N M Simon

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint The association of comorbid anxiety disorders with suicide attempts and suicidal ideation in outpatients with bipolar disorder
    Naomi M Simon
    Department of Psychiatry, Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Suite 2200, Boston, MA 02114, USA
    J Psychiatr Res 41:255-64. 2007
  2. pmc Informing the symptom profile of complicated grief
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Disorders and Complicated Grief Program, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Depress Anxiety 28:118-26. 2011
  3. doi request reprint Treating complicated grief
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Disorders and Complicated Grief Program, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    JAMA 310:416-23. 2013
  4. ncbi request reprint An open-label trial of risperidone augmentation for refractory anxiety disorders
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, Boston, Mass, USA
    J Clin Psychiatry 67:381-5. 2006
  5. ncbi request reprint Understanding the link between anxiety symptoms and suicidal ideation and behaviors in outpatients with bipolar disorder
    Naomi M Simon
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston MA 02114, United States
    J Affect Disord 97:91-9. 2007
  6. ncbi request reprint Preliminary support for gender differences in response to fluoxetine for generalized anxiety disorder
    Naomi M Simon
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Depress Anxiety 23:373-6. 2006
  7. ncbi request reprint The relationship of anxiety disorders, anxiety sensitivity and pulmonary dysfunction with dyspnea-related distress and avoidance
    Naomi M Simon
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 194:951-7. 2006
  8. pmc A detailed examination of cytokine abnormalities in Major Depressive Disorder
    N M Simon
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Eur Neuropsychopharmacol 18:230-3. 2008
  9. ncbi request reprint The prevalence and correlates of psychiatric comorbidity in individuals with complicated grief
    Naomi M Simon
    Massachusetts General Hospital and Harvard Medical School, MA, USA
    Compr Psychiatry 48:395-9. 2007
  10. doi request reprint Quetiapine augmentation of paroxetine CR for the treatment of refractory generalized anxiety disorder: preliminary findings
    Naomi M Simon
    Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Psychopharmacology (Berl) 197:675-81. 2008

Detail Information

Publications60

  1. ncbi request reprint The association of comorbid anxiety disorders with suicide attempts and suicidal ideation in outpatients with bipolar disorder
    Naomi M Simon
    Department of Psychiatry, Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Suite 2200, Boston, MA 02114, USA
    J Psychiatr Res 41:255-64. 2007
    ....
  2. pmc Informing the symptom profile of complicated grief
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Disorders and Complicated Grief Program, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Depress Anxiety 28:118-26. 2011
    ..We sought to add empirical support to the current dialogue by examining the commonly used Inventory of Complicated Grief (ICG) scale completed by 782 bereaved individuals...
  3. doi request reprint Treating complicated grief
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Disorders and Complicated Grief Program, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    JAMA 310:416-23. 2013
    ..The resulting syndrome of complicated grief causes substantial distress and functional impairment even years after a loss, yet knowing when and how to intervene can be a challenge...
  4. ncbi request reprint An open-label trial of risperidone augmentation for refractory anxiety disorders
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, Boston, Mass, USA
    J Clin Psychiatry 67:381-5. 2006
    ..There is a paucity of data to support "next-step" treatments for the many patients with anxiety disorders who remain symptomatic after initial pharmacotherapy...
  5. ncbi request reprint Understanding the link between anxiety symptoms and suicidal ideation and behaviors in outpatients with bipolar disorder
    Naomi M Simon
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston MA 02114, United States
    J Affect Disord 97:91-9. 2007
    ..Prior studies suggest an association between anxiety comorbidity and suicidal ideation and behaviors in bipolar disorder. However, the nature of this association remains unclear...
  6. ncbi request reprint Preliminary support for gender differences in response to fluoxetine for generalized anxiety disorder
    Naomi M Simon
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Depress Anxiety 23:373-6. 2006
    ..Larger placebo-controlled trials are needed to more definitively examine gender and treatment response in anxiety disorders...
  7. ncbi request reprint The relationship of anxiety disorders, anxiety sensitivity and pulmonary dysfunction with dyspnea-related distress and avoidance
    Naomi M Simon
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 194:951-7. 2006
    ....
