Genomes and Genes
Richard I Sherwood
Affiliation: Massachusetts General Hospital
- A multi-parametric flow cytometric assay to analyze DNA-protein interactionsMandana Arbab
Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Nucleic Acids Res 41:e38. 2013..Combinatorial fluorescent staining allows simultaneous analysis of sequence-specific TF-DNA interaction and chromatin modification. MagPIE provides a simple and robust method to analyze complex epigenetic interactions in vitro...
- Wnt signaling specifies and patterns intestinal endodermRichard I Sherwood
Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Mech Dev 128:387-400. 2011..These findings shed light on the mechanism of embryonic intestinal induction and provide a method to manipulate intestinal development from embryonic stem cells...
- Prostaglandin E2 regulates liver versus pancreas cell-fate decisions and endodermal outgrowthSahar Nissim
Gastroenterology Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA Genetics Division, Brigham and Women s Hospital, Boston, MA 02115, USA Dana Farber Cancer Institute, Boston, MA 02115, USA
Dev Cell 28:423-37. 2014..PGE2 remains important for adult organ growth, as it modulates liver regeneration. This work provides in vivo evidence that PGE2 may act as a morphogen to regulate cell-fate decisions and outgrowth of the embryonic endodermal anlagen. ..
- Discovery of directional and nondirectional pioneer transcription factors by modeling DNase profile magnitude and shapeRichard I Sherwood
1 Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA 2
Nat Biotechnol 32:171-8. 2014..Our results support a model of hierarchical TF binding in which directional and nondirectional pioneer activity shapes the chromatin landscape for population by settler TFs. ..