P K Sorger

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Spindle checkpoint proteins and chromosome-microtubule attachment in budding yeast
    Emily S Gillett
    Massachusetts Institute of Technology, Department of Biology, 77 Massachusetts Ave, 68 371 Cambridge, MA 02139, USA
    J Cell Biol 164:535-46. 2004
  2. pmc Analysis of kinesin motor function at budding yeast kinetochores
    Jessica D Tytell
    Department of Biology and 2Biological Engineering Division Massachusetts Institute of Technology Cambridge MA 02139, USA
    J Cell Biol 172:861-74. 2006
  3. pmc The Open Microscopy Environment (OME) Data Model and XML file: open tools for informatics and quantitative analysis in biological imaging
    Ilya G Goldberg
    Laboratory of Genetics National Institute on Aging, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USA
    Genome Biol 6:R47. 2005
  4. pmc Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins
    Patrick Meraldi
    Department of Biology, Massachusetts Institute of Technology, Massachusetts Ave, Cambridge, MA 02139, USA
    Genome Biol 7:R23. 2006
  5. ncbi request reprint A reductionist's systems biology: opinion
    Peter K Sorger
    Department of Biology, Massachusetts Institute of Technology, Room 68 371, 77 Mass Ave, Cambridge, MA 02139, USA
    Curr Opin Cell Biol 17:9-11. 2005
  6. ncbi request reprint Tracing the pathway of spindle assembly checkpoint signaling
    E S Gillett
    Massachusetts Institute of Technology, Dept of Biology, Cambridge 02139, USA
    Dev Cell 1:162-4. 2001
  7. ncbi request reprint Molecular analysis of kinetochore-microtubule attachment in budding yeast
    X He
    Massachusetts Institute of Technology, Department of Biology, Cambridge, MA 02139, USA
    Cell 106:195-206. 2001
  8. ncbi request reprint A role for the Adenomatous Polyposis Coli protein in chromosome segregation
    K B Kaplan
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Cell Biol 3:429-32. 2001
  9. pmc Retention of the BUB3 checkpoint protein on lagging chromosomes
    M J Martinez-Exposito
    Department of Biology, 68 371, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 96:8493-8. 1999
  10. pmc The unstable F-box protein p58-Ctf13 forms the structural core of the CBF3 kinetochore complex
    I D Russell
    Massachusetts Institute of Technology, Department of Biology, Cambridge, Massachusetts 02139, USA
    J Cell Biol 145:933-50. 1999

Collaborators

  • Kevin A Janes
  • Ulrik B Nielsen
  • Stephen C Harrison
  • I S Nathke
  • J R Swedlow
  • A A Hyman
  • A Grancell
  • JEFFREY W HARPER
  • Frank Stegmeier
  • Andrew D McAinsh
  • Jing Chen
  • Michael Yaffe
  • Ilya G Goldberg
  • MARC WALLACE KIRSCHNER
  • Khuloud Jaqaman
  • Patrick Meraldi
  • Douglas A Lauffenburger
  • Viji M Draviam
  • John G Albeck
  • Ronnie R Wei
  • Julio Saez-Rodriguez
  • Bree B Aldridge
  • Birgit Schoeberl
  • K B Kaplan
  • Peter De Wulf
  • Christopher W Espelin
  • Melody K Morris
  • John J Bellizzi
  • Théodora Niault
  • John M Burke
  • V M Draviam
  • Jonathan B Fitzgerald
  • B B Aldridge
  • Jessica D Tytell
  • Aurora A Burds
  • Robert S Hagan
  • J J L Miranda
  • Emily S Gillett
  • X He
  • E S Gillett
  • M Dobles
  • Bjorn Millard
  • Jeremy Muhlich
  • M J Martinez-Exposito
  • Arthur Goldsipe
  • Mingsheng Zhang
  • I D Russell
  • Leonidas G Alexopoulos
  • Grzegorz Nalepa
  • Robert Benezra
  • Katja Wassmann
  • Rocio Sotillo
  • Anthony Liang
  • Stephen J Elledge
  • Khaled Hached
  • Bernard Maro
  • Gregory J Hannon
  • Mathew E Sowa
  • Esther Rheinbay
  • Nicholas A Larsen
  • G Haller
  • B Aldridge
  • D A Lauffenburger
  • Gavin MacBeath
  • Jason R Schnell
  • Suzanne Gaudet
  • James J Chou
  • Forest M White
  • Art Kudla
  • I Shapiro
  • Emily Pace
  • Viara Garantcharova
  • Shavonne Howard
  • Annegret Schulze Lutum
  • Stephanie Xie
  • Kim T Simons
  • A A Burds
  • S S Bekir
  • D R Rines
  • C W Espelin
  • R Benezra
  • V Liberal
  • M L Scott
  • J Copeland

Detail Information

Publications43

  1. pmc Spindle checkpoint proteins and chromosome-microtubule attachment in budding yeast
    Emily S Gillett
    Massachusetts Institute of Technology, Department of Biology, 77 Massachusetts Ave, 68 371 Cambridge, MA 02139, USA
    J Cell Biol 164:535-46. 2004
    ..We propose that differences in the behavior of spindle checkpoint proteins in animal cells and budding yeast result primarily from evolutionary divergence in spindle assembly pathways...
