D E Singer

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Antithrombotic therapy in atrial fibrillation: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Daniel E Singer
    Clinical Epidemiology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Chest 133:546S-592S. 2008
  2. ncbi Impact of global geographic region on time in therapeutic range on warfarin anticoagulant therapy: data from the ROCKET AF clinical trial
    Daniel E Singer
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Am Heart Assoc 2:e000067. 2013
  3. ncbi A 60-year-old woman with atrial fibrillation
    Daniel E Singer
    Harvard Medical School and General Medicine Division, Massachusetts General Hospital, Boston 02114, USA
    JAMA 290:2182-9. 2003
  4. ncbi Antithrombotic therapy in atrial fibrillation: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy
    Daniel E Singer
    Clinical Epidemiology Unit, S50 9, Massachusetts General Hospital, Boston, MA 02114, USA
    Chest 126:429S-456S. 2004
  5. ncbi Should patient characteristics influence target anticoagulation intensity for stroke prevention in nonvalvular atrial fibrillation?: the ATRIA study
    Daniel E Singer
    Clinical Epidemiology Unit, General Medicine Division, Massachusetts General Hospital, Boston, MA 02114, USA
    Circ Cardiovasc Qual Outcomes 2:297-304. 2009
  6. ncbi Antithrombotic therapy in atrial fibrillation
    D E Singer
    Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Clin Geriatr Med 17:131-47. 2001
  7. ncbi The net clinical benefit of warfarin anticoagulation in atrial fibrillation
    Daniel E Singer
    Massachusetts General Hospital, Boston, Massachussetts 02114, USA
    Ann Intern Med 151:297-305. 2009
  8. ncbi The Maine Lumbar Spine Study, Part III. 1-year outcomes of surgical and nonsurgical management of lumbar spinal stenosis
    S J Atlas
    Medical Practices Evaluation Center, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Spine (Phila Pa 1976) 21:1787-94; discussion 1794-5. 1996
  9. ncbi Effect of intensity of oral anticoagulation on stroke severity and mortality in atrial fibrillation
    Elaine M Hylek
    General Medicine Division, Clinical Epidemiology Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    N Engl J Med 349:1019-26. 2003
  10. ncbi Metabolic risk factors worsen continuously across the spectrum of nondiabetic glucose tolerance. The Framingham Offspring Study
    J B Meigs
    Massachusetts General Hospital, Harvard Medical School, Boston University School of Public Health, 02114, USA
    Ann Intern Med 128:524-33. 1998

Research Grants

  1. Harvard Planning Grant for Institutional Clinical and Translational Science Award
    Daniel Singer; Fiscal Year: 2006
  2. EPIDEMIOLOGY OF ANTICOAGULATION IN ATRIAL FIBRILLATION
    Daniel Singer; Fiscal Year: 2005
  3. EPIDEMIOLOGY OF ANTICOAGULATION IN ATRIAL FIBRILLATION
    Daniel Singer; Fiscal Year: 2000

Collaborators

Detail Information

Publications87

  1. ncbi Antithrombotic therapy in atrial fibrillation: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Daniel E Singer
    Clinical Epidemiology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Chest 133:546S-592S. 2008
    ..However, in patients without contraindications to anticoagulation, we suggest beginning IV heparin or LMWH at presentation (Grade 2C)...
  2. ncbi Impact of global geographic region on time in therapeutic range on warfarin anticoagulant therapy: data from the ROCKET AF clinical trial
    Daniel E Singer
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Am Heart Assoc 2:e000067. 2013
    ..Time in therapeutic range (TTR) is a widely cited measure of the quality of VKA therapy. We sought to identify factors associated with TTR in a large, international clinical trial...
  3. ncbi A 60-year-old woman with atrial fibrillation
    Daniel E Singer
    Harvard Medical School and General Medicine Division, Massachusetts General Hospital, Boston 02114, USA
    JAMA 290:2182-9. 2003
  4. ncbi Antithrombotic therapy in atrial fibrillation: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy
    Daniel E Singer
    Clinical Epidemiology Unit, S50 9, Massachusetts General Hospital, Boston, MA 02114, USA
    Chest 126:429S-456S. 2004
    ..However, in patients without contraindications to anticoagulation, we suggest beginning IV heparin or low molecular weight heparin at presentation (Grade 2C)...
