D H Solomon

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi request reprint Comparative cancer risk associated with methotrexate, other non-biologic and biologic disease-modifying anti-rheumatic drugs
    Daniel H Solomon
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, MA Division of Pharmacoepidemiology, Brigham and Women s Hospital, Boston, MA Electronic address
    Semin Arthritis Rheum 43:489-97. 2014
  2. pmc Malignancy validation in a United States registry of rheumatoid arthritis patients
    Mark C Fisher
    Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    BMC Musculoskelet Disord 13:85. 2012
  3. pmc Sustained rheumatoid arthritis remission is uncommon in clinical practice
    Femke H M Prince
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Arthritis Res Ther 14:R68. 2012
  4. pmc The relationship between hand osteoarthritis and serum leptin concentration in participants of the Third National Health and Nutrition Examination Survey
    Mei Massengale
    Division of Rheumatology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Arthritis Res Ther 14:R132. 2012
  5. doi request reprint Defining the epidemiology of bisphosphonate-associated osteonecrosis of the jaw: prior work and current challenges
    D H Solomon
    Division of Pharmacoepidemiology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA, USA
    Osteoporos Int 24:237-44. 2013
  6. pmc Hydroxychloroquine improves insulin sensitivity in obese non-diabetic individuals
    Emileigh Mercer
    Division of Rheumatology, Brigham and Women s Hospital Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Arthritis Res Ther 14:R135. 2012
  7. pmc Use of administrative claims data for comparative effectiveness research of rheumatoid arthritis treatments
    Seo Young Kim
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, 1620 Tremont Street, Suite 3030, Boston MA 02120, USA
    Arthritis Res Ther 13:129. 2011
  8. doi request reprint Osteoporosis telephonic intervention to improve medication regimen adherence: a large, pragmatic, randomized controlled trial
    Daniel H Solomon
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Arch Intern Med 172:477-83. 2012
  9. pmc Primary care physicians' perspectives towards managing rheumatoid arthritis: room for improvement
    Katie L Garneau
    Division of Rheumatology, Brigham and Women s Hospital, 75 Francis Street, PBB B3, Boston, MA 02115, USA
    Arthritis Res Ther 13:R189. 2011
  10. pmc Decreasing medical complications for total knee arthroplasty: effect of critical pathways on outcomes
    M Elaine Husni
    Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    BMC Musculoskelet Disord 11:160. 2010

Collaborators

Detail Information

Publications135 found, 100 shown here

  1. doi request reprint Comparative cancer risk associated with methotrexate, other non-biologic and biologic disease-modifying anti-rheumatic drugs
    Daniel H Solomon
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, MA Division of Pharmacoepidemiology, Brigham and Women s Hospital, Boston, MA Electronic address
    Semin Arthritis Rheum 43:489-97. 2014
    ..Methotrexate has not been the focus of most contemporary pharmacoepidemiologic studies of cancer...
  2. pmc Malignancy validation in a United States registry of rheumatoid arthritis patients
    Mark C Fisher
    Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    BMC Musculoskelet Disord 13:85. 2012
    ..However, little is known on the accuracy of physician reported malignancies compared to pertinent medical record review in large cohort studies...
  3. pmc Sustained rheumatoid arthritis remission is uncommon in clinical practice
    Femke H M Prince
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Arthritis Res Ther 14:R68. 2012
    ..Remission is an important goal of therapy in rheumatoid arthritis (RA), but data on duration of remission are lacking. Our objective was to describe the duration of remission in RA, assessed by different criteria...
  4. pmc The relationship between hand osteoarthritis and serum leptin concentration in participants of the Third National Health and Nutrition Examination Survey
    Mei Massengale
    Division of Rheumatology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Arthritis Res Ther 14:R132. 2012
    ..However, this hypothesis has not been tested in large-scale hand OA cohorts. Our study aimed to determine whether there is a cross-sectional relationship between serum leptin levels and hand OA in a population-based sample of US adults...
  5. doi request reprint Defining the epidemiology of bisphosphonate-associated osteonecrosis of the jaw: prior work and current challenges
    D H Solomon
    Division of Pharmacoepidemiology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA, USA
    Osteoporos Int 24:237-44. 2013
    ..We examined the literature and two new cohorts for BONJ. The literature suggests an incidence rate of 0.028 % to 4.3 %. Our cohort studies found an incidence of 0.02 % (95 % CI 0.004 %-0.11 %)...
  6. pmc Hydroxychloroquine improves insulin sensitivity in obese non-diabetic individuals
    Emileigh Mercer
    Division of Rheumatology, Brigham and Women s Hospital Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Arthritis Res Ther 14:R135. 2012
    ..To investigate the mechanism of this effect, we examined the effect of HCQ on insulin resistance, insulin sensitivity, and pancreatic β-cell secretion of insulin in non-diabetic, obese subjects...
