C N Soares

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi The perimenopause, depressive disorders, and hormonal variability
    C N Soares
    Perinatal and Reproductive Psychiatry Clinical Research Program, Center for Women s Mental Health, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Sao Paulo Med J 119:78-83. 2001
  2. ncbi Efficacy of citalopram as a monotherapy or as an adjunctive treatment to estrogen therapy for perimenopausal and postmenopausal women with depression and vasomotor symptoms
    Claudio N Soares
    Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital and the Department of Psychiatry, Harvard Medical School, Boston, 02114, USA
    J Clin Psychiatry 64:473-9. 2003
  3. ncbi Effect of reproductive hormones and selective estrogen receptor modulators on mood during menopause
    Claudio N Soares
    Harvard Medical School, MGH Center for Women s Mental Health, Boston, Massachusetts 02114, USA
    Drugs Aging 20:85-100. 2003
  4. ncbi Menopause and mood
    Claudio N Soares
    Center for Women s Mental Health, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Clin Obstet Gynecol 47:576-91. 2004
  5. ncbi Efficacy of estradiol for the treatment of depressive disorders in perimenopausal women: a double-blind, randomized, placebo-controlled trial
    C N Soares
    Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, Harvard Medical School, 15 Parkman St, WACC 812, Boston, MA 02114, USA
    Arch Gen Psychiatry 58:529-34. 2001
  6. ncbi Characteristics of women with premenstrual dysphoric disorder (PMDD) who did or did not report history of depression: a preliminary report from the Harvard Study of Moods and Cycles
    C N Soares
    Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, USA
    J Womens Health Gend Based Med 10:873-8. 2001
  7. ncbi An open trial of mirtazapine in menopausal women with depression unresponsive to estrogen replacement therapy
    H Joffe
    Perinatal and Reproductive Psychiatry Clinical Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Womens Health Gend Based Med 10:999-1004. 2001
  8. ncbi Postpartum onset obsessive-compulsive disorder: diagnosis and management
    M Brandes
    Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02114, USA
    Arch Womens Ment Health 7:99-110. 2004
  9. ncbi Sex- and age-related differences in major depressive disorder with comorbid anxiety treated with fluoxetine
    P Cassano
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, U S A
    Arch Womens Ment Health 7:167-71. 2004
  10. ncbi Escitalopram versus ethinyl estradiol and norethindrone acetate for symptomatic peri- and postmenopausal women: impact on depression, vasomotor symptoms, sleep, and quality of life
    Claudio N Soares
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Menopause 13:780-6. 2006

Detail Information

Publications35

  1. ncbi The perimenopause, depressive disorders, and hormonal variability
    C N Soares
    Perinatal and Reproductive Psychiatry Clinical Research Program, Center for Women s Mental Health, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Sao Paulo Med J 119:78-83. 2001
    ..In addition, we review the existing data regarding the potential efficacy of estrogen as an antidepressant agent (monotherapy, augmentation strategy or prophylaxis)...
  2. ncbi Efficacy of citalopram as a monotherapy or as an adjunctive treatment to estrogen therapy for perimenopausal and postmenopausal women with depression and vasomotor symptoms
    Claudio N Soares
    Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital and the Department of Psychiatry, Harvard Medical School, Boston, 02114, USA
    J Clin Psychiatry 64:473-9. 2003
    ..It is still unclear whether the use of antidepressants alone may alleviate menopause-related mood and vasomotor symptoms or enhance the response observed with short-term use of estrogen therapy...
  3. ncbi Effect of reproductive hormones and selective estrogen receptor modulators on mood during menopause
    Claudio N Soares
    Harvard Medical School, MGH Center for Women s Mental Health, Boston, Massachusetts 02114, USA
    Drugs Aging 20:85-100. 2003
    ..There are some preliminary data suggesting the efficacy of antidepressants for the treatment of hot flushes; existing data on diet supplements and herbal products have shown more mixed results...
