Jan L Shifren

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Testosterone patch for the treatment of hypoactive sexual desire disorder in naturally menopausal women: results from the INTIMATE NM1 Study
    Jan L Shifren
    Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA 02114, USA
    Menopause 13:770-9. 2006
  2. ncbi Surgical menopause: effects on psychological well-being and sexuality
    Jan L Shifren
    Vincent OB GYN Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Menopause 14:586-91. 2007
  3. ncbi A randomized, open-label, crossover study comparing the effects of oral versus transdermal estrogen therapy on serum androgens, thyroid hormones, and adrenal hormones in naturally menopausal women
    Jan L Shifren
    Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, Boston, MA 02114, USA
    Menopause 14:985-94. 2007
  4. ncbi A comparison of the short-term effects of oral conjugated equine estrogens versus transdermal estradiol on C-reactive protein, other serum markers of inflammation, and other hepatic proteins in naturally menopausal women
    Jan L Shifren
    Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, 670 Albany Street, Boston, MA 02118, USA
    J Clin Endocrinol Metab 93:1702-10. 2008
  5. ncbi Sexual problems and distress in United States women: prevalence and correlates
    Jan L Shifren
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Obstet Gynecol 112:970-8. 2008
  6. ncbi Help-seeking behavior of women with self-reported distressing sexual problems
    Jan L Shifren
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Womens Health (Larchmt) 18:461-8. 2009
  7. ncbi Role of hormone therapy in the management of menopause
    Jan L Shifren
    Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, and Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Obstet Gynecol 115:839-55. 2010
  8. ncbi Short-term use of estradiol for depression in perimenopausal and postmenopausal women: a preliminary report
    Lee S Cohen
    Perinatal and Reproductive Psychiatry Clinical Research Program and Vicent Memorail Obstetrics and Gynecology Service, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 160:1519-22. 2003
  9. ncbi The role of androgens in female sexual dysfunction
    Jan L Shifren
    Menopause Program, Vincent Memorial Obstetrics and Gynecology Service, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Mayo Clin Proc 79:S19-24. 2004
  10. pmc Sexual function in nondepressed women using escitalopram for vasomotor symptoms: a randomized controlled trial
    Susan D Reed
    Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Obstet Gynecol 119:527-38. 2012