  5. ncbi Should patient characteristics influence target anticoagulation intensity for stroke prevention in nonvalvular atrial fibrillation?: the ATRIA study
    Daniel E Singer
    Clinical Epidemiology Unit, General Medicine Division, Massachusetts General Hospital, Boston, MA 02114, USA
    Circ Cardiovasc Qual Outcomes 2:297-304. 2009
    ..0 to 3.0 for preventing ischemic stroke in atrial fibrillation. We assessed whether the INR target should be adjusted based on selected patient characteristics...
  6. ncbi Antithrombotic therapy in atrial fibrillation
    D E Singer
    Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Clin Geriatr Med 17:131-47. 2001
    ..Discoveries of new antithrombotic agents and new drugs and devices for preservation of sinus rhythm could radically improve stroke-preventive strategies for AF...
  7. ncbi The net clinical benefit of warfarin anticoagulation in atrial fibrillation
    Daniel E Singer
    Massachusetts General Hospital, Boston, Massachussetts 02114, USA
    Ann Intern Med 151:297-305. 2009
    ..These guidelines rely on ischemic stroke rates observed in older trials and do not explicitly account for increased risk for hemorrhage...
  8. ncbi The Maine Lumbar Spine Study, Part III. 1-year outcomes of surgical and nonsurgical management of lumbar spinal stenosis
    S J Atlas
    Medical Practices Evaluation Center, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Spine (Phila Pa 1976) 21:1787-94; discussion 1794-5. 1996
    ..Comparisons of outcomes by treatment received must be made cautiously because of differences in baseline characteristics. A determination of whether the outcomes observed persist requires long-term follow-up...
  9. ncbi Effect of intensity of oral anticoagulation on stroke severity and mortality in atrial fibrillation
    Elaine M Hylek
    General Medicine Division, Clinical Epidemiology Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    N Engl J Med 349:1019-26. 2003
    ..0 or greater reduces not only the frequency of ischemic stroke but also its severity and the risk of death from stroke. Our findings provide further evidence against the use of lower INR target levels in patients with atrial fibrillation...
  10. ncbi Metabolic risk factors worsen continuously across the spectrum of nondiabetic glucose tolerance. The Framingham Offspring Study
    J B Meigs
    Massachusetts General Hospital, Harvard Medical School, Boston University School of Public Health, 02114, USA
    Ann Intern Med 128:524-33. 1998
    ..Categorical definitions for glucose intolerance imply that risk thresholds exist, but metabolic risk for type 2 diabetes mellitus or cardiovascular disease may increase continuously as glucose intolerance increases...
  11. ncbi National patterns of warfarin use in atrial fibrillation
    R S Stafford
    General Internal Medicine Unit, Massachusetts General Hospital, Boston, USA
    Arch Intern Med 156:2537-41. 1996
    ..Despite consensus that patients with atrial fibrillation benefit from warfarin sodium anticoagulation, little is known about national trends and predictors of anticoagulant use...
  12. ncbi National trends in antiarrhythmic and antithrombotic medication use in atrial fibrillation
    Margaret C Fang
    Massachusetts General Hospital, Boston, USA
    Arch Intern Med 164:55-60. 2004
    ..Atrial fibrillation is the most common cardiac arrhythmia associated with significant medical complications. We examined trends in the medical therapy of atrial fibrillation in the United States from 1991 through 2000...
  13. ncbi The Quebec Task Force classification for Spinal Disorders and the severity, treatment, and outcomes of sciatica and lumbar spinal stenosis
    S J Atlas
    Medical Practices Evaluation Center, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Spine (Phila Pa 1976) 21:2885-92. 1996
    ..These results provide validation for the classification and its wider adoption. Nonetheless, improved diagnostic classifications are needed to predict outcomes better in patients with sciatica who undergo surgery...
  14. ncbi Efficacy of a smoking cessation program for hospital patients
    N A Rigotti
    Tobacco Research and Treatment Center Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Arch Intern Med 157:2653-60. 1997
    ..A hospital-based intervention may promote smoking cessation after discharge...
  15. ncbi Surgical and nonsurgical management of lumbar spinal stenosis: four-year outcomes from the maine lumbar spine study
    S J Atlas
    Medical Practices Evaluation Center and the General Medicine Division, Medical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Spine (Phila Pa 1976) 25:556-62. 2000
    ..A prospective cohort study of patients with lumbar spinal stenosis recruited from the practices of orthopedic surgeons and neurosurgeons throughout Maine...
  16. ncbi Long-term disability and return to work among patients who have a herniated lumbar disc: the effect of disability compensation
    S J Atlas
    Massachusetts General Hospital, Boston 02114, USA
    J Bone Joint Surg Am 82:4-15. 2000
    ..Therefore, we believe that it is important to describe the long-term outcomes for patients who have herniation of a lumbar disc and sciatica according to the Workers' Compensation status at the time of the preoperative consultation...
