Brigham and Women s Hospital Harvard Medical School, Boston, MA, USA
Eur J Radiol 59:203-7. 2006..To determine whether the phase of menstrual cycle at the time of MR-guided focused ultrasound surgery (MRgFUS) treatment for uterine leiomyomas affects treatment outcome... - Uterine leiomyomas: MR imaging-based thermometry and thermal dosimetry during focused ultrasound thermal ablationNathan Mcdannold
Department of Radiology, Harvard Medical School, Brigham and Women s Hospital, 221 Longwood Ave LMRC, 007c, Boston, MA 02115, USA
Radiology 240:263-72. 2006..To retrospectively evaluate magnetic resonance (MR) imaging-based thermometry and thermal dosimetry during focused ultrasound treatments of uterine leiomyomas (ie, fibroids)... - Development of a research agenda for uterine artery embolization: proceedings from a multidisciplinary research consensus panelJames B Spies
Department of Radiology, Georgetown University Hospital, Washington, DC 20007-2113, USA
J Vasc Interv Radiol 17:1871-9. 2006 - Polycystic ovary syndrome and risk of uterine leiomyomataLauren A Wise
Slone Epidemiology Center, Boston University, Boston, Massachusetts 02215, USA
Fertil Steril 87:1108-15. 2007..To examine the association between polycystic ovary syndrome (PCOS) and the risk of uterine leiomyomata (UL)... - Uterine leiomyomas: MR imaging-guided focused ultrasound surgery--results of different treatment protocolsFiona M Fennessy
Department of Radiology, Harvard Medical School Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
Radiology 243:885-93. 2007..To prospectively assess patient response (after 12 months) to magnetic resonance (MR) imaging-guided focused ultrasound surgery in treatment of uterine leiomyomas by using two treatment protocols... - Sustained relief of leiomyoma symptoms by using focused ultrasound surgeryElizabeth A Stewart
Departments of Obstetrics, Gynecology and Reproductive Biology and Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Obstet Gynecol 110:279-87. 2007..To assess several measures of the long-term outcome of magnetic resonance-guided focused ultrasound surgery for symptomatic uterine leiomyomata... - Perceived racial discrimination and risk of uterine leiomyomataLauren A Wise
Slone Epidemiology Center, Boston University, Boston, MA 02215, USA
Epidemiology 18:747-57. 2007..Black women also report higher levels of racial discrimination. We evaluated the hypothesis that greater exposure to racism increases myoma risk in black women... - The impact of race as a risk factor for symptom severity and age at diagnosis of uterine leiomyomata among affected sistersKaren L Huyck
Department of Pathology, University of Vermont College of Medicine, Burlington, VT, USA
Am J Obstet Gynecol 198:168.e1-9. 2008..The objective of the study was to identify risk factors for uterine leiomyomata (UL) in a racially diverse population of women with a family history of UL, and to evaluate their contribution to disease severity and age at diagnosis... 
Magnetic resonance-guided focused ultrasound surgerySusan B A Hudson
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, College of Medicine, Mayo Clinic, Rochester, Minnesota 55901, USA
Clin Obstet Gynecol 51:159-66. 2008..Magnetic resonance-guided focused ultrasound surgery is a new noninvasive therapy that has been proven to be both safe and efficacious in the treatment of fibroids...- Avoiding treatment of leiomyosarcomas: the role of magnetic resonance in focused ultrasound surgeryAmber Samuel
Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Fertil Steril 90:850.e9-12. 2008..To report early diagnosis of a uterine leiomyosarcoma during screening for magnetic resonance imaging-guided focused ultrasound surgery (MRgFUS) for leiomyomas... - Uterine artery embolization versus myomectomy: a multicenter comparative studyScott C Goodwin
Department of Veterans Affairs, The University of California, Los Angeles, California, USA
Fertil Steril 85:14-21. 2006..To determine whether there is significant quality of life score improvement after uterine artery embolization (UAE) and to compare UAE and myomectomy outcomes... - MR imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility studyClare M C Tempany
Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
Radiology 226:897-905. 2003..MR imaging-guided focused ultrasound causes thermocoagulation and necrosis in uterine leiomyomas and is feasible and safe, without serious consequences... - Focused ultrasound treatment of uterine fibroid tumors: safety and feasibility of a noninvasive thermoablative techniqueElizabeth A Stewart
Departments of Obstetrics, Gynecology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Obstet Gynecol 189:48-54. 2003..The purpose of this study was to determine the safety and efficacy of focused ultrasound surgery with magnetic resonance imaging guidance for the noninvasive treatment of uterine leiomyomas... - Reproductive factors, hormonal contraception, and risk of uterine leiomyomata in African-American women: a prospective studyLauren A Wise
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02215, USA
