Allen Steere

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Lyme borreliosis in 2005, 30 years after initial observations in Lyme Connecticut
    Allen C Steere
    Center for Immunology and Inflammatory Diseases, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Wien Klin Wochenschr 118:625-33. 2006
  2. ncbi request reprint Prospective study of serologic tests for lyme disease
    Allen C Steere
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Clin Infect Dis 47:188-95. 2008
  3. pmc Borrelia burgdorferi stimulation of chemokine secretion by cells of monocyte lineage in patients with Lyme arthritis
    Junghee J Shin
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Arthritis Res Ther 12:R168. 2010
  4. ncbi request reprint Asymptomatic infection with Borrelia burgdorferi
    Allen C Steere
    Division of Rheumatology Immunology, Tufts University School of Medicine, New England Medical Center, Boston, MA, USA
    Clin Infect Dis 37:528-32. 2003
  5. ncbi request reprint Therapy for Lyme arthritis: strategies for the treatment of antibiotic-refractory arthritis
    Allen C Steere
    Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Arthritis Rheum 54:3079-86. 2006
  6. pmc Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptide
    Allen C Steere
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 203:961-71. 2006
  7. pmc The emergence of Lyme disease
    Allen C Steere
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 113:1093-101. 2004
  8. ncbi request reprint Elucidation of Lyme arthritis
    Allen C Steere
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Rev Immunol 4:143-52. 2004
  9. pmc Relationship between immunity to Borrelia burgdorferi outer-surface protein A (OspA) and Lyme arthritis
    Allen C Steere
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Clin Infect Dis 52:s259-65. 2011
  10. ncbi request reprint A 58-year-old man with a diagnosis of chronic lyme disease
    Allen C Steere
    Harvard Medical School and Comprehensive Arthritis Center, Massachusetts General Hospital, Boston, MA 02129, USA
    JAMA 288:1002-10. 2002

Research Grants

  1. LYME ARTHRITIS: A NEW EPIDEMIC DISEASE
    Allen C Steere; Fiscal Year: 2010
  2. LYME ARTHRITIS- A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 2002
  3. LYME ARTHRITIS- A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 2003
  4. LYME ARTHRITIS- A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 2002
  5. LYME ARTHRITIS- A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 2004
  6. LYME ARTHRITIS- A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 2005
  7. LYME ARTHRITIS- A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 2004
  8. LYME ARTHRITIS: A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 2006
  9. Diagnosis and Pathogenesis of Early Lyme Disease
    Allen Steere; Fiscal Year: 2007
  10. LYME ARTHRITIS: A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 2007

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Lyme borreliosis in 2005, 30 years after initial observations in Lyme Connecticut
    Allen C Steere
    Center for Immunology and Inflammatory Diseases, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Wien Klin Wochenschr 118:625-33. 2006
    ..The purpose of this review is to discuss the current status of Lyme borreliosis, including areas in which knowledge of the infection is still incomplete...
  2. ncbi request reprint Prospective study of serologic tests for lyme disease
    Allen C Steere
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Clin Infect Dis 47:188-95. 2008
    ..However, these tests have not been assessed prospectively...
  3. pmc Borrelia burgdorferi stimulation of chemokine secretion by cells of monocyte lineage in patients with Lyme arthritis
    Junghee J Shin
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Arthritis Res Ther 12:R168. 2010
    ..We hypothesized that B. burgdorferi stimulates chemokine secretion from monocytes/macrophages in multiple ways, thereby linking innate and adaptive immune responses...
  4. ncbi request reprint Asymptomatic infection with Borrelia burgdorferi
    Allen C Steere
    Division of Rheumatology Immunology, Tufts University School of Medicine, New England Medical Center, Boston, MA, USA
    Clin Infect Dis 37:528-32. 2003
    ..burgdorferi in participants of a large Lyme disease vaccine trial. We show that infection with B. burgdorferi may be asymptomatic but that asymptomatic infection is unusual in the United States...