  17. ncbi Apolipoprotein E isoform polymorphisms are not associated with insulin resistance: the Framingham Offspring Study
    J B Meigs
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Diabetes Care 23:669-74. 2000
    ..We examined the relationship between insulin resistance and apo(e) polymorphisms among participants in the Framingham Offspring Study...
  18. ncbi Hyperinsulinemia, hyperglycemia, and impaired hemostasis: the Framingham Offspring Study
    J B Meigs
    General Medicine Division and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Institute for Prevention of Cardiovascular Disease, Boston 02114, USA
    JAMA 283:221-8. 2000
    ..Hyperinsulinemia associated with glucose intolerance may increase risk directly, or its effect could be mediated through impaired hemostatic function...
  19. ncbi Safely increasing the proportion of patients with community-acquired pneumonia treated as outpatients: an interventional trial
    S J Atlas
    Medical Practices Evaluation Center and the General Medicine Division, Medical Services, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Arch Intern Med 158:1350-6. 1998
    ..Such patients should be candidates for outpatient treatment, yet many are hospitalized...
  20. ncbi Surgical and nonsurgical management of sciatica secondary to a lumbar disc herniation: five-year outcomes from the Maine Lumbar Spine Study
    S J Atlas
    General Medicine Division and the Medical Practices Evaluation Center, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Spine (Phila Pa 1976) 26:1179-87. 2001
    ..A prospective cohort study...
  21. ncbi Risk variable clustering in the insulin resistance syndrome. The Framingham Offspring Study
    J B Meigs
    General Internal Medicine Unit, Massachusetts General Hospital, Boston 02114, USA
    Diabetes 46:1594-600. 1997
    ..Insulin resistance (reflected by hyperinsulinemia) alone did not appear to underlie all features of the insulin resistance syndrome...
  22. ncbi Health care resource utilization associated with a diabetes center and a general medicine clinic
    Elbert S Huang
    General Medicine Division, University of Chicago, Chicago, Illinoos 60637, USA
    J Gen Intern Med 19:28-35. 2004
    ..We compared the health care utilization associated with a diabetes center (DC) and a general medicine clinic (GMC)...
  23. ncbi Clinical predictors of prolonged delay in return of the international normalized ratio to within the therapeutic range after excessive anticoagulation with warfarin
    E M Hylek
    General Medicine Division, Clinical Epidemiology Unit, Massachusetts General Hospital, 50 Staniford Street, 9th Floor, Boston, MA 02114, USA
    Ann Intern Med 135:393-400. 2001
    ..Decompensated congestive heart failure and active cancer greatly increase this risk...
  24. ncbi Recent national patterns of warfarin use in atrial fibrillation
    R S Stafford
    Massachusetts General Hospital, Medical Services and Department of Medicine, Harvard Medical School, Boston, USA
    Circulation 97:1231-3. 1998
    ..We wished to examine recent national trends and predictors of warfarin sodium use in atrial fibrillation...
  25. ncbi Clinical inertia in the management of Type 2 diabetes metabolic risk factors
    R W Grant
    General Medicine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Diabet Med 21:150-5. 2004
    ..We assessed intensification of medical therapy over time, comparing the management of hyperglycaemia, hypertension, and hyperlipidaemia...
  26. ncbi The effect of interventions to prevent cardiovascular disease in patients with type 2 diabetes mellitus
    E S Huang
    General Medicine Division, University of Chicago, Chicago, Illinois 60637, USA
    Am J Med 111:633-42. 2001
    ..Intensive glucose lowering is essential for the prevention of microvascular disease, but improvements in cholesterol and blood pressure levels are central to reducing cardiovascular disease in these patients...
  27. ncbi Smoking by patients in a smoke-free hospital: prevalence, predictors, and implications
    N A Rigotti
    Tobacco Research and Treatment Center, Boston, MA 02114, USA
    Prev Med 31:159-66. 2000
    ..Hospitalization in a smoke-free hospital might precipitate nicotine withdrawal in smokers, but it might also offer smokers an opportunity to stop smoking...
  28. ncbi Development and validation of a new health-related quality of life instrument for patients with sinusitis
    Steven J Atlas
    General Medicine Division and the Clinical Epidemiology Unit, Medical Services, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Qual Life Res 14:1375-86. 2005
    ..This study used patient focus and pretesting groups followed by a prospective cohort study to develop and validate a HRQL instrument for patients with sinusitis...