  8. pmc A detailed examination of cytokine abnormalities in Major Depressive Disorder
    N M Simon
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Eur Neuropsychopharmacol 18:230-3. 2008
    ..These data support a generalized chronic inflammatory state in MDD, and implicate additional cytokines and chemokines previously linked to cardiovascular disease...
  9. ncbi request reprint The prevalence and correlates of psychiatric comorbidity in individuals with complicated grief
    Naomi M Simon
    Massachusetts General Hospital and Harvard Medical School, MA, USA
    Compr Psychiatry 48:395-9. 2007
    ..One issue that remains under debate is whether this condition can be clearly distinguished from other psychiatric disorders, such as major depression and posttraumatic stress disorder, with which CG frequently coexists...
  10. doi request reprint Quetiapine augmentation of paroxetine CR for the treatment of refractory generalized anxiety disorder: preliminary findings
    Naomi M Simon
    Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Psychopharmacology (Berl) 197:675-81. 2008
    ..More data are needed to guide "next step" strategies for patients with generalized anxiety disorder (GAD) remaining symptomatic despite initial pharmacotherapy...
  11. pmc Impact of concurrent naturalistic pharmacotherapy on psychotherapy of complicated grief
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital and Harvard Medical School, Boston MA 02114, USA
    Psychiatry Res 159:31-6. 2008
    ..77%). Our naturalistic data underscore the need for prospective, randomized controlled studies of CG pharmacotherapy and psychotherapy alone and in combination...
  12. ncbi request reprint Paroxetine CR augmentation for posttraumatic stress disorder refractory to prolonged exposure therapy
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 69:400-5. 2008
    ..This study prospectively examines the relative efficacy of augmentation of continued prolonged exposure therapy (PE) with paroxetine CR versus placebo for individuals remaining symptomatic despite a course of PE...
  13. doi request reprint Open-label support for duloxetine for the treatment of panic disorder
    Naomi M Simon
    Department of Psychiatry, Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA
    CNS Neurosci Ther 15:19-23. 2009
    ....
  14. ncbi request reprint Generalized anxiety disorder and psychiatric comorbidities such as depression, bipolar disorder, and substance abuse
    Naomi M Simon
    Massachusetts General Hospital, Center for Anxiety and Traumatic Stress Disorders, Department of Psychiatry, Simches 2200, 185 Cambridge St, Boston, MA 02114, USA
    J Clin Psychiatry 70:10-4. 2009
    ..Research into the biology and psychopathology underlying the high rate of comorbidity of GAD and into efficacious interventions for GAD with comorbidity is needed...
  15. pmc Childhood maltreatment linked to greater symptom severity and poorer quality of life and function in social anxiety disorder
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Depress Anxiety 26:1027-32. 2009
    ..We hypothesized that a history of childhood maltreatment would be associated with greater SAD symptom severity and poorer associated function...
  16. pmc Next-step strategies for panic disorder refractory to initial pharmacotherapy: a 3-phase randomized clinical trial
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, Simches Research Building, 2nd Floor, 185 Cambridge St, Boston, MA 02114, USA
    J Clin Psychiatry 70:1563-70. 2009
    ..More data are needed to guide next-step interventions for panic disorder refractory to initial intervention...
  17. ncbi request reprint Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated aging
    Naomi M Simon
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Biol Psychiatry 60:432-5. 2006
    ..We propose that chronic stress associated with mood disorders may contribute to excess vulnerability for diseases of aging such as cardiovascular disease and possibly some cancers through accelerated organismal aging...
  18. ncbi request reprint Citalopram for social phobia: a clinical case series
    N M Simon
    Anxiety Disorders Program, Massachusetts General Hospital, Boston 02114, USA
    Prog Neuropsychopharmacol Biol Psychiatry 25:1469-74. 2001
    ..This series of patients improved significantly on all measures. Results suggest that citalopram may be a safe and effective treatment for social anxiety disorder...
