Research Topics
| Sonya S ShinSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
Research Grants
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Detail Information
Publications
Impact of rapid drug susceptibility testing for tuberculosis: program experience in Lima, PeruS S Shin
Division of Global Health Equity, and Division of Infectious Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Int J Tuberc Lung Dis 16:1538-43. 2012..Programmatic implementation of decentralized rapid drug susceptibility testing (DST) in Lima, Peru...
Implementing evidence-based alcohol interventions in a resource-limited setting: novel delivery strategies in Tomsk, RussiaSonya S Shin
Harvard Medical School, Division of Global Health Equity, Brigham and Women s Hospital, Boston, MA 02115, USA
Harv Rev Psychiatry 20:58-67. 2012..We also discuss the implications of these lessons learned within the context of meeting the challenge of providing evidence-based care in resource-limited settings...
A web-based laboratory information system to improve quality of care of tuberculosis patients in Peru: functional requirements, implementation and usage statisticsJoaquin A Blaya
1Division of Health Sciences and Technology, Harvard Medical School MIT, 77 Massachusetts Ave Cambridge, MA 02139, USA
BMC Med Inform Decis Mak 7:33. 2007....
Adverse reactions among patients being treated for MDR-TB in Tomsk, RussiaS S Shin
Division of Social Medicine and Health Inequalities, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Int J Tuberc Lung Dis 11:1314-20. 2007..Treatment of multidrug-resistant tuberculosis (MDR-TB) is challenging because of the toxicity of second-line medications. Little is known about whether adverse events impact treatment outcome...- Psychosocial impact of poverty on antiretroviral nonadherence among HIV-TB coinfected patients in Lima, PeruSonya Shin
Brigham and Women s Hospital, Division of Social Medicine and Health Inequalities, Boston, MA 02115, USA
J Int Assoc Physicians AIDS Care (Chic) 7:74-81. 2008..Tuberculosis and HIV coinfection poses unique clinical and psychosocial complexities that can impact nonadherence to highly active antiretroviral treatment (HAART)... - Scale-up of multidrug-resistant tuberculosis laboratory services, PeruSonya S Shin
Division of Social Medicine and Health Inequalities, Brigham and Women s Hospital, Boston, Massachusetts 02120, USA
Emerg Infect Dis 14:701-8. 2008..Hurdles included logistics, coordinating with policy, competing interests, changing personnel, communications, and evaluation. Operational research guided laboratory scale-up and identified barriers to effective capacity building... - Development of extensively drug-resistant tuberculosis during multidrug-resistant tuberculosis treatmentSonya S Shin
Division of Global Health Equity, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Respir Crit Care Med 182:426-32. 2010..Preventing this amplification of resistance will likely improve clinical outcomes and delay the secondary spread of XDR-TB... - Alcohol consumption among men and women with tuberculosis in Tomsk, RussiaSonya S Shin
Division of Global Health Equity, Brigham and Women s Hospital, Boston, MA 02115, USA
Cent Eur J Public Health 18:132-8. 2010..We conclude that Russian women with alcohol use disorders consume almost as much alcohol as men and may be at greater risk for negative social and medical consequences... - How does directly observed therapy work? The mechanisms and impact of a comprehensive directly observed therapy intervention of highly active antiretroviral therapy in PeruSonya Shin
Division of Global Health Equity, Brigham and Women s Hospital, Boston, MA 02115, USA
Health Soc Care Community 19:261-71. 2011..Based on our prior quantitative and qualitative outcomes reported here, we argue that DOT of highly active antiretroviral therapy could be designed to optimise psychosocial recovery during the period of DOT... - Mental Health Burden Among Impoverished HIV-Positive Patients in PeruSonya Shin
