J R Sims

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Arterial occlusion revealed by CT angiography predicts NIH stroke score and acute outcomes after IV tPA treatment
    John R Sims
    Department of Neurology, Massachusetts General Hospital, CNY 149, Room 6403, Charlestown, MA 02129, USA
    AJNR Am J Neuroradiol 26:246-51. 2005
  2. ncbi ABC/2 for rapid clinical estimate of infarct, perfusion, and mismatch volumes
    J R Sims
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, 02129, USA
    Neurology 72:2104-10. 2009
  3. ncbi Sonic hedgehog regulates ischemia/hypoxia-induced neural progenitor proliferation
    John R Sims
    Department of Radiology and Neuroscience Center, Harvard Medical School, Massachusetts General Hospital, Stroke and Neurovascular Regulation Laboratory, Charlestown, Mass 02129, USA
    Stroke 40:3618-26. 2009
  4. ncbi Early release of HMGB-1 from neurons after the onset of brain ischemia
    Jianhua Qiu
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 28:927-38. 2008
  5. ncbi Sonic hedgehog inversely regulates the expression of angiopoietin-1 and angiopoietin-2 in fibroblasts
    Sae Won Lee
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Int J Mol Med 19:445-51. 2007
  6. ncbi Dopamine receptor activation modulates GABA neuron migration from the basal forebrain to the cerebral cortex
    James E Crandall
    Eunice Kennedy Shriver Center for Mental Retardation, Physiology, University of Massachusetts Medical School, Waltham, Massachusetts 02452, USA
    J Neurosci 27:3813-22. 2007

Research Grants

  1. Ischemic Injury and Sonic Hedgehog's Role Neural Progenitor Response
    John Sims; Fiscal Year: 2007

Collaborators

Detail Information

Publications6

  1. ncbi Arterial occlusion revealed by CT angiography predicts NIH stroke score and acute outcomes after IV tPA treatment
    John R Sims
    Department of Neurology, Massachusetts General Hospital, CNY 149, Room 6403, Charlestown, MA 02129, USA
    AJNR Am J Neuroradiol 26:246-51. 2005
    ..We postulated that acute stroke patients receiving IV tPA with patent vasculature or occult arterial occlusion by CT angiography (CTA) would have better outcomes and decreased hemorrhagic risk...
  2. ncbi ABC/2 for rapid clinical estimate of infarct, perfusion, and mismatch volumes
    J R Sims
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, 02129, USA
    Neurology 72:2104-10. 2009
    ..Rapid and easy clinical assessments for volumes of infarction and perfusion mismatch are needed. We tested whether simple geometric models generated accurate estimates of these volumes...
  3. ncbi Sonic hedgehog regulates ischemia/hypoxia-induced neural progenitor proliferation
    John R Sims
    Department of Radiology and Neuroscience Center, Harvard Medical School, Massachusetts General Hospital, Stroke and Neurovascular Regulation Laboratory, Charlestown, Mass 02129, USA
    Stroke 40:3618-26. 2009
    ..Brain ischemia causes increased proliferation of hippocampal NPCs. We therefore examined whether Shh regulates the increase in proliferation of NPCs after ischemia/hypoxia...
  4. ncbi Early release of HMGB-1 from neurons after the onset of brain ischemia
    Jianhua Qiu
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 28:927-38. 2008
    ..In conclusion, HMGB-1 is released early after ischemic injury from neurons and may contribute to the initial stages of the inflammatory response...
  5. ncbi Sonic hedgehog inversely regulates the expression of angiopoietin-1 and angiopoietin-2 in fibroblasts
    Sae Won Lee
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Int J Mol Med 19:445-51. 2007
    ..Collectively, our results suggest that Shh may contribute to blood vessel growth, maturation and stabilization in a neurovascular network by reciprocally regulating the vascular morphogens Ang-1 and Ang-2 in a cell-type-specific manner...
  6. ncbi Dopamine receptor activation modulates GABA neuron migration from the basal forebrain to the cerebral cortex
    James E Crandall
    Eunice Kennedy Shriver Center for Mental Retardation, Physiology, University of Massachusetts Medical School, Waltham, Massachusetts 02452, USA
    J Neurosci 27:3813-22. 2007
    ....

Research Grants2

  1. Ischemic Injury and Sonic Hedgehog's Role Neural Progenitor Response
    John Sims; Fiscal Year: 2007
    ....