  19. ncbi request reprint The implications of medical and psychiatric comorbidity with panic disorder
    Naomi M Simon
    Massachusetts General Hospital, Harvard Medical School, Boston, Mass, USA
    J Clin Psychiatry 66:8-15. 2005
    ..The implications of mood disorder and its medical comorbidity for the identification and treatment of panic disorder are discussed...
  20. ncbi request reprint Bupropion sustained release for panic disorder
    Naomi M Simon
    Department of Psychiatry, Harvard University, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Psychopharmacol Bull 37:66-72. 2003
    ..Although results may be influenced by the open nature of this trial, our findings suggest that bupropion SR may be effective for the treatment of panic disorder. Further controlled study of its efficacy for this condition are warranted...
  21. ncbi request reprint Comparing anxiety disorders and anxiety-related traits in bipolar disorder and unipolar depression
    Naomi M Simon
    WACC 815, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA
    J Psychiatr Res 37:187-92. 2003
    ..Further research is needed to clarify the etiologic basis of anxiety disorder/BPD comorbidity and to optimize treatment strategies for patients with these co-occurring disorders...
  22. ncbi request reprint Changes in anxiety sensitivity with pharmacotherapy for panic disorder
    Naomi M Simon
    Anxiety Disorders Program, Massachusetts General Hospital and Harvard Medical School, WACC 812, 15 Parkman Street, Boston, MA 02114, USA
    J Psychiatr Res 38:491-5. 2004
    ..Implications of these findings are discussed relative to optimizing pharmacologic treatment of panic disorder...
  23. ncbi request reprint Quality of life in social anxiety disorder compared with panic disorder and the general population
    Naomi M Simon
    Anxiety Disorders Program, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Psychiatr Serv 53:714-8. 2002
    ..Quality of life in a treatment-seeking cohort of patients with social anxiety disorder was compared with that of patients with panic disorder who were matched for age, comorbid illnesses, and gender and with population-based norms...
  24. ncbi request reprint Anxiety disorder comorbidity in bipolar disorder patients: data from the first 500 participants in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Related Disorders, Wang ACC 815, Massachusetts General Hospital, 15 Parkman St, Boston, MA 02114, USA
    Am J Psychiatry 161:2222-9. 2004
    ..The authors provide a detailed perspective on the correlates of comorbid anxiety in a large, well-characterized sample of bipolar disorder patients...
  25. ncbi request reprint Fluoxetine for vestibular dysfunction and anxiety: a prospective pilot study
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Related Disorders, Massachusetts General Hospital, WACC 815, Boston, MA 02114, USA
    Psychosomatics 46:334-9. 2005
    ..The data add to the literature suggesting a role for selective serotonin reuptake inhibitors in the treatment of dizziness and anxiety...
  26. ncbi request reprint Panic disorder and bipolar disorder: anxiety sensitivity as a potential mediator of panic during manic states
    Naomi M Simon
    Massachusetts General Hospital, WACC 815, 15 Parkman Street, Boston, Massachusetts 02114, United States
    J Affect Disord 87:101-5. 2005
    ..Anxiety sensitivity (AS), a risk factor for PD appears greater in bipolar disorder compared to unipolar depression, although the association of specific mood states with AS remains unknown...
  27. ncbi request reprint Hypothyroidism and hyperthyroidism in anxiety disorders revisited: new data and literature review
    Naomi M Simon
    Anxiety Disorders Program, Massachusetts General Hospital and Harvard Medical School, 15 Parkman Street, WAC 815, Boston, MA 02114, USA
    J Affect Disord 69:209-17. 2002
    ..The need for thyroid screening of patients presenting with panic disorder (PD), social phobia (SP) or generalized anxiety disorder (GAD) remains uncertain...
  28. ncbi request reprint Longitudinal outcome with pharmacotherapy in a naturalistic study of panic disorder
    Naomi M Simon
    Anxiety Disorders Program, Massachusetts General Hospital and Harvard Medical School, 15 Parkman Street, WAC 815, Boston, MA 02114, USA
    J Affect Disord 69:201-8. 2002
    ..It is critically important to obtain more information on the effectiveness of medications over time for patients who initially responded to pharmacotherapy for panic disorder...