  7. pmc Use of administrative claims data for comparative effectiveness research of rheumatoid arthritis treatments
    Seo Young Kim
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, 1620 Tremont Street, Suite 3030, Boston MA 02120, USA
    Arthritis Res Ther 13:129. 2011
    ..A novel, claims-based algorithm to evaluate the clinical effectiveness of rheumatoid arthritis medications has been developed and its performance seems promising, although further validation is needed...
  8. doi request reprint Osteoporosis telephonic intervention to improve medication regimen adherence: a large, pragmatic, randomized controlled trial
    Daniel H Solomon
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Arch Intern Med 172:477-83. 2012
    ..We examined the effectiveness of a telephone-based counseling program rooted in motivational interviewing to improve adherence to a medication regimen for osteoporosis...
  9. pmc Primary care physicians' perspectives towards managing rheumatoid arthritis: room for improvement
    Katie L Garneau
    Division of Rheumatology, Brigham and Women s Hospital, 75 Francis Street, PBB B3, Boston, MA 02115, USA
    Arthritis Res Ther 13:R189. 2011
    ..Many people with rheumatoid arthritis (RA) do not receive care from a rheumatologist. We surveyed primary care physicians (PCPs) to better understand their attitudes, knowledge, and practices regarding the optimal treatment of RA...
  10. pmc Decreasing medical complications for total knee arthroplasty: effect of critical pathways on outcomes
    M Elaine Husni
    Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    BMC Musculoskelet Disord 11:160. 2010
    ..However, pathway effectiveness is difficult to determine given methodological flaws, such as small or single center cohorts. We studied the effect of critical pathways on total knee replacement outcomes in a large population-based study...
  11. pmc Validation of rheumatoid arthritis diagnoses in health care utilization data
    Seo Young Kim
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Arthritis Res Ther 13:R32. 2011
    ..Health care utilization databases have been increasingly used for studies of rheumatoid arthritis (RA). However, the accuracy of RA diagnoses in these data has been inconsistent...
  12. pmc Pain persists in DAS28 rheumatoid arthritis remission but not in ACR/EULAR remission: a longitudinal observational study
    Yvonne C Lee
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, 75 Francis Street, PBB B3, Boston, MA, USA
    Arthritis Res Ther 13:R83. 2011
    ..We assessed the prevalence of pain in RA patients in remission according to the Disease Activity Score (DAS28-CRP4) and the American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) remission criteria...
  13. pmc Bisphosphonates and risk of atrial fibrillation: a meta-analysis
    Seo Young Kim
    Division of Rheumatology, Allergy and Immunology, Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA, 02115, USA
    Arthritis Res Ther 12:R30. 2010
    ....
  14. pmc Risk of osteoporotic fracture in a large population-based cohort of patients with rheumatoid arthritis
    Seo Young Kim
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Arthritis Res Ther 12:R154. 2010
    ..Although osteoporosis has been reported to be more common in patients with rheumatoid arthritis (RA), little is known whether the risk of osteoporotic fractures in these patients differs by age, sex, and anatomic site...
  15. pmc The relationship between disease activity, sleep, psychiatric distress and pain sensitivity in rheumatoid arthritis: a cross-sectional study
    Yvonne C Lee
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, 75 Francis Street, PBB B3, Boston, MA 02115, USA
    Arthritis Res Ther 11:R160. 2009
    ..The etiology of RA pain is likely multifactorial, including both inflammatory and non-inflammatory components. In this study, we examine the association between disease activity, sleep, psychiatric distress and pain sensitivity in RA...
  16. pmc Development of a health care utilisation data-based index for rheumatoid arthritis severity: a preliminary study
    Gladys Ting
    Department of Medicine, Division of Pharmacoepidemiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Arthritis Res Ther 10:R95. 2008
    ....
  17. pmc A blinded randomized controlled trial of motivational interviewing to improve adherence with osteoporosis medications: design of the OPTIMA trial
    D H Solomon
    Division of Rheumatology, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Osteoporos Int 21:137-44. 2010
    ..Recruitment and randomization have been successful. Also, the counseling intervention has been well accepted by subjects randomized to this treatment arm...
  18. doi request reprint Osteoporosis treatments and adverse events
    Daniel H Solomon
    Division of Rheumatology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Curr Opin Rheumatol 21:363-8. 2009
    ..Recent case reports cite a range of potential adverse events. We review data regarding atrial fibrillation, bone pain, osteonecrosis of the jaw (ONJ), atypical fractures, and osteosarcoma...
  19. doi request reprint Risk of fractures in older adults using antihypertensive medications
    Daniel H Solomon
    Division of Rheumatology and Pharmacoepidemiology, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Bone Miner Res 26:1561-7. 2011
    ..It is concluded that the risk of fracture differs across users of different antihypertensive medications...
