Jordan T Shin

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Hemodynamic effects of inhaled nitric oxide in right ventricular myocardial infarction and cardiogenic shock
    Ignacio Inglessis
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    J Am Coll Cardiol 44:793-8. 2004
  2. doi request reprint Overexpression of human amyloidogenic light chains causes heart failure in embryonic zebrafish: a preliminary report
    Jordan T Shin
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Amyloid 19:191-6. 2012
  3. pmc High-resolution cardiovascular function confirms functional orthology of myocardial contractility pathways in zebrafish
    Jordan T Shin
    Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Cardiovascular Research Center, 149 13th Street, Charlestown, MA 02129, USA
    Physiol Genomics 42:300-9. 2010
  4. pmc Heart failure and pulmonary hypertension
    Jordan T Shin
    Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Heart Fail Clin 6:215-22. 2010
  5. ncbi request reprint From Zebrafish to human: modular medical models
    Jordan T Shin
    Cardiovascular Research Center and Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Annu Rev Genomics Hum Genet 3:311-40. 2002
  6. pmc Human-zebrafish non-coding conserved elements act in vivo to regulate transcription
    Jordan T Shin
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital and Harvard Medical School Charlestown, MA 02129, USA
    Nucleic Acids Res 33:5437-45. 2005
  7. doi request reprint Eya4 regulation of Na+/K+-ATPase is required for sensory system development in zebrafish
    Libin Wang
    Harvard Medical School, Department of Genetics, and Howard Hughes Medical Institute, Division of Hematology Oncology, Children s Hospital Boston, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Development 135:3425-34. 2008
  8. ncbi request reprint A novel locus for dilated cardiomyopathy, diffuse myocardial fibrosis, and sudden death on chromosome 10q25-26
    Patrick T Ellinor
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Am Coll Cardiol 48:106-11. 2006
  9. ncbi request reprint Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss
    Jost Schönberger
    Harvard Medical School, Department of Genetics, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Genet 37:418-22. 2005
  10. ncbi request reprint Klf2 is an essential regulator of vascular hemodynamic forces in vivo
    John S Lee
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Dev Cell 11:845-57. 2006

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Hemodynamic effects of inhaled nitric oxide in right ventricular myocardial infarction and cardiogenic shock
    Ignacio Inglessis
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    J Am Coll Cardiol 44:793-8. 2004
    ..We sought to determine whether or not inhaled nitric oxide (NO) could improve hemodynamic function in patients with right ventricular myocardial infarction (RVMI) and cardiogenic shock (CS)...
  2. doi request reprint Overexpression of human amyloidogenic light chains causes heart failure in embryonic zebrafish: a preliminary report
    Jordan T Shin
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Amyloid 19:191-6. 2012
    ..This model will allow exploration of amyloid pathophysiology and testing of interventions to reduce and reverse the deleterious effects of amyloidosis on myocardial function...
  3. pmc High-resolution cardiovascular function confirms functional orthology of myocardial contractility pathways in zebrafish
    Jordan T Shin
    Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Cardiovascular Research Center, 149 13th Street, Charlestown, MA 02129, USA
    Physiol Genomics 42:300-9. 2010
    ....
  4. pmc Heart failure and pulmonary hypertension
    Jordan T Shin
    Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Heart Fail Clin 6:215-22. 2010
    ..Translation of emerging basic science insights in the vascular biology of PH and BMP signaling will provide novel therapeutic strategies for the spectrum of pulmonary hypertensive diseases...
  5. ncbi request reprint From Zebrafish to human: modular medical models
    Jordan T Shin
    Cardiovascular Research Center and Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Annu Rev Genomics Hum Genet 3:311-40. 2002
    ..Each mutation, once cloned, provides candidate genes and pathways for evaluation in the human. The collection of mutations in their entirety potentially provides a medical taxonomy, one based in developmental biology and genetics...
  6. pmc Human-zebrafish non-coding conserved elements act in vivo to regulate transcription
    Jordan T Shin
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital and Harvard Medical School Charlestown, MA 02129, USA
    Nucleic Acids Res 33:5437-45. 2005
    ..Together, these data support the utility of comparative genomics of distantly related vertebrate species to identify REs and provide a scaleable, in vivo quantitative assay to define functional activity of candidate REs...
  7. doi request reprint Eya4 regulation of Na+/K+-ATPase is required for sensory system development in zebrafish
    Libin Wang
    Harvard Medical School, Department of Genetics, and Howard Hughes Medical Institute, Division of Hematology Oncology, Children s Hospital Boston, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Development 135:3425-34. 2008
    ..We conclude that eya4 regulation of Na+/K+-ATPase is crucial for the development of mechanosensory cells and the maintenance of cardiac function in zebrafish...
  8. ncbi request reprint A novel locus for dilated cardiomyopathy, diffuse myocardial fibrosis, and sudden death on chromosome 10q25-26
    Patrick T Ellinor
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Am Coll Cardiol 48:106-11. 2006
    ..We sought to identify the genetic locus for an inherited form of dilated cardiomyopathy (DCM) that is characterized by diffuse myocardial fibrosis and sudden death...
  9. ncbi request reprint Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss
    Jost Schönberger
    Harvard Medical School, Department of Genetics, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Genet 37:418-22. 2005
    ..These data define unrecognized and crucial roles for Eya4-Six-mediated transcriptional regulation in normal heart function...
  10. ncbi request reprint Klf2 is an essential regulator of vascular hemodynamic forces in vivo
    John S Lee
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Dev Cell 11:845-57. 2006
    ..These findings identify Klf2 as an essential hemodynamic regulator in vivo and suggest that hemodynamic regulation in response to fluid shear stress is required for cardiovascular development and function...
  11. ncbi request reprint Locus for atrial fibrillation maps to chromosome 6q14-16
    Patrick T Ellinor
    Cardiovascular Research Center, Cardiac Arrhythmia Service, and Cardiology Division, Massachusetts General Hospital, Boston, Mass 02129, USA
    Circulation 107:2880-3. 2003
    ..Inherited forms of AF exist, but the causative gene has been defined only in a single family. We have identified a large family (family FAF-1) in which AF segregates as a Mendelian trait...
  12. pmc Mutant desmocollin-2 causes arrhythmogenic right ventricular cardiomyopathy
    Arnd Heuser
    Max Delbrueck Center for Molecular Medicine, Franz Volhard Clinic, HELIOS Clinics GmbH, Charite, Humboldt University, Berlin, Germany
    Am J Hum Genet 79:1081-8. 2006
    ..These data identify DSC2 mutations as a cause of ARVC in humans and demonstrate that physiologic levels of DSC2 are crucial for normal cardiac desmosome formation, early cardiac morphogenesis, and cardiac function...