  29. ncbi The effect of warfarin and intensity of anticoagulation on outcome of intracerebral hemorrhage
    Jonathan Rosand
    Neurology Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA
    Arch Intern Med 164:880-4. 2004
    ..The data suggest that careful control of the INR, already known to limit the risk of warfarin-related ICH, may also limit its severity...
  30. ncbi Bupropion for smokers hospitalized with acute cardiovascular disease
    Nancy A Rigotti
    Tobacco Research and Treatment Center, General Medicine Division, and Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Am J Med 119:1080-7. 2006
    ..Bupropion is effective for smoking cessation, but its safety and efficacy in hospitalized smokers with acute cardiovascular disease is unknown...
  31. ncbi The impact of disability compensation on long-term treatment outcomes of patients with sciatica due to a lumbar disc herniation
    Steven J Atlas
    General Medicine Division, Medical Services, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Spine (Phila Pa 1976) 31:3061-9. 2006
    ..Prospective, observational study...
  32. ncbi Association between antibiotic prescribing and visit duration in adults with upper respiratory tract infections
    Jeffrey A Linder
    Division of General Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Clin Ther 25:2419-30. 2003
    ..One of the reasons physicians may prescribe an antibiotic inappropriately is to save time...
  33. ncbi Validity of a new health-related quality of life instrument for patients with chronic sinusitis
    Steven J Atlas
    General Medicine Division and the Clinical Epidemiology Unit, Medical Services, Massachusetts General Hospital, and the Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    Laryngoscope 115:846-54. 2005
    ..If validated in other patient populations, this disease-specific instrument may be useful in assessing severity and outcomes of treatment for sinusitis...
  34. ncbi Health-related quality of life of adults with upper respiratory tract infections
    Jeffrey A Linder
    Division of General Medicine, Brigham and Women s Hospital, Boston, MA 02115
    J Gen Intern Med 18:802-7. 2003
    ..To determine the impact that upper respiratory tract infections have on patients' physical, social, and emotional functioning, we measured the health-related quality of life (HRQL) of adults with upper respiratory tract infections...
  35. ncbi Desire for antibiotics and antibiotic prescribing for adults with upper respiratory tract infections
    Jeffrey A Linder
    Division of General Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Gen Intern Med 18:795-801. 2003
    ..We also sought to identify factors independently associated with wanting antibiotics and antibiotic prescribing...
  36. ncbi Trends in complexity of diabetes care in the United States from 1991 to 2000
    Richard W Grant
    General Medicine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, 50 Staniford Street, Ninth Floor, Boston, MA 02114, USA
    Arch Intern Med 164:1134-9. 2004
    ..During the decade from 1991 to 2000, the standard of care for diabetes mellitus evolved to require more intensive management of glycemia, blood pressure, and cholesterol levels...
  37. ncbi The unmet health care needs of homeless adults: a national study
    Travis P Baggett
    General Medicine Division, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Public Health 100:1326-33. 2010
    ..We assessed the prevalence and predictors of past-year unmet needs for 5 types of health care services in a national sample of homeless adults...
  38. ncbi Frequent outpatient contact and decreasing medication affordability in patients with diabetes from 1997 to 2004
    Richard W Grant
    General Medicine Units, Massachusetts General Hospital, 50-9 Staniford St, Boston, MA 02114, USA
    Diabetes Care 29:1386-8. 2006
  39. ncbi Impact of concurrent medication use on statin adherence and refill persistence
    Richard W Grant
    General Medicine Unit, Department of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, USA
    Arch Intern Med 164:2343-8. 2004
    ..Effective therapy for chronic illness requires daily medication adherence (DMA) for prolonged periods. Overall medical regimen complexity may represent one barrier to successful adherence...
  40. ncbi Long-term outcomes of surgical and nonsurgical management of sciatica secondary to a lumbar disc herniation: 10 year results from the maine lumbar spine study
    Steven J Atlas
    General Medicine Division and the Clinical Epidemiology Unit, Medical Services, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Spine (Phila Pa 1976) 30:927-35. 2005
    ..A prospective cohort study...
  41. ncbi Long-term outcomes of surgical and nonsurgical management of lumbar spinal stenosis: 8 to 10 year results from the maine lumbar spine study
    Steven J Atlas
    General Medicine Division and the Clinical Epidemiology Unit, Medical Services, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Spine (Phila Pa 1976) 30:936-43. 2005
    ..A prospective observational cohort study...
  42. ncbi Protecting an endangered species: training physicians to conduct clinical research
    Mary Ellen J Goldhamer
    Massachusetts General Hospital, Bulfinch Medical Group, Boston, MA 02114, USA
    Acad Med 84:439-45. 2009
    ..The authors sought to evaluate the research careers of physician graduates and to determine correlates of National Institutes of Health (NIH) grant funding...