  5. ncbi request reprint Therapy for Lyme arthritis: strategies for the treatment of antibiotic-refractory arthritis
    Allen C Steere
    Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Arthritis Rheum 54:3079-86. 2006
  6. pmc Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptide
    Allen C Steere
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 203:961-71. 2006
    ..4; P < 0.001). We conclude that binding of a single spirochetal peptide to certain DRB molecules is a marker for antibiotic-refractory Lyme arthritis and might play a role in the pathogenesis of the disease...
  7. pmc The emergence of Lyme disease
    Allen C Steere
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 113:1093-101. 2004
    ..Ecological conditions favorable to the disease, and the challenge of prevention, predict that Lyme disease will be a continuing public health concern...
  8. ncbi request reprint Elucidation of Lyme arthritis
    Allen C Steere
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Rev Immunol 4:143-52. 2004
    ..The elucidation of Lyme arthritis, from acute infection to chronic synovitis, might help in our understanding not only of this entity, but also of other forms of chronic inflammatory arthritis, including rheumatoid arthritis...
  9. pmc Relationship between immunity to Borrelia burgdorferi outer-surface protein A (OspA) and Lyme arthritis
    Allen C Steere
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Clin Infect Dis 52:s259-65. 2011
    ..Thus, a vaccine-induced immune response to OspA does not replicate the sequence of events needed in the natural infection to induce antibiotic-refractory Lyme arthritis...
  10. ncbi request reprint A 58-year-old man with a diagnosis of chronic lyme disease
    Allen C Steere
    Harvard Medical School and Comprehensive Arthritis Center, Massachusetts General Hospital, Boston, MA 02129, USA
    JAMA 288:1002-10. 2002
  11. ncbi request reprint Systemic symptoms without erythema migrans as the presenting picture of early Lyme disease
    Allen C Steere
    Division of Rheumatology Immunology, Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts, USA
    Am J Med 114:58-62. 2003
  12. ncbi request reprint Prospective study of coinfection in patients with erythema migrans
    Allen C Steere
    Division of Rheumatology and Immunology, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Clin Infect Dis 36:1078-81. 2003
    ..phagocytophila and 2 (2%) had coinfection with B. microti. We concluded that the frequency of coinfection with these agents was low among patients with erythema migrans in the study areas...
  13. ncbi request reprint Binding of outer surface protein A and human lymphocyte function-associated antigen 1 peptides to HLA-DR molecules associated with antibiotic treatment-resistant Lyme arthritis
    Allen C Steere
    Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts, USA
    Arthritis Rheum 48:534-40. 2003
    ..To assess the binding of outer surface protein A (OspA) and human lymphocyte function-associated antigen 1 (hLFA-1) peptides to 5 major histocompatibility complex (MHC) molecules...
  14. ncbi request reprint Decline in the frequencies of Borrelia burgdorferi OspA161 175-specific T cells after antibiotic therapy in HLA-DRB1*0401-positive patients with antibiotic-responsive or antibiotic-refractory lyme arthritis
    Priya Kannian
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 179:6336-42. 2007
    ..However, the marked decline in the frequency of such cells with antibiotic therapy suggests that persistent synovitis in the refractory group is not perpetuated by these cells...
  15. pmc Analysis of Borrelia burgdorferi genotypes in patients with Lyme arthritis: High frequency of ribosomal RNA intergenic spacer type 1 strains in antibiotic-refractory arthritis
    Kathryn L Jones
    Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Arthritis Rheum 60:2174-82. 2009
    ..The goal of this study was to determine the B burgdorferi genotypes in the joints of patients with Lyme arthritis...
  16. ncbi request reprint The VlsE (IR6) peptide ELISA in the serodiagnosis of lyme facial paralysis
    Miikka Peltomaa
    Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Otol Neurotol 25:838-41. 2004
    ....