  2. pmc Analysis of kinesin motor function at budding yeast kinetochores
    Jessica D Tytell
    Department of Biology and 2Biological Engineering Division Massachusetts Institute of Technology Cambridge MA 02139, USA
    J Cell Biol 172:861-74. 2006
    ..These data demonstrate roles for structurally diverse motors in the complex processes of chromosome segregation and reveal important similarities and intriguing differences between higher and lower eukaryotes...
  3. pmc The Open Microscopy Environment (OME) Data Model and XML file: open tools for informatics and quantitative analysis in biological imaging
    Ilya G Goldberg
    Laboratory of Genetics National Institute on Aging, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USA
    Genome Biol 6:R47. 2005
    ..The OME Data Model, expressed in Extensible Markup Language (XML) and realized in a traditional database, is both extensible and self-describing, allowing it to meet emerging imaging and analysis needs...
  4. pmc Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins
    Patrick Meraldi
    Department of Biology, Massachusetts Institute of Technology, Massachusetts Ave, Cambridge, MA 02139, USA
    Genome Biol 7:R23. 2006
    ....
  5. ncbi request reprint A reductionist's systems biology: opinion
    Peter K Sorger
    Department of Biology, Massachusetts Institute of Technology, Room 68 371, 77 Mass Ave, Cambridge, MA 02139, USA
    Curr Opin Cell Biol 17:9-11. 2005
    ....
  6. ncbi request reprint Tracing the pathway of spindle assembly checkpoint signaling
    E S Gillett
    Massachusetts Institute of Technology, Dept of Biology, Cambridge 02139, USA
    Dev Cell 1:162-4. 2001
    ..Interestingly, a paper from Hongtao Yu and colleagues in this issue of Developmental Cell suggests that the Cdc20/APC can also be inhibited in a Mad2-independent manner by a complex of proteins that includes BubR1...
  7. ncbi request reprint Molecular analysis of kinetochore-microtubule attachment in budding yeast
    X He
    Massachusetts Institute of Technology, Department of Biology, Cambridge, MA 02139, USA
    Cell 106:195-206. 2001
    ..The proteins include both molecular motors and microtubule associated proteins (MAPs), implying that motors and MAPs function together in binding chromosomes to spindle microtubules...
  8. ncbi request reprint A role for the Adenomatous Polyposis Coli protein in chromosome segregation
    K B Kaplan
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Cell Biol 3:429-32. 2001
    ..Our data are consistent with a role for APC in kinetochore-microtubule attachment and suggest that truncations in APC that eliminate microtubule binding may contribute to chromosomal instability in cancer cells...
  9. pmc Retention of the BUB3 checkpoint protein on lagging chromosomes
    M J Martinez-Exposito
    Department of Biology, 68 371, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 96:8493-8. 1999
    ..Intriguingly, the number of lagging chromosomes with high Bub3 staining increases dramatically in cells treated with low (and pharmacologically relevant) concentrations of the chemotherapeutic taxol and the microtubule poison nocodazole...
  10. pmc The unstable F-box protein p58-Ctf13 forms the structural core of the CBF3 kinetochore complex
    I D Russell
    Massachusetts Institute of Technology, Department of Biology, Cambridge, Massachusetts 02139, USA
    J Cell Biol 145:933-50. 1999
    ..This pathway may constitute an editing mechanism preventing the formation of ectopic kinetochores and ensuring the fidelity of chromosome segregation...
  11. pmc Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells
    V M Draviam
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    EMBO J 25:2814-27. 2006
    ..We propose that impaired EB1 or APC function generates lesions invisible to the spindle checkpoint and thereby promotes low levels of CIN expected to fuel aneuploidy and possibly tumorigenesis...