Am J Epidemiol 159:113-23. 2004..No consistent patterns were observed for other forms of hormonal contraception. Reproductive history is an important determinant of leiomyomata risk in premenopausal US Black women. Progestin-only injectables may reduce risk... - Uterine leiomyomas: MR imaging-guided focused ultrasound surgery--imaging predictors of successZsuzsanna M Lénárd
Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
Radiology 249:187-94. 2008..To retrospectively assess the magnetic resonance (MR) imaging predictors of success at reducing uterine leiomyoma volume and achieving patient symptom relief 12 months after MR imaging-guided focused ultrasound surgery... - Risk of uterine leiomyomata in relation to tobacco, alcohol and caffeine consumption in the Black Women's Health StudyLauren A Wise
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Hum Reprod 19:1746-54. 2004..Tobacco, alcohol and caffeine consumption may influence risk of uterine leiomyomata via changes in ovarian function or hormone metabolism... - Involvement of fumarate hydratase in nonsyndromic uterine leiomyomas: genetic linkage analysis and FISH studiesKaren L Gross
Department of Pathology, University of Vermont, Burlington, Vermont, USA
Genes Chromosomes Cancer 41:183-90. 2004..7 at D1S547, P = 0.04). FISH results showed that one copy of FH was absent in 9 of 11 ULs. These data indicate that loss of FH might be a significant event in the pathogenesis of a subset of nonsyndromic ULs... - Age-specific incidence rates for self-reported uterine leiomyomata in the Black Women's Health StudyLauren A Wise
Slone Epidemiology Center, Boston University, Boston, Massachusetts 02215, USA
Obstet Gynecol 105:563-8. 2005..We estimated overall and age-specific incidence rates for self-reported uterine leiomyomata in a large cohort of African-American women in the United States... - Focused ultrasound surgery of intramural leiomyomas may facilitate fertility: a case reportMiriam M F Hanstede
Department of Obstetrics, Gynecology, and Reproductive Biology, Boston, Massachusetts, USA
Fertil Steril 88:497.e5-7. 2007..To describe a successful pregnancy after a change in configuration of the endometrial cavity after magnetic resonance imaging-guided focused ultrasound surgery (MRgFUS) for leiomyomas... - Granulocyte macrophage colony-stimulating factor in adenomyosis and autologous endometriumAnthony M Propst
Department of Obstetrics, Gynecology, and Reproductive Biology, Division of Reproductive Medicine, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Soc Gynecol Investig 9:93-7. 2002..We determined whether adenomyosis expresses GM-CSF, and if present, compared GM-CSF protein expression in adenomyosis with that in autologous endometrium... - Does the introduction of new technology change population demographics? Minimally invasive technologies and endometrial polypsNorma F Chavez
Center for Uterine Fibroids, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
Gynecol Obstet Invest 54:217-20. 2002..To determine if the characteristics of women with endometrial polyps changed as minimally invasive modalities for diagnosis and surgical treatment were integrated to our clinical practice... - Uterine fibroids: the elephant in the roomCheryl Lyn Walker
Department of Carcinogenesis, University of Texas and MD Anderson Cancer Center, Park Road 1C, Smithville, TX 78957, USA
Science 308:1589-92. 2005..As new therapies are developed, the heterogeneity of this disease becomes therapeutically relevant. An awareness of the role of genetics, the extracellular matrix, and hormones in tumor etiology is key to understanding this disease... - Neuropathic uterine pain after hysterectomy. A case reportNorma F Chavez
Center for Uterine Fibroids, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Reprod Med 48:466-8. 2003..Attention to appropriate history and physical examination may lead to an increase in the diagnosis of neuropathic pain in gynecology patients. This may have implications for persistent pain in other gynecologic diseases... - Influence of body size and body fat distribution on risk of uterine leiomyomata in U.S. black womenLauren A Wise
Department of Epidemiology, Harvard School of Public Health, 1010 Commonwealth Avenue, Boston, MA 02215, USA
Epidemiology 16:346-54. 2005..We prospectively investigated the risk of self-reported uterine leiomyomata in relation to body mass index (BMI), weight change, height, waist and hip circumferences, and waist-to-hip ratio in a large cohort of U.S black women... - New interventional techniques for adenomyosisJaron Rabinovici
Department of Obstetrics and Gynecology, The Chaim Sheba Medical Center, Senior Lecturer, Sackler Medical School, Tel Aviv University, Tel Hashomer 52621, Israel
Best Pract Res Clin Obstet Gynaecol 20:617-36. 2006..Based on the evidence presented in this chapter it seems that adenomyosis has become an entity that might be treatable by new, minimally invasive or non-invasive treatments... - The direct and indirect cost burden of clinically significant and symptomatic uterine fibroidsDavid W Lee
Health Economics and Outcomes Research, GE Healthcare, Waukesha, WI, USA
J Occup Environ Med 49:493-506. 2007..To estimate direct medical costs and indirect (productivity related) for women age 25 to 54 who had clinically significant and symptomatic uterine fibroids (UF)...