Ken Solt

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi request reprint General anesthesia: activating a sleep switch?
    Ken Solt
    Department of Anesthesia, Harvard Medical School, and Massachusetts General Hospital, Boston, MA 02114, USA
    Curr Biol 22:R918-9. 2012
  2. pmc Methylphenidate actively induces emergence from general anesthesia
    Ken Solt
    Department of Anaesthesia, Harvard Medical School, Boston, Massachusetts, USA
    Anesthesiology 115:791-803. 2011
  3. ncbi request reprint General anesthetic-induced channel gating enhancement of 5-hydroxytryptamine type 3 receptors depends on receptor subunit composition
    Ken Solt
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, 02114, USA
    J Pharmacol Exp Ther 315:771-6. 2005
  4. ncbi request reprint Differential modulation of human N-methyl-D-aspartate receptors by structurally diverse general anesthetics
    Ken Solt
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Anesth Analg 102:1407-11. 2006
  5. ncbi request reprint Differential effects of serotonin and dopamine on human 5-HT3A receptor kinetics: interpretation within an allosteric kinetic model
    Ken Solt
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Neurosci 27:13151-60. 2007
  6. pmc Inhibition of human alpha4beta2 neuronal nicotinic acetylcholine receptors by volatile aromatic anesthetics depends on drug hydrophobicity
    Ken Solt
    Department of Anaesthesia, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Anesth Analg 110:455-60. 2010
  7. pmc Active emergence from propofol general anesthesia is induced by methylphenidate
    Jessica J Chemali
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Anesthesiology 116:998-1005. 2012
  8. pmc Kinetics of anesthetic-induced conformational transitions in a four-alpha-helix bundle protein
    Ken Solt
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, 55 Fruit Street, Clinics Building 3, Boston, Massachusetts 02114, USA
    Biochemistry 45:1435-41. 2006
  9. ncbi request reprint Correlating the clinical actions and molecular mechanisms of general anesthetics
    Ken Solt
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02114, USA
    Curr Opin Anaesthesiol 20:300-6. 2007
  10. ncbi request reprint Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on ligand-gated ion channels
    S Shaukat Husain
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114 USA
    J Med Chem 49:4818-25. 2006

