Sabrina L Spencer

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi request reprint An ordinary differential equation model for the multistep transformation to cancer
    Sabrina L Spencer
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
    J Theor Biol 231:515-24. 2004
  2. pmc Modeling somatic evolution in tumorigenesis
    Sabrina L Spencer
    Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    PLoS Comput Biol 2:e108. 2006
  3. pmc Modeling a snap-action, variable-delay switch controlling extrinsic cell death
    John G Albeck
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA
    PLoS Biol 6:2831-52. 2008

Collaborators

  • John M Burke
  • John G Albeck
  • Douglas A Lauffenburger
  • Peter K Sorger

Detail Information

Publications3

  1. ncbi request reprint An ordinary differential equation model for the multistep transformation to cancer
    Sabrina L Spencer
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
    J Theor Biol 231:515-24. 2004
    ..This paper presents a novel approach to viewing the genetic basis of cancer from a systems biology perspective and provides the groundwork for other models that can be directly tied to clinical and molecular data...
  2. pmc Modeling somatic evolution in tumorigenesis
    Sabrina L Spencer
    Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    PLoS Comput Biol 2:e108. 2006
    ..The model offers insight into how the sequence of acquired mutations affects the timing and cellular makeup of the resulting tumor and how the cellular-level population dynamics drive neoplastic evolution...
  3. pmc Modeling a snap-action, variable-delay switch controlling extrinsic cell death
    John G Albeck
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA
    PLoS Biol 6:2831-52. 2008
    ..We find that the pattern of interactions among Bcl-2 family members, the partitioning of Smac from its binding partner XIAP, and the mechanics of pore assembly are all critical for snap-action control...