Agata Smogorzewska

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Regulation of telomerase by telomeric proteins
    Agata Smogorzewska
    The Rockefeller University, New York, New York 10021, USA
    Annu Rev Biochem 73:177-208. 2004
  2. pmc Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4
    Yonghwan Kim
    Laboratory of Genome Maintenance, Rockefeller University, New York, NY 10065 6399, USA
    Blood 121:54-63. 2013
  3. ncbi Homologous recombination generates T-loop-sized deletions at human telomeres
    Richard C Wang
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Cell 119:355-68. 2004
  4. pmc Different telomere damage signaling pathways in human and mouse cells
    Agata Smogorzewska
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, NY 10021, USA
    EMBO J 21:4338-48. 2002
  5. ncbi DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2
    Agata Smogorzewska
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Curr Biol 12:1635-44. 2002
  6. ncbi DNA damage foci at dysfunctional telomeres
    Hiroyuki Takai
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10021, USA
    Curr Biol 13:1549-56. 2003
  7. pmc Fanconi anaemia and the repair of Watson and Crick DNA crosslinks
    Molly C Kottemann
    Laboratory of Genome Maintenance, The Rockefeller University, New York 10065, USA
    Nature 493:356-63. 2013
  8. doi Ubiquitylation and the Fanconi anemia pathway
    Elizabeth Garner
    Laboratory of Genome Maintenance, The Rockefeller University, New York, NY 10065, USA
    FEBS Lett 585:2853-60. 2011
  9. pmc Structure of the FANCI-FANCD2 complex: insights into the Fanconi anemia DNA repair pathway
    Woo Joo
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Science 333:312-6. 2011
  10. ncbi Senescence induced by altered telomere state, not telomere loss
    Jan Karlseder
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 295:2446-9. 2002

Collaborators

  • Titia de Lange
  • Arleen D Auerbach
  • Jan Karlseder
  • Helmut Hanenberg
  • Y Shiloh
  • Yonghwan Kim
  • Stephen J Elledge
  • Shuhei Matsuoka
  • Molly C Kottemann
  • Francis P Lach
  • Elizabeth Garner
  • Woo Joo
  • Bryan A Ballif
  • Bin Wang
  • Steven P Gygi
  • Richard C Wang
  • Hiroyuki Takai
  • Uma Veturi
  • Gabriella S Spitz
  • Rohini Desetty
  • Nicole S Persky
  • Nikola P Pavletich
  • Derek G Rudge
  • Olga Buzovetsky
  • Guozhou Xu
  • Corey E Bakalarski
  • Kristen E Hurov
  • E Robert McDonald
  • Zhenming Zhao
  • Nicole Solimini
  • Dong Zhang
  • Yaniv Lerenthal
  • Ji Luo

Detail Information

Publications14

  1. ncbi Regulation of telomerase by telomeric proteins
    Agata Smogorzewska
    The Rockefeller University, New York, New York 10021, USA
    Annu Rev Biochem 73:177-208. 2004
    ..Here we discuss the details of telomerase and its regulation by the telomere...
  2. pmc Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4
    Yonghwan Kim
    Laboratory of Genome Maintenance, Rockefeller University, New York, NY 10065 6399, USA
    Blood 121:54-63. 2013
    ..These results demonstrate that SLX4 modulates multiple DNA repair pathways by regulating appropriate nucleases...
  3. ncbi Homologous recombination generates T-loop-sized deletions at human telomeres
    Richard C Wang
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Cell 119:355-68. 2004
    ..These findings show that t-loop deletion by HR influences the integrity and dynamics of mammalian telomeres...
  4. pmc Different telomere damage signaling pathways in human and mouse cells
    Agata Smogorzewska
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, NY 10021, USA
    EMBO J 21:4338-48. 2002
    ..These findings reveal a fundamental difference in telomere damage signaling in human and mouse cells that bears on the use of mouse models for the telomere tumor suppressor pathway...
  5. ncbi DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2
    Agata Smogorzewska
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Curr Biol 12:1635-44. 2002
    ..However, the molecular nature of these fusions and the mechanism by which they occur have not been elucidated...
  6. ncbi DNA damage foci at dysfunctional telomeres
    Hiroyuki Takai
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10021, USA
    Curr Biol 13:1549-56. 2003
    ..Furthermore, induction of TIFs through TRF2 inhibition provides an opportunity to study the DNA damage response within the context of well-defined, physically marked lesions...
  7. pmc Fanconi anaemia and the repair of Watson and Crick DNA crosslinks
    Molly C Kottemann
    Laboratory of Genome Maintenance, The Rockefeller University, New York 10065, USA
    Nature 493:356-63. 2013
    ..Recent advances have identified endogenous aldehydes as possible culprits of DNA damage that may induce the phenotypes seen in patients with Fanconi anaemia...
  8. doi Ubiquitylation and the Fanconi anemia pathway
    Elizabeth Garner
    Laboratory of Genome Maintenance, The Rockefeller University, New York, NY 10065, USA
    FEBS Lett 585:2853-60. 2011
    ..Importantly, ubiquitylation provides the foundations for cross-talk between repair pathways, which in concert with the FA pathway, resolve interstrand crosslink damage and maintain genomic stability...
  9. pmc Structure of the FANCI-FANCD2 complex: insights into the Fanconi anemia DNA repair pathway
    Woo Joo
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Science 333:312-6. 2011
    ....
  10. ncbi Senescence induced by altered telomere state, not telomere loss
    Jan Karlseder
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 295:2446-9. 2002
    ..Thus, replicative senescence is induced by a change in the protected status of shortened telomeres rather than by a complete loss of telomeric DNA...
  11. pmc Mutations of the SLX4 gene in Fanconi anemia
    Yonghwan Kim
    Laboratory of Genome Maintenance, The Rockefeller University, New York, New York, USA
    Nat Genet 43:142-6. 2011
    ....
  12. ncbi ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
    Shuhei Matsuoka
    Department of Genetics and Center for Genetics and Genomics, Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 316:1160-6. 2007
    ..This database paints a much broader landscape for the DDR than was previously appreciated and opens new avenues of investigation into the responses to DNA damage in mammals...
  13. pmc Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response
    Bin Wang
    Department of Genetics, Center for Genetics and Genomics, Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 316:1194-8. 2007
    ..The RAP80-Abraxas complex may help recruit BRCA1 to DNA damage sites in part through recognition of ubiquitinated proteins...
  14. pmc Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair
    Agata Smogorzewska
    Department of Genetics, Howard Hughes Medical Institute, Center for Genetics and Genomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cell 129:289-301. 2007
    ..Mutation in FANCI is responsible for loss of a functional FA pathway in a patient with Fanconi anemia complementation group I...