S Sonis

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint New trends in the management of oral mucositis
    Stephen Sonis
    Division of Dentistry, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    J Natl Compr Canc Netw 3:S54-6. 2005
  2. pmc Serum amyloid P ameliorates radiation-induced oral mucositis and fibrosis
    Lynne A Murray
    Promedior, Inc, 371 Phoenixville Pike, Malvern, PA, 19355, USA
    Fibrogenesis Tissue Repair 3:11. 2010
  3. doi request reprint Oral mucositis
    Stephen T Sonis
    Brigham and Women s Hospital and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Anticancer Drugs 22:607-12. 2011
  4. pmc Efficacy of palifermin (keratinocyte growth factor-1) in the amelioration of oral mucositis
    Stephen T Sonis
    Brigham and Women s Hospital and the Dana Farber Cancer Institute, Boston, MA, USA
    Core Evid 4:199-205. 2010
  5. doi request reprint SNP-based Bayesian networks can predict oral mucositis risk in autologous stem cell transplant recipients
    St Sonis
    Inform Genomics, Boston, MA, USA
    Oral Dis 19:721-7. 2013
  6. ncbi request reprint The relationship between mucosal cyclooxygenase-2 (COX-2) expression and experimental radiation-induced mucositis
    S T Sonis
    Division of Oral Medicine, Oral and Maxillofacial Surgery and Dentistry, Brigham and Women s Hospital, 75 Francis Street, Boston, Massachusetts, USA
    Oral Oncol 40:170-6. 2004
  7. doi request reprint Preliminary characterization of oral lesions associated with inhibitors of mammalian target of rapamycin in cancer patients
    Stephen Sonis
    Division of Oral Medicine and Dentistry, Brigham and Women s Hospital and Dana Farber Cancer Institute, Boston, MA02115, USA
    Cancer 116:210-5. 2010
  8. doi request reprint Mucositis: The impact, biology and therapeutic opportunities of oral mucositis
    Stephen T Sonis
    Harvard Farber Cancer Center, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Oral Oncol 45:1015-20. 2009
  9. ncbi request reprint A biological approach to mucositis
    Stephen T Sonis
    Division of Oral Medicine at Brigham and Women s Hospital and the Dana Farber Cancer Institute, Boston, Massachusetts, USA
    J Support Oncol 2:21-32; discussion 35-6. 2004
  10. ncbi request reprint Oral mucositis in cancer therapy
    Stephen T Sonis
    Department of Oral Medicine Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA
    J Support Oncol 2:3-8. 2004

Collaborators

Detail Information

Publications43

  1. ncbi request reprint New trends in the management of oral mucositis
    Stephen Sonis
    Division of Dentistry, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    J Natl Compr Canc Netw 3:S54-6. 2005
  2. pmc Serum amyloid P ameliorates radiation-induced oral mucositis and fibrosis
    Lynne A Murray
    Promedior, Inc, 371 Phoenixville Pike, Malvern, PA, 19355, USA
    Fibrogenesis Tissue Repair 3:11. 2010
    ..To evaluate the effect of the anti-fibrotic protein serum amyloid P (SAP) on radiation-induced oral mucositis (OM) and fibrosis in a hamster cheek-pouch model...
  3. doi request reprint Oral mucositis
    Stephen T Sonis
    Brigham and Women s Hospital and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Anticancer Drugs 22:607-12. 2011
    ..Although there are currently few treatment options for oral mucositis at the moment, the recognition that its underlying biology is complex has provided a range of treatment options that are currently being developed...
  4. pmc Efficacy of palifermin (keratinocyte growth factor-1) in the amelioration of oral mucositis
    Stephen T Sonis
    Brigham and Women s Hospital and the Dana Farber Cancer Institute, Boston, MA, USA
    Core Evid 4:199-205. 2010
    ..Palifermin is the first pharmaceutical/biological agent approved for the intervention of oral mucositis. The major objective of this review is to evaluate the evidence supporting the use of palifermin...
  5. doi request reprint SNP-based Bayesian networks can predict oral mucositis risk in autologous stem cell transplant recipients
    St Sonis
    Inform Genomics, Boston, MA, USA
    Oral Dis 19:721-7. 2013
    ..Our objective was to develop a probabilistic graphical model in which a cluster of single-nucleotide polymorphisms (SNPs) derived from salivary DNA could be used as a tool to predict SOM risk...
  6. ncbi request reprint The relationship between mucosal cyclooxygenase-2 (COX-2) expression and experimental radiation-induced mucositis
    S T Sonis
    Division of Oral Medicine, Oral and Maxillofacial Surgery and Dentistry, Brigham and Women s Hospital, 75 Francis Street, Boston, Massachusetts, USA
    Oral Oncol 40:170-6. 2004
    ..The kinetics of COX-2 expression relative to mucositis progression suggests that COX-2 is not a primary driver of radiation injury, but instead plays an amplifying role...
