R Neal Smith

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Partial therapeutic response to Rituximab for the treatment of chronic alloantibody mediated rejection of kidney allografts
    R Neal Smith
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Transpl Immunol 27:107-13. 2012
  2. pmc Chronic alloantibody mediated rejection
    R Neal Smith
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Semin Immunol 24:115-21. 2012
  3. doi request reprint Pathology of an islet transplant 2 years after transplantation: evidence for a nonimmunological loss
    R Neal Smith
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Transplantation 86:54-62. 2008
  4. pmc Distinct requirements for achievement of allotolerance versus reversal of autoimmunity via nonmyeloablative mixed chimerism induction in NOD mice
    Boris Nikolic
    Nephrology Division, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Transplantation 89:23-32. 2010
  5. pmc Divergent role of donor dendritic cells in rejection versus tolerance of allografts
    Takuya Ueno
    Transplantation Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Am Soc Nephrol 20:535-44. 2009
  6. ncbi request reprint Role of ICOS pathway in autoimmune and alloimmune responses in NOD mice
    Mohammed Javeed I Ansari
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Clin Immunol 126:140-7. 2008
  7. pmc Contributions of direct and indirect alloresponses to chronic rejection of kidney allografts in nonhuman primates
    Ognjenka Nadazdin
    Department of Surgery, Transplant Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Immunol 187:4589-97. 2011
  8. ncbi request reprint Prolonged survival of fetal pig islet xenografts in mice lacking the capacity for an indirect response
    Maria Koulmanda
    Islet Transplantation Research Laboratory, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Xenotransplantation 11:525-30. 2004
  9. doi request reprint Immunomodulatory function of bone marrow-derived mesenchymal stem cells in experimental autoimmune type 1 diabetes
    Paolo Fiorina
    Transplantation Research Center, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 183:993-1004. 2009
  10. ncbi request reprint Kidney transplantation: mechanisms of rejection and acceptance
    Lynn D Cornell
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Annu Rev Pathol 3:189-220. 2008

