J R Sims
Affiliation: Massachusetts General Hospital
- Arterial occlusion revealed by CT angiography predicts NIH stroke score and acute outcomes after IV tPA treatmentJohn R Sims
Department of Neurology, Massachusetts General Hospital, CNY 149, Room 6403, Charlestown, MA 02129, USA
AJNR Am J Neuroradiol 26:246-51. 2005..We postulated that acute stroke patients receiving IV tPA with patent vasculature or occult arterial occlusion by CT angiography (CTA) would have better outcomes and decreased hemorrhagic risk...
- ABC/2 for rapid clinical estimate of infarct, perfusion, and mismatch volumesJ R Sims
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, 02129, USA
Neurology 72:2104-10. 2009..Rapid and easy clinical assessments for volumes of infarction and perfusion mismatch are needed. We tested whether simple geometric models generated accurate estimates of these volumes...
- Sonic hedgehog regulates ischemia/hypoxia-induced neural progenitor proliferationJohn R Sims
Department of Radiology and Neuroscience Center, Harvard Medical School, Massachusetts General Hospital, Stroke and Neurovascular Regulation Laboratory, Charlestown, Mass 02129, USA
Stroke 40:3618-26. 2009..Brain ischemia causes increased proliferation of hippocampal NPCs. We therefore examined whether Shh regulates the increase in proliferation of NPCs after ischemia/hypoxia...
- Early release of HMGB-1 from neurons after the onset of brain ischemiaJianhua Qiu
Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
J Cereb Blood Flow Metab 28:927-38. 2008..In conclusion, HMGB-1 is released early after ischemic injury from neurons and may contribute to the initial stages of the inflammatory response...
- Sonic hedgehog inversely regulates the expression of angiopoietin-1 and angiopoietin-2 in fibroblastsSae Won Lee
Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Int J Mol Med 19:445-51. 2007..Collectively, our results suggest that Shh may contribute to blood vessel growth, maturation and stabilization in a neurovascular network by reciprocally regulating the vascular morphogens Ang-1 and Ang-2 in a cell-type-specific manner...
- Dopamine receptor activation modulates GABA neuron migration from the basal forebrain to the cerebral cortexJames E Crandall
Eunice Kennedy Shriver Center for Mental Retardation, Physiology, University of Massachusetts Medical School, Waltham, Massachusetts 02452, USA
J Neurosci 27:3813-22. 2007....
- Ischemic Injury and Sonic Hedgehog's Role Neural Progenitor ResponseJohn Sims; Fiscal Year: 2007....