Research Topics
| Aneesh SinghalSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Detail Information
Publications
Evaluating effects of normobaric oxygen therapy in acute stroke with MRI-based predictive modelsOna Wu
Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, Boston MA 02114, USA
Med Gas Res 2:5. 2012..abstract:..- Combination therapy with normobaric oxygen (NBO) plus thrombolysis in experimental ischemic strokeNorio Fujiwara
Neuroprotection Research Laboratory, Departments of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
BMC Neurosci 10:79. 2009..NBO was maintained for 3 hours. Infarct volume, brain swelling and hemorrhagic transformation were quantified at 24 hours. Outcome assessments were blinded to therapy... - Stability of large diffusion/perfusion mismatch in anterior circulation strokes for 4 or more hoursR Gilberto Gonzalez
Neuroradiology Division, Department of Radiology, Massachusetts General Hospital, Boston, Harvard Medical School, Boston, MA 02114, USA
BMC Neurol 10:13. 2010..The purpose of this study was to determine the persistence of a diffusion/perfusion mismatch in patients with ICA or proximal MCA occlusions... 
Oxygen therapy in stroke: past, present, and futureAneesh B Singhal
Massachusetts General Hospital, Stroke Research Center, 175 Cambridge Street, Suite 300, Boston, MA 02114, USA
Int J Stroke 1:191-200. 2006..This article reviews the history, rationale, mechanisms of action and adverse effects of hyperoxia, the key results of previous hyperoxia studies, and the potential role of oxygen therapy in contemporary stroke treatment...
Advances in emerging nondrug therapies for acute stroke 2007Aneesh B Singhal
Neuroprotection Research Laboratory, Harvard Medical School, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
Stroke 39:289-91. 2008- A pilot study of normobaric oxygen therapy in acute ischemic strokeAneesh B Singhal
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
Stroke 36:797-802. 2005..Therapies that transiently prevent ischemic neuronal death can potentially extend therapeutic time windows for stroke thrombolysis. We conducted a pilot study to investigate the effects of high-flow oxygen in acute ischemic stroke... - SSRI and statin use increases the risk for vasospasm after subarachnoid hemorrhageA B Singhal
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Neurology 64:1008-13. 2005..Use of medications with vasoconstrictive or vasodilatory effects can potentially affect the risk for vasospasm after aneurysmal subarachnoid hemorrhage (SAH)... - A review of oxygen therapy in ischemic strokeAneesh B Singhal
Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
Neurol Res 29:173-83. 2007..This article reviews the history and current rationale for using oxygen therapy in stroke, the mechanisms of action of HBO and the results of animal and human studies of hyperoxia in cerebrovascular diseases... - Postpartum angiopathy and other cerebral vasoconstriction syndromesAneesh B Singhal
Stroke Service, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Neurocrit Care 3:91-7. 2005..This article presents an illustrative case report and reviews the historical aspects, clinical and imaging characteristics, etiology, differential diagnosis, management, and prognosis of cerebral vasoconstriction syndromes... - Cerebral venous sinus thrombosis associated with hepatic cirrhosisA B Singhal
VBK 802, Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
J Neurol Sci 171:65-8. 1999..He was treated with low molecular weight heparin and underwent an orthotopic liver transplant after three months. Follow-up helical CT venogram showed resolution of the sinus thrombosis... - Postpartum angiopathy with reversible posterior leukoencephalopathyAneesh B Singhal
Stroke Service, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
Arch Neurol 61:411-6. 2004..The pathophysiological features of RPLS are related to small-vessel dysfunction and breakdown of the blood-brain barrier... - Advances in stroke neuroprotection: hyperoxia and beyondAneesh B Singhal
Harvard Medical School, Boston, MA, USA
Neuroimaging Clin N Am 15:697-720, xii-xiii. 2005..These and other developments over the past decade raise expectations that successful stroke neuroprotection is imminent... - Cerebral vasoconstriction and stroke after use of serotonergic drugsA B Singhal
Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
Neurology 58:130-3. 2002..These cases, and the literature, suggest that the use of serotonin-enhancing drugs can precipitate a cerebrovascular syndrome due to reversible, multifocal arterial narrowing... - Normobaric hyperoxia reduces MRI diffusion abnormalities and infarct size in experimental strokeAneesh B Singhal
Neuroprotection Research Laboratory, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Neurology 58:945-52. 2002..Hyperbaric oxygen therapy is considered an important stroke treatment strategy... - Acute ischemic stroke patterns in infective and nonbacterial thrombotic endocarditis: a diffusion-weighted magnetic resonance imaging studyAneesh B Singhal
Stroke Service, Department of Neurology, Massachusetts General Hospital, and Harvard Medical School, Boston, Mass 02114, USA