  4. ncbi Menopause and mood
    Claudio N Soares
    Center for Women s Mental Health, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Clin Obstet Gynecol 47:576-91. 2004
  5. ncbi Efficacy of estradiol for the treatment of depressive disorders in perimenopausal women: a double-blind, randomized, placebo-controlled trial
    C N Soares
    Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, Harvard Medical School, 15 Parkman St, WACC 812, Boston, MA 02114, USA
    Arch Gen Psychiatry 58:529-34. 2001
    ..This study investigated the efficacy of 17beta-estradiol for the treatment of clinically significant depressive disorders in endocrinologically confirmed perimenopausal women...
  6. ncbi Characteristics of women with premenstrual dysphoric disorder (PMDD) who did or did not report history of depression: a preliminary report from the Harvard Study of Moods and Cycles
    C N Soares
    Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, USA
    J Womens Health Gend Based Med 10:873-8. 2001
    ....
  7. ncbi An open trial of mirtazapine in menopausal women with depression unresponsive to estrogen replacement therapy
    H Joffe
    Perinatal and Reproductive Psychiatry Clinical Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Womens Health Gend Based Med 10:999-1004. 2001
    ..Mirtazapine is an effective treatment for major depression in perimenopausal and postmenopausal women whose depression precedes ERT use and does not respond to ERT or whose depression develops after ERT is initiated...
  8. ncbi Postpartum onset obsessive-compulsive disorder: diagnosis and management
    M Brandes
    Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02114, USA
    Arch Womens Ment Health 7:99-110. 2004
    ..Issues regarding pharmacologic treatment of OCD in breastfeeding mothers are also reviewed...
  9. ncbi Sex- and age-related differences in major depressive disorder with comorbid anxiety treated with fluoxetine
    P Cassano
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, U S A
    Arch Womens Ment Health 7:167-71. 2004
    ..To examine sex- and age-related differences of treatment outcome in a cohort of outpatients with major depressive disorder (MDD), with and without comorbid anxiety, treated with fluoxetine...
  10. ncbi Escitalopram versus ethinyl estradiol and norethindrone acetate for symptomatic peri- and postmenopausal women: impact on depression, vasomotor symptoms, sleep, and quality of life
    Claudio N Soares
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Menopause 13:780-6. 2006
    ..To examine the efficacy and tolerability of escitalopram (ESCIT) compared to estrogen and progestogen therapy (EPT) for the treatment of symptomatic peri- and postmenopausal women...
  11. ncbi Physical activity and risk of vasomotor symptoms in women with and without a history of depression: results from the Harvard Study of Moods and Cycles
    Rebecca C Thurston
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Menopause 13:553-60. 2006
    ..To examine whether physical activity was associated with decreased risk of vasomotor symptoms in a prospective study of women transitioning through menopause...
  12. ncbi Risk for new onset of depression during the menopausal transition: the Harvard study of moods and cycles
    Lee S Cohen
    Perinatal and Reproductive Psychiatry Clinical Research Program and Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, 02114, USA
    Arch Gen Psychiatry 63:385-90. 2006
    ..However, it is unclear whether this period is one of increased risk for major depressive disorder, particularly for women who have not had a previous episode of depression...
  13. ncbi Sleep disorders in women: clinical evidence and treatment strategies
    Claudio N Soares
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
    Psychiatr Clin North Am 29:1095-113; abstract xi. 2006
    ..This review focuses on clinical evidence for sleep disorders in women and discusses existing evidence of risk factors and treatment options for insomnia and sleep-disordered breathing in women...
  14. ncbi Eszopiclone in patients with insomnia during perimenopause and early postmenopause: a randomized controlled trial
    Claudio N Soares
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada, and Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA
    Obstet Gynecol 108:1402-10. 2006
    ..To evaluate eszopiclone 3 mg for treatment of insomnia in perimenopausal and early postmenopausal women, as well as the impact of insomnia treatment on mood, menopause-related symptoms, and quality of life...