Collaborators

Detail Information

Publications31

  1. pmc Partial therapeutic response to Rituximab for the treatment of chronic alloantibody mediated rejection of kidney allografts
    R Neal Smith
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Transpl Immunol 27:107-13. 2012
    ..Therefore, no efficacious therapy to treat CAMR is presently available to prevent the progression of CAMR to kidney allograft failure...
  2. pmc Chronic alloantibody mediated rejection
    R Neal Smith
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Semin Immunol 24:115-21. 2012
    ..Therapy, which is problematic for this disease, is also discussed, including on-going and potential therapies and their limitations...
  3. doi request reprint Pathology of an islet transplant 2 years after transplantation: evidence for a nonimmunological loss
    R Neal Smith
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Transplantation 86:54-62. 2008
    ..After each islet transplant, she gradually lost insulin independence while maintaining low levels of C-peptide secretion...
  4. pmc Distinct requirements for achievement of allotolerance versus reversal of autoimmunity via nonmyeloablative mixed chimerism induction in NOD mice
    Boris Nikolic
    Nephrology Division, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Transplantation 89:23-32. 2010
    ..We developed low intensity regimens for the induction of mixed chimerism and examined the effects on autoimmunity in prediabetic nonobese diabetic (NOD) mice...
  5. pmc Divergent role of donor dendritic cells in rejection versus tolerance of allografts
    Takuya Ueno
    Transplantation Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Am Soc Nephrol 20:535-44. 2009
    ..These data indicate the importance of the CX3CR1 pathway in the generation of heart tissue dendritic cells and the divergent role of tissue/dendritic cells in rejection versus tolerance...
  6. ncbi request reprint Role of ICOS pathway in autoimmune and alloimmune responses in NOD mice
    Mohammed Javeed I Ansari
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Clin Immunol 126:140-7. 2008
    ..We conclude that in islet transplantation and autoimmune diabetes, ICOS blockade can be effective in inhibiting alloimmunity and preventing autoimmunity but is ineffective in inhibiting recurrence of autoimmunity...
  7. pmc Contributions of direct and indirect alloresponses to chronic rejection of kidney allografts in nonhuman primates
    Ognjenka Nadazdin
    Department of Surgery, Transplant Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Immunol 187:4589-97. 2011
    ....
  8. ncbi request reprint Prolonged survival of fetal pig islet xenografts in mice lacking the capacity for an indirect response
    Maria Koulmanda
    Islet Transplantation Research Laboratory, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Xenotransplantation 11:525-30. 2004
    ....
  9. doi request reprint Immunomodulatory function of bone marrow-derived mesenchymal stem cells in experimental autoimmune type 1 diabetes
    Paolo Fiorina
    Transplantation Research Center, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 183:993-1004. 2009
    ..These data provide important preclinical data supporting the basis for further development of allogeneic MSC-based therapies for T1D and, potentially, for other autoimmune disorders...
  10. ncbi request reprint Kidney transplantation: mechanisms of rejection and acceptance
    Lynn D Cornell
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Annu Rev Pathol 3:189-220. 2008
    ..Studies in animals have replicated many pathologic features of acute and chronic rejection. We illuminate the pathogenesis of human pathology by reflection from experimental models...
  11. ncbi request reprint The role of CC chemokine receptor 5 (CCR5) in islet allograft rejection
    Reza Abdi
    Laboratory of Immunogenetics and Transplantation, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Diabetes 51:2489-95. 2002
    ..Targeting this chemokine receptor, therefore, may provide a clinically useful strategy to prevent islet allograft rejection...
  12. pmc Morphometric and visual evaluation of fibrosis in renal biopsies
    Alton B Farris
    Pathology Service, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Am Soc Nephrol 22:176-86. 2011
    ..01 to 0.001). Considering efficiency, reproducibility, and functional correlation, two current techniques stand out as potentially the best for clinical trials: collagen III morphometry and visual assessment of trichrome-stained slides...
  13. ncbi request reprint Biliverdin, a natural product of heme catabolism, induces tolerance to cardiac allografts
    Kenichiro Yamashita
    Department of Surgery, Immunobiology Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Ave, Boston, MA 02215, USA
    FASEB J 18:765-7. 2004
    ..These findings support the potential use of biliverdin, a natural product, in transplantation and other T cell mediated immune disorders...
  14. pmc Up to 9-day survival and control of thrombocytopenia following alpha1,3-galactosyl transferase knockout swine liver xenotransplantation in baboons
    Karen Kim
    Department of Surgery, Massachusetts General Hospital, Boston, MA, USA
    Xenotransplantation 19:256-64. 2012
    ..We are reporting our results using GalT-KO liver grafts...
  15. ncbi request reprint Antibody-mediated organ-allograft rejection
    Robert B Colvin
    Department of Pathology, Warren 225, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02140, USA
    Nat Rev Immunol 5:807-17. 2005
    ..Antibody and complement also induce gene expression by endothelial cells, which is thought to remodel arteries and basement membranes, leading to fixed and irreversible anatomical lesions that permanently compromise graft function...