  7. doi request reprint Preliminary characterization of oral lesions associated with inhibitors of mammalian target of rapamycin in cancer patients
    Stephen Sonis
    Division of Oral Medicine and Dentistry, Brigham and Women s Hospital and Dana Farber Cancer Institute, Boston, MA02115, USA
    Cancer 116:210-5. 2010
    ..An analysis of the appearance, course, and toxicity associations of mTOR inhibitor-associated stomatitis (mIAS) demonstrated that the condition is distinct from conventional mucositis (CM) and more closely resembles aphthous stomatitis...
  8. doi request reprint Mucositis: The impact, biology and therapeutic opportunities of oral mucositis
    Stephen T Sonis
    Harvard Farber Cancer Center, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Oral Oncol 45:1015-20. 2009
    ..A number of eclectic molecules, all designed to interfere with pathways that lead to injury are in pre-clinical and clinical development...
  9. ncbi request reprint A biological approach to mucositis
    Stephen T Sonis
    Division of Oral Medicine at Brigham and Women s Hospital and the Dana Farber Cancer Institute, Boston, Massachusetts, USA
    J Support Oncol 2:21-32; discussion 35-6. 2004
    ..Each phase offers a potential target for therapeutic intervention...
  10. ncbi request reprint Oral mucositis in cancer therapy
    Stephen T Sonis
    Department of Oral Medicine Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA
    J Support Oncol 2:3-8. 2004
    ..Continued research is needed to optimize when these treatments should be administered during the course of cancer therapy to maximize therapeutic benefit...
  11. ncbi request reprint Is oral mucositis an inevitable consequence of intensive therapy for hematologic cancers?
    Stephen T Sonis
    Brigham and Women s Hospital, Boston, MA 02115, USA
    Nat Clin Pract Oncol 2:134-5. 2005
  12. ncbi request reprint Gene expression changes in peripheral blood cells provide insight into the biological mechanisms associated with regimen-related toxicities in patients being treated for head and neck cancers
    S Sonis
    Division of Oral Medicine and Head and Neck Cancer, Dana Farber Cancer Institute, Boston, MA, USA
    Oral Oncol 43:289-300. 2007
    ..to evaluate potential relationships between the expression of particular genes, canonical pathways, and functional networks in explaining the pathogenesis of regimen-related toxicities...
  13. ncbi request reprint Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients
    Stephen T Sonis
    Division of Oral Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer 100:1995-2025. 2004
    ....
  14. ncbi request reprint The pathobiology of mucositis
    Stephen T Sonis
    Division of Oral Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Nat Rev Cancer 4:277-84. 2004
  15. ncbi request reprint Pathobiology of oral mucositis: novel insights and opportunities
    Stephen T Sonis
    Department of Oral Medicine, Harvard Medical School Boston, Massachusetts, USA
    J Support Oncol 5:3-11. 2007
    ..Insights into the mechanisms of oral mucositis are generating new approaches for effective, targeted treatment...
  16. doi request reprint Regimen-related gastrointestinal toxicities in cancer patients
    Stephen T Sonis
    Harvard Farber Cancer Center, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Curr Opin Support Palliat Care 4:26-30. 2010
    ..The purpose of this review is to describe the scope, risk factors, pathobiology, and treatment opportunities for mucositis...
  17. doi request reprint New thoughts on the initiation of mucositis
    S T Sonis
    Harvard Farber Cancer Center, Brigham and Women s Hospital, Boston, MA 02115, USA
    Oral Dis 16:597-600. 2010
    ..This essay proposes new thoughts on the phase's components, how they might interact, and how they present new opportunities for treatment interventions and mucositis risk prediction...
  18. doi request reprint Bony changes in the jaws of rats treated with zoledronic acid and dexamethasone before dental extractions mimic bisphosphonate-related osteonecrosis in cancer patients
    Stephen T Sonis
    Division of Oral Medicine, Dana Farber Harvard Cancer Center, Boston, MA, United States
    Oral Oncol 45:164-72. 2009
    ....
  19. ncbi request reprint The biologic role for nuclear factor-kappaB in disease and its potential involvement in mucosal injury associated with anti-neoplastic therapy
    Stephen T Sonis
    Department of Oral Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Crit Rev Oral Biol Med 13:380-9. 2002
    ..This paper provides a review of the structure and function of NF-kappaB and speculates how its apparent enigmatic effect on normal and tumor cells may occur...