  12. ncbi request reprint Regulating the yeast kinetochore by ubiquitin-dependent degradation and Skp1p-mediated phosphorylation
    K B Kaplan
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 91:491-500. 1997
    ..We propose that coupled activation and destruction link the assembly of Cbf3p to the duplication of centromeres in S phase...
  13. ncbi request reprint Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2
    M Dobles
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 101:635-45. 2000
    ..Thus, the spindle assembly checkpoint is required for accurate chromosome segregation in mitotic mouse cells, and for embryonic viability, even in the absence of spindle damage...
  14. ncbi request reprint Chromosome movement: kinetochores motor along
    A Grancell
    Department of Biology, Cambridge, Massachusetts 02139, USA
    Curr Biol 8:R382-5. 1998
    ..The kinetochore-associated CENP-E motor protein is critical for the sustained movement of chromosomes towards the metaphase plate during chromosome congression...
  15. pmc A dual role for Bub1 in the spindle checkpoint and chromosome congression
    Patrick Meraldi
    Department of Biology and Biological Engineering, MIT, Cambridge, MA 02139 4307, USA
    EMBO J 24:1621-33. 2005
    ..Thus, Bub1 and Aurora B appear to function in parallel pathways that promote formation of stable bipolar kinetochore-microtubule attachments...
  16. ncbi request reprint Structure, function, and regulation of budding yeast kinetochores
    Andrew D McAinsh
    Department of Biology, and Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Cell Dev Biol 19:519-39. 2003
    ..location of centromeres? What are the protein components of kinetochores, and how do they assemble a MT attachment site? How do MT attachments generate force? How do cells sense the state of attachment via the spindle assembly checkpoint?..
  17. ncbi request reprint The yeast DASH complex forms closed rings on microtubules
    J J L Miranda
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nat Struct Mol Biol 12:138-43. 2005
    ..We discuss potential roles for such collar-like structures in maintaining microtubule attachment and spindle integrity during chromosome segregation...
  18. ncbi request reprint Timing and checkpoints in the regulation of mitotic progression
    Patrick Meraldi
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Dev Cell 7:45-60. 2004
    ..We propose that cytosolic Mad2-BubR1 is essential to restrain anaphase onset early in mitosis when kinetochores are still assembling...
  19. pmc The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation
    Andrew D McAinsh
    Department of Biology, MIT, Cambridge, MA, USA
    EMBO J 25:4033-49. 2006
    ....
  20. pmc Binding of the essential Saccharomyces cerevisiae kinetochore protein Ndc10p to CDEII
    Christopher W Espelin
    Department of Biology, Massachusetts Institute of Technology, Cambridge Massachusetts 02139, USA
    Mol Biol Cell 14:4557-68. 2003
    ..A similar type of polymeric structure on chromosome arms may mediate other chromosome-spindle interactions...
  21. ncbi request reprint A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling
    Viji M Draviam
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Nat Cell Biol 9:556-64. 2007
    ....
  22. ncbi request reprint Direct Lyapunov exponent analysis enables parametric study of transient signalling governing cell behaviour
    B B Aldridge
    Biological Engineering Division, Center for Cell Decision Processes, MIT, Cambridge, MA 02139, USA
    Syst Biol (Stevenage) 153:425-32. 2006
    ..It is anticipated that DLE analysis will facilitate theoretical investigation of phenotypic outcomes in larger models of signalling networks...
  23. pmc Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes
    Peter De Wulf
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Dev 17:2902-21. 2003
    ..In addition, we propose that the three complexes have different functions with respect to force generation and MT attachment...
  24. ncbi request reprint A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis
    Kevin A Janes
    Biological Engineering Division, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 310:1646-53. 2005
    ..Projection along these axes captures the entire measured apoptotic network, suggesting that cell survival is determined by signaling through this canonical basis set...
  25. ncbi request reprint Chromosome segregation and genomic stability
    Viji M Draviam
    Department of Biology, Cambridge, Massachusetts 02139, USA
    Curr Opin Genet Dev 14:120-5. 2004
    ..Current research in the field is focused on elucidating the molecular basis of CIN, including the possible roles of defects in the spindle checkpoint and other regulators of mitosis...
  26. ncbi request reprint A data-driven computational model of the ErbB receptor signaling network
    Birgit Schoeberl
    Merrimack Pharmaceuticals, Cambridge, MA 02141, USA
    Conf Proc IEEE Eng Med Biol Soc 1:53-4. 2006
    ..As a biological system we examine signaling mediated ErbB receptor family as the current literature is very controversial...