  20. pmc Risk of diabetes among patients with rheumatoid arthritis, psoriatic arthritis and psoriasis
    Daniel H Solomon
    Division of Rheumatology, Department of Medicine, Boston, MA 02115, USA
    Ann Rheum Dis 69:2114-7. 2010
    ..To examine the risk of diabetes mellitus (DM) among subjects with rheumatoid arthritis (RA), psoriatic arthritis or psoriasis (PsA/PsO), compared with non-rheumatic controls...
  21. doi request reprint The comparative safety of opioids for nonmalignant pain in older adults
    Daniel H Solomon
    Division of Pharmacoepidemiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Arch Intern Med 170:1979-86. 2010
    ..However, there is relatively little information about the comparative safety of opioids. Therefore, we sought to compare the safety of opioids commonly used for nonmalignant pain...
  22. doi request reprint Predictors of very low adherence with medications for osteoporosis: towards development of a clinical prediction rule
    D H Solomon
    Division of Rheumatology, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Osteoporos Int 22:1737-43. 2011
    ..When combined into a summative score, 62% with seven or more points on the score demonstrated very low adherence. This compares with 17% subjects with fewer than seven points (c-statistic = 0.74)...
  23. pmc The relationship between focal erosions and generalized osteoporosis in postmenopausal women with rheumatoid arthritis
    Daniel H Solomon
    Brigham and Women s Hospital, Division of Rheumatology, Boston, Massachusetts 02115, USA
    Arthritis Rheum 60:1624-31. 2009
    ..The aim of this study was to determine whether lower BMD is associated with higher erosion scores among patients with RA...
  24. pmc The relation between bisphosphonate use and non-union of fractures of the humerus in older adults
    D H Solomon
    Division of Pharmacoepidemiology, Harvard Medical School, Boston, MA, USA
    Osteoporos Int 20:895-901. 2009
    ..37, 95% confidence interval (CI) 1.13-4.96]. Clinicians might consider waiting for several months before introduction of a bisphosphonate after a fracture...
  25. pmc A cohort study of thiazolidinediones and fractures in older adults with diabetes
    Daniel H Solomon
    Division of Rheumatology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    J Clin Endocrinol Metab 94:2792-8. 2009
    ..Recent results from several randomized controlled trials find an increased risk of fracture with TZDs compared with other oral antidiabetic agents...
  26. ncbi request reprint The comparative safety and effectiveness of TNF-alpha antagonists [corrected]
    Daniel H Solomon
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, MA 02120, USA
    J Manag Care Pharm 13:S7-18. 2007
    ....
  27. doi request reprint The comparative safety of analgesics in older adults with arthritis
    Daniel H Solomon
    Division of Pharmacoepidemiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Arch Intern Med 170:1968-76. 2010
    ..The safety of alternative analgesics is unclear. We examined the comparative safety of nonselective NSAIDs (nsNSAIDs), selective cyclooxygenase 2 inhibitors (coxibs), and opioids...
  28. doi request reprint Association between disease-modifying antirheumatic drugs and diabetes risk in patients with rheumatoid arthritis and psoriasis
    Daniel H Solomon
    Division of Pharmacoepidemiology, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    JAMA 305:2525-31. 2011
    ..Rheumatoid arthritis (RA) and psoriasis have been linked with insulin resistance and diabetes mellitus (DM). Prior investigations suggest that systemic immunosuppressive drugs may improve insulin resistance and reduce the risk of DM...
  29. doi request reprint Postfracture interventions disseminated through health care and drug insurers: attempting to integrate fragmented health care delivery
    D H Solomon
    Division of Rheumatology, Brigham and Women s Hospital, 75 Francis Street, PBB B3, Boston, MA 02115, USA
    Osteoporos Int 22:465-9. 2011
    ..The strengths and weaknesses of each of these potential levers for improvement were explored. Postfracture osteoporosis care is sub-optimal and challenging to improve in fragmented health care delivery systems...
  30. pmc Use of disease-modifying medications for rheumatoid arthritis by race and ethnicity in the National Ambulatory Medical Care Survey
    Daniel H Solomon
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Care Res (Hoboken) 64:184-9. 2012
    ..We investigated the use of DMARDs in patients with RA in a nationally representative sample of visits to US physicians in the National Ambulatory Care Medical Survey (NAMCS)...
  31. ncbi request reprint Performance of a rheumatoid arthritis records-based index of severity
    Gladys Ting
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
    J Rheumatol 32:1679-87. 2005
    ..To assess the performance of a rheumatoid arthritis (RA) records-based index of severity (RARBIS) developed by a Delphi panel process in a cohort of patients with RA...