  17. doi request reprint 2-tiered antibody testing for early and late Lyme disease using only an immunoglobulin G blot with the addition of a VlsE band as the second-tier test
    John A Branda
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Clin Infect Dis 50:20-6. 2010
    ..IgG VlsE antibody testing, by itself, improves early sensitivity, but may lower specificity. We studied whether elements of the 2 approaches could be combined to produce a second-tier IgG blot that performs well throughout the infection...
  18. pmc Treg cell numbers and function in patients with antibiotic-refractory or antibiotic-responsive Lyme arthritis
    Shiqian Shen
    Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Arthritis Rheum 62:2127-37. 2010
    ..In a murine model of antibiotic-refractory Lyme arthritis, the numbers of Treg cells are dramatically reduced. The aim of this study was to examine Treg cell numbers and function in patients with antibiotic-refractory Lyme arthritis...
  19. ncbi request reprint Persistence of the antibody response to the VlsE sixth invariant region (IR6) peptide of Borrelia burgdorferi after successful antibiotic treatment of Lyme disease
    Miikka Peltomaa
    Division of Rheumatology and Immunology, Tufts New England Medical Center, Boston, Massachusetts, USA
    J Infect Dis 187:1178-86. 2003
    ..We conclude that persistence of the anti-VlsE antibody response for months or years after antibiotic treatment cannot be equated with spirochetal persistence in Lyme disease...
  20. ncbi request reprint Role of aggrecanase 1 in Lyme arthritis
    Aruna K Behera
    Tupper Research Institute, Tufts University School of Medicine, Boston, Massachusetts, USA
    Arthritis Rheum 54:3319-29. 2006
    ..The role of aggrecanases in Lyme arthritis has not yet been determined. We therefore sought to delineate the contribution of aggrecanases to joint destruction in Lyme arthritis...
  21. pmc Human Lyme arthritis and the immunoglobulin G antibody response to the 37-kilodalton arthritis-related protein of Borrelia burgdorferi
    Carlos A Salazar
    Massachusetts General Hospital, 55 Fruit St, CNY 149 8301, Boston, MA 02114, USA
    Infect Immun 73:2951-7. 2005
    ..Thus, after the first several weeks of infection, 60 to 80% of patients had IgG antibody responses to GST-Arp, but this response did not correlate with the severity or duration of Lyme arthritis...
  22. ncbi request reprint Antibody responses to Borrelia burgdorferi in patients with antibiotic-refractory, antibiotic-responsive, or non-antibiotic-treated Lyme arthritis
    Priya Kannian
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Arthritis Rheum 56:4216-25. 2007
    ..To compare the pattern of antibody responses to Borrelia burgdorferi in patients with antibiotic-refractory, antibiotic-responsive, or non-antibiotic-treated Lyme arthritis as an indirect measure of spirochetal persistence or eradication...
  23. doi request reprint Higher mRNA levels of chemokines and cytokines associated with macrophage activation in erythema migrans skin lesions in patients from the United States than in patients from Austria with Lyme borreliosis
    Kathryn L Jones
    Division of Rheumatology, Allergy, and Immunology, Center for Immunology and Inflammatory Diseases, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Clin Infect Dis 46:85-92. 2008
    ..afzelii infection in Europe. However, reasons for these differences are not yet known...
  24. pmc Strong IgG antibody responses to Borrelia burgdorferi glycolipids in patients with Lyme arthritis, a late manifestation of the infection
    Kathryn L Jones
    Division of Rheumatology, Allergy, and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Clin Immunol 132:93-102. 2009
    ..Thus, almost all patients with Lyme arthritis have strong IgG antibody responses to B. burgdorferi glycolipid antigens...
  25. pmc Borrelia burgdorferi stimulates macrophages to secrete higher levels of cytokines and chemokines than Borrelia afzelii or Borrelia garinii
    Klemen Strle
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Infect Dis 200:1936-43. 2009
    ..These results demonstrate in vitro and in vivo that B. burgdorferi has greater inflammatory potential than B. afzelii and B. garinii, which may account in part for variations in the clinical manifestations of Lyme borreliosis...