  43. ncbi Medication adherence before an increase in antihypertensive therapy: a cohort study using pharmacy claims data
    Richard W Grant
    General Medicine Division, Department of Medicine, Massachusetts General Hospital, USA
    Clin Ther 27:773-81. 2005
    ..Less than one third of patients with hypertension achieve optimal blood pressure control. Poor medication adherence has been identified as one contributor to uncontrolled blood pressure...
  44. ncbi The effect of surgical and nonsurgical treatment on longitudinal outcomes of lumbar spinal stenosis over 10 years
    Yuchiao Chang
    General Medicine Division and the Clinical Epidemiology Unit, Medical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Am Geriatr Soc 53:785-92. 2005
    ..To assess the relative effect of initial surgical and nonsurgical treatment on longitudinal outcomes of patients with lumbar spinal stenosis over a 10-year follow-up period...
  45. ncbi A controlled trial of population management: diabetes mellitus: putting evidence into practice (DM-PEP)
    Richard W Grant
    General Medicine Division, Massachusetts General Hospital, Boston, MA, USA
    Diabetes Care 27:2299-305. 2004
    ..Population-level strategies to organize and deliver care may improve diabetes management. We conducted a multiclinic controlled trial of population management in patients with type 2 diabetes...
  46. ncbi The Maine-Seattle back questionnaire: a 12-item disability questionnaire for evaluating patients with lumbar sciatica or stenosis: results of a derivation and validation cohort analysis
    Steven J Atlas
    General Medicine Division and the Clinical Epidemiology Unit, Medical Services, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Spine (Phila Pa 1976) 28:1869-76. 2003
    ..Analysis of health-related quality of life data obtained from a prospective cohort study of patients with sciatica due to an intervertebral disc herniation or lumbar spinal stenosis...
  47. ncbi Polypharmacy and medication adherence in patients with type 2 diabetes
    Richard W Grant
    General Medicine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Diabetes Care 26:1408-12. 2003
    ..To determine medication adherence and predictors of suboptimal adherence in a community cohort of patients with diabetes and to test the hypothesis that adherence decreases with increased number of medicines prescribed...
  48. ncbi A controlled trial of web-based diabetes disease management: the MGH diabetes primary care improvement project
    James B Meigs
    Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes Care 26:750-7. 2003
    ..To test effects of a web-based decision support tool, the diabetes Disease Management Application (DMA), developed to improve evidence-based management of type 2 diabetes...
  49. ncbi Measures of health-related quality of life for adults with acute sinusitis. A systematic review
    Jeffrey A Linder
    Division of General Medicine, Brigham and Women s Hospital and the General Medicine Division, Massachusetts General Hospital, Boston, Mass, USA
    J Gen Intern Med 18:390-401. 2003
    ..We identified symptom scores and HRQL instruments for adults with sinusitis and assessed their performance characteristics...
  50. ncbi Comparison of hyperglycemia, hypertension, and hypercholesterolemia management in patients with type 2 diabetes
    Richard W Grant
    General Medicine Division, Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Med 112:603-9. 2002
    ..Given the prevalence of cardiovascular disease in patients with type 2 diabetes, increased screening for hypercholesterolemia and more aggressive drug therapy for hypercholesterolemia and hypertension are needed...
  51. ncbi Improving adherence and reducing medication discrepancies in patients with diabetes
    Richard W Grant
    General Medicine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114 2517, USA
    Ann Pharmacother 37:962-9. 2003
    ..To improve medication adherence by reducing self-reported adherence barriers, and to identify medication discrepancies by comparing physician-prescribed and patient-reported medical regimens...
  52. ncbi Processes of care, illness severity, and outcomes in the management of community-acquired pneumonia at academic hospitals
    J Dedier
    Section of General Internal Medicine Research Unit, Department of Medicine, Boston Medical Center, 91 E Concord St, Suite 200, Boston, MA 02118 2393, USA
    Arch Intern Med 161:2099-104. 2001
    ....
  53. ncbi National patterns in the treatment of smokers by physicians
    A N Thorndike
    Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston 02114, USA
    JAMA 279:604-8. 1998
    ..There are few national data on how physicians' practices compare with these standards...
  54. ncbi Challenges to the effective use of unfractionated heparin in the hospitalized management of acute thrombosis
    Elaine M Hylek
    General Medicine Division/Clinical Epidemiology Unit, Ninth Floor, Massachusetts General Hospital, 50 Staniford St, Boston, MA 02114, USA
    Arch Intern Med 163:621-7. 2003
    ..Strategies are needed to improve the overall quality of anticoagulant care, including the substitution of low-molecular-weight heparin for unfractionated heparin, where appropriate...