  32. ncbi request reprint Simultaneous assessment of short-term gastrointestinal benefits and cardiovascular risks of selective cyclooxygenase 2 inhibitors and nonselective nonsteroidal antiinflammatory drugs: an instrumental variable analysis
    Sebastian Schneeweiss
    Harvard Medical School, Division of Pharmacoepidemiology and Pharmacoeconomics, Boston, MA 021205, USA
    Arthritis Rheum 54:3390-8. 2006
    ....
  33. pmc Nonoccupational risk factors for carpal tunnel syndrome
    D H Solomon
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. 02115, USA
    J Gen Intern Med 14:310-4. 1999
    ..Further investigation in detailed clinical studies will be necessary to confirm whether changes in corticosteroid use and hormone replacement therapy offer additional means of risk reduction for this common condition...
  34. ncbi request reprint Anti-tumor necrosis factor alpha therapy and the risk of serious bacterial infections in elderly patients with rheumatoid arthritis
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
    Arthritis Rheum 56:1754-64. 2007
    ..To assess the association between the initiation of anti-tumor necrosis factor alpha (anti-TNFalpha) therapy and the risk of serious bacterial infections in routine care...
  35. ncbi request reprint Accuracy of Medicare claims-based diagnosis of acute myocardial infarction: estimating positive predictive value on the basis of review of hospital records
    Yuka Kiyota
    Division of Pharmacoepidemiology and Pharmacoeconomics, Boston, Mass USA
    Am Heart J 148:99-104. 2004
    ....
  36. pmc Patterns of cardiovascular risk in rheumatoid arthritis
    D H Solomon
    Division of Pharmacoepidemiology, Brigham and Women s Hospital, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    Ann Rheum Dis 65:1608-12. 2006
    ..This study investigated the relative risk of myocardial infarction, stroke and CVD mortality in adults with rheumatoid arthritis compared with adults without rheumatoid arthritis across age groups, sex and prior CVD event status...
  37. pmc Comparative gastrointestinal safety of weekly oral bisphosphonates
    S M Cadarette
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Osteoporos Int 20:1735-47. 2009
    ..We compared the gastrointestinal safety between weekly alendronate and weekly risedronate and found no important difference between new users of these agents...
  38. pmc Measuring quality of care for rheumatic diseases using an electronic medical record
    J C Agnew-Blais
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Ann Rheum Dis 68:680-4. 2009
    ....
  39. pmc Interventions to improve adherence and persistence with osteoporosis medications: a systematic literature review
    T Gleeson
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, PBB B3, Boston, MA 02115, USA
    Osteoporos Int 20:2127-34. 2009
    ..Few interventions were efficacious, and no clear trends regarding successful intervention techniques were identified. However, periodic follow-up interaction between patients and health professionals appeared to be beneficial...
  40. doi request reprint Pharmacologic regimens for knee osteoarthritis prevention: can they be cost-effective?
    E Losina
    Orthopaedic and Arthritis Center for Outcomes Research, Department of Orthopaedic Surgery, Brigham and Women s Hospital, Boston, MA, USA Section of Clinical Sciences, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA, USA Harvard Medical School, Boston, MA, USA Boston University School of Public Health, Boston, MA, USA Electronic address
    Osteoarthritis Cartilage 22:415-30. 2014
    ..We sought to determine the target populations and drug efficacy, toxicity, cost, and initiation age thresholds under which a pharmacologic regimen for knee osteoarthritis (OA) prevention could be cost-effective...
  41. ncbi request reprint Uric acid lowering therapy: prescribing patterns in a large cohort of older adults
    D H Solomon
    Division of Pharmacoepidemiology, Brigham and Women s Hospital, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    Ann Rheum Dis 67:609-13. 2008
    ..Uric acid lowering therapy (UALT) is considered a chronic treatment for gout. Relatively little is known about adherence to UALT...
  42. ncbi request reprint The medical license number accurately identifies the prescribing physician in a large pharmacy claims database
    M Alan Brookhart
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
    Med Care 45:907-10. 2007
    ..We studied the accuracy of the medical license number in data from a state-run drug benefit plan by assessing its consistency with 2 external sources of data...
  43. pmc Ninety-one osteoporosis patients affected with bisphosphonate-related osteonecrosis of the jaw: a case series
    E Mercer
    Division of Rheumatology, Brigham and Women s Hospital, 75 Francis Street, PBB B3, Boston, MA 02115, USA
    Calcif Tissue Int 93:241-8. 2013
    ..The findings of this study confirm that BRONJ primarily affects the mandible, a substantial minority present without pain, and patients typically improve with treatment...
  44. ncbi request reprint Access to bone mineral density testing in patients at risk for osteoporosis
    D H Solomon
    Division of Pharmacoepidemiology, Brigham and Women s Hospital, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    Osteoporos Int 17:1749-54. 2006
    ..We assessed whether access to bone mineral density (BMD) testing was a predictor of osteoporosis management in an at-risk population of patients from New Jersey...
