James Shorter

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi request reprint Prions as adaptive conduits of memory and inheritance
    James Shorter
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Nat Rev Genet 6:435-50. 2005
  2. pmc Destruction or potentiation of different prions catalyzed by similar Hsp104 remodeling activities
    James Shorter
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Mol Cell 23:425-38. 2006
  3. ncbi request reprint Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers
    James Shorter
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 304:1793-7. 2004
  4. ncbi request reprint Prime time for alpha-synuclein
    Aaron D Gitler
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    J Neurosci 27:2433-4. 2007
  5. pmc The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis
    Aaron D Gitler
    Whitehead Institute for Biomedical Research and Howard Hughes Medical Institute, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 105:145-50. 2008
  6. pmc Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs
    Huan Wang
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 805b Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:7159-64. 2008
  7. pmc Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions
    James Shorter
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Stellar Chance Laboratories, Philadelphia, PA 19104, USA
    EMBO J 27:2712-24. 2008
  8. pmc Asymmetric deceleration of ClpB or Hsp104 ATPase activity unleashes protein-remodeling activity
    Shannon M Doyle
    Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health NIH, Bethesda, Maryland 20892, USA
    Nat Struct Mol Biol 14:114-22. 2007
  9. pmc Atypical AAA+ subunit packing creates an expanded cavity for disaggregation by the protein-remodeling factor Hsp104
    Petra Wendler
    Department of Crystallography, Birkbeck College, Malet Street, London WC1E 7HX, UK
    Cell 131:1366-77. 2007
  10. pmc Hsp110 chaperones regulate prion formation and propagation in S. cerevisiae by two discrete activities
    Heather Sadlish
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, DKFZ ZMBH Alliance, Universitat Heidelberg, Heidelberg, Germany
    PLoS ONE 3:e1763. 2008

Collaborators

  • Susan Lindquist
  • Jean Christophe Rochet
  • Guy A Caldwell
  • Aaron D Gitler
  • Andrew D Steele
  • Huan Wang
  • Christophe Lo Bianco
  • Heather Sadlish
  • Shannon M Doyle
  • Petra Wendler
  • Matthew Beard
  • Samrat Mukhopadhyay
  • Blake E Roberts
  • Linhui Julie Su
  • Jonathan King
  • Martin L Duennwald
  • Peter Weigele
  • Barbara J Blanchard
  • Leslie M Rozeboom
  • Takeshi Iwatsubo
  • Bernd Bukau
  • Ashok A Deniz
  • Claes Andréasson
  • Yingxin L Zhang
  • Patrick Aebischer
  • Heike Rampelt
  • Renee D Wegrzyn
  • Edward J Hennessy
  • Etienne Regulier
  • Drees Griffin
  • Rajaraman Krishnan
  • Stephen L Buchwald
  • Hilal Lashuel
  • Vernon M Ingram
  • Helen R Saibil
  • Michal Zolkiewski
  • Celia Plisson
  • Sue Wickner
  • Joel R Hoskins
  • Anil G Cashikar
  • Ayano Satoh
  • Graham Warren

Detail Information

Publications13

  1. ncbi request reprint Prions as adaptive conduits of memory and inheritance
    James Shorter
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Nat Rev Genet 6:435-50. 2005
    ..We then describe situations in which prion-enciphered events might have essential roles in long-term memory formation, transcriptional memory and genome-wide expression patterns...
  2. pmc Destruction or potentiation of different prions catalyzed by similar Hsp104 remodeling activities
    James Shorter
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Mol Cell 23:425-38. 2006
    ..In vivid distinction, the endpoint of Ure2 fragmentation is short prion fibers with enhanced infectivity and self-replicating ability. These advances explain the distinct effects of Hsp104 on the inheritance of the two prions...
  3. ncbi request reprint Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers
    James Shorter
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 304:1793-7. 2004
    ..These Hsp104 activities differed in their reaction mechanism and can explain [PSI+] inheritance patterns...
  4. ncbi request reprint Prime time for alpha-synuclein
    Aaron D Gitler
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    J Neurosci 27:2433-4. 2007
  5. pmc The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis
    Aaron D Gitler
    Whitehead Institute for Biomedical Research and Howard Hughes Medical Institute, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 105:145-50. 2008
    ..Thus, alpha-syn causes general defects in vesicle trafficking, to which dopaminergic neurons are especially sensitive...
  6. pmc Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs
    Huan Wang
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 805b Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:7159-64. 2008
    ..Our studies provide mechanistic insights and reinvigorate hopes for small-molecule therapies that specifically disrupt intermolecular amyloid contacts...
  7. pmc Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions
    James Shorter
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Stellar Chance Laboratories, Philadelphia, PA 19104, USA
    EMBO J 27:2712-24. 2008
    ..This activity is reduced when Ssa1, or enhanced when Ssb1, is incorporated into nascent prions. These findings illuminate several facets of the chaperone interplay that underpins [PSI(+)] inheritance...
  8. pmc Asymmetric deceleration of ClpB or Hsp104 ATPase activity unleashes protein-remodeling activity
    Shannon M Doyle
    Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health NIH, Bethesda, Maryland 20892, USA
    Nat Struct Mol Biol 14:114-22. 2007
    ..We suggest that this versatility in reaction mechanism enables ClpB and Hsp104 to reactivate the entire aggregated proteome after stress and enables Hsp104 to control prion inheritance...
  9. pmc Atypical AAA+ subunit packing creates an expanded cavity for disaggregation by the protein-remodeling factor Hsp104
    Petra Wendler
    Department of Crystallography, Birkbeck College, Malet Street, London WC1E 7HX, UK
    Cell 131:1366-77. 2007
    ..The large cavity could enable the uptake of polypeptide loops without a requirement for exposed N or C termini...
  10. pmc Hsp110 chaperones regulate prion formation and propagation in S. cerevisiae by two discrete activities
    Heather Sadlish
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, DKFZ ZMBH Alliance, Universitat Heidelberg, Heidelberg, Germany
    PLoS ONE 3:e1763. 2008
    ..This activity is not essential for prion formation under conditions of Sup35 overproduction, however, it may be relevant for spontaneous [PSI(+)] formation as well as for protection of the prion trait upon physiological Hsp104 induction...
  11. ncbi request reprint A cryptic Rab1-binding site in the p115 tethering protein
    Matthew Beard
    Department of Physiology and Cellular Biophysics, Columbia University, New York, New York 10032, USA
    J Biol Chem 280:25840-8. 2005
    ..Regulation of this interaction by proteins such as GM130 and Giantin may control the membrane recruitment of p115 by Rab1...
  12. pmc Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease
    Christophe Lo Bianco
    Wallenberg Neuroscience Center, Division of Neurobiology, Department of Experimental Medical Science, Lund University, Lund, Sweden
    J Clin Invest 118:3087-97. 2008
    ..Hsp104 likely protects dopaminergic neurons by antagonizing toxic alpha-synuclein assemblies and might have therapeutic potential for PD and other neurodegenerative amyloidoses...
  13. ncbi request reprint Hsp104: a weapon to combat diverse neurodegenerative disorders
    James Shorter
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6059, USA
    Neurosignals 16:63-74. 2008
    ..Here, I review the modus operandi of Hsp104 and showcase efforts to unleash Hsp104 on the protein-misfolding events connected to disparate neurodegenerative amyloidoses...