Sabrina L Spencer
Affiliation: Massachusetts Institute of Technology
- An ordinary differential equation model for the multistep transformation to cancerSabrina L Spencer
Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
J Theor Biol 231:515-24. 2004..This paper presents a novel approach to viewing the genetic basis of cancer from a systems biology perspective and provides the groundwork for other models that can be directly tied to clinical and molecular data...
- Modeling somatic evolution in tumorigenesisSabrina L Spencer
Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
PLoS Comput Biol 2:e108. 2006..The model offers insight into how the sequence of acquired mutations affects the timing and cellular makeup of the resulting tumor and how the cellular-level population dynamics drive neoplastic evolution...
- Modeling a snap-action, variable-delay switch controlling extrinsic cell deathJohn G Albeck
Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA
PLoS Biol 6:2831-52. 2008..We find that the pattern of interactions among Bcl-2 family members, the partitioning of Smac from its binding partner XIAP, and the mechanics of pore assembly are all critical for snap-action control...