  27. ncbi request reprint Physicochemical modelling of cell signalling pathways
    Bree B Aldridge
    Center for Cell Decision Processes, Department Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Nat Cell Biol 8:1195-203. 2006
    ....
  28. ncbi request reprint Collecting and organizing systematic sets of protein data
    John G Albeck
    Center for Cell Decision Processes, Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nat Rev Mol Cell Biol 7:803-12. 2006
    ..The key is to use several measurement technologies simultaneously and, recognizing each of their limits, to assemble a self-consistent compendium of systematic data...
  29. ncbi request reprint Cue-signal-response analysis of TNF-induced apoptosis by partial least squares regression of dynamic multivariate data
    Kevin A Janes
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Comput Biol 11:544-61. 2004
    ..Importantly, informative protein predictors of cell responses are always multivariate, demonstrating the multicomponent nature of the decision process...
  30. ncbi request reprint Systems biology and combination therapy in the quest for clinical efficacy
    Jonathan B Fitzgerald
    Merrimack Pharmaceuticals, One Kendall Square, Building 700 2nd floor, Cambridge, Massachusetts 02139, USA
    Nat Chem Biol 2:458-66. 2006
    ....
  31. pmc Logic-based models for the analysis of cell signaling networks
    Melody K Morris
    Center for Cell Decision Process and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Biochemistry 49:3216-24. 2010
    ....
  32. ncbi request reprint The response of human epithelial cells to TNF involves an inducible autocrine cascade
    Kevin A Janes
    Center for Cell Decision Processes, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Cell 124:1225-39. 2006
    ..quot; Time-dependent crosstalk of synergistic and antagonistic autocrine circuits may serve to link cellular responses to the local environment...
  33. pmc Generating chromosome instability through the simultaneous deletion of Mad2 and p53
    Aurora A Burds
    Department of Biology, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 102:11296-301. 2005
    ..We conclude that the mitotic checkpoint is not essential for viability per se and that a CIN phenotype can be established in culture through the inactivation of both the Mad2- and p53-dependent checkpoint pathways...
  34. pmc Comparative autoregressive moving average analysis of kinetochore microtubule dynamics in yeast
    Khuloud Jaqaman
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California
    Biophys J 91:2312-25. 2006
    ....
  35. pmc Molecular organization of the Ndc80 complex, an essential kinetochore component
    Ronnie R Wei
    Department of Biological Chemistry and Molecular Pharmacology, and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:5363-7. 2005
    ....
  36. pmc Flexible informatics for linking experimental data to mathematical models via DataRail
    Julio Saez-Rodriguez
    Center for Cell Decision Processes, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Bioinformatics 24:840-7. 2008
    ....
  37. pmc Quantitative analysis of pathways controlling extrinsic apoptosis in single cells
    John G Albeck
    Department of Systems Biology, Harvard Medical School, WAB Room 438, 200 Longwood Avenue, Boston, MA 02115, USA
    Mol Cell 30:11-25. 2008
    ..Together, these findings provide a quantitative picture of caspase regulatory networks and their failure modes...
  38. pmc Changing Mad2 levels affects chromosome segregation and spindle assembly checkpoint control in female mouse meiosis I
    Théodora Niault
    CNRS UMR7622 Biologie du Développement, Paris, France
    PLoS ONE 2:e1165. 2007
    ..Furthermore, SAC control is impaired in mad2+/- oocytes, also leading to the generation of aneuploidies in meiosis I...
  39. pmc Crystal structure of the yeast inner kinetochore subunit Cep3p
    John J Bellizzi
    Jack and Eileen Connors Laboratory of Structural Biology, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Structure 15:1422-30. 2007
    ..We have, using the structure of Cep3p (47-608) and the known structures of Zn(2)Cys(6)-cluster domains, modeled the interaction of Cep3p with CDEIII...
  40. ncbi request reprint Cell biology: the more MAD, the merrier
    Robert S Hagan
    Nature 434:575-7. 2005
  41. ncbi request reprint Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities
    Frank Stegmeier
    Howard Hughes Medical Institute, Department of Genetics, Harvard Partners Center for Genetics and Genomics, Boston, Massachusetts 02115, USA
    Nature 446:876-81. 2007
    ....
  42. pmc Informatics and quantitative analysis in biological imaging
    Jason R Swedlow
    Division of Gene Regulation and Expression, Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland
    Science 300:100-2. 2003
    ..With this design, OME provides a first step toward biological image informatics...
  43. ncbi request reprint Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain
    Ronnie R Wei
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Structure 14:1003-9. 2006
    ....