  26. pmc Searching for borrelial T cell epitopes associated with antibiotic-refractory Lyme arthritis
    Elise E Drouin
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Mol Immunol 45:2323-32. 2008
    ..Therefore, while additional Bb epitopes may be involved in the development of antibiotic-refractory Lyme arthritis, recognition of OspA(163-175) remains the only known Bb epitope associated with this disease course...
  27. pmc Role of adrenomedullin in Lyme disease
    Meghan L Marre
    Graduate Program in Immunology, Sackler School of Graduate Biomedical Sciences, Tufts University, 155 Harrison Avenue, Boston, Massachusetts 02111, USA
    Infect Immun 78:5307-13. 2010
    ..Taken together, these results suggest that B. burgdorferi increases the production of adrenomedullin, which in turn negatively regulates the B. burgdorferi-stimulated inflammatory response...
  28. pmc Inflammatory cytokine production predominates in early Lyme disease in patients with erythema migrans
    Lisa Glickstein
    Division of Rheumatology Immunology, New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Infect Immun 71:6051-3. 2003
    ..In contrast, with the exception of interleukin-13, anti-inflammatory cytokine production was negligible. Thus, B. burgdorferi antigens in early Lyme disease often induce a strong inflammatory response...
  29. ncbi request reprint Molecular characterization of the OspA(161-175) T cell epitope associated with treatment-resistant Lyme arthritis: differences among the three pathogenic species of Borrelia burgdorferi sensu lato
    Elise E Drouin
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Autoimmun 23:281-92. 2004
    ..These observations are consistent with the hypothesis that T cell recognition of this epitope is important in the induction of autoimmunity in treatment-resistant Lyme arthritis...
  30. ncbi request reprint High levels of inflammatory chemokines and cytokines in joint fluid and synovial tissue throughout the course of antibiotic-refractory lyme arthritis
    Junghee J Shin
    Massachusetts General Hospital, and Harvard Medical School, Boston, Massachussets 02114, USA
    Arthritis Rheum 56:1325-35. 2007
    ..To investigate the possible role of chemokines and cytokines in the pathogenesis of Lyme arthritis...
  31. pmc Borrelia burgdorferi genetic markers and disseminated disease in patients with early Lyme disease
    Kathryn L Jones
    Division of Rheumatology, Allergy, and Immunology, Center for Immunology and Inflammatory Disease, Harvard Medical School, Massachusetts General Hospital, 55 Fruit St, CNY 149 8301, Boston, MA 02114, USA
    J Clin Microbiol 44:4407-13. 2006
    ..We conclude that B. burgdorferi strains vary in their capacity to disseminate, but almost all strains isolated from EM lesions sometimes caused disseminated disease...
  32. pmc Human homologues of a Borrelia T cell epitope associated with antibiotic-refractory Lyme arthritis
    Elise E Drouin
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Mol Immunol 45:180-9. 2008
    ..However, molecular mimicry due to sequence homology between OspA(165-173) and a human peptide seems unlikely to be the critical mechanism...
  33. ncbi request reprint In situ diversification of the antibody repertoire in chronic Lyme arthritis synovium
    Srimoyee Ghosh
    Department of Pathology, Tufts University School of Medicine, Boston, MA 02111, USA
    J Immunol 174:2860-9. 2005
    ..Intraclonal diversity among plasma cells of close physical proximity points toward an ongoing process of diversification and affinity maturation, possibly driven by the chronic presence of an autoantigen...
  34. pmc Borrelia burgdorferi infection regulates CD1 expression in human cells and tissues via IL1-β
    Konstantin Yakimchuk
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Eur J Immunol 41:694-705. 2011
    ..burgdorferi infection and suggests a stepwise mechanism whereby bacterial cell walls, TLR activation and cytokine release cause DC precursors to express group 1 CD1 proteins...
