Tara L Spires

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia
    Tara L Spires-Jones
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School Charlestown, MA, USA
    Front Pharmacol 3:42. 2012
  2. pmc Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β
    Robert M Koffie
    Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA
    Brain 135:2155-68. 2012
  3. pmc Spines, plasticity, and cognition in Alzheimer's model mice
    Tara Spires-Jones
    Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neural Plast 2012:319836. 2012
  4. pmc T cell mediated cerebral hemorrhages and microhemorrhages during passive Aβ immunization in APPPS1 transgenic mice
    Melanie Meyer-Luehmann
    MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Department of Neurology, Alzheimer s Disease Research Laboratory, 02129 Charlestown, MA USA
    Mol Neurodegener 6:22. 2011
  5. pmc Monitoring protein aggregation and toxicity in Alzheimer's disease mouse models using in vivo imaging
    Tara L Spires-Jones
    Massachusetts General Hospital Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA
    Methods 53:201-7. 2011
  6. pmc Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy
    Tara L Spires
    Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown 02129, USA
    Am J Pathol 168:1598-607. 2006
  7. pmc Are tangles as toxic as they look?
    Tara L Spires-Jones
    Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA
    J Mol Neurosci 45:438-44. 2011
  8. pmc Alzheimer's disease: synapses gone cold
    Robert M Koffie
    Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA
    Mol Neurodegener 6:63. 2011
  9. ncbi Neuronal structure is altered by amyloid plaques
    Tara L Spires
    Department of Neurology, Alzheimer s Disease Research Laboratory, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Rev Neurosci 15:267-78. 2004
  10. ncbi Dendritic spine pathology and deficits in experience-dependent dendritic plasticity in R6/1 Huntington's disease transgenic mice
    Tara L Spires
    University Laboratory of Physiology, University of Oxford, Parks Road, Oxford, OX1 3PT, UK
    Eur J Neurosci 19:2799-807. 2004