  45. ncbi request reprint Patterns of medication use before and after bone densitometry: factors associated with appropriate treatment
    D H Solomon
    Division of Rheumatology, Allergy, Immunology, Robert B Brigham Multipurpose Arthritis and Musculoskeletal Diseases Center, Boston, Massachusetts, USA
    J Rheumatol 27:1496-500. 2000
    ..We examined the medications used by women before and after bone densitometry to determine whether patient or physician factors were associated with appropriate osteoporosis therapy...
  46. pmc Relative effectiveness of osteoporosis drugs for preventing nonvertebral fracture
    Suzanne M Cadarette
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, and Boston University, Boston, Massachusetts 02120, USA
    Ann Intern Med 148:637-46. 2008
    ..Little information is available on the comparative effectiveness of osteoporosis pharmacotherapies...
  47. ncbi request reprint Adherence to lipid-lowering therapy and the use of preventive health services: an investigation of the healthy user effect
    M Alan Brookhart
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02120, USA
    Am J Epidemiol 166:348-54. 2007
    ..Further work is needed to identify study design and analysis methods that can be used to minimize the healthy user bias in studies of preventive therapies...
  48. ncbi request reprint Economic consequences of routine coronary angiography in low- and intermediate-risk patients with unstable angina pectoris
    Akshay S Desai
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
    Am J Cardiol 92:363-7. 2003
    ....
  49. ncbi request reprint Explained variation in a model of therapeutic decision making is partitioned across patient, physician, and clinic factors
    M Alan Brookhart
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    J Clin Epidemiol 59:18-25. 2006
    ..A statistical method is presented for attributing explained variation in patient care to different levels of aggregation in a multilevel model with the aim of prioritizing and targeting quality improvement interventions...
  50. ncbi request reprint A Medicare database review found that physician preferences increasingly outweighed patient characteristics as determinants of first-time prescriptions for COX-2 inhibitors
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    J Clin Epidemiol 58:98-102. 2005
    ..We sought to quantify the relative contributions of patient vs. physician factors to the decision to prescribe selective cyclooxygenase-2 (COX-2) inhibitors during the first 2 years of their availability...
  51. pmc Predictors of discontinuation of tumor necrosis factor inhibitors in patients with rheumatoid arthritis
    Sandeep K Agarwal
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Rheumatol 35:1737-44. 2008
    ..Our goal was to determine the discontinuation rate of TNF inhibitors and identify predictors associated with discontinuation...
  52. pmc Disease-modifying drugs for knee osteoarthritis: can they be cost-effective?
    E Losina
    Orthopaedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Osteoarthritis Cartilage 21:655-67. 2013
    ..Disease-modifying osteoarthritis drugs (DMOADs) are under development. Our goal was to determine efficacy, toxicity, and cost thresholds under which DMOADs would be a cost-effective knee OA treatment...
  53. ncbi request reprint Clinical presentation of myocardial infarction contributes to lower use of coronary angiography in patients with chronic kidney disease
    D M Charytan
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    Kidney Int 71:938-45. 2007
    ..However, the clinical features of MI do not account for its underuse in MI patients with CKD Stages 4/5. Whether reduced use of angiography in patients with advanced CKD is justified must be evaluated in formal risk-benefit analyses...
  54. doi request reprint Antidepressants and fracture risk in older adults: a comparative safety analysis
    J J Gagne
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Clin Pharmacol Ther 89:880-7. 2011
    ..Although SSRI use was associated with the highest rate of fractures, variation in fracture risk across specific antidepressant medications did not depend on affinity for serotonin transport receptors...
  55. ncbi request reprint Use of risk stratification to identify patients with unstable angina likeliest to benefit from an invasive versus conservative management strategy
    D H Solomon
    Division of Pharmacoepidemiology and Pharmacoeconomics, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 38:969-76. 2001
    ..This study was designed to determine whether patient characteristics collected at presentation can identify which patients benefit from immediate coronary angiography and revascularization...
  56. ncbi request reprint HMG-CoA reductase inhibitors and the risk of hip fractures in elderly patients
    P S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115
    JAMA 283:3211-6. 2000
    ....
  57. doi request reprint Infliximab and other immunomodulating drugs in patients with inflammatory bowel disease and the risk of serious bacterial infections
    S Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 021205, USA
    Aliment Pharmacol Ther 30:253-64. 2009
    ..There remain concerns about the safety of infliximab therapy in patients with inflammatory bowel disease (IBD)...
  58. ncbi request reprint Adjusting for unmeasured confounders in pharmacoepidemiologic claims data using external information: the example of COX2 inhibitors and myocardial infarction
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
    Epidemiology 16:17-24. 2005
    ..We show how to assess the impact of confounding by factors not measured in Medicare claims data in a study of the association between selective COX2 inhibitors and acute myocardial infarction (MI)...