  35. ncbi request reprint Case records of the Massachusetts General Hospital. Case 11-2007. A 59-year-old man with neck pain, weakness in the arms, and cranial-nerve palsies
    David M Greer
    Department of Neurology, Massachusetts General Hospital, USA
    N Engl J Med 356:1561-70. 2007
  36. pmc Induction of host matrix metalloproteinases by Borrelia burgdorferi differs in human and murine lyme arthritis
    Aruna K Behera
    Tufts New England Medical Center, 750 Washington St, Boston, MA 02111, USA
    Infect Immun 73:126-34. 2005
    ..Differences between human and murine Lyme arthritis may be related to the lack of induction of collagenases, such MMP-1 and MMP-13, in mouse joints...
  37. ncbi request reprint Case records of the Massachusetts General Hospital. Case 14-2005. A 38-year-old man with fever and blurred vision
    Sekar Kathiresan
    Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, USA
    N Engl J Med 352:2003-12. 2005
  38. ncbi request reprint Cerebellar ataxia as the presenting manifestation of Lyme disease
    Ravit Arav-Boger
    Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Pediatr Infect Dis J 21:353-6. 2002
    ..Treatment with intravenous antibiotics led to rapid resolution of persistent cerebellar findings...
  39. ncbi request reprint Serodiagnosis of Lyme disease by kinetic enzyme-linked immunosorbent assay using recombinant VlsE1 or peptide antigens of Borrelia burgdorferi compared with 2-tiered testing using whole-cell lysates
    Rendi Murphree Bacon
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA
    J Infect Dis 187:1187-99. 2003
    ..burgdorferi in patients with acute erythema migrans. In later stages of Lyme disease, the sensitivities of the in parallel tests and 2-tiered testing were high and statistically equivalent...
  40. ncbi request reprint Duration of antibiotic therapy for Lyme disease
    Allen C Steere
    Ann Intern Med 138:761-2. 2003
  41. pmc A genome-wide proteome array reveals a limited set of immunogens in natural infections of humans and white-footed mice with Borrelia burgdorferi
    Alan G Barbour
    Pacific Southwest Center for Research on Emerging Infections, University of California Irvine, 3012 Hewitt, Irvine, CA 92697 4028, USA
    Infect Immun 76:3374-89. 2008
    ..These results indicate that the majority of deduced proteins of B. burgdorferi do not elicit antibody responses during infection and that the limited sets of immunogens are similar for two different host species...
  42. ncbi request reprint Clinical characteristics and treatment outcome of early Lyme disease in patients with microbiologically confirmed erythema migrans
    Robert P Smith
    Maine Medical Center, Portland, Maine, USA
    Ann Intern Med 136:421-8. 2002
    ..Lyme disease has a wide spectrum of clinical manifestations. Diagnosis is usually based on the clinical and serologic picture rather than on microbiological confirmation...
  43. pmc Chemokine signatures in the skin disorders of Lyme borreliosis in Europe: predominance of CXCL9 and CXCL10 in erythema migrans and acrodermatitis and CXCL13 in lymphocytoma
    Robert R Mullegger
    Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, A 8036 Graz, Austria
    Infect Immun 75:4621-8. 2007
    ..Thus, erythema migrans and acrodermatitis chronica atrophicans have high levels of the T-cell-active chemokines CXCL9 and CXCL10, whereas borrelial lymphocytoma has high levels of the B-cell-active chemokine CXCL13...
  44. ncbi request reprint A critical appraisal of "chronic Lyme disease"
    Henry M Feder
    Department of Family Medicine and Pediatrics, Connecticut Children s Medical Center, Hartford, CT, USA
    N Engl J Med 357:1422-30. 2007
  45. ncbi request reprint The presenting manifestations of Lyme disease and the outcomes of treatment
    Allen C Steere
    N Engl J Med 348:2472-4. 2003
  46. doi request reprint Anti-tumor necrosis factor-alpha activation of Borrelia burgdorferi spirochetes in antibiotic-treated murine Lyme borreliosis: an unproven conclusion
    Gary P Wormser
    J Infect Dis 196:1865-6; author reply 1866-7. 2007
  47. ncbi request reprint The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America
    Gary P Wormser
    Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Clin Infect Dis 43:1089-134. 2006
    ..Tables list the doses and durations of antimicrobial therapy recommended for treatment and prevention of Lyme disease and provide a partial list of therapies to be avoided. A definition of post-Lyme disease syndrome is proposed...