  29. ncbi request reprint Pharmacotherapy for bipolar disorder and comorbid conditions: baseline data from STEP-BD
    Naomi M Simon
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychopharmacol 24:512-20. 2004
    ..Our findings highlight the need for greater clinical guidance and treatment options for patients with bipolar disorder and comorbidity...
  30. ncbi request reprint Does recovery from substance use disorder matter in patients with bipolar disorder?
    Roger D Weiss
    Department of Psychiatry, Harvard Medical School, Boston, USA
    J Clin Psychiatry 66:730-5; quiz 808-9. 2005
    ..To examine the potential impact of recovery from substance use disorder (SUD) on the course of bipolar disorder among patients diagnosed with both bipolar and substance use disorders according to DSM-IV criteria...
  31. doi request reprint Broad spectrum of cytokine abnormalities in panic disorder and posttraumatic stress disorder
    E A Hoge
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Depress Anxiety 26:447-55. 2009
    ..Much less is known about cytokines in anxiety disorders such as posttraumatic stress disorder (PTSD) and panic disorder (PD). We hypothesized that PD and PTSD would be associated with a generalized proinflammatory cytokine signature...
  32. ncbi request reprint Prospective 12-month course of bipolar disorder in out-patients with and without comorbid anxiety disorders
    M W Otto
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Br J Psychiatry 189:20-5. 2006
    ..The impact of anxiety disorders has not been well delineated in prospective studies of bipolar disorder...
  33. doi request reprint The role of anxiety sensitivity in sleep disturbance in panic disorder
    E A Hoge
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114 2790, USA
    J Anxiety Disord 25:536-8. 2011
    ..Our data suggest that sleep disturbance, and in particular sleep latency, in PD may be partly due to high levels of AS, which can be targeted with cognitive-behavioral therapeutic strategies...
  34. ncbi request reprint Anxiety is associated with impulsivity in bipolar disorder
    Charles T Taylor
    Department of Psychiatry, Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Anxiety Disord 22:868-76. 2008
    ..These data demonstrate that anxiety is positively associated with impulsivity in patients with BD. Further studies are needed to elucidate the implications of and reasons for this association...
  35. ncbi request reprint An open-label study of levetiracetam for the treatment of social anxiety disorder
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Related Disorders, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 65:1219-22. 2004
    ..Levetiracetam thus warrants systematic evaluation as a treatment option for anxiety disorders...
  36. ncbi request reprint Ropinirole for antidepressant-induced sexual dysfunction
    J J Worthington
    Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Int Clin Psychopharmacol 17:307-10. 2002
    ..The addition of ropinirole may represent a potentially useful treatment strategy for antidepressant-induced sexual dysfunction...
  37. doi request reprint Brain GABA levels in patients with bipolar disorder
    Rebecca E Kaufman
    Massachusetts General Hospital Department of Psychiatry, Boston, MA 02114, United States
    Prog Neuropsychopharmacol Biol Psychiatry 33:427-34. 2009
    ..GENERAL METHODS: We used magnetic resonance spectroscopy (MRS) to examine whole brain and regional GABA, glutamate and glutamine in 13 patients with bipolar disorder compared to a matched group of 11 healthy controls...
  38. ncbi request reprint Augmentation of exposure therapy with D-cycloserine for social anxiety disorder
    Stefan G Hofmann
    Department of Psychology and Center for Anxiety and Related Disorders, Boston University, Boston, MA 02215, USA
    Arch Gen Psychiatry 63:298-304. 2006
    ....
  39. doi request reprint Efficacy of CBT for benzodiazepine discontinuation in patients with panic disorder: Further evaluation
    Michael W Otto
    Department of Psychology, Boston University, 648 Beacon Street, 5th Floor, Boston, MA 02215, USA
    Behav Res Ther 48:720-7. 2010
    ..These findings suggest that CBT provides specific efficacy for the successful discontinuation from BZs, even when controlling for therapist contact and relaxation training...