  59. ncbi request reprint Self-management education programs in chronic disease: a systematic review and methodological critique of the literature
    Asra Warsi
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02120, USA
    Arch Intern Med 164:1641-9. 2004
    ..We evaluated the efficacy of patient self-management educational programs for chronic diseases and critically reviewed their methodology...
  60. ncbi request reprint Veteran's affairs hospital discharge databases coded serious bacterial infections accurately
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    J Clin Epidemiol 60:397-409. 2007
    ..We sought to test the ability of large health care utilization databases to accurately identify serious bacterial infections and opportunistic infections leading to hospital admission...
  61. pmc Confounder summary scores when comparing the effects of multiple drug exposures
    Suzanne M Cadarette
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Pharmacoepidemiol Drug Saf 19:2-9. 2010
    ..We compared three analytic strategies to control for confounding based on measured variables: conventional multivariable, exposure propensity score (EPS), and disease risk score (DRS)...
  62. pmc Evaluating short-term drug effects using a physician-specific prescribing preference as an instrumental variable
    M Alan Brookhart
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02120, USA
    Epidemiology 17:268-75. 2006
    ..Instrumental variable methods have been proposed as a potential approach to control confounding by indication in nonexperimental studies of treatment effects; however, good instruments are hard to find...
  63. ncbi request reprint Academic detailing to improve use of broad-spectrum antibiotics at an academic medical center
    D H Solomon
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, 221 Longwood Ave, Suite 341, Boston, MA 02115, USA
    Arch Intern Med 161:1897-902. 2001
    ..We tested the efficacy of a targeted one-on-one educational program ("academic detailing") designed to improve the appropriateness of broad-spectrum antibiotic use...
  64. ncbi request reprint Referrals for musculoskeletal disorders: patterns, predictors, and outcomes
    D H Solomon
    Robert B Brigham Multipurpose Arthritis and Musculoskeletal Diseases Center, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Rheumatol 28:2090-5. 2001
    ..To examine factors associated with musculoskeletal referral and determine whether referral influences clinical outcomes...
  65. ncbi request reprint A computer based intervention to reduce unnecessary serologic testing
    D H Solomon
    Robert B Brigham Multipurpose Arthritis and Musculoskeletal Diseases Center, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Rheumatol 26:2578-84. 1999
    ....
  66. doi request reprint Osteoporosis medication use in nursing home patients with fractures in 1 US state
    Seema Parikh
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Womens Hospital, Harvard Medical School, Boston, MA 02120, USA
    Arch Intern Med 168:1111-5. 2008
    ..We studied the patterns and predictors of osteoporosis medication use in elderly patients who sustained a fracture and were admitted to an NH...
  67. pmc Oral bisphosphonates and risk of subtrochanteric or diaphyseal femur fractures in a population-based cohort
    Seo Young Kim
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, MA, USA
    J Bone Miner Res 26:993-1001. 2011
    ..However, this study cannot exclude the possibility that long-term bisphosphonate use may increase the risk of these fractures...
  68. pmc Can improved prescription medication labeling influence adherence to chronic medications? An evaluation of the Target pharmacy label
    William H Shrank
    Department of Medicine, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street Suite 3030, Boston, MA 02120, USA
    J Gen Intern Med 24:570-8. 2009
    ..A new prescription medication labeling system was implemented by Target pharmacies in May 2005 and aimed to improve readability and understanding...
  69. pmc Cost-effectiveness of total knee arthroplasty in the United States: patient risk and hospital volume
    Elena Losina
    Department of Orthopedic Surgery, Orthopedic and Arthritis Center for Outcomes Research, Brigham and Women s Hospital, Boston, MA 02115, USA
    Arch Intern Med 169:1113-21; discussion 1121-2. 2009
    ..However, to our knowledge, the cost-effectiveness of TKA and the influences of hospital volume and patient risk on TKA cost-effectiveness have not been investigated in the United States...
  70. pmc A SAS macro for a clustered permutation test
    Margaret R Stedman
    Department of Biostatistics, Boston University School of Public Health, Boston, MA, United States
    Comput Methods Programs Biomed 95:89-94. 2009
    ..We describe a flexible and efficient SAS macro that implements the 2-sample clustered permutation test. We discuss the theory and applications behind this test as well as details of the SAS code...
  71. doi request reprint Using genetic and clinical data to understand response to disease-modifying anti-rheumatic drug therapy: data from the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study
    Christine K Iannaccone
    Department of Medicine, Brigham and Women s Hospital, PBB B3, 75 Francis Street, Boston, MA 02115, USA
    Rheumatology (Oxford) 50:40-6. 2011
    ....
  72. doi request reprint Aberrant IgG galactosylation precedes disease onset, correlates with disease activity, and is prevalent in autoantibodies in rheumatoid arthritis
    Altan Ercan
    Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Rheum 62:2239-48. 2010
    ..To examine the association between aberrant IgG galactosylation and disease parameters in rheumatoid arthritis (RA)...