  16. ncbi request reprint Mixed hematopoietic chimerism allows cure of autoimmune diabetes through allogeneic tolerance and reversal of autoimmunity
    Boris Nikolic
    Renal Unit, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 53:376-83. 2004
    ..Thus, mixed hematopoietic chimerism induces tolerance to donor islets and reverses established autoimmunity in diabetic NOD mice...
  17. ncbi request reprint Pig islet xenografts are resistant to autoimmune destruction by non-obese diabetic recipients after anti-CD4 treatment
    Maria Koulmanda
    Islet Transplantation Laboratory, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Xenotransplantation 10:178-84. 2003
    ..The difficulty in obtaining indefinite islet xenograft survival in NOD recipients occurs independently from the development of destructive autoimmunity...
  18. doi request reprint Dense IgG4 plasma cell infiltrates associated with chronic infectious aortitis: implications for the diagnosis of IgG4-related disease
    Zakir Siddiquee
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston MA, 02114, USA
    Cardiovasc Pathol 21:470-5. 2012
    ..Chronic infectious aortitis can also display lymphoplasmacytic infiltrates, but the degree of IgG4 expression in these cases has not been specifically evaluated...
  19. ncbi request reprint Thrombophilia associated with anti-CD154 monoclonal antibody treatment and its prophylaxis in nonhuman primates
    Ichiro Koyama
    Department of Surgery, Transplantation Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Transplantation 77:460-2. 2004
    ..The authors previously reported thromboembolic complications associated with anti-CD154 monoclonal antibody (mAb) treatment in nonhuman primates. The underlying mechanisms of this complication and its management have not been established...
  20. ncbi request reprint Emerging role of B cells in chronic allograft dysfunction
    Robert B Colvin
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Kidney Int 78:S13-7. 2010
    ..Prognosis is poor, especially when recognized after graft dysfunction has developed. Improved detection and treatment are critically needed for this common cause of late graft loss...
  21. doi request reprint Classification of amyloid deposits in diagnostic cardiac specimens by immunofluorescence
    A Bernard Collins
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Cardiovasc Pathol 18:205-16. 2009
    ..Immunofluorescence staining on fresh frozen tissue is generally considered superior to immunoperoxidase staining for subtyping amyloid; however, this technique has not previously been reported in a series of cardiac specimens...
  22. pmc The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice
    Mohammed Javeed I Ansari
    Laboratory of Immunogenetics and Transplantation, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Exp Med 198:63-9. 2003
    ....
  23. ncbi request reprint Carbon monoxide protects pancreatic beta-cells from apoptosis and improves islet function/survival after transplantation
    Lukas Gunther
    Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Diabetes 51:994-9. 2002
    ..These findings suggest a potential therapeutic application for CO in improving islet function/survival after transplantation in humans...
  24. ncbi request reprint Fabry disease in mice protects against lethal disease caused by Shiga toxin-expressing enterohemorrhagic Escherichia coli
    Salvatore A Cilmi
    Infectious Disease Division, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    J Infect Dis 194:1135-40. 2006
    ..These results suggest that excess amounts of Gb3 in alpha-GalA-deficient mice may impair toxin delivery to susceptible tissues...
  25. pmc Whole-slide imaging digital pathology as a platform for teleconsultation: a pilot study using paired subspecialist correlations
    David C Wilbur
    Department of Pathology, James Homer Wright Pathology Laboratories, Massachusetts General Hospital, and the Department of Pathology, Harvard Medical School, Boston, MA 02114, USA
    Arch Pathol Lab Med 133:1949-53. 2009
    ..Before implementation, technical issues, pathologist adaptability, and morphologic pitfalls must be well characterized...
  26. ncbi request reprint Case records of the Massachusetts General Hospital. Case 28-2005. A 42-year-old man with weight loss, weakness, and a rash
    Myles Wolf
    Nephrology Division, Department of Medicine, Massachusetts General Hospital, Boston, USA
    N Engl J Med 353:1148-57. 2005
  27. ncbi request reprint Case records of the Massachusetts General Hospital. Case 17-2005. A 22-year-old woman with back and leg pain and respiratory failure
    Benjamin D Medoff
    Pulmonary and Critical Care Unit, Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, USA
    N Engl J Med 352:2425-34. 2005
  28. ncbi request reprint Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 21-2003. A 72-year-old man with repetitive strokes in the posterior circulation
    Michael Ronthal
    Department of Neurology, Beth Israel Deaconess Medical Center, Massachusetts General Hospital, Boston, USA
    N Engl J Med 349:170-80. 2003
  29. ncbi request reprint Higher frequency of high-grade rejections in cardiac allograft patients after Quilty B lesions or grade 2/4 rejections
    R Neal Smith
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Transplantation 73:1928-32. 2002
    ....
  30. ncbi request reprint Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury
    Leo E Otterbein
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Montefiore University Hospital, Pittsburgh, Pennsylvania, USA
    Nat Med 9:183-90. 2003
    ..These findings demonstrate a protective role for CO in vascular injury and support its use as a therapeutic agent...
  31. ncbi request reprint Chemokines and chronic heart allograft rejection
    R Neal Smith
    Transplantation 84:442-4. 2007