  55. ncbi Smoking cessation following admission to a coronary care unit
    N A Rigotti
    General Internal Medicine Unit, Massachusetts General Hospital, Boston 02114
    J Gen Intern Med 6:305-11. 1991
    ..Smoking cessation in this setting should improve patient outcomes because cessation reduces cardiovascular mortality, even when quitting occurs after the onset of CHD...
  56. ncbi Comparison of risk stratification schemes to predict thromboembolism in people with nonvalvular atrial fibrillation
    Margaret C Fang
    Department of Medicine, University of California at San Francisco, San Francisco, California, USA
    J Am Coll Cardiol 51:810-5. 2008
    ..We assessed 5 risk stratification schemes for their ability to predict atrial fibrillation (AF)-related thromboembolism in a large community-based cohort...
  57. ncbi Tests of glycemia for the diagnosis of type 2 diabetes mellitus
    R Graham Barr
    Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ann Intern Med 137:263-72. 2002
    ..The glycemic threshold for type 2 diabetes should be established by cost-effectiveness analysis. The clinical diagnosis of diabetes mellitus could be streamlined by incorporation of hemoglobin A1c into established criteria...
  58. ncbi Are patients more likely to see physicians of the same sex? Recent national trends in primary care medicine
    Margaret C Fang
    Division of General Internal Medicine Hospitalist Group, Department of Medicine, University of California, San Francisco, 94143, USA
    Am J Med 117:575-81. 2004
    ..We assessed national trends in the proportion of women among patients seeing female physicians, and compared visit characteristics and preventive services among visits to female and male primary care physicians...
  59. ncbi Processes and outcomes of care for patients with community-acquired pneumonia: results from the Pneumonia Patient Outcomes Research Team (PORT) cohort study
    M J Fine
    Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, PA, USA
    Arch Intern Med 159:970-80. 1999
    ....
  60. ncbi Fasting plasma homocysteine levels in the insulin resistance syndrome: the Framingham offspring study
    J B Meigs
    General Medicine Division and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes Care 24:1403-10. 2001
    ..We examined relationships between homocysteine levels and features of insulin resistance syndrome (IRS)...
  61. ncbi National trends in the use of antibiotics by primary care physicians for adult patients with cough
    J P Metlay
    General Medicine Division, Massachusetts Division, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Arch Intern Med 158:1813-8. 1998
    ..Efforts to reduce the inappropriate use will need to be evaluated against current trends in the outpatient use of antibiotics...
  62. ncbi The use of nicotine-replacement therapy by hospitalized smokers
    N A Rigotti
    Tobacco Research and Treatment Program, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Am J Prev Med 17:255-9. 1999
    ..The extent of NRT use in the hospital setting is unknown. We describe the prevalence and patterns of NRT use in hospitalized smokers...
  63. ncbi The Maine Lumbar Spine Study, Part II. 1-year outcomes of surgical and nonsurgical management of sciatica
    S J Atlas
    Medical Practices Evaluation Center, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Spine (Phila Pa 1976) 21:1777-86. 1996
    ..These results should be interpreted cautiously, because surgical treatment was not assigned randomly. Long-term follow-up will determine if these differences persist...
  64. ncbi Arterial blood gas and pulse oximetry in initial management of patients with community-acquired pneumonia
    K P Levin
    Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    J Gen Intern Med 16:590-8. 2001
    ..Increasing the assessment of arterial oxygenation among patients with CAP is likely to increase the detection of arterial hypoxemia, particularly among outpatients...
  65. ncbi Noninvasive testing of asymptomatic bilateral hilar adenopathy
    P L Carr
    Department of Medicine, Massachusetts General Hospital, Boston 02114
    J Gen Intern Med 5:138-46. 1990
    ..Patients who are both ACE- and PPD-, particularly if white, may have a high enough risk of lymphoma to consider invasive biopsy...
  66. ncbi Measuring symptomatic and functional recovery in patients with community-acquired pneumonia
    J P Metlay
    Department of Medicine, Massachusetts General Hospital, Boston 02114, USA
    J Gen Intern Med 12:423-30. 1997
    ..Delayed resolution of symptoms is associated with increased utilization of outpatient physician visits...
  67. ncbi The triage decision in pulmonary edema
    M H Katz
    Department of Medicine, Massachusetts General Hospital, Boston 02114
    J Gen Intern Med 3:533-9. 1988
    ..In a model containing a term for the physicians' actual triage decision, all four independent predictors remained significant, producing an overall sensitivity of 81% and an overall specificity of 69%...