  15. ncbi Relative antidepressant efficacy of bupropion and the selective serotonin reuptake inhibitors in major depressive disorder: gender-age interactions
    George I Papakostas
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Int Clin Psychopharmacol 22:226-9. 2007
    ..This finding could, however, not be replicated when improvement in anxious/somatic symptoms was defined as a continuous measure...
  16. ncbi Treatment of depression and menopause-related symptoms with the serotonin-norepinephrine reuptake inhibitor duloxetine
    Hadine Joffe
    Perinatal and Reproductive Psychiatry Program, Department of Psychiatry, Massachusetts General Hospital, Boston, Mass 02114, USA
    J Clin Psychiatry 68:943-50. 2007
    ..Treatment strategies that target all of these symptoms together have not been investigated to date...
  17. ncbi Menopausal transition and depression: who is at risk and how to treat it?
    Claudio N Soares
    Women s Health Concerns Clinic, St Joseph s Healthcare Hamilton, 301 James St South, FB number 638, Hamilton, ON L8P 3B6, Canada
    Expert Rev Neurother 7:1285-93. 2007
    ..Hormonal and nonhormonal factors that may contribute to the occurrence of physical and/or psychiatric complaints during the menopausal transition are discussed. Lastly, existing evidence-based treatment strategies are summarized...
  18. ncbi Treatment of premenstrual worsening of depression with adjunctive oral contraceptive pills: a preliminary report
    Hadine Joffe
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 68:1954-62. 2007
    ..Oral contraceptive pills (OCPs) stabilize reproductive hormones and treat premenstrual dysphoric disorder. Management of depression that breaks through premenstrually has not been studied...
  19. ncbi Depression during the menopausal transition: window of vulnerability or continuum of risk?
    Claudio N Soares
    Menopause 15:207-9. 2008
  20. doi Paroxetine versus placebo for women in midlife after hormone therapy discontinuation
    Claudio N Soares
    Perinatal and Reproductive Psychiatry Program, Massachusetts General Hospital, Boston, USA
    Am J Med 121:159-162.e1. 2008
    ..This study examines the efficacy of paroxetine controlled-release versus placebo for the treatment of women with vasomotor symptoms after discontinuing hormone therapy...
  21. ncbi Diagnosis and management of mood disorders during the menopausal transition
    Lee S Cohen
    Department of Perinatal and Reproductive Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Med 118:93-7. 2005
    ..The benefits and risks of using hormonal and nonhormonal strategies for the management of depression and other menopause-related somatic symptoms are critically reviewed...
  22. ncbi Depression during menopausal transition: a review of treatment strategies and pathophysiological correlates
    Benicio N Frey
    Women s Health Concerns Clinic WHCC, Department of Psychiatry and Behavioural Neurosciences, McMaster University, James Street South, FB 638, Hamilton, ON L8P 3B6, Canada
    Menopause Int 14:123-8. 2008
    ..The identification of individuals whom might be at a higher risk for depression during menopausal transition could guide preventive strategies for this population...
  23. ncbi Prevalence and predictors of premenstrual dysphoric disorder (PMDD) in older premenopausal women. The Harvard Study of Moods and Cycles
    Lee S Cohen
    Harvard Medical School, Boston, MA, USA
    J Affect Disord 70:125-32. 2002
    ..Consistent data on the prevalence and predictors of premenstrual dysphoric disorder (PMDD) in the general population are lacking...
  24. ncbi Vasomotor symptoms are associated with depression in perimenopausal women seeking primary care
    Hadine Joffe
    Perinatal and Reproductive Psychiatry Program, Reproductive Endocrine Unit, and Medical Service, Massachusetts General Hospital, Boston, MA, USA
    Menopause 9:392-8. 2002
    ..To compare the relationship between vasomotor symptoms (hot flushes and night sweats) and depression in perimenopausal women with that in postmenopausal and older premenopausal women...
  25. ncbi Depression and its influence on reproductive endocrine and menstrual cycle markers associated with perimenopause: the Harvard Study of Moods and Cycles
    Bernard L Harlow
    Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115, USA
    Arch Gen Psychiatry 60:29-36. 2003
    ..Few studies have determined the impact of a lifetime history of major depression on an early transition to menopause...
