Frank Stegmeier

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc The role of the polo kinase Cdc5 in controlling Cdc14 localization
    Rosella Visintin
    Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Mol Biol Cell 14:4486-98. 2003
  2. ncbi request reprint Closing mitosis: the functions of the Cdc14 phosphatase and its regulation
    Frank Stegmeier
    Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Genet 38:203-32. 2004
  3. ncbi request reprint Cdc14 and condensin control the dissolution of cohesin-independent chromosome linkages at repeated DNA
    Damien D'Amours
    Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17 233, 40 Ames Street, Cambridge, MA 02139, USA
    Cell 117:455-69. 2004
  4. ncbi request reprint Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities
    Frank Stegmeier
    Howard Hughes Medical Institute, Department of Genetics, Harvard Partners Center for Genetics and Genomics, Boston, Massachusetts 02115, USA
    Nature 446:876-81. 2007
  5. ncbi request reprint The replication fork block protein Fob1 functions as a negative regulator of the FEAR network
    Frank Stegmeier
    Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17 233, 40 Ames St, Cambridge, MA 02139, USA
    Curr Biol 14:467-80. 2004
  6. doi request reprint PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers
    Susan Wee
    Novartis Institutes for BioMedical Research, Cambridge, MA, USA
    Cancer Res 69:4286-93. 2009
  7. ncbi request reprint A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling
    Viji M Draviam
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Nat Cell Biol 9:556-64. 2007
  8. doi request reprint Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
    Shih Min A Huang
    Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nature 461:614-20. 2009
  9. pmc The tumor suppressor CYLD regulates entry into mitosis
    Frank Stegmeier
    Department of Genetics, Harvard Medical School, Center for Genetics and Genomics, Howard Hughes Medical Institute, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:8869-74. 2007
  10. ncbi request reprint Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphase
    Frank Stegmeier
    Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17 233, 40 Ames Street, Cambridge, MA 02139, USA
    Cell 108:207-20. 2002

Collaborators

Detail Information

Publications14

  1. pmc The role of the polo kinase Cdc5 in controlling Cdc14 localization
    Rosella Visintin
    Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Mol Biol Cell 14:4486-98. 2003
    ..Cdc5 promotes Cdc14 phosphorylation and, by stimulating the MEN, Cfi1/Net1 phosphorylation. Furthermore, we suggest that Cdc14 release from the nucleolus only occurs when Cdc14 and Cfi1/Net1 are both phosphorylated...
  2. ncbi request reprint Closing mitosis: the functions of the Cdc14 phosphatase and its regulation
    Frank Stegmeier
    Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Genet 38:203-32. 2004
    ..Here, we review the functions of Cdc14 and how this phosphatase is regulated to accomplish the coupling of mitotic processes. We also discuss the function and regulation of Cdc14 in other eukaryotes, emphasizing conserved features...
  3. ncbi request reprint Cdc14 and condensin control the dissolution of cohesin-independent chromosome linkages at repeated DNA
    Damien D'Amours
    Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17 233, 40 Ames Street, Cambridge, MA 02139, USA
    Cell 117:455-69. 2004
    ..This dual role of the FEAR network in initiating mitotic exit and promoting chromosome segregation ensures that exit from mitosis is coupled to the completion of chromosome segregation...
  4. ncbi request reprint Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities
    Frank Stegmeier
    Howard Hughes Medical Institute, Department of Genetics, Harvard Partners Center for Genetics and Genomics, Boston, Massachusetts 02115, USA
    Nature 446:876-81. 2007
    ....
  5. ncbi request reprint The replication fork block protein Fob1 functions as a negative regulator of the FEAR network
    Frank Stegmeier
    Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17 233, 40 Ames St, Cambridge, MA 02139, USA
    Curr Biol 14:467-80. 2004
    ..The Cdc14 early anaphase release (FEAR) network promotes activation of the phosphatase during early anaphase, whereas the mitotic exit network (MEN) activates Cdc14 during late stages of anaphase...
  6. doi request reprint PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers
    Susan Wee
    Novartis Institutes for BioMedical Research, Cambridge, MA, USA
    Cancer Res 69:4286-93. 2009
    ..Our study provides molecular insights that help explain the heterogeneous response of KRAS mutant cancers to MEK pathway inhibition and presents a strong rationale for the clinical testing of combination MEK and PI3K targeted therapies...
  7. ncbi request reprint A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling
    Viji M Draviam
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Nat Cell Biol 9:556-64. 2007
    ....
  8. doi request reprint Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
    Shih Min A Huang
    Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nature 461:614-20. 2009
    ..Thus, our study provides new mechanistic insights into the regulation of axin protein homeostasis and presents new avenues for targeted Wnt pathway therapies...
  9. pmc The tumor suppressor CYLD regulates entry into mitosis
    Frank Stegmeier
    Department of Genetics, Harvard Medical School, Center for Genetics and Genomics, Howard Hughes Medical Institute, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:8869-74. 2007
    ..We propose that this additional function of CYLD could provide an explanation for the benign nature of most cylindroma lesions...
  10. ncbi request reprint Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphase
    Frank Stegmeier
    Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17 233, 40 Ames Street, Cambridge, MA 02139, USA
    Cell 108:207-20. 2002
    ..We propose that one function of Cdc14 released by the FEAR network is to stimulate MEN activity...
  11. pmc Targeting HSF1 sensitizes cancer cells to HSP90 inhibition
    Yaoyu Chen
    Oncology, Novartis Institutes for BioMedical Research, Cambridge, MA, USA
    Oncotarget 4:816-29. 2013
    ....
  12. pmc PTEN-deficient cancers depend on PIK3CB
    Susan Wee
    Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:13057-62. 2008
    ..This unexpected finding demonstrates the need to tailor therapeutic approaches to the genetic basis of PI3K pathway activation to achieve optimal treatment response...
  13. pmc A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells
    Frank Stegmeier
    Harvard University Medical School, Department of Genetics, Center for Genetics and Genomics, Howard Hughes Medical Institute, and Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:13212-7. 2005
    ..The high penetrance of these vectors will facilitate genomewide loss-of-function screens and is an important step toward using bar-coding strategies to follow loss of specific sequences in complex populations...
  14. pmc Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/beta-catenin signaling
    Alix Scholer-Dahirel
    Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 108:17135-40. 2011
    ..These results support efforts to treat human colorectal cancer by pharmacological inhibition of the Wnt/β-catenin pathway...