Jan L Shifren
Affiliation: Massachusetts General Hospital
- Testosterone patch for the treatment of hypoactive sexual desire disorder in naturally menopausal women: results from the INTIMATE NM1 StudyJan L Shifren
Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA 02114, USA
Menopause 13:770-9. 2006..To evaluate the efficacy and safety of a testosterone patch for the treatment of women with hypoactive sexual desire disorder after natural menopause...
- Surgical menopause: effects on psychological well-being and sexualityJan L Shifren
Vincent OB GYN Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Menopause 14:586-91. 2007..Women anticipating surgical menopause often have significant concerns regarding the effects of surgery on psychological well-being and sexuality...
- A randomized, open-label, crossover study comparing the effects of oral versus transdermal estrogen therapy on serum androgens, thyroid hormones, and adrenal hormones in naturally menopausal womenJan L Shifren
Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, Boston, MA 02114, USA
Menopause 14:985-94. 2007....
- A comparison of the short-term effects of oral conjugated equine estrogens versus transdermal estradiol on C-reactive protein, other serum markers of inflammation, and other hepatic proteins in naturally menopausal womenJan L Shifren
Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, 670 Albany Street, Boston, MA 02118, USA
J Clin Endocrinol Metab 93:1702-10. 2008....
- Sexual problems and distress in United States women: prevalence and correlatesJan L Shifren
Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Obstet Gynecol 112:970-8. 2008..To estimate the prevalence of self-reported sexual problems (any, desire, arousal, and orgasm), the prevalence of problems accompanied by personal distress, and to describe related correlates...
- Help-seeking behavior of women with self-reported distressing sexual problemsJan L Shifren
Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Womens Health (Larchmt) 18:461-8. 2009..The objective was to describe the healthcare and information-seeking behavior of women with self-reported sexual problems and accompanying sexually related personal distress identified from a large, population-based U.S. survey...
- Role of hormone therapy in the management of menopauseJan L Shifren
Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, and Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Obstet Gynecol 115:839-55. 2010..Women must be informed of the potential benefits and risks of all therapeutic options, and care should be individualized, based on a woman's medical history, needs, and preferences...
- Short-term use of estradiol for depression in perimenopausal and postmenopausal women: a preliminary reportLee S Cohen
Perinatal and Reproductive Psychiatry Clinical Research Program and Vicent Memorail Obstetrics and Gynecology Service, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Psychiatry 160:1519-22. 2003..The authors examined the effect of a 4-week course of estrogen therapy on depression in perimenopausal and postmenopausal women...
- The role of androgens in female sexual dysfunctionJan L Shifren
Menopause Program, Vincent Memorial Obstetrics and Gynecology Service, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
Mayo Clin Proc 79:S19-24. 2004..Possible risks include hirsutism, acne, liver dysfunction, lowering of the voice, adverse lipid changes, virilization of a female fetus, and, as androgens are aromatized to estrogens, potentially the risks of estrogen therapy...
- Sexual function in nondepressed women using escitalopram for vasomotor symptoms: a randomized controlled trialSusan D Reed
Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, Washington 98104, USA
Obstet Gynecol 119:527-38. 2012..Information on sexual function in nondepressed midlife women using selective serotonin reuptake inhibitors for vasomotor symptoms is lacking; any treatments that might impair function are of concern...
- Efficacy of citalopram as a monotherapy or as an adjunctive treatment to estrogen therapy for perimenopausal and postmenopausal women with depression and vasomotor symptomsClaudio N Soares
Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital and the Department of Psychiatry, Harvard Medical School, Boston, 02114, USA
J Clin Psychiatry 64:473-9. 2003..It is still unclear whether the use of antidepressants alone may alleviate menopause-related mood and vasomotor symptoms or enhance the response observed with short-term use of estrogen therapy...
- Androgen deficiency in the oophorectomized womanJan L Shifren
Massachusetts General Hospital, Vincent Obstetrics and Gynecology Service, Boston, Massachusetts 02114, USA
Fertil Steril 77:S60-2. 2002..Studies of both the consequences of oophorectomy and the effects of testosterone replacement are consistent with an important role for androgens in female sexual function and psychological well-being...
- Self-reported sleep in postmenopausal womenQuentin R Regestein
Brigham and Women s Hospital and Massachusetts General Hospital, Boston, MA, USA
Menopause 11:198-207. 2004..A secondary aim was to find if self-reported sleep showed expected correlations with hyperarousal (Hyperarousal Scale)...
- Absence of polycystic ovary syndrome features in human immunodeficiency virus-infected women despite significant hyperinsulinemia and truncal adiposityStine Johnsen
Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Clin Endocrinol Metab 90:5596-604. 2005..CONCLUSIONS: These data demonstrate that among HIV-infected subjects with severe abdominal fat accumulation and hyperinsulinemia, common features of polycystic ovary syndrome are not seen...
- Is testosterone or estradiol the hormone of desire? A novel study of the effects of testosterone treatment and aromatase inhibition in postmenopausal womenJan L Shifren
Menopause 13:8-9. 2006
- Safety and efficacy of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: a randomized, placebo-controlled trialGlenn D Braunstein
Department of Medicine, Cedars Sinai Medical Center, Los Angeles, Calif, 90048, USA
Arch Intern Med 165:1582-9. 2005..Oophorectomy reduces serum testosterone levels. We studied the efficacy and safety of transdermal testosterone in treating hypoactive sexual desire disorder in surgically menopausal women...
- Influence of raloxifene on the efficacy of an estradiol-releasing ring for treating vaginal atrophy in postmenopausal womenJoann V Pinkerton
University of Virginia Health System, Charlottesville, VA, USA
Menopause 10:45-52. 2003..CONCLUSIONS: Concomitant administration of raloxifene does not alter the effects of the 17beta-estradiol ring on alleviating signs and symptoms of genitourinary atrophy in postmenopausal women...
- Transdermal testosterone for women: a new physiological approach for androgen therapyNorman A Mazer
Department of Medical Affairs, Watson Laboratories, Inc, 417 Wakara Way, Suite 100, Salt Lake City, UT 84108, USA
Obstet Gynecol Surv 58:489-500. 2003..Although still in development, transdermal testosterone therapy appears to be a promising new approach for providing physiologically based androgen therapy to women...
- Is there a role for testosterone therapy in premenopausal women?Jan L Shifren
Menopause 10:383-4. 2003
- Experts offer advice on testosterone testing and whether to discontinue hormone therapy before surgeryLeon Speroff
Oregon Health and Science University, Portland, USA
Geriatrics 63:2 p following 31. 2008
- Safety profile of transdermal testosterone therapy in womenJan L Shifren
Am J Obstet Gynecol 189:898-9; author reply 899. 2003
- Endocrine aspects of female sexual dysfunctionSusan R Davis
NHMRC Centre of Clinical Research Excellence, The Jean Hailes Foundation and Monash University, Clayton, Vic, Australia
J Sex Med 1:82-6. 2004..Various endogenous hormones, including estrogen, testosterone, progesterone and prolactin, may influence female sexual function...