  20. ncbi request reprint Oral complications of cancer therapy
    Stephen T Sonis
    Department of Oral Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, Brigham and Women s Hospital, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Oncology (Williston Park) 16:680-6; discussion 686, 691-2, 695. 2002
    ..A surge of investigational interest has been directed at understanding the mechanisms of these stomatotoxicities and at developing treatment strategies to combat them...
  21. ncbi request reprint The gene expression sequence of radiated mucosa in an animal mucositis model
    S T Sonis
    Division of Oral Medicine, Oral and Maxillofacial Surgery and Dentistry, Brigham and Women s Hospital and the Department of Otal Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, USA
    Cell Prolif 35:93-102. 2002
    ..Our results demonstrate the sequential upregulation of a series of genes that, when taken collectively, suggest an intricate functional interaction...
  22. doi request reprint Attenuation of radiation- and chemoradiation-induced mucositis using gamma-D-glutamyl-L-tryptophan (SCV-07)
    B Watkins
    Biomodels, L L C Watertown, MA, USA
    Oral Dis 16:655-60. 2010
    ..To evaluate the efficacy of a novel immunomodulating peptide (SCV-07) in attenuating the course of radiation-induced mucositis in an established animal model of oral mucositis (OM)...
  23. pmc Management of oral mucositis in patients who have cancer
    Rajesh V Lalla
    Division of Oral Medicine, Department of Oral Health and Diagnostic Sciences, University of Connecticut Health Center MC 1605, 263 Farmington Avenue, Farmington, CT 06030, USA
    Dent Clin North Am 52:61-77, viii. 2008
    ..These agents are discussed in the context of recently updated evidence-based clinical management guidelines...
  24. ncbi request reprint Pathobiology of mucositis
    Stephen T Sonis
    Harvard School of Dental Medicine, Boston, MA, USA
    Semin Oncol Nurs 20:11-5. 2004
    ..To describe the pathogenesis of mucositis, summarize the techniques used to study the condition, and describe the current five-phase model that defines mucositis pathogenesis...
  25. doi request reprint Efficacy of superoxide dismutase mimetic M40403 in attenuating radiation-induced oral mucositis in hamsters
    Christopher K Murphy
    ActivBiotics, Inc, Lexington, Massachusetts, USA
    Clin Cancer Res 14:4292-7. 2008
    ..The ability of i.p. administered M40403 to decrease the duration and severity of oral mucositis was assessed after treatment at different doses and dosing schedules. Oral mucositis was scored using the WHO grading scale...
  26. ncbi request reprint A phase I/II double-blind, placebo-controlled study of recombinant human interleukin-11 for mucositis and acute GVHD prevention in allogeneic stem cell transplantation
    J H Antin
    Department of Adult Oncology and Biostatistical Science, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Bone Marrow Transplant 29:373-7. 2002
    ..The use of IL-11 as GVHD prophylaxis in allogeneic transplantation cannot be recommended as administered in this trial...
  27. ncbi request reprint Caspase-11 is not necessary for chemotherapy-induced intestinal mucositis
    Shin Jung Kang
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    DNA Cell Biol 23:490-5. 2004
    ..These findings suggest that while caspase-11 activation occurs in response to melphalan, it does not have a primary role in the pathogenesis of intestinal mucositis...
  28. ncbi request reprint Gene expression profiling by DNA microarrays and its application to dental research
    Winston Patrick Kuo
    Department of Oral Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, USA
    Oral Oncol 38:650-6. 2002
    ..The technology permits the simultaneous analysis of tens of thousands of genes for the purposes of gene discovery, disease diagnosis. improved drug development, and therapeutics tailored to specific disease processes...
  29. ncbi request reprint Microarrays and clinical dentistry
    Winston Patrick Kuo
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Mass 02115, USA
    J Am Dent Assoc 134:456-62. 2003
    ....
  30. ncbi request reprint Deciphering gene expression profiles generated from DNA microarrays and their applications in oral medicine
    Winston Patrick Kuo
    Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Cambridge, MA 02115, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97:584-91. 2004
    ....
  31. ncbi request reprint Serum levels of NFkappaB and pro-inflammatory cytokines following administration of mucotoxic drugs
    Richard M Logan
    Oral Pathology, School of Dentistry, Faculty of Health Sciences, The University of Adelaide, South Australia, Australia
    Cancer Biol Ther 7:1139-45. 2008
    ..The aims of this study were to determine whether changes in serum levels of NFkappaB, TNF, IL-1beta and IL-6 following administration of different drugs predicted histological evidence of tissue damage...