Research Grants27

  1. LYME ARTHRITIS: A NEW EPIDEMIC DISEASE
    Allen C Steere; Fiscal Year: 2010
    ..Furthermore, this work brings us closer to the long-term goal of direct comparisons of antigens in Lyme arthritis and rheumatoid arthritis synovia. ..
  2. LYME ARTHRITIS- A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 2002
    ..Thus, it is currently the only human system in which it is possible to explore specific infectious and autoimmune mechanisms that may lead to chronic inflammatory arthritis. ..
  3. LYME ARTHRITIS- A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 2003
    ..Thus, it is currently the only human system in which it is possible to explore specific infectious and autoimmune mechanisms that may lead to chronic inflammatory arthritis. ..
  4. LYME ARTHRITIS- A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 2002
    ..Thus, it is currently the only human system in which it is possible to explore specific infectious and autoimmune mechanisms that may lead to chronic inflammatory arthritis. ..
  5. LYME ARTHRITIS- A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 2004
    ..Thus, it is currently the only human system in which it is possible to explore specific infectious and autoimmune mechanisms that may lead to chronic inflammatory arthritis. ..
  6. LYME ARTHRITIS- A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 2005
    ..Thus, it is currently the only human system in which it is possible to explore specific infectious and autoimmune mechanisms that may lead to chronic inflammatory arthritis. ..
  7. LYME ARTHRITIS- A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 2004
    ..Thus, it is currently the only human system in which it is possible to explore specific infectious and autoimmune mechanisms that may lead to chronic inflammatory arthritis. ..
  8. LYME ARTHRITIS: A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 2006
    ..Furthermore, this work brings us closer to the long-term goal of direct comparisons of antigens in Lyme arthritis and rheumatoid arthritis synovia. ..
  9. Diagnosis and Pathogenesis of Early Lyme Disease
    Allen Steere; Fiscal Year: 2007
    ..In addition, greater knowledge of spirochetal virulence and host factors associated with severe disease may allow the development of laboratory markers for patients who would benefit from more intensive treatment. ..
  10. LYME ARTHRITIS: A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 2007
    ..Furthermore, this work brings us closer to the long-term goal of direct comparisons of antigens in Lyme arthritis and rheumatoid arthritis synovia. ..
  11. LYME ARTHRITIS: A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 2009
    ..Furthermore, this work brings us closer to the long-term goal of direct comparisons of antigens in Lyme arthritis and rheumatoid arthritis synovia. ..
  12. LYME ARTHRITIS- A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 2001
    ..Thus, it is currently the only human system in which it is possible to explore specific infectious and autoimmune mechanisms that may lead to chronic inflammatory arthritis. ..
  13. LYME ARTHRITIS--A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 2000
    ....
  14. LYME ARTHRITIS--A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 1999
    ....
  15. LYME ARTHRITIS--A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 1992
    ..This work will help to solve the current problem areas in the diagnosis and treatment of Lyme disease...
  16. LYME ARTHRITIS: A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 1990
    ..This work will provide important information about the diagnosis and treatment of Lyme disease, and may have implications for other rheumatic diseases...
  17. LYME ARTHRITIS: A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 1991
    ..This work will provide important information about the diagnosis and treatment of Lyme disease, and may have implications for other rheumatic diseases...
  18. LYME ARTHRITIS: A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 1993
    ..This work will help to solve the current problem areas in the diagnosis and treatment of Lyme disease...