Collaborators

Detail Information

Publications20

  1. pmc Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia
    Tara L Spires-Jones
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School Charlestown, MA, USA
    Front Pharmacol 3:42. 2012
    ..This study provides proof-of-concept for therapeutic benefits of SIRT2 inhibitors in both tau-associated FTD and Alzheimer's disease, and suggests that development of potent, brain permeable SIRT2 inhibitors is warranted...
  2. pmc Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β
    Robert M Koffie
    Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA
    Brain 135:2155-68. 2012
    ....
  3. pmc Spines, plasticity, and cognition in Alzheimer's model mice
    Tara Spires-Jones
    Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neural Plast 2012:319836. 2012
    ..Understanding the underpinnings of dementia in AD will be essential to develop and evaluate therapeutic approaches for this widespread and devastating disease...
  4. pmc T cell mediated cerebral hemorrhages and microhemorrhages during passive Aβ immunization in APPPS1 transgenic mice
    Melanie Meyer-Luehmann
    MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Department of Neurology, Alzheimer s Disease Research Laboratory, 02129 Charlestown, MA USA
    Mol Neurodegener 6:22. 2011
    ..Neuropathological investigations of patients who died after the trial showed clearance of amyloid pathology, but also a powerful immune response involving activated T cells probably underlying the negative effects of the immunization...
  5. pmc Monitoring protein aggregation and toxicity in Alzheimer's disease mouse models using in vivo imaging
    Tara L Spires-Jones
    Massachusetts General Hospital Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA
    Methods 53:201-7. 2011
    ..This technique allows longitudinal imaging of pathological aggregation of proteins and the subsequent changes in surrounding neuropil neurodegeneration and recovery after therapeutic interventions...
  6. pmc Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy
    Tara L Spires
    Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown 02129, USA
    Am J Pathol 168:1598-607. 2006
    ..Together, these results imply that neurofibrillary tangles do not necessarily lead to neuronal death...
  7. pmc Are tangles as toxic as they look?
    Tara L Spires-Jones
    Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA
    J Mol Neurosci 45:438-44. 2011
    ....
  8. pmc Alzheimer's disease: synapses gone cold
    Robert M Koffie
    Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA
    Mol Neurodegener 6:63. 2011
    ..Here, we review recent findings concerning AD pathogenesis with a particular focus on how Aβ impacts synapses...
  9. ncbi Neuronal structure is altered by amyloid plaques
    Tara L Spires
    Department of Neurology, Alzheimer s Disease Research Laboratory, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Rev Neurosci 15:267-78. 2004
    ....
  10. ncbi Dendritic spine pathology and deficits in experience-dependent dendritic plasticity in R6/1 Huntington's disease transgenic mice
    Tara L Spires
    University Laboratory of Physiology, University of Oxford, Parks Road, Oxford, OX1 3PT, UK
    Eur J Neurosci 19:2799-807. 2004
    ..Furthermore, we demonstrate that Huntington's disease pathology interferes with the normal plastic response of dendritic spines to environmental enrichment...
  11. pmc Wheel running from a juvenile age delays onset of specific motor deficits but does not alter protein aggregate density in a mouse model of Huntington's disease
    Anton van Dellen
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK
    BMC Neurosci 9:34. 2008
    ..Furthermore, wheel running initiated in adulthood ameliorates the rear-paw clasping motor sign, but not an accelerating rotarod deficit...
  12. ncbi Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism
    Tara L Spires
    University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, United Kingdom
    J Neurosci 24:2270-6. 2004
    ..These results suggest that environmental enrichment benefits animals at early stages of the disease by rescuing protein deficits, possibly through rescuing transcription or protein transport problems...
  13. ncbi Environmental enrichment reduces neuronal intranuclear inclusion load but has no effect on messenger RNA expression in a mouse model of Huntington disease
    Caroline L Benn
    Mass General Institute for Neurodegenerative Disease, Charlestown, Massachusetts, USA
    J Neuropathol Exp Neurol 69:817-27. 2010
    ..Thus, the therapeutic effects of environmental enrichment likely contribute to decreasing aggregated polyglutamine protein levels without exerting strong effects on gene expression...
  14. pmc Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy
    Tara L Spires
    Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 25:7278-87. 2005
    ..Decreased spine density will likely contribute to altered neural system function and behavioral impairments observed in Tg2576 mice...
  15. ncbi Activity-dependent regulation of synapse and dendritic spine morphology in developing barrel cortex requires phospholipase C-beta1 signalling
    Tara L Spires
    University Laboratory of Physiology, University of Oxford, Parks Road, Oxford, UK
    Cereb Cortex 15:385-93. 2005
    ..Interrupting this regulation leads to changes in synapse and dendritic spine morphology, possibly altering post-synaptic integration of signal...
  16. pmc Transgenic models of Alzheimer's disease: learning from animals
    Tara L Spires
    Harvard Medical School, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    NeuroRx 2:423-37. 2005
    ..This chapter reviews animal models of AD and their contributions to developing therapeutic approaches for AD...
  17. ncbi Nature, nurture and neurology: gene-environment interactions in neurodegenerative disease. FEBS Anniversary Prize Lecture delivered on 27 June 2004 at the 29th FEBS Congress in Warsaw
    Tara L Spires
    MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
    FEBS J 272:2347-61. 2005
    ..Here, we review the studies of environmental enrichment relevant to some major neurodegenerative diseases and discuss their research and clinical implications...
  18. ncbi Spine tingling polymorphisms--is apolipoprotein E involved in dendritic shape and plasticity?
    Tara L Spires
    MassGeneral Institute for Neurodegenerative Disease Harvard Medical School, Charlestown, MA, United States
    Neurobiol Aging 28:687-8; discussion 704-6. 2007
  19. ncbi Molecular mechanisms mediating pathological plasticity in Huntington's disease and Alzheimer's disease
    Tara L Spires
    MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, MA, USA
    J Neurochem 100:874-82. 2007
    ..This review will present evidence for altered plasticity in Huntington's and Alzheimer's diseases, relate these findings to symptomatology, and review possible causes and commonalities...
  20. ncbi Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo
    Tudor A Fulga
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Harvard New Research Building Room 652, 77 Louis Pasteur Avenue, Boston, MA 02115, USA
    Nat Cell Biol 9:139-48. 2007
    ..These findings raise the possibility that a direct interaction between tau and actin may be a critical mediator of tau-induced neurotoxicity in Alzheimer's disease and related disorders...