Joshua M Shulman

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi Parkinson's disease: genetics and pathogenesis
    Joshua M Shulman
    Department of Neurology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Annu Rev Pathol 6:193-222. 2011
  2. pmc A coding variant in CR1 interacts with APOE-ε4 to influence cognitive decline
    Brendan T Keenan
    Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Mol Genet 21:2377-88. 2012
  3. pmc A genome-wide scan for common variants affecting the rate of age-related cognitive decline
    Philip L De Jager
    Institute for the Neurosciences, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Neurobiol Aging 33:1017.e1-15. 2012
  4. pmc Functional screening of Alzheimer pathology genome-wide association signals in Drosophila
    Joshua M Shulman
    Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Hum Genet 88:232-8. 2011
  5. pmc Alzheimer disease susceptibility loci: evidence for a protein network under natural selection
    Towfique Raj
    Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences Department of Neurology, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Am J Hum Genet 90:720-6. 2012
  6. pmc CR1 is associated with amyloid plaque burden and age-related cognitive decline
    Lori B Chibnik
    Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital, Boston, MA, USA
    Ann Neurol 69:560-9. 2011
  7. pmc Intermediate phenotypes identify divergent pathways to Alzheimer's disease
    Joshua M Shulman
    Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    PLoS ONE 5:e11244. 2010

Collaborators

Detail Information

Publications7

  1. doi Parkinson's disease: genetics and pathogenesis
    Joshua M Shulman
    Department of Neurology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Annu Rev Pathol 6:193-222. 2011
    ....
  2. pmc A coding variant in CR1 interacts with APOE-ε4 to influence cognitive decline
    Brendan T Keenan
    Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Mol Genet 21:2377-88. 2012
    ..We thus implicate C1q and MBL, which bind to LHR-D, as likely targets of the variant's effect and suggest that CR1 may be an important intermediate in the clearance of Aβ42 particles by C1q...
  3. pmc A genome-wide scan for common variants affecting the rate of age-related cognitive decline
    Philip L De Jager
    Institute for the Neurosciences, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Neurobiol Aging 33:1017.e1-15. 2012
    ....
  4. pmc Functional screening of Alzheimer pathology genome-wide association signals in Drosophila
    Joshua M Shulman
    Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Hum Genet 88:232-8. 2011
    ..Our strategy of coupling genome-wide association in humans with functional screening in a model organism is likely to be a powerful approach for gene discovery in AD and other complex genetic disorders...
  5. pmc Alzheimer disease susceptibility loci: evidence for a protein network under natural selection
    Towfique Raj
    Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences Department of Neurology, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Am J Hum Genet 90:720-6. 2012
    ..The context for selection is probably unrelated to AD itself; it is likely that these genes interact in another context, such as in immune cells, where we observe cis-regulatory effects at several of the selected AD loci...
  6. pmc CR1 is associated with amyloid plaque burden and age-related cognitive decline
    Lori B Chibnik
    Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital, Boston, MA, USA
    Ann Neurol 69:560-9. 2011
    ..We leveraged available neuropsychological and autopsy data from 2 cohort studies to investigate whether these loci are associated with cognitive decline and AD neuropathology...
  7. pmc Intermediate phenotypes identify divergent pathways to Alzheimer's disease
    Joshua M Shulman
    Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    PLoS ONE 5:e11244. 2010
    ..However, little is known of the role of these candidate genes in influencing intermediate phenotypes associated with a diagnosis of AD, including cognitive decline or AD neuropathologic burden...