  26. ncbi Short-term use of estradiol for depression in perimenopausal and postmenopausal women: a preliminary report
    Lee S Cohen
    Perinatal and Reproductive Psychiatry Clinical Research Program and Vicent Memorail Obstetrics and Gynecology Service, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 160:1519-22. 2003
    ..The authors examined the effect of a 4-week course of estrogen therapy on depression in perimenopausal and postmenopausal women...
  27. ncbi Assessment and treatment of hot flushes and menopausal mood disturbance
    Hadine Joffe
    Department of Psychiatry, Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, WACC, Boston, MA 02114, USA
    Psychiatr Clin North Am 26:563-80. 2003
    ..As further evidence of the benefits of psychoactive medications for menopausal symptoms is established, the choice between using hormonal and nonhormonal therapies for management of menopausal symptoms will continue to evolve...
  28. ncbi Efficacy and tolerability of premenstrual use of venlafaxine (flexible dose) in the treatment of premenstrual dysphoric disorder
    Lee S Cohen
    Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital MGH, Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychopharmacol 24:540-3. 2004
    ..05 for all comparisons, Wilcoxon tests). Intermittent treatment was well tolerated. This preliminary report suggests that premenstrual use of venlafaxine is an efficacious and well-tolerated treatment for premenstrual dysphoric disorder...
  29. ncbi Paroxetine controlled release for premenstrual dysphoric disorder: a double-blind, placebo-controlled trial
    Lee S Cohen
    Perinatal and Reproductive Psychiatry Program, Massachusetts General Hospital, 15 Parkman Street, WACC 812, Boston, MA 02114, USA
    Psychosom Med 66:707-13. 2004
    ..This study was designed to assess the efficacy and tolerability of multiple doses of paroxetine controlled release (CR) in PMDD...
  30. ncbi Bupropion SR for the treatment of postpartum depression: a pilot study
    Ruta M Nonacs
    Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital MGH, Boston, 02114, USA
    Int J Neuropsychopharmacol 8:445-9. 2005
    ..5 (range 37.5-300). Bupropion SR was well tolerated, and no subjects discontinued treatment as a result of medication side-effects. Bupropion SR represents an effective and well-tolerated antidepressant for the treatment of PPD...
  31. ncbi Treatment of menopause-related mood disturbances
    Claudio N Soares
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, ON, Canada
    CNS Spectr 10:489-97. 2005
    ....
  32. ncbi Antidepressant response and well-being in pre-, peri- and postmenopausal women with major depressive disorder treated with fluoxetine
    Paolo Cassano
    The Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Psychother Psychosom 74:362-5. 2005
    ..We assessed the impact of menopausal status on treatment response and well-being in a cohort of outpatient women with major depressive disorder (DSM-III-R criteria), who received treatment with fluoxetine (20 mg/day for 8 weeks)...
  33. ncbi Hormones and mental health: where do we stand in the post-WHI era?
    Claudio N Soares
    Rev Bras Psiquiatr 25:198-9. 2003
  34. ncbi Dysfunctional attitudes and episodes of major depression: Predictive validity and temporal stability in never-depressed, depressed, and recovered women
    Michael W Otto
    Center for Anxiety and Related Disorders, Boston University, MA 02215, USA
    J Abnorm Psychol 116:475-83. 2007
    ..N. Weissman & A. T. Beck, 1978) when the formerly depressed and never-depressed cohorts were considered separately. Implications for cognitive theories are discussed...
  35. ncbi [Trauma & the reproductive lifecycle in women]
    Leslie Born
    Clínica de Preocupações com a Saúde da Mulher, St Joseph s Healthcare, Hamilton, Canada
    Rev Bras Psiquiatr 27:S65-72. 2005
    ..Current options available for the treatment of such symptoms, including group and counselling therapies and debriefing are critically reviewed...