  73. pmc Explaining the cardiovascular risk associated with rheumatoid arthritis: traditional risk factors versus markers of rheumatoid arthritis severity
    Daniel H Solomon
    Brigham and Women s Hospital, Boston Massachusetts 02115, USA
    Ann Rheum Dis 69:1920-5. 2010
    ..The authors examined the relative importance of traditional CV risk factors and RA markers in predicting CV events...
  74. pmc Tumor necrosis factor blockade and the risk of viral infection
    Seo Young Kim
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Nat Rev Rheumatol 6:165-74. 2010
    ..In addition, implications for clinical practice and possible preventative approaches are discussed...
  75. pmc The use of glucocorticoids in rheumatoid arthritis--no 'rational' approach yet
    Sonali P Desai
    Brigham and Women s Hospital, Division of Rheumatology, Immunology, and Allergy, 75 Francis Street, Boston, MA 02115, USA
    Arthritis Res Ther 12:127. 2010
    ..The relationship between glucocorticoids and bone mineral density in rheumatoid arthritis is complex. Further study into the optimal dosing, timing and duration of glucocorticoid use in rheumatoid arthritis is necessary...
  76. doi request reprint The risk of infection associated with tumor necrosis factor alpha antagonists: making sense of epidemiologic evidence
    Daniel H Solomon
    Brigham and Women s Hospital, Division of Rheumatology, Immunology and Allergy, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Arthritis Rheum 58:919-28. 2008
  77. ncbi request reprint Does self-management education benefit all populations with arthritis? A randomized controlled trial in a primary care physician network
    Daniel H Solomon
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Rheumatol 29:362-8. 2002
    ..We conducted a randomized controlled trial of the ASMP course in a large primary care physician network...
  78. ncbi request reprint Cardiovascular outcomes in new users of coxibs and nonsteroidal antiinflammatory drugs: high-risk subgroups and time course of risk
    Daniel H Solomon
    Division of Pharmacoepidemiology, Brigham and Women s Hospital, Boston, Massachusetts 02120, USA
    Arthritis Rheum 54:1378-89. 2006
    ..This study was undertaken to examine, in a large group of new users of coxibs and NSAIDs, the rate of cardiovascular events, their time course, and whether baseline cardiovascular risk modified the rate ratios (RRs) for future events...
  79. ncbi request reprint Prescription opioid use among older adults with arthritis or low back pain
    Daniel H Solomon
    Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Ste, 3030, Boston, MA 02120, USA
    Arthritis Rheum 55:35-41. 2006
    ..To examine patterns of chronic opioid use in selected groups with arthritis and low back pain and compare them with patterns among persons with ischemic heart disease...
  80. ncbi request reprint Identification of individuals with CKD from Medicare claims data: a validation study
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Am J Kidney Dis 46:225-32. 2005
    ..The validity of this approach to identify patients with CKD has not been sufficiently studied...
  81. ncbi request reprint Educational outreach (academic detailing) regarding osteoporosis in primary care
    Jennifer M Polinski
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Pharmacoepidemiol Drug Saf 14:843-50. 2005
    ..Academic detailing programs have improved physician's prescribing behaviors; however, the feasibility of large-scale programs across a large, geographically disperse state is unclear...
  82. ncbi request reprint Osteoporosis action: design of the healthy bones project trial
    Daniel H Solomon
    Division of Pharmacoepidemiology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA, USA
    Contemp Clin Trials 26:78-94. 2005
    ..All outcomes will be analyzed using random effects models accounting for clustering of subjects within physicians' practices...
  83. ncbi request reprint Medication use patterns for osteoporosis: an assessment of guidelines, treatment rates, and quality improvement interventions
    Daniel H Solomon
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02120, USA
    Mayo Clin Proc 80:194-202. 2005
    ..To assess current osteoporosis treatment guidelines, studies of osteoporosis treatment, and interventions to improve osteoporosis treatment...
  84. ncbi request reprint Development and assessment of indicators of rheumatoid arthritis severity: results of a Delphi panel
    Danielle Cabral
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 53:61-6. 2005
    ..To develop a set of indicators for assessing the severity of rheumatoid arthritis (RA) through medical records...
  85. ncbi request reprint Adherence with osteoporosis practice guidelines: a multilevel analysis of patient, physician, and practice setting characteristics
    Daniel H Solomon
    Division of Pharmacoepidemiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
    Am J Med 117:919-24. 2004
    ..The diagnosis and treatment of patients at risk of fragility fractures is uncommon. We examined the patient, physician, and practice characteristics associated with adherence to local osteoporosis guidelines...