Stroke 33:1267-73. 2002..We compared patterns of acute and recurrent ischemic stroke in IE and NBTE, using diffusion-weighted MRI (DWI)... - Effects of normobaric hyperoxia in a rat model of focal cerebral ischemia-reperfusionAneesh B Singhal
Neuroprotection Research Laboratory, Department of Neurology, Massachusetts General Hospital, Charlestown 02129, USA
J Cereb Blood Flow Metab 22:861-8. 2002..These results indicate that hyperoxia treatment during focal cerebral ischemia-reperfusion is neuroprotective, and does not increase oxidative stress... - Reversible cerebral vasoconstriction syndromes: analysis of 139 casesAneesh B Singhal
Department of Neurology, Massachusetts General Hospital, Boston, 02114, USA
Arch Neurol 68:1005-12. 2011..To compare the clinical, laboratory, and imaging features of patients with reversible cerebral vasoconstriction syndromes evaluated at 2 academic centers, compare subgroups, and investigate treatment effects... - Diffusion-weighted magnetic resonance imaging abnormalities in Bartonella encephalopathyAneesh B Singhal
Department of Neurology, Massachusetts General Hospital, Biogen, Inc MAP, Boston, USA
J Neuroimaging 13:79-82. 2003..In patients with unexplained, refractory seizures, the presence of DWI abnormalities warrants a search for unusual infectious or inflammatory disorders, like Bartonella encephalitis... - Interexaminer difference in infarct volume measurements on MRI: a source of variance in stroke researchHakan Ay
Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 2301, Charlestown MA 02129, USA
Stroke 39:1171-6. 2008..We sought to quantify the variance imposed by measurement error in DWI and PWI lesion volume measurements in ischemic stroke... - Serial MRI changes in comatose cardiac arrest patientsDavid Greer
Department of Neurology, Yale University School of Medicine, New Haven, CT 06530, USA
Neurocrit Care 14:61-7. 2011..However, MRI changes evolve temporally and spatially, which may lead to misinterpretation and misclassification of patients... - Clinical MRI interpretation for outcome prediction in cardiac arrestDavid Greer
Department of Neurology, Yale University School of Medicine, LLCI 912, 15 York Street, New Haven, CT 06520, USA
Neurocrit Care 17:240-4. 2012..We sought to determine whether clinical interpretation of diffusion-weighted imaging (DWI) helps to determine poor outcome in comatose cardiac arrest patients... - Wake-up stroke: clinical and neuroimaging characteristicsGisele S Silva
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA giselesampaio hotmail com
Cerebrovasc Dis 29:336-42. 2010..In these patients, in whom the time from symptom onset is uncertain, brain imaging is a potential strategy to characterize the ischemia duration and the presence of salvageable brain tissue... - Hyperdense basilar artery sign on unenhanced CT predicts thrombus and outcome in acute posterior circulation strokeGregory V Goldmakher
Massachusetts General Hospital, Department of Neurology, MGH Stroke Research Center, 175 Cambridge Street, suite 300 Boston, MA 02114, USA
Stroke 40:134-9. 2009..Our purpose was to determine whether the hyperdense basilar artery (HDBA) sign has utility in detecting thrombosis and predicting outcome in patients presenting with signs and symptoms of posterior circulation stroke... - Admission international normalized ratio and acute infarct volume in ischemic strokeHakan Ay
Department of Neurology, Stroke Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
Ann Neurol 64:499-506. 2008..We explored the relation between admission international normalized ratio (INR) and acute infarct volume in patients with ischemic stroke... - Spontaneous hyperacute postischemic hemorrhage leading to deathEric E Smith
Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Neuroimaging 14:361-4. 2004..In patients with ischemic stroke, MRI findings such as hyperacute petechial hemorrhage or chronic cerebral microbleeds might predict subsequent parenchymal hemorrhage and thus have implications for tissue plasminogen activator use... - Reversible posterior leukoencephalopathy, cerebral vasoconstriction, and strokes after intravenous immune globulin therapy in guillain-barre syndromeChristine E Doss-Esper
Department of Neurology, Division of Critical Care and Emergency Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02114, USA
J Neuroimaging 15:188-92. 2005..Possible interrelationships and mechanisms of these complications are discussed... - A computerized algorithm for etiologic classification of ischemic stroke: the Causative Classification of Stroke SystemHakan Ay
AA Martinos Center for Biomedical Imaging and Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
Stroke 38:2979-84. 2007..In this article, we present an automated version of the SSS-TOAST, the Causative Classification System (CCS), to facilitate its utility in multicenter settings... - Collateral vessels on CT angiography predict outcome in acute ischemic strokeMatthew B Maas
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass, USA