  68. ncbi An instrument for determining the amount of NIH support for clinical investigations at one academic health center
    Ann E Taylor
    Harvard Medical School, Clinical Research Support Office, Clinical Research Program, Massachusetts General Hospital, MA 02114, USA
    Acad Med 77:824-30. 2002
    ..Data on the clinical component of an institution's research effort should be collected prospectively and nationally to inform the optimal allocation of research resources and the alignment of the AHC's infrastructure...
  69. ncbi Death and disability from warfarin-associated intracranial and extracranial hemorrhages
    Margaret C Fang
    The Department of Medicine, Hospitalist Group, University of California, San Francisco, Calif 94143, USA
    Am J Med 120:700-5. 2007
    ..We examined the rates of death and disability resulting from warfarin-associated intracranial and extracranial hemorrhages in a large cohort of patients with atrial fibrillation...
  70. ncbi Stroke prevention in atrial fibrillation: another step sideways
    Alan S Go
    Division of Research, Kaiser Permanente of Northern California, Oakland, CA 94612, USA
    Lancet 371:278-80. 2008
  71. ncbi Anticoagulation therapy for stroke prevention in atrial fibrillation: how well do randomized trials translate into clinical practice?
    Alan S Go
    Division of Research, Kaiser Permanente of Northern California, Oakland, CA 94612, USA
    JAMA 290:2685-92. 2003
    ..Warfarin has been shown to be highly efficacious for preventing thromboembolism in atrial fibrillation in randomized trials, but its effectiveness and safety in clinical practice is less clear...
  72. ncbi Age and the risk of warfarin-associated hemorrhage: the anticoagulation and risk factors in atrial fibrillation study
    Margaret C Fang
    University of California at San Francisco, 94143, USA
    J Am Geriatr Soc 54:1231-6. 2006
    ..To assess whether older age is independently associated with hemorrhage risk in patients with atrial fibrillation, whether or not they are taking warfarin therapy...
  73. ncbi Comparison of 12 risk stratification schemes to predict stroke in patients with nonvalvular atrial fibrillation
    Robert G Hart
    Stroke 39:1901-10. 2008
    ..Additional research to identify an optimum scheme for primary prevention and subsequent standardization of recommendations may lead to more uniform selection of patients for anticoagulant prophylaxsis...
  74. ncbi Rationale and design of a prospective study of the clinical significance of atrial arrhythmias detected by implanted device diagnostics: the TRENDS study
    Taya V Glotzer
    Hackensack University Medical Center, Hackensack, NJ, USA
    J Interv Card Electrophysiol 15:9-14. 2006
    ..Improved assessment of the impact of AF burden on stroke risk will allow more targeted and safer use of antithrombotic therapy...
  75. ncbi Factor V Leiden and risk of ischemic stroke in nonvalvular atrial fibrillation: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study
    Alan S Go
    Division of Research, Kaiser Permanente of Northern California, Oakland, CA, USA
    J Thromb Thrombolysis 15:41-6. 2003
    ..Since atrial and venous pressures are similar, genetic variants that promote venous thromboembolism may increase the risk of atrial thrombi and subsequent stroke in atrial fibrillation...
  76. ncbi Anticoagulation for atrial fibrillation
    Margaret C Fang
    University of California, San Francisco, 533 Parnassus Avenue, Box 0131, San Francisco, CA 94143, USA
    Cardiol Clin 22:47-62. 2004
    ....
  77. ncbi Oral anticoagulants vs. aspirin for stroke prevention in patients with non-valvular atrial fibrillation: the verdict is in
    Carl van Walraven
    Clinical Epidemiology Unit Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Card Electrophysiol Rev 7:374-8. 2003
    ..Since high-risk AF patients appear to benefit most from OAC, determining stroke risk in AF patients is very important...
  78. ncbi Oral anticoagulants vs aspirin in nonvalvular atrial fibrillation: an individual patient meta-analysis
    Carl van Walraven
    Clinical Epidemiology Unit, Ottawa Health Research Institute, F 6, Ottawa Hospital, Civic Campus, 1053 Carling Ave, Ottawa, Ontario, Canada K1Y 4E9
    JAMA 288:2441-8. 2002
    ..Patients with nonvalvular atrial fibrillation (AF) have an increased risk of stroke and other vascular events...