Detail Information

Publications23

  1. ncbi Testosterone patch for the treatment of hypoactive sexual desire disorder in naturally menopausal women: results from the INTIMATE NM1 Study
    Jan L Shifren
    Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA 02114, USA
    Menopause 13:770-9. 2006
    ..To evaluate the efficacy and safety of a testosterone patch for the treatment of women with hypoactive sexual desire disorder after natural menopause...
  2. ncbi Surgical menopause: effects on psychological well-being and sexuality
    Jan L Shifren
    Vincent OB GYN Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Menopause 14:586-91. 2007
    ..Women anticipating surgical menopause often have significant concerns regarding the effects of surgery on psychological well-being and sexuality...
  3. ncbi A randomized, open-label, crossover study comparing the effects of oral versus transdermal estrogen therapy on serum androgens, thyroid hormones, and adrenal hormones in naturally menopausal women
    Jan L Shifren
    Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, Boston, MA 02114, USA
    Menopause 14:985-94. 2007
    ....
  4. ncbi A comparison of the short-term effects of oral conjugated equine estrogens versus transdermal estradiol on C-reactive protein, other serum markers of inflammation, and other hepatic proteins in naturally menopausal women
    Jan L Shifren
    Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, 670 Albany Street, Boston, MA 02118, USA
    J Clin Endocrinol Metab 93:1702-10. 2008
    ....
  5. ncbi Sexual problems and distress in United States women: prevalence and correlates
    Jan L Shifren
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Obstet Gynecol 112:970-8. 2008
    ..To estimate the prevalence of self-reported sexual problems (any, desire, arousal, and orgasm), the prevalence of problems accompanied by personal distress, and to describe related correlates...
  6. ncbi Help-seeking behavior of women with self-reported distressing sexual problems
    Jan L Shifren
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Womens Health (Larchmt) 18:461-8. 2009
    ..The objective was to describe the healthcare and information-seeking behavior of women with self-reported sexual problems and accompanying sexually related personal distress identified from a large, population-based U.S. survey...
  7. ncbi Role of hormone therapy in the management of menopause
    Jan L Shifren
    Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, and Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Obstet Gynecol 115:839-55. 2010
    ..Women must be informed of the potential benefits and risks of all therapeutic options, and care should be individualized, based on a woman's medical history, needs, and preferences...
  8. ncbi Short-term use of estradiol for depression in perimenopausal and postmenopausal women: a preliminary report
    Lee S Cohen
    Perinatal and Reproductive Psychiatry Clinical Research Program and Vicent Memorail Obstetrics and Gynecology Service, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 160:1519-22. 2003
    ..The authors examined the effect of a 4-week course of estrogen therapy on depression in perimenopausal and postmenopausal women...
  9. ncbi The role of androgens in female sexual dysfunction
    Jan L Shifren
    Menopause Program, Vincent Memorial Obstetrics and Gynecology Service, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Mayo Clin Proc 79:S19-24. 2004
    ..Possible risks include hirsutism, acne, liver dysfunction, lowering of the voice, adverse lipid changes, virilization of a female fetus, and, as androgens are aromatized to estrogens, potentially the risks of estrogen therapy...
  10. pmc Sexual function in nondepressed women using escitalopram for vasomotor symptoms: a randomized controlled trial
    Susan D Reed
    Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Obstet Gynecol 119:527-38. 2012
    ..Information on sexual function in nondepressed midlife women using selective serotonin reuptake inhibitors for vasomotor symptoms is lacking; any treatments that might impair function are of concern...
  11. pmc Sexual function in women on estradiol or venlafaxine for hot flushes: a randomized controlled trial
    Susan D Reed
    Departments of Obstetrics and Gynecology and Epidemiology, University of Washington School of Medicine, The Group Health Research Institute, and the Data Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, Washington the Departments of Psychiatry and Medicine, Brigham and Women s Hospital, the Departments of Psychiatry and Obstetrics and Gynecology, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts and the Departments of Obstetrics and Gynecology and Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
    Obstet Gynecol 124:233-41. 2014
    ..To evaluate sexual function in midlife women taking low-dose oral estradiol or venlafaxine for hot flushes...
  12. ncbi Efficacy of citalopram as a monotherapy or as an adjunctive treatment to estrogen therapy for perimenopausal and postmenopausal women with depression and vasomotor symptoms
    Claudio N Soares
    Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital and the Department of Psychiatry, Harvard Medical School, Boston, 02114, USA
    J Clin Psychiatry 64:473-9. 2003
    ..It is still unclear whether the use of antidepressants alone may alleviate menopause-related mood and vasomotor symptoms or enhance the response observed with short-term use of estrogen therapy...
  13. ncbi Androgen deficiency in the oophorectomized woman
    Jan L Shifren
    Massachusetts General Hospital, Vincent Obstetrics and Gynecology Service, Boston, Massachusetts 02114, USA
    Fertil Steril 77:S60-2. 2002
    ..Studies of both the consequences of oophorectomy and the effects of testosterone replacement are consistent with an important role for androgens in female sexual function and psychological well-being...
  14. ncbi Self-reported sleep in postmenopausal women
    Quentin R Regestein
    Brigham and Women s Hospital and Massachusetts General Hospital, Boston, MA, USA
    Menopause 11:198-207. 2004
    ..A secondary aim was to find if self-reported sleep showed expected correlations with hyperarousal (Hyperarousal Scale)...
  15. ncbi Absence of polycystic ovary syndrome features in human immunodeficiency virus-infected women despite significant hyperinsulinemia and truncal adiposity
    Stine Johnsen
    Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:5596-604. 2005
    ..It is unknown whether insulin resistance and truncal adiposity are associated with features of the polycystic ovary syndrome in this population...
  16. ncbi Is testosterone or estradiol the hormone of desire? A novel study of the effects of testosterone treatment and aromatase inhibition in postmenopausal women
    Jan L Shifren
    Menopause 13:8-9. 2006
  17. ncbi Safety and efficacy of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: a randomized, placebo-controlled trial
    Glenn D Braunstein
    Department of Medicine, Cedars Sinai Medical Center, Los Angeles, Calif, 90048, USA
    Arch Intern Med 165:1582-9. 2005
    ..Oophorectomy reduces serum testosterone levels. We studied the efficacy and safety of transdermal testosterone in treating hypoactive sexual desire disorder in surgically menopausal women...
  18. ncbi Influence of raloxifene on the efficacy of an estradiol-releasing ring for treating vaginal atrophy in postmenopausal women
    Joann V Pinkerton
    University of Virginia Health System, Charlottesville, VA, USA
    Menopause 10:45-52. 2003
    ..To determine the potential interaction of oral raloxifene 60 mg/day on the efficacy of a low-dose, estradiol-releasing vaginal ring used to treat signs and symptoms of vaginal atrophy in postmenopausal women...
  19. ncbi Transdermal testosterone for women: a new physiological approach for androgen therapy
    Norman A Mazer
    Department of Medical Affairs, Watson Laboratories, Inc, 417 Wakara Way, Suite 100, Salt Lake City, UT 84108, USA
    Obstet Gynecol Surv 58:489-500. 2003
    ..Although still in development, transdermal testosterone therapy appears to be a promising new approach for providing physiologically based androgen therapy to women...
  20. ncbi Is there a role for testosterone therapy in premenopausal women?
    Jan L Shifren
    Menopause 10:383-4. 2003
  21. ncbi Safety profile of transdermal testosterone therapy in women
    Jan L Shifren
    Am J Obstet Gynecol 189:898-9; author reply 899. 2003
  22. ncbi Experts offer advice on testosterone testing and whether to discontinue hormone therapy before surgery
    Leon Speroff
    Oregon Health and Science University, Portland, USA
    Geriatrics 63:2 p following 31. 2008
  23. ncbi Endocrine aspects of female sexual dysfunction
    Susan R Davis
    NHMRC Centre of Clinical Research Excellence, The Jean Hailes Foundation and Monash University, Clayton, Vic, Australia
    J Sex Med 1:82-6. 2004
    ..Various endogenous hormones, including estrogen, testosterone, progesterone and prolactin, may influence female sexual function...