  86. ncbi request reprint Multifaceted intervention to improve rheumatologists' management of glucocorticoid-induced osteoporosis: a randomized controlled trial
    Daniel H Solomon
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
    Arthritis Rheum 51:383-7. 2004
    ..To assess the effectiveness of a multifaceted intervention to improve the management of glucocorticoid-induced osteoporosis (GIOP)...
  87. ncbi request reprint Which patients with unstable angina or non-Q-wave myocardial infarction should have immediate cardiac catheterization? A clinical decision rule for predicting who will fail medical therapy
    Daniel H Solomon
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, 221 Longwood Avenue, Suite 341, Boston, MA 02115, USA
    J Clin Epidemiol 55:121-8. 2002
    ..Such a rule may be useful for identifying patients who should be considered for early cardiac catheterization...
  88. ncbi request reprint Which patients with knee problems are likely to benefit from nonarthroplasty surgery? Development of a clinical prediction rule
    Daniel H Solomon
    Division of Pharmacoepidemiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Arch Intern Med 164:509-13. 2004
    ..We examined factors associated with the clinical presentation of patients judged likely by orthopedic surgeons to benefit from nonarthroplasty knee surgery...
  89. ncbi request reprint Conversion from intravenous to oral medications: assessment of a computerized intervention for hospitalized patients
    Michael A Fischer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Departments of Medicine and Emergency Medicine, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    Arch Intern Med 163:2585-9. 2003
    ..We examined the effect of a computer-based intervention to prompt physicians to switch appropriate patients from intravenous to oral medications...
  90. ncbi request reprint Underuse of osteoporosis medications in elderly patients with fractures
    Daniel H Solomon
    Division of Pharmacoepidemiology, Brigham and Women s Hospital, Boston, Massachusetts 02120, USA
    Am J Med 115:398-400. 2003
  91. ncbi request reprint Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritis
    Daniel H Solomon
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 107:1303-7. 2003
    ..Rheumatoid arthritis may be associated with an increased risk of cardiovascular disease. We compared the incidence rates of myocardial infarction and stroke in subjects with and without rheumatoid arthritis...
  92. ncbi request reprint Pharmacoepidemiology and rheumatic diseases: 2001-2002
    Daniel H Solomon
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Curr Opin Rheumatol 15:122-6. 2003
    ....
  93. ncbi request reprint Contribution of hospital characteristics to the volume-outcome relationship: dislocation and infection following total hip replacement surgery
    Daniel H Solomon
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 46:2436-44. 2002
    ..We evaluated the contribution of hospital structural characteristics to the volume-outcome relationship in THR by examining the rates and predictors of postoperative complications...
  94. ncbi request reprint Nonsteroidal anti-inflammatory drug use and acute myocardial infarction
    Daniel H Solomon
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 162:1099-104. 2002
    ..Although aspirin has been shown to protect patients from acute myocardial infarction (AMI), the effect of nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) is not clear...
  95. ncbi request reprint Development of a preliminary index that predicts adverse events after total knee replacement
    Daniel H Solomon
    Division of Pharmacoepidemiology, Brigham and Women s Hospital, Boston, Massachusetts 02120, USA
    Arthritis Rheum 54:1536-42. 2006
    ....
  96. ncbi request reprint Physician follow-up and provider continuity are associated with long-term medication adherence: a study of the dynamics of statin use
    M Alan Brookhart
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Arch Intern Med 167:847-52. 2007
    ....
  97. ncbi request reprint Osteoporosis improvement: a large-scale randomized controlled trial of patient and primary care physician education
    Daniel H Solomon
    Division of Pharmacoepidemiology, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Bone Miner Res 22:1808-15. 2007
    ..04; 95% ci, 0.85-1.26)...
  98. ncbi request reprint Design of cluster-randomized trials of quality improvement interventions aimed at medical care providers
    Robert J Glynn
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Med Care 45:S38-43. 2007
    ..Such trials are frequently embedded in health care systems with available automated records, which can be used to enhance the design of the trial...
  99. ncbi request reprint Kidney function and use of recommended medications after myocardial infarction in elderly patients
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    Clin J Am Soc Nephrol 1:796-801. 2006
    ..Differences in other characteristics such as age, rather than kidney function, may be responsible for much or all the reported reduction in use of preventive medications after MI seen in patients with chronic kidney disease...
  100. ncbi request reprint Agreement of diagnosis and its date for hematologic malignancies and solid tumors between medicare claims and cancer registry data
    Soko Setoguchi
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Cancer Causes Control 18:561-9. 2007
    ..However, linkage between cancer registry and claims data including pharmacy-dispensing information is not always available. We examined the accuracy of claims-based definitions of incident cancers and their date of diagnosis...
  101. doi request reprint Percutaneous vertebroplasty among low income Medicare beneficiaries
    Daniel H Solomon
    Divisions of Pharmacoepidemiology, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
    Spine (Phila Pa 1976) 32:2910-4. 2007
    ..Cohort...