Division of Global Health Equity, Brigham and Women s Hospital, Boston, MA, USA, Socios En Salud Sucursal Perú, Lima, Peru, Harvard Medical School, Boston, MA, USA, Division of Infectious Diseases, Brigham and Women s Hospital, Boston MA, USA
J Int Assoc Physicians AIDS Care (Chic) 10:18-25. 2011.... - Treatment outcomes in an integrated civilian and prison MDR-TB treatment program in RussiaS S Shin
Division of Social Medicine and Health Inequalities, Brigham and Women s Hospital, Boston, MA 02120, USA
Int J Tuberc Lung Dis 10:402-8. 2006..Multidrug-resistant tuberculosis (MDR-TB) is a major problem in countries of the former Soviet Union in both the civilian and prison sectors... - Hypokalemia among patients receiving treatment for multidrug-resistant tuberculosisSonya Shin
Division of Infectious Diseases, Brigham and Women s Hospital, Boston, MA, USA
Chest 125:974-80. 2004..Hypokalemia was observed to be an important adverse effect encountered in this cohort... - Community-based treatment of multidrug-resistant tuberculosis in Lima, Peru: 7 years of experienceSonya Shin
Division of Social Medicine and Health Inequalities, Brigham and Women s Hospital, 1620 Tremont St 3rd Floor, Boston, MA 02120 1613, USA
Soc Sci Med 59:1529-39. 2004..We describe the first such program and highlight the crucial components and most critical challenges to creating a successful community-based MDR-TB treatment program... - rpoB gene mutations in clinical isolates of multidrug-resistant Mycobacterium tuberculosis in northern Lima, PeruS S Shin
Division of Social Medicine and Health Inequalities, Brigham and Women s Hospital, Boston, MA 02120 1613, USA
Microb Drug Resist 11:26-30. 2005..Isolates from 42 of these patients were subjected to DNA sequencing of the rpoB gene region responsible for rifampin resistance. We determined the frequency of types of mutations in the rpoB gene among these Peruvian isolates... - Treatment of multidrug-resistant tuberculosis during pregnancy: a report of 7 casesSonya Shin
Program in Infectious Disease and Social Change, Department of Social Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Clin Infect Dis 36:996-1003. 2003..In each of these 7 cases, excellent treatment outcomes were obtained for the women and their children. Under certain circumstances, MDR-TB can be successfully treated during pregnancy... - Peripheral neuropathy associated with treatment for multidrug-resistant tuberculosisS S Shin
Brigham and Women s Hospital, Boston Massachusetts, USA
Int J Tuberc Lung Dis 7:347-53. 2003..To review the incidence and management of peripheral neuropathy in patients receiving therapy for MDR-TB... - Comprehensive treatment of extensively drug-resistant tuberculosisCarole D Mitnick
Harvard Medical School, Boston, USA
N Engl J Med 359:563-74. 2008..We describe the management of extensively drug-resistant tuberculosis and treatment outcomes among patients who were referred for individualized outpatient therapy in Peru... - Treatment of extensively drug-resistant tuberculosis in Tomsk, Russia: a retrospective cohort studySalmaan Keshavjee
Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA
Lancet 372:1403-9. 2008..Mycobacterium tuberculosis strains that cause untreatable drug-resistant disease are a threat worldwide. We describe the treatment, management, and outcomes of patients with extensively drug-resistant tuberculosis in Tomsk, Russia... - Food insufficiency is a risk factor for suboptimal antiretroviral therapy adherence among HIV-infected adults in urban PeruMolly F Franke
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
AIDS Behav 15:1483-9. 2011..R. per 5 point increase:0.91; C.I.:[0.85, 0.98]) and good baseline adherence self-efficacy (O.R.:0.25; C.I.:[0.09, 0.69]). Interventions that ensure food security for HIV-infected individuals may help sustain high levels of adherence... - Targeted drug-resistance testing strategy for multidrug-resistant tuberculosis detection, Lima, Peru, 2005-2008Gustavo E Velásquez
Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Emerg Infect Dis 17:432-40. 2011..The proportion of MDR TB detected by using guidelines was higher than that detected by a concurrent national drug-resistance survey, indicating that the strategy effectively identified patients for DST... - Risk factors for in-hospital mortality among children with tuberculosis: the 25-year experience in PeruPeter C Drobac
Partners In Health, Boston, Massachusetts 02115, USA
Pediatrics 130:e373-9. 2012..We examined factors associated with in-hospital death among children with tuberculosis (TB). We hypothesized that a negative response to tuberculin skin testing (TST) would predict decreased survival... - Validation and abbreviation of an HIV stigma scale in an adult spanish-speaking population in urban PeruMolly F Franke
Partners In Health, Boston, MA, 02199, USA
AIDS Behav 14:189-99. 2010..The resulting abridged scale contained 21 of the 40 original items and revealed properties similar to the full Spanish version... - Risk factors and mortality associated with default from multidrug-resistant tuberculosis treatmentMolly F Franke
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Clin Infect Dis 46:1844-51. 2008.... - Expanding tuberculosis case detection by screening household contactsMercedes C Becerra
Department of Social Medicine, Harvard Medical School, Boston, MA, USA
Public Health Rep 120:271-7. 2005..Results suggest that contact tracing in such settings may be a powerful means of improving case detection rates for active TB disease... - Using treatment failure under effective directly observed short-course chemotherapy programs to identify patients with multidrug-resistant tuberculosisM C Becerra
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Int J Tuberc Lung Dis 4:108-14. 2000..Public ambulatory care centers in three districts of northern metropolitan Lima, Peru... - Programmes and principles in treatment of multidrug-resistant tuberculosisJoia S Mukherjee
Brigham and Women s Hospital, Division of Social Medicine and Health Inequalities, Boston, MA, USA
Lancet 363:474-81. 2004..As treatment of MDR-TB becomes increasingly available in resource-poor areas, where it is needed most, further clinical and operational research is urgently needed to guide clinicians in the management of this disease... - Integration of alcohol use disorders identification and management in the tuberculosis programme in Tomsk Oblast, RussiaTrini A Mathew
Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, MS 39216, USA
Eur J Public Health 19:16-8. 2009..We then hired specialists and addressed licensing requirements to provide on-site addictions care. Our experience offers a successful model in the management of co-occurring AUDs among patients with chronic medical problems... - Long-term follow-up for multidrug-resistant tuberculosisSonya S Shin
Brigham and Women's Hospital, Boston, Massachusetts, USA
Emerg Infect Dis 12:687-8. 2006..Among 86 patients considered cured after completion of treatment, 97% remain healthy; 1 patient relapsed. Employment increased from 34% before treatment to 71%. We observed favorable long-term outcomes among MDR-TB patients... - Effect of administering short-course, standardized regimens in individuals infected with drug-resistant Mycobacterium tuberculosis strainsJ J Furin
Department of Social Medicine, Harvard Medical School, Boston, MA 02115, USA
Eur J Clin Microbiol Infect Dis 19:132-6. 2000..Development of antituberculous-drug resistance through inadvertent, inadequate therapy appears to be the most likely explanation for the increased resistance seen in these three patients... - Epidemiology and treatment of multidrug resistant tuberculosisCarole D Mitnick
Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts 02199, USA
Semin Respir Crit Care Med 29:499-524. 2008..Further delays in scale-up, however, risk continued generation and transmission of resistant tuberculosis, as well as associated morbidity and mortality... - Community-based therapy for children with multidrug-resistant tuberculosisPeter C Drobac
Social Medicine and Health Inequalities, Brigham and Women s Hospital, Boston, MA 02120, USA
