Research Topics
| Ken SoltSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
General anesthesia: activating a sleep switch?Ken Solt
Department of Anesthesia, Harvard Medical School, and Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, 55 Fruit Street, GRB 444, Boston, MA 02114, USA Electronic address
Curr Biol 22:R918-9. 2012..A widely used general anesthetic directly depolarizes sleep-promoting cells in the brain at doses that produce unconsciousness. The activation of an endogenous sleep pathway likely plays a role in general anesthesia...
Differential modulation of human N-methyl-D-aspartate receptors by structurally diverse general anestheticsKen Solt
Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Anesth Analg 102:1407-11. 2006..Such differences may be useful for defining the role that this receptor plays in producing the in vivo actions of general anesthetics...- General anesthetic-induced channel gating enhancement of 5-hydroxytryptamine type 3 receptors depends on receptor subunit compositionKen Solt
Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, 02114, USA
J Pharmacol Exp Ther 315:771-6. 2005.... 
Methylphenidate actively induces emergence from general anesthesiaKen Solt
Department of Anaesthesia, Harvard Medical School, Boston, Massachusetts, USA
Anesthesiology 115:791-803. 2011..In this study, the authors tested the hypothesis that methylphenidate (an inhibitor of dopamine and norepinephrine transporters) induces emergence from isoflurane general anesthesia...- Differential effects of serotonin and dopamine on human 5-HT3A receptor kinetics: interpretation within an allosteric kinetic modelKen Solt
Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Neurosci 27:13151-60. 2007.... - Active emergence from propofol general anesthesia is induced by methylphenidateJessica J Chemali
Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Anesthesiology 116:998-1005. 2012..The objective of this study was to test the hypothesis that methylphenidate actively induces emergence from propofol general anesthesia... - Inhibition of human alpha4beta2 neuronal nicotinic acetylcholine receptors by volatile aromatic anesthetics depends on drug hydrophobicityKen Solt
Department of Anaesthesia, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Anesth Analg 110:455-60. 2010..In this study, we tested the hypothesis that aromatic anesthetics reversibly inhibit alpha(4)beta(2) neuronal nACh receptor function and sought to determine the structural correlates of receptor inhibition... - Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on ligand-gated ion channelsS Shaukat Husain
Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114 USA
J Med Chem 49:4818-25. 2006..Thus, they have the necessary pharmacological and photochemical properties to be useful in identifying the site of etomidate-induced anesthesia... - Activation of D1 dopamine receptors induces emergence from isoflurane general anesthesiaNorman E Taylor
Department of Anaesthesia, Harvard Medical School, Boston, MA, USA
Anesthesiology 118:30-9. 2013..Methylphenidate inhibits dopamine and norepinephrine reuptake transporters. The objective of this study was to test the hypothesis that selective dopamine receptor activation induces emergence from isoflurane anesthesia... - Inhaled anesthetics do not combine to produce synergistic effects regarding minimum alveolar anesthetic concentration in ratsEdmond I Eger
Department of Anesthesia, S 455, University of California, San Francisco, CA 94143 0464, USA
Anesth Analg 107:479-85. 2008.... - Volatile aromatic anesthetics variably impact human gamma-aminobutyric acid type A receptor functionElizabeth W Kelly
Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Anesth Analg 105:1287-92, table of contents. 2007..In this study, we sought to assess the potential role that GABA(A) receptors play in mediating the behavioral actions of volatile aromatic anesthetics... - Correlating the clinical actions and molecular mechanisms of general anestheticsKen Solt
Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02114, USA
Curr Opin Anaesthesiol 20:300-6. 2007..To summarize recent in-vitro and in-vivo research on molecular mechanisms of general anesthetics' actions... - Kinetics of anesthetic-induced conformational transitions in a four-alpha-helix bundle proteinKen Solt
Department of Anesthesia and Critical Care, Massachusetts General Hospital, 55 Fruit Street, Clinics Building 3, Boston, Massachusetts 02114, USA
Biochemistry 45:1435-41. 2006.... - General anesthetics have additive actions on three ligand gated ion channelsAndrew Jenkins
Department of Anesthesiology, Emory University School of Medicine, 1462 Clifton Rd NE Suite 420, Atlanta, GA 30322, USA
Anesth Analg 107:486-93. 2008.... - Modulation of human 5-hydroxytryptamine type 3AB receptors by volatile anesthetics and n-alcoholsRenna Stevens
Neuroscience Program, University of California at San Diego, USA
J Pharmacol Exp Ther 314:338-45. 2005..Incorporation of the 5-HT3B subunit alters either the anesthetic binding site or the allosteric interactions between anesthetic binding and channel opening... - Hexafluorobenzene acts in the spinal cord, whereas o-difluorobenzene acts in both brain and spinal cord, to produce immobilityJoseph F Antognini
Department of Anesthesiology and Pain Medicine, University of California, Davis, California 95616, USA
Anesth Analg 104:822-8. 2007..We sought to test such an applicability by determining whether the cord mediated the immobilizing effects of two aromatic anesthetics that differ greatly in their ability to block N-methyl-d-aspartate receptors... - Do N-methyl-D-aspartate receptors mediate the capacity of inhaled anesthetics to suppress the temporal summation that contributes to minimum alveolar concentration?Robert C Dutton
Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California 94143 0464, USA
Anesth Analg 102:1412-8. 2006..NMDA receptor blockade may contribute to the MAC produced by inhaled anesthetics that potently inhibit NMDA receptors in vitro but not those that have a limited in vitro effect... - Contrasting roles of the N-methyl-D-aspartate receptor in the production of immobilization by conventional and aromatic anestheticsEdmond I Eger
Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
Anesth Analg 102:1397-406. 2006..We conclude that some aromatic anesthetics may produce immobility in the face of noxious stimulation by blocking the action of glutamate on NMDA receptors but that conventional inhaled anesthetics do not... - Binding of the general anesthetics chloroform and 2,2,2-trichloroethanol to the hydrophobic core of a four-alpha-helix bundle proteinsJonas S Johansson
Department of Anesthesia, University of Pennsylvania, Philadelphia, PA 19104, USA
Photochem Photobiol 77:89-95. 2003..The results indicate that chloroform, halothane and 2,2,2-trichloroethanol may occupy the same sites on protein targets...