  40. ncbi request reprint A randomized controlled trial of venlafaxine ER and paroxetine in the treatment of outpatients with panic disorder
    Mark Pollack
    Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114 2790, USA
    Psychopharmacology (Berl) 194:233-42. 2007
    ..Few randomized, placebo-controlled trials have evaluated the comparative efficacy and tolerability of more than one pharmacological agent for panic disorder...
  41. ncbi request reprint Persistent posttraumatic stress disorder following September 11 in patients with bipolar disorder
    Mark H Pollack
    Department of Psychiatry, Massachusetts General Hospital, Boston, Mass, USA
    J Clin Psychiatry 67:394-9. 2006
    ....
  42. doi request reprint A comparison of emotional approach coping (EAC) between individuals with anxiety disorders and nonanxious controls
    Luana Marques
    Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    CNS Neurosci Ther 15:100-6. 2009
    ..Overall, gender did not moderate the anxiety-EAC effect, but the results suggested that women utilize EAC to a greater degree than men. Clinical techniques designed to improve emotional coping may be beneficial to individuals with ADs...
  43. ncbi request reprint Complicated grief and its correlates in patients with bipolar disorder
    Naomi M Simon
    Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 66:1105-10. 2005
    ..We investigated the frequency and implications of loss of loved ones in an ongoing study of bipolar disorder...
  44. ncbi request reprint Rates of isolated sleep paralysis in outpatients with anxiety disorders
    Michael W Otto
    Center for Anxiety and Related Disorders, Boston University, 648 Beacon St, Floor 6, Boston, MA 02114, USA
    J Anxiety Disord 20:687-93. 2006
    ..Results are discussed relative to other variables predicting variability in the occurrence of ISP...
  45. pmc Cigarette smoking is associated with suicidality in bipolar disorder
    Michael J Ostacher
    Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Bipolar Disord 11:766-71. 2009
    ..Cigarette smoking in individuals with bipolar disorder has been associated with suicidal behavior, although the precise relationship between the two remains unclear...
  46. ncbi request reprint Olanzapine augmentation of fluoxetine for refractory generalized anxiety disorder: a placebo controlled study
    Mark H Pollack
    Center for Anxiety and Traumatic Stress Related Disorders, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Biol Psychiatry 59:211-5. 2006
    ..We present one of the first randomized controlled trials for refractory GAD, comprising double blind augmentation with olanzapine or placebo for patients remaining symptomatic on fluoxetine...
  47. doi request reprint Oxytocin levels in social anxiety disorder
    Elizabeth A Hoge
    Department of Economics, Claremont University, Claremont, CA, USA
    CNS Neurosci Ther 14:165-70. 2008
    ..These findings may suggest a possible role for oxytocin as a facilitator of social behavior, an effect which may not be fully utilized in individuals with severe social anxiety...
  48. ncbi request reprint Aripiprazole as augmentation treatment of refractory generalized anxiety disorder and panic disorder
    Elizabeth A Hoge
    Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
    CNS Spectr 13:522-7. 2008
    ..Individuals with anxiety disorders often remain symptomatic despite treatment with a first-line pharmacologic agent. More research examining pharmacotherapy augmentation strategies to improve outcomes is needed...
  49. ncbi request reprint Novel treatment approaches for refractory anxiety disorders
    Mark H Pollack
    Harvard Medical School and Center for Anxiety and Traumatic Stress Related Disorders, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Depress Anxiety 25:467-76. 2008
    ..Progress in the development of new treatments has great promise, but will only succeed through a concerted research effort that systematically evaluates potential areas of importance and properly uses scarce resources...
  50. ncbi request reprint Cross-cultural differences in somatic presentation in patients with generalized anxiety disorder
    Elizabeth A Hoge
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 194:962-6. 2006
    ..Possible explanations include differences in cultural traditions of describing distress and the mind-body dichotomy...
  51. doi request reprint High-field MRS study of GABA, glutamate and glutamine in social anxiety disorder: response to treatment with levetiracetam
    Mark H Pollack
    Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, United States
    Prog Neuropsychopharmacol Biol Psychiatry 32:739-43. 2008
    ..Abnormalities in brain gamma-aminobutyric acid (GABA) and glutamate may be relevant to the underlying pathophysiology of anxiety disorders including social anxiety disorder (SAD)...
