Agata Smogorzewska

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Regulation of telomerase by telomeric proteins
    Agata Smogorzewska
    The Rockefeller University, New York, New York 10021, USA
    Annu Rev Biochem 73:177-208. 2004
  2. ncbi Homologous recombination generates T-loop-sized deletions at human telomeres
    Richard C Wang
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Cell 119:355-68. 2004
  3. ncbi Different telomere damage signaling pathways in human and mouse cells
    Agata Smogorzewska
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, NY 10021, USA
    EMBO J 21:4338-48. 2002
  4. ncbi DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2
    Agata Smogorzewska
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Curr Biol 12:1635-44. 2002
  5. ncbi DNA damage foci at dysfunctional telomeres
    Hiroyuki Takai
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10021, USA
    Curr Biol 13:1549-56. 2003
  6. ncbi Ubiquitylation and the Fanconi anemia pathway
    Elizabeth Garner
    Laboratory of Genome Maintenance, The Rockefeller University, New York, NY 10065, USA
    FEBS Lett 585:2853-60. 2011
  7. ncbi Senescence induced by altered telomere state, not telomere loss
    Jan Karlseder
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 295:2446-9. 2002
  8. ncbi Structure of the FANCI-FANCD2 complex: insights into the Fanconi anemia DNA repair pathway
    Woo Joo
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Science 333:312-6. 2011
  9. ncbi Mutations of the SLX4 gene in Fanconi anemia
    Yonghwan Kim
    Laboratory of Genome Maintenance, The Rockefeller University, New York, New York, USA
    Nat Genet 43:142-6. 2011
  10. ncbi ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
    Shuhei Matsuoka
    Department of Genetics and Center for Genetics and Genomics, Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 316:1160-6. 2007

Collaborators

  • Titia de Lange
  • Jan Karlseder
  • Arleen D Auerbach
  • Helmut Hanenberg
  • Y Shiloh
  • Stephen J Elledge
  • Shuhei Matsuoka
  • Woo Joo
  • Yonghwan Kim
  • Elizabeth Garner
  • Steven P Gygi
  • Bin Wang
  • Bryan A Ballif
  • Richard C Wang
  • Hiroyuki Takai
  • Francis P Lach
  • Nikola P Pavletich
  • Rohini Desetty
  • Derek G Rudge
  • Olga Buzovetsky
  • Nicole S Persky
  • Guozhou Xu
  • Yaniv Lerenthal
  • E Robert McDonald
  • Ji Luo
  • Zhenming Zhao
  • Corey E Bakalarski
  • Kristen E Hurov
  • Dong Zhang
  • Nicole Solimini

Detail Information

Publications12

  1. ncbi Regulation of telomerase by telomeric proteins
    Agata Smogorzewska
    The Rockefeller University, New York, New York 10021, USA
    Annu Rev Biochem 73:177-208. 2004
    ..Here we discuss the details of telomerase and its regulation by the telomere...
  2. ncbi Homologous recombination generates T-loop-sized deletions at human telomeres
    Richard C Wang
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Cell 119:355-68. 2004
    ..These findings show that t-loop deletion by HR influences the integrity and dynamics of mammalian telomeres...
  3. ncbi Different telomere damage signaling pathways in human and mouse cells
    Agata Smogorzewska
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, NY 10021, USA
    EMBO J 21:4338-48. 2002
    ..These findings reveal a fundamental difference in telomere damage signaling in human and mouse cells that bears on the use of mouse models for the telomere tumor suppressor pathway...
  4. ncbi DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2
    Agata Smogorzewska
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Curr Biol 12:1635-44. 2002
    ..However, the molecular nature of these fusions and the mechanism by which they occur have not been elucidated...
  5. ncbi DNA damage foci at dysfunctional telomeres
    Hiroyuki Takai
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10021, USA
    Curr Biol 13:1549-56. 2003
    ..Furthermore, induction of TIFs through TRF2 inhibition provides an opportunity to study the DNA damage response within the context of well-defined, physically marked lesions...
  6. ncbi Ubiquitylation and the Fanconi anemia pathway
    Elizabeth Garner
    Laboratory of Genome Maintenance, The Rockefeller University, New York, NY 10065, USA
    FEBS Lett 585:2853-60. 2011
    ..Importantly, ubiquitylation provides the foundations for cross-talk between repair pathways, which in concert with the FA pathway, resolve interstrand crosslink damage and maintain genomic stability...
  7. ncbi Senescence induced by altered telomere state, not telomere loss
    Jan Karlseder
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 295:2446-9. 2002
    ..Thus, replicative senescence is induced by a change in the protected status of shortened telomeres rather than by a complete loss of telomeric DNA...
  8. ncbi Structure of the FANCI-FANCD2 complex: insights into the Fanconi anemia DNA repair pathway
    Woo Joo
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Science 333:312-6. 2011
    ....
  9. ncbi Mutations of the SLX4 gene in Fanconi anemia
    Yonghwan Kim
    Laboratory of Genome Maintenance, The Rockefeller University, New York, New York, USA
    Nat Genet 43:142-6. 2011
    ....
  10. ncbi ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
    Shuhei Matsuoka
    Department of Genetics and Center for Genetics and Genomics, Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 316:1160-6. 2007
    ..This database paints a much broader landscape for the DDR than was previously appreciated and opens new avenues of investigation into the responses to DNA damage in mammals...
  11. ncbi Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response
    Bin Wang
    Department of Genetics, Center for Genetics and Genomics, Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 316:1194-8. 2007
    ..The RAP80-Abraxas complex may help recruit BRCA1 to DNA damage sites in part through recognition of ubiquitinated proteins...
  12. ncbi Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair
    Agata Smogorzewska
    Department of Genetics, Howard Hughes Medical Institute, Center for Genetics and Genomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cell 129:289-301. 2007
    ..Mutation in FANCI is responsible for loss of a functional FA pathway in a patient with Fanconi anemia complementation group I...