  32. ncbi request reprint Evaluation of pain associated with oral mucositis during the acute period after administration of high-dose chemotherapy
    David Cella
    Institute for Health Services Research and Policy Studies, Evanston Northwestern Healthcare and Northwestern University, Evanston, Illinois 60201, USA
    Cancer 98:406-12. 2003
    ..The findings of the current study may provide a clinical context for understanding the relation between objective indicators and patients' perceptions of OM...
  33. ncbi request reprint A phase III, randomized, double-blind, placebo-controlled, multinational trial of iseganan for the prevention of oral mucositis in patients receiving stomatotoxic chemotherapy (PROMPT-CT trial)
    Francis J Giles
    Department of Leukemia, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 428, Houston, TX 77030, USA
    Leuk Lymphoma 44:1165-72. 2003
    ..6 and 2.0 (P = 0.0131). Iseganan was well tolerated; no systemic absorption was detected. Iseganan is safe and may be effective in reducing UOM and its clinical sequelae...
  34. ncbi request reprint Preclinical characterization of CG53135 (FGF-20) in radiation and concomitant chemotherapy/radiation-induced oral mucositis
    Enrique Alvarez
    CuraGen Corp, Branford, Connecticut 06405, USA
    Clin Cancer Res 9:3454-61. 2003
    ..The purpose of this study was to evaluate the activity of CG53135 (FGF-20), a protein with in vitro mitogenic activity on epithelial and mesenchymal cells, in two in vivo models of oral mucositis (OM)...
  35. ncbi request reprint Characterisation of mucosal changes in the alimentary tract following administration of irinotecan: implications for the pathobiology of mucositis
    Richard M Logan
    Oral Pathology, School of Dentistry, Faculty of Health Sciences, The University of Adelaide, North Terrace, SA 5005, Australia
    Cancer Chemother Pharmacol 62:33-41. 2008
    ....
  36. ncbi request reprint Updated clinical practice guidelines for the prevention and treatment of mucositis
    Dorothy M Keefe
    Department of Medical Oncology, Royal Adelaide Hospital, Adelaide, Australia
    Cancer 109:820-31. 2007
    ..These efforts are likely to have significant clinical and economic impact on the treatment of cancer patients. Cancer 2007;109:820-31. (c) 2007 American Cancer Society...
  37. ncbi request reprint Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucositis
    Edward B Rubenstein
    Department of Palliative Care and Rehabilitation Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 100:2026-46. 2004
    ....
  38. ncbi request reprint Nuclear factor-kappaB (NF-kappaB) and cyclooxygenase-2 (COX-2) expression in the oral mucosa following cancer chemotherapy
    Richard M Logan
    Oral Pathology, School of Dentistry, The University of Adelaide, Adelaide, North Terrace, SA 5005, Australia
    Oral Oncol 43:395-401. 2007
    ....
  39. ncbi request reprint Effects of ceramide inhibition on experimental radiation-induced oral mucositis
    Debby Hwang
    Department of Periodontology, School of Dental Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100:321-9. 2005
    ..In response to IR or other cellular stresses, ceramide production occurs either by the hydrolytic action of sphingomyelinase (SMase) or de novo via ceramide synthase...
  40. doi request reprint Velafermin (rhFGF-20) reduces the severity and duration of hamster cheek pouch mucositis induced by fractionated radiation
    Gulshan Ara
    CuraGen Corporation, Branford, Connecticut, USA
    Int J Radiat Biol 84:401-12. 2008
    ..Our present study assessed the impact of velafermin on the severity and duration of oral mucositis that occurred as a consequence of fractionated radiation...
  41. ncbi request reprint The role of pro-inflammatory cytokines in cancer treatment-induced alimentary tract mucositis: pathobiology, animal models and cytotoxic drugs
    Richard M Logan
    Oral Pathology, School of Dentistry, Faculty of Health Sciences, The University of Adelaide, North Terrace, Adelaide SA 5005, Australia
    Cancer Treat Rev 33:448-60. 2007
    ....
  42. ncbi request reprint Emerging drugs for chemotherapy-induced mucositis
    Dorothy M Keefe
    Royal Adelaide Hospital, RAH Cancer Centre, North Terrace, Adelaide, SA 5000, Australia
    Expert Opin Emerg Drugs 13:511-22. 2008
    ..The pathobiology of mucositis is complex, and agents that target mechanisms to prevent mucositis or accelerate healing are in high demand...
  43. ncbi request reprint Antimicrobial therapy to prevent or treat oral mucositis
    J Peter Donnelly
    Supportive Care Studies, Department of Haematology, University Medical Centre, St Radboud, Nijmegen, Netherlands
    Lancet Infect Dis 3:405-12. 2003
    ..Hence, there is a need to better understand the role of the microflora in the cause of oral mucositis if an antimicrobial agent for prevention and treatment of this disease is to be developed...