Stroke 40:3001-5. 2009.... - Normobaric hyperoxia extends the reperfusion window in focal cerebral ischemiaHahn Young Kim
Neuroprotection Research Laboratory, Departments of Neurology and Radiology, Massachusetts General Hospital, Charlestown, USA
Ann Neurol 57:571-5. 2005..Normobaric hyperoxia may be a clinically feasible adjunct method for significantly increasing the time window for effective thrombolytic therapy in acute ischemic stroke... - CT angiography and CT perfusion in post-CEA hyperperfusion syndromeSusanne Muehlschlegel
Department of Neurology, Division of Neurocritical Care and Stroke, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Neurology 68:1437. 2007 - National Institutes of Health Stroke Scale score is poorly predictive of proximal occlusion in acute cerebral ischemiaMatthew B Maas
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass, USA
Stroke 40:2988-93. 2009..Use of National Institutes of Health Stroke Scale (NIHSS) score to predict a proximal arterial occlusion (PO) is suggested by several case series as a viable method of selecting cases appropriate for multimodal imaging... - Severity of leukoaraiosis and susceptibility to infarct growth in acute strokeHakan Ay
A A Martinos Center for Biomedical Imaging and Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
Stroke 39:1409-13. 2008..We hypothesized that the volume of LA correlated with the proportion of initially ischemic but eventually infarcted tissue in acute human stroke... - Age-dependent susceptibility to infarct growth in womenFigen Gokcay
AA Martinos Center for Biomedical Imaging and Stroke Service, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
Stroke 42:947-51. 2011..We sought to identify whether the proportion of initially ischemic to eventually infarcted tissue was different between men and women with ischemic stroke... - Correlation between brain reorganization, ischemic damage, and neurologic status after transient focal cerebral ischemia in rats: a functional magnetic resonance imaging studyRick M Dijkhuizen
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Neurosci 23:510-7. 2003.... - Connectivity alterations assessed by combining fMRI and MR-compatible hand robots in chronic strokeDionyssios Mintzopoulos
NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Shriner s Burn Institute, Harvard Medical School, Boston, MA 02114, USA
Neuroimage 47:T90-7. 2009..Assessing changes in connectivity by means of fMRI and MR_CHIROD might be used in the future to further elucidate the neural network plasticity that underlies functional recovery in chronic stroke patients... - An evidence-based causative classification system for acute ischemic strokeHakan Ay
A A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Ann Neurol 58:688-97. 2005..The SSS-TOAST is a dynamic algorithm that can accommodate modifications as new epidemiological data accumulate and diagnostic techniques advance... - Acute brain infarct: detection and delineation with CT angiographic source images versus nonenhanced CT scansErica C S Camargo
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, GRB 239, Boston, MA 02114 2622, USA
Radiology 244:541-8. 2007.... - The pattern of leptomeningeal collaterals on CT angiography is a strong predictor of long-term functional outcome in stroke patients with large vessel intracranial occlusionFabricio O Lima
Stroke Service, Department of Neurology, Massachusetts General Hospital, Boston, Mass 02114, USA
Stroke 41:2316-22. 2010..The role of noninvasive methods in the evaluation of collateral circulation has yet to be defined. We hypothesized that a favorable pattern of leptomeningeal collaterals, as identified by CT angiography, correlates with improved outcomes... - Multiple punctate cerebral hemorrhages in acute leukemia with blast crisisSherry H-Y Chou
J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA 02114, USA
Neurology 68:953. 2007 - Cerebral vasoconstriction syndromesAneesh B Singhal
Harvard Medical School, Assistant in Neurology, Massachusetts General Hospital, and Spaulding Rehabilitation Hospital, Boston, Massachusetts, USA
Top Stroke Rehabil 11:1-6. 2004..This article reviews the history, clinical and radiological characteristics, differential diagnosis, and management of cerebral vasoconstriction syndromes... - The real estate factor: quantifying the impact of infarct location on stroke severityNina M Menezes
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and the Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, Boston, MA, USA
Stroke 38:194-7. 2007..In the current study, we sought to quantify the impact of location on neurological deficit severity and to delineate this impact from that of volume... - Update of the stroke therapy academic industry roundtable preclinical recommendationsMarc Fisher
Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Stroke 40:2244-50. 2009..Although the recommendations cannot be validated until effective therapies based on them emerge from clinical trials, it is hoped that adherence to them might enhance the chances for success... - Subarachnoid hemorrhage without evident cause on initial angiography studies: diagnostic yield of subsequent angiography and other neuroimaging testsMehmet A Topcuoglu
Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Neurosurg 98:1235-40. 2003..Newer, noninvasive imaging techniques provide little diagnostic yield... - Diffusion MRI in three types of anoxic encephalopathyAneesh B Singhal
Stroke Service, Department of Neurology, VBK 802, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
J Neurol Sci 196:37-40. 2002..The prognosis after anoxic encephalopathy depends on the underlying mechanism and its severity, which may be reflected by DWI abnormalities... - Headache: when is neurologic imaging indicated?Pamela W Schaefer
Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Am Coll Radiol 4:566-9. 2007 - Stroke Therapy Academic Industry Roundtable (STAIR) recommendations for extended window acute stroke therapy trialsJeffrey L Saver
Department of Neurology, Geffen School of Medicine, UCLA, Los Angeles, CA, USA
Stroke 40:2594-600. 2009..a. thrombolysis or devices may be acceptable. Statistical considerations and definitions of successful recanalization/reperfusion are suggested for these trials... - Effect of normobaric oxygen therapy in a rat model of intracerebral hemorrhageNorio Fujiwara
ACC 729 C, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Stroke 42:1469-72. 2011..Normobaric oxygen (NBO) therapy may be neuroprotective in acute ischemic stroke. However, how NBO may affect intracerebral hemorrhage is unclear. We tested NBO in a rat model of striatal intracerebral hemorrhage... - Comatose patients with cardiac arrest: predicting clinical outcome with diffusion-weighted MR imagingOna Wu
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129, USA
Radiology 252:173-81. 2009..To examine whether the severity and spatial distribution of reductions in apparent diffusion coefficient (ADC) are associated with clinical outcomes in patients who become comatose after cardiac arrest... - Oxygen therapy in ischemic strokeJohn H Zhang
Stroke 34:e152-3; author reply e153-5. 2003 - Magnetic resonance spectroscopy study of oxygen therapy in ischemic strokeAneesh B Singhal
Stroke 38:2851-4. 2007..N-acetyl-aspartate decreased in patients receiving room air but not in NBO-treated patients. CONCLUSIONS: These data suggest that NBO improves aerobic metabolism and preserves neuronal integrity in the ischemic brain... - Effects of common medications on cerebral vasospasm after subarachnoid haemorrhageMehmet Akif Topcuoglu
Akdeniz University Hospitals, Neurology Department, Antalya, 07059, Turkey
Expert Opin Drug Saf 5:57-65. 2006..Recognition of these pharmacological effects is important because medications that can worsen or alleviate vasospasm are frequently administered to SAH patients to treat coincident medical problems... - Narrative review: reversible cerebral vasoconstriction syndromesLeonard H Calabrese
Cleveland Clinic Lerner College of Medicine of Case Western Reserve University and Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Ann Intern Med 146:34-44. 2007..In this review, we describe our current understanding of RCVS; summarize its key clinical, laboratory, and imaging features; and discuss strategies for diagnostic evaluation and treatment... - Relationship between hyperglycemia and symptomatic vasospasm after subarachnoid hemorrhageNeeraj Badjatia
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Crit Care Med 33:1603-9; quiz 1623. 2005..9% vs. 18.8%; p < .001). CONCLUSIONS: Mean inpatient blood glucose value is associated with the development of VSP and may represent a target for therapy to prevent VSP and improve clinical outcomes... - Primary central nervous system vasculitis: progress and questionsLeonard H Calabrese
Ann Neurol 62:430-2. 2007 - Effect of clipping, craniotomy, or intravascular coiling on cerebral vasospasm and patient outcome after aneurysmal subarachnoid hemorrhageBrian L Hoh
Neurosurgical Service, Endovascular Neurosurgery and Interventional Neuroradiology, and Cerebrovascular Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Neurosurgery 55:779-86; discussion 786-9. 2004.... - Neuroprotection: lessons from a spectrum of neurological disordersWendy R Galpern
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Int J Stroke 1:97-9. 2006
Research Grants
- Normobaric Hyperoxia in Acute Ischemic StrokeAneesh Singhal; Fiscal Year: 2007..Breathing high-flow oxygen may prove to be a simple, practical, portable, and potentially cost-effective therapy that improves stroke outcomes, either independently or by extending the time window for IV tPA. ..
- Normobaric Hyperoxia in Acute Ischemic StrokeAneesh Singhal; Fiscal Year: 2009..Breathing high-flow oxygen may prove to be a simple, practical, portable, and potentially cost-effective therapy that improves stroke outcomes, either independently or by extending the time window for IV tPA. ..
- Normobaric Hyperoxia in Acute Ischemic StrokeAneesh B Singhal; Fiscal Year: 2010..Breathing high-flow oxygen may prove to be a simple, practical, portable, and potentially cost-effective therapy that improves stroke outcomes, either independently or by extending the time window for IV tPA. ..