Collaborators

Detail Information

Publications20

  1. doi request reprint General anesthesia: activating a sleep switch?
    Ken Solt
    Department of Anesthesia, Harvard Medical School, and Massachusetts General Hospital, Boston, MA 02114, USA
    Curr Biol 22:R918-9. 2012
    ..A widely used general anesthetic directly depolarizes sleep-promoting cells in the brain at doses that produce unconsciousness. The activation of an endogenous sleep pathway likely plays a role in general anesthesia...
  2. pmc Methylphenidate actively induces emergence from general anesthesia
    Ken Solt
    Department of Anaesthesia, Harvard Medical School, Boston, Massachusetts, USA
    Anesthesiology 115:791-803. 2011
    ..In this study, the authors tested the hypothesis that methylphenidate (an inhibitor of dopamine and norepinephrine transporters) induces emergence from isoflurane general anesthesia...
  3. ncbi request reprint General anesthetic-induced channel gating enhancement of 5-hydroxytryptamine type 3 receptors depends on receptor subunit composition
    Ken Solt
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, 02114, USA
    J Pharmacol Exp Ther 315:771-6. 2005
    ....
  4. ncbi request reprint Differential modulation of human N-methyl-D-aspartate receptors by structurally diverse general anesthetics
    Ken Solt
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Anesth Analg 102:1407-11. 2006
    ..Such differences may be useful for defining the role that this receptor plays in producing the in vivo actions of general anesthetics...
  5. ncbi request reprint Differential effects of serotonin and dopamine on human 5-HT3A receptor kinetics: interpretation within an allosteric kinetic model
    Ken Solt
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Neurosci 27:13151-60. 2007
    ....
  6. pmc Inhibition of human alpha4beta2 neuronal nicotinic acetylcholine receptors by volatile aromatic anesthetics depends on drug hydrophobicity
    Ken Solt
    Department of Anaesthesia, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Anesth Analg 110:455-60. 2010
    ..In this study, we tested the hypothesis that aromatic anesthetics reversibly inhibit alpha(4)beta(2) neuronal nACh receptor function and sought to determine the structural correlates of receptor inhibition...
  7. pmc Active emergence from propofol general anesthesia is induced by methylphenidate
    Jessica J Chemali
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Anesthesiology 116:998-1005. 2012
    ..The objective of this study was to test the hypothesis that methylphenidate actively induces emergence from propofol general anesthesia...
  8. pmc Kinetics of anesthetic-induced conformational transitions in a four-alpha-helix bundle protein
    Ken Solt
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, 55 Fruit Street, Clinics Building 3, Boston, Massachusetts 02114, USA
    Biochemistry 45:1435-41. 2006
    ....
  9. ncbi request reprint Correlating the clinical actions and molecular mechanisms of general anesthetics
    Ken Solt
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02114, USA
    Curr Opin Anaesthesiol 20:300-6. 2007
    ..To summarize recent in-vitro and in-vivo research on molecular mechanisms of general anesthetics' actions...
  10. ncbi request reprint Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on ligand-gated ion channels
    S Shaukat Husain
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114 USA
    J Med Chem 49:4818-25. 2006
    ..Thus, they have the necessary pharmacological and photochemical properties to be useful in identifying the site of etomidate-induced anesthesia...
  11. pmc Activation of D1 dopamine receptors induces emergence from isoflurane general anesthesia
    Norman E Taylor
    Department of Anaesthesia, Harvard Medical School, Boston, MA, USA
    Anesthesiology 118:30-9. 2013
    ..Methylphenidate inhibits dopamine and norepinephrine reuptake transporters. The objective of this study was to test the hypothesis that selective dopamine receptor activation induces emergence from isoflurane anesthesia...
  12. doi request reprint Inhaled anesthetics do not combine to produce synergistic effects regarding minimum alveolar anesthetic concentration in rats
    Edmond I Eger
    Department of Anesthesia, S 455, University of California, San Francisco, CA 94143 0464, USA
    Anesth Analg 107:479-85. 2008
    ....
  13. ncbi request reprint Volatile aromatic anesthetics variably impact human gamma-aminobutyric acid type A receptor function
    Elizabeth W Kelly
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Anesth Analg 105:1287-92, table of contents. 2007
    ..In this study, we sought to assess the potential role that GABA(A) receptors play in mediating the behavioral actions of volatile aromatic anesthetics...
  14. doi request reprint Assessing the effects of pharmacological agents on respiratory dynamics using time-series modeling
    Kin Foon Kevin Wong
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02129, USA
    IEEE Trans Biomed Eng 60:1118-25. 2013
    ..This paradigm can be readily adapted to analyze the dynamics of other respiratory variables before and after pharmacologic treatments...
  15. ncbi request reprint Binding of the general anesthetics chloroform and 2,2,2-trichloroethanol to the hydrophobic core of a four-alpha-helix bundle proteins
    Jonas S Johansson
    Department of Anesthesia, University of Pennsylvania, Philadelphia, PA 19104, USA
    Photochem Photobiol 77:89-95. 2003
    ..The results indicate that chloroform, halothane and 2,2,2-trichloroethanol may occupy the same sites on protein targets...
  16. pmc General anesthetics have additive actions on three ligand gated ion channels
    Andrew Jenkins
    Department of Anesthesiology, Emory University School of Medicine, 1462 Clifton Rd NE Suite 420, Atlanta, GA 30322, USA
    Anesth Analg 107:486-93. 2008
    ....
  17. ncbi request reprint Modulation of human 5-hydroxytryptamine type 3AB receptors by volatile anesthetics and n-alcohols
    Renna Stevens
    Neuroscience Program, University of California at San Diego, USA
    J Pharmacol Exp Ther 314:338-45. 2005
    ..Incorporation of the 5-HT3B subunit alters either the anesthetic binding site or the allosteric interactions between anesthetic binding and channel opening...
  18. ncbi request reprint Hexafluorobenzene acts in the spinal cord, whereas o-difluorobenzene acts in both brain and spinal cord, to produce immobility
    Joseph F Antognini
    Department of Anesthesiology and Pain Medicine, University of California, Davis, California 95616, USA
    Anesth Analg 104:822-8. 2007
    ..We sought to test such an applicability by determining whether the cord mediated the immobilizing effects of two aromatic anesthetics that differ greatly in their ability to block N-methyl-d-aspartate receptors...
  19. ncbi request reprint Do N-methyl-D-aspartate receptors mediate the capacity of inhaled anesthetics to suppress the temporal summation that contributes to minimum alveolar concentration?
    Robert C Dutton
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California 94143 0464, USA
    Anesth Analg 102:1412-8. 2006
    ..NMDA receptor blockade may contribute to the MAC produced by inhaled anesthetics that potently inhibit NMDA receptors in vitro but not those that have a limited in vitro effect...
  20. ncbi request reprint Contrasting roles of the N-methyl-D-aspartate receptor in the production of immobilization by conventional and aromatic anesthetics
    Edmond I Eger
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
    Anesth Analg 102:1397-406. 2006
    ..We conclude that some aromatic anesthetics may produce immobility in the face of noxious stimulation by blocking the action of glutamate on NMDA receptors but that conventional inhaled anesthetics do not...