Pediatrics 117:2022-9. 2006.... - Use of spatial information to predict multidrug resistance in tuberculosis patients, PeruHsien Ho Lin
Brigham and Women s Hospital, Boston, Massachusetts, USA
Emerg Infect Dis 18:811-3. 2012..We found that crude representation of spatial location at the level of the health center improved prediction of multidrug resistance... - Causes of death during tuberculosis treatment in Tomsk Oblast, RussiaT A Mathew
Brigham and Women s Hospital, Boston, Massachusetts, USA
Int J Tuberc Lung Dis 10:857-63. 2006..Tuberculosis (TB) incidence and mortality in Russia have risen dramatically over the past 15 years... - Treating multidrug-resistant tuberculosis in Tomsk, Russia: developing programs that address the linkage between poverty and diseaseS Keshavjee
Division of Social Medicine and Health Inequalities, Brigham and Women s Hospital, FXB Bldg 7th floor, 651 Huntington Ave, Boston, MA 02115, USA
Ann N Y Acad Sci 1136:1-11. 2008..The model of MDR-TB care in Tomsk is applicable for other resource-poor settings facing challenges to TB and MDR-TB control... - Occurrence of serious adverse effects in patients receiving community-based therapy for multidrug-resistant tuberculosisJ J Furin
Department of Social Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Int J Tuberc Lung Dis 5:648-55. 2001..A community-based treatment program for multidrug-resistant tuberculosis (MDR-TB) in an urban shantytown of Lima, Peru... - Clinical and programmatic considerations in the treatment of MDR-TB in children: a series of 16 patients from Lima, PeruJ S Mukherjee
Division of Social Medicine and Health Inequalities, Brigham and Women s Hospital, Boston, Massachusetts, USA
Int J Tuberc Lung Dis 7:637-44. 2003..Tuberculosis is a common cause of morbidity and mortality for children throughout the developing world. Children may also be infected with MDR-TB, yet most developing countries do not specifically address pediatric MDR-TB... - Validation of a rapid method for detection of M. tuberculosis resistance to isoniazid and rifampin in Lima, PeruL A Solis
Instituto Nacional de Salud, Lima, Peru
Int J Tuberc Lung Dis 9:760-4. 2005.... - Expanding global HIV treatment: case studies from the fieldJ J Furin
Division of Social Medicine and Health Inequalities, Brigham and Women s Hospital, FXB Bldg 7th floor, 651 Huntington Ave, Boston, MA 02115, USA
Ann N Y Acad Sci 1136:12-20. 2008..It also discusses unique programs aimed at addressing the complex realities of the world in which HIV thrives. These programs can act as models of HIV prevention and treatment... - Acquisition of drug resistance in multidrug-resistant Mycobacterium tuberculosis during directly observed empiric retreatment with standardized regimensL L Han
Massachusetts State Laboratory Institute, Boston, Massachusetts, USA
Int J Tuberc Lung Dis 9:818-21. 2005..In this limited group of MDR-TB patients, acquisition of resistance was common during failure of empiric drug regimens. Further study is needed to confirm these findings... - Electronic laboratory system reduces errors in National Tuberculosis Program: a cluster randomized controlled trialJ A Blaya
Decision Systems Group, Brigham and Women s Hospital, Boston, Massachusetts 02215, USA
Int J Tuberc Lung Dis 14:1009-15. 2010..To evaluate the impact of the e-Chasqui laboratory information system in reducing reporting errors compared to the current paper system...
Research Grants
- Evaluation of MDR-TB Treatment Strategies in Lima, PeruSonya Shin; Fiscal Year: 2006..abstract_text> ..
- Effectiveness of Alcohol Interventions Among TB Patients in Tomsk, RussiaSonya Shin; Fiscal Year: 2007..Finally, we have a diverse interdisciplinary team that has been able to formulate an integrated biosocial and culturally-appropriate approach to treating AUDs in this population. ..
- Community-based accompaniment with supervised antiretrovirals in Lima, PeruSonya Shin; Fiscal Year: 2009....
- Community-based accompaniment with supervised antiretrovirals in Lima, PeruSonya S Shin; Fiscal Year: 2010....