  79. ncbi Depressive symptom burden as a barrier to screening for breast and cervical cancers
    Paul A Pirraglia
    Division of General Internal Medicine, Rhode Island Hospital, Providence, RI, USA
    J Womens Health (Larchmt) 13:731-8. 2004
    ..CONCLUSIONS: The presence of a high depressive symptom burden is a modest independent risk factor for lack of subsequent mammography. Ensuring that depressed patients receive regular cancer screening services is important...
  80. ncbi Can patients be anticoagulated after intracerebral hemorrhage? A decision analysis
    Mark H Eckman
    Division of General Internal Medicine and the Center for Clinical Effectiveness, University of Cincinnati, Cincinnati, OH, USA
    Stroke 34:1710-6. 2003
    ....
  81. ncbi Severe community-acquired pneumonia: use of intensive care services and evaluation of American and British Thoracic Society Diagnostic criteria
    Derek C Angus
    Department of Critical Care Medicine, and Division of General Internal Medicine, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Respir Crit Care Med 166:717-23. 2002
    ..In conclusion, ICU use for CAP is common and expensive but admission rates are variable. Clinical prediction rules for severe CAP do not appear adequately robust to guide clinical care at the current time...
  82. ncbi Advanced age, anticoagulation intensity, and risk for intracranial hemorrhage among patients taking warfarin for atrial fibrillation
    Margaret C Fang
    Division of General Internal Medicine, Hospitalist Group, University of California, San Francisco, San Francisco 94143, USA
    Ann Intern Med 141:745-52. 2004
    ..However, higher intensities increase hemorrhage risk. Optimal use of warfarin for atrial fibrillation requires precise information on the risk for intracranial hemorrhage as a function of patient age and anticoagulation intensity...
  83. ncbi Antithrombotic therapy for stroke prevention in atrial fibrillation
    Alan S Go
    Division of Research, Kaiser Permanente of Northern California, 2000 Broadway St, 3rd Floor, Oakland, CA 94612 2304, USA
    Prog Cardiovasc Dis 48:108-24. 2005
    ....
  84. ncbi Gender differences in the risk of ischemic stroke and peripheral embolism in atrial fibrillation: the AnTicoagulation and Risk factors In Atrial fibrillation (ATRIA) study
    Margaret C Fang
    University of California, San Francisco, CA 94143, USA
    Circulation 112:1687-91. 2005
    ..We examined data from a large contemporary cohort of AF patients to address this question...
  85. ncbi Community-acquired pneumonia and do not resuscitate orders
    Thomas J Marrie
    Department of Medicine, Dalhousie University and the Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada
    J Am Geriatr Soc 50:290-9. 2002
    ..From a cohort of patients with community-acquired pneumonia (CAP) who required admission to hospital, to describe the subset of patients having a do not resuscitate (DNR) order and to compare them with those who did not have such an order...
  86. ncbi Causes of death for patients with community-acquired pneumonia: results from the Pneumonia Patient Outcomes Research Team cohort study
    Eric M Mortensen
    Center for the Study of Health Disparities, VA Pittsburgh Healthcare Systems (Mail Stop 130-U, University Drive C, Location 11E127, Pittsburgh, PA 15240-1001, USA
    Arch Intern Med 162:1059-64. 2002
    ..Differences in the timing of death and risk factors for mortality suggest that future studies of community-acquired pneumonia should differentiate all-cause and pneumonia-related mortality...
  87. ncbi Outcomes in lower respiratory tract infections and the impact of antimicrobial drug resistance
    Joshua P Metlay
    Veterans Affairs Medical Center and Division of General Internal Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Clin Microbiol Infect 8:1-11. 2002
    ..Additional studies are urgently needed to assess better whether the current empiric treatment guidelines are adequate or will need to be adjusted as patterns of resistance continue to evolve...

Research Grants10

  1. Harvard Planning Grant for Institutional Clinical and Translational Science Award
    Daniel Singer; Fiscal Year: 2006
    ..We believe our planning process is specific, innovative yet disciplined, and should be robust. A full and competitive CTSA application will be produced in a timely manner. ..
  2. EPIDEMIOLOGY OF ANTICOAGULATION IN ATRIAL FIBRILLATION
    Daniel Singer; Fiscal Year: 2005
    ..In all, continued study of our cohort will efficiently provide powerful insights into optimizing stroke prevention strategies for the many older Americans with AF. ..
  3. EPIDEMIOLOGY OF ANTICOAGULATION IN ATRIAL FIBRILLATION
    Daniel Singer; Fiscal Year: 2000
    ..comparison of the quality of anticoagulation provided by anticoagulation units versus that of primary physicians. The investigators state that this research should lead to important health and economic benefits for older Americans. ..