Jason D Shepherd

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking
    Shoaib Chowdhury
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 52:445-59. 2006
  2. doi New views of Arc, a master regulator of synaptic plasticity
    Jason D Shepherd
    Department of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Neurosci 14:279-84. 2011
  3. ncbi The cell biology of synaptic plasticity: AMPA receptor trafficking
    Jason D Shepherd
    The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Annu Rev Cell Dev Biol 23:613-43. 2007
  4. pmc Loss of Arc renders the visual cortex impervious to the effects of sensory experience or deprivation
    Cortina L McCurry
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Neurosci 13:450-7. 2010
  5. pmc Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors
    Jason D Shepherd
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 52:475-84. 2006
  6. ncbi Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction
    Salvatore Oddo
    Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697, USA
    Neuron 39:409-21. 2003
  7. pmc Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD
    Sungjin Park
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 20205, USA
    Neuron 59:70-83. 2008

Collaborators

  • Mark F Bear
  • Mriganka Sur
  • M P Mattson
  • R S Petralia
  • F M LaFerla
  • T E Golde
  • Shoaib Chowdhury
  • Cortina L McCurry
  • Sungjin Park
  • Dietmar Kuhl
  • Paul F Worley
  • Richard L Huganir
  • Salvatore Oddo
  • Kuan H Wang
  • Daniela Tropea
  • Walter Kaufmann
  • Alexey G Ryazanov
  • David J Linden
  • Joo Min Park
  • Jin Ah Kim
  • Sangmok Kim
  • Constance L Smith-Hicks
  • Niels Plath
  • Gregory Lyford
  • Hiroyuki Okuno
  • Antonella Caccamo
  • Yama Akbari
  • M Paul Murphy
  • Rakez Kayed
  • Raju Metherate

Detail Information

Publications7

  1. pmc Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking
    Shoaib Chowdhury
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 52:445-59. 2006
    ..These findings reveal a novel molecular pathway that is regulated by Arc/Arg3.1 and likely contributes to late-phase synaptic plasticity and memory consolidation...
  2. doi New views of Arc, a master regulator of synaptic plasticity
    Jason D Shepherd
    Department of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Neurosci 14:279-84. 2011
    ....
  3. ncbi The cell biology of synaptic plasticity: AMPA receptor trafficking
    Jason D Shepherd
    The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Annu Rev Cell Dev Biol 23:613-43. 2007
    ..Here we describe the life cycle of AMPARs, from their biogenesis, through their journey to the synapse, and ultimately through their demise, and discuss how the modulation of this process is essential for brain function...
  4. pmc Loss of Arc renders the visual cortex impervious to the effects of sensory experience or deprivation
    Cortina L McCurry
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Neurosci 13:450-7. 2010
    ..These data suggest that Arc is required for the experience-dependent processes that normally establish and modify synaptic connections in visual cortex...
  5. pmc Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors
    Jason D Shepherd
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 52:475-84. 2006
    ..1 is required for memory consolidation, reveal the importance of Arc/Arg3.1's dynamic expression as it exerts continuous and precise control over synaptic strength and cellular excitability...
  6. ncbi Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction
    Salvatore Oddo
    Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697, USA
    Neuron 39:409-21. 2003
    ....
  7. pmc Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD
    Sungjin Park
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 20205, USA
    Neuron 59:70-83. 2008
    ..1. We propose a model in which eEF2K-eEF2 and FMRP coordinately control the dynamic translation of Arc/Arg3.1 mRNA in dendrites that is critical for synapse-specific LTD...