Research Topics
Genomes and Genes | Frank StegmeierSummaryAffiliation: Massachusetts Institute of Technology Country: USA Publications
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Publications
The role of the polo kinase Cdc5 in controlling Cdc14 localizationRosella Visintin
Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Mol Biol Cell 14:4486-98. 2003..Cdc5 promotes Cdc14 phosphorylation and, by stimulating the MEN, Cfi1/Net1 phosphorylation. Furthermore, we suggest that Cdc14 release from the nucleolus only occurs when Cdc14 and Cfi1/Net1 are both phosphorylated...
Closing mitosis: the functions of the Cdc14 phosphatase and its regulationFrank Stegmeier
Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Annu Rev Genet 38:203-32. 2004..Here, we review the functions of Cdc14 and how this phosphatase is regulated to accomplish the coupling of mitotic processes. We also discuss the function and regulation of Cdc14 in other eukaryotes, emphasizing conserved features...- Cdc14 and condensin control the dissolution of cohesin-independent chromosome linkages at repeated DNADamien D'Amours
Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17 233, 40 Ames Street, Cambridge, MA 02139, USA
Cell 117:455-69. 2004..This dual role of the FEAR network in initiating mitotic exit and promoting chromosome segregation ensures that exit from mitosis is coupled to the completion of chromosome segregation... - Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activitiesFrank Stegmeier
Howard Hughes Medical Institute, Department of Genetics, Harvard Partners Center for Genetics and Genomics, Boston, Massachusetts 02115, USA
Nature 446:876-81. 2007.... - The replication fork block protein Fob1 functions as a negative regulator of the FEAR networkFrank Stegmeier
Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17 233, 40 Ames St, Cambridge, MA 02139, USA
Curr Biol 14:467-80. 2004..The Cdc14 early anaphase release (FEAR) network promotes activation of the phosphatase during early anaphase, whereas the mitotic exit network (MEN) activates Cdc14 during late stages of anaphase... - A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signallingViji M Draviam
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Nat Cell Biol 9:556-64. 2007.... 
PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancersSusan Wee
Novartis Institutes for BioMedical Research, Cambridge, MA, USA
Cancer Res 69:4286-93. 2009..Our study provides molecular insights that help explain the heterogeneous response of KRAS mutant cancers to MEK pathway inhibition and presents a strong rationale for the clinical testing of combination MEK and PI3K targeted therapies...- Tankyrase inhibition stabilizes axin and antagonizes Wnt signallingShih Min A Huang
Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
Nature 461:614-20. 2009..Thus, our study provides new mechanistic insights into the regulation of axin protein homeostasis and presents new avenues for targeted Wnt pathway therapies... - The tumor suppressor CYLD regulates entry into mitosisFrank Stegmeier
Department of Genetics, Harvard Medical School, Center for Genetics and Genomics, Howard Hughes Medical Institute, Brigham and Women s Hospital, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 104:8869-74. 2007..We propose that this additional function of CYLD could provide an explanation for the benign nature of most cylindroma lesions... - Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphaseFrank Stegmeier
Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17 233, 40 Ames Street, Cambridge, MA 02139, USA
Cell 108:207-20. 2002..We propose that one function of Cdc14 released by the FEAR network is to stimulate MEN activity... - PTEN-deficient cancers depend on PIK3CBSusan Wee
Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 105:13057-62. 2008..This unexpected finding demonstrates the need to tailor therapeutic approaches to the genetic basis of PI3K pathway activation to achieve optimal treatment response... - A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cellsFrank Stegmeier
Harvard University Medical School, Department of Genetics, Center for Genetics and Genomics, Howard Hughes Medical Institute, and Brigham and Women's Hospital, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 102:13212-7. 2005..The high penetrance of these vectors will facilitate genomewide loss-of-function screens and is an important step toward using bar-coding strategies to follow loss of specific sequences in complex populations... - Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/beta-catenin signalingAlix Scholer-Dahirel
Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 108:17135-40. 2011..These results support efforts to treat human colorectal cancer by pharmacological inhibition of the Wnt/β-catenin pathway...