  52. ncbi request reprint A double-blind study of the efficacy of venlafaxine extended-release, paroxetine, and placebo in the treatment of panic disorder
    Mark H Pollack
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Depress Anxiety 24:1-14. 2007
    ..Adverse events were mild or moderate and similar between active treatment groups. Venlafaxine ER and paroxetine were effective and well tolerated in the treatment of panic disorder...
  53. ncbi request reprint Valproic acid for the treatment of social anxiety disorder
    Gustavo Kinrys
    Massachusetts General Hospital, Boston 02114, USA
    Int Clin Psychopharmacol 18:169-72. 2003
    ..The results from this open-label trial suggest the potential efficacy of valproic acid for the treatment of social anxiety disorder. Placebo-controlled trials are indicated to confirm these findings...
  54. ncbi request reprint Combined paroxetine and clonazepam treatment strategies compared to paroxetine monotherapy for panic disorder
    Mark H Pollack
    Department of Psychiatry, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    J Psychopharmacol 17:276-82. 2003
    ..Initiating combined treatment followed by benzodiazepine taper after a few weeks may provide early benefit while avoiding the potential adverse consequences of long-term combination therapy...
  55. doi request reprint A PET study of tiagabine treatment implicates ventral medial prefrontal cortex in generalized social anxiety disorder
    Karleyton C Evans
    Department of Psychiatry, Psychiatric Neuroscience Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Neuropsychopharmacology 34:390-8. 2009
    ..Given the pharmacological profile of tiagabine, these findings suggest that its therapeutic effects in gSAD may be mediated by GABAergic modulation within the vmPFC...
  56. ncbi request reprint Complicated grief and impaired sleep in patients with bipolar disorder
    Guy Maytal
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Bipolar Disord 9:913-7. 2007
    ..To examine the relationship of sleep disturbance with complicated grief (CG) in patients with bipolar disorder (BD)...
  57. ncbi request reprint Examination of the decline in symptoms of anxiety and depression in generalized anxiety disorder: impact of anxiety sensitivity on response to pharmacotherapy
    Bunmi O Olatunji
    Department of Psychology, Vanderbilt University, Nashville, Tennessee 37203, USA
    Depress Anxiety 25:167-71. 2008
    ..These findings suggest that the decline in anxiety symptoms is independent of the decline in symptoms of depression during pharmacotherapy for GAD and specific AS dimensions may predict symptom change in GAD...
  58. ncbi request reprint Untangling depression and anxiety: clinical challenges
    Martin B Keller
    J Clin Psychiatry 66:1477-84. 2005
  59. ncbi request reprint Complicated grief: a case series using escitalopram
    Naomi M Simon
    Am J Psychiatry 164:1760-1. 2007
  60. ncbi request reprint Baseline predictors of serious adverse events at one year among patients with bipolar disorder in STEP-BD
    James M Martinez
    Mood Disorders Center, Menninger Department of Psychiatry, Baylor College of Medicine, Ben Taub Hospital, Houston, TX 77030, USA
    Psychiatr Serv 56:1541-8. 2005
    ..Little is known about serious adverse events that occur in the context of clinical care for bipolar disorder. This study examined predictors of serious adverse events in a large cohort of patients with bipolar disorder...

Research Grants7

  1. TREATMENT REFRACTORY PANIC DISORDER
    Naomi Simon; Fiscal Year: 2004
    ..abstract_text> ..
  2. Depression DNA Damage and Telomeres: A Chronic Stress Model of Accelerated Aging
    Naomi Simon; Fiscal Year: 2007
    ....
  3. Depression DNA Damage and Telomeres: A Chronic Stress Model of Accelerated Aging
    Naomi M Simon; Fiscal Year: 2010
    ....
  4. 2/4-Optimizing Treatment of Complicated Grief
    Naomi M Simon; Fiscal Year: 2010
    ..We will explore mediator and moderator hypotheses to answer questions about how these treatments work and who might benefit most from each approach. Answers to these questions have important public health significance. ..