Research Topics
Species | Morgan H ShengSummaryAffiliation: Massachusetts Institute of Technology Country: USA Publications
Research Grants
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Detail Information
Publications
Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1Albert Y Hung
The Institute of Physical and Chemical Research RIKEN Massachusetts Institute of Technology Neuroscience Research Center, Cambridge, Massachusetts 02139, USA
J Neurosci 28:1697-708. 2008....- A novel mechanism of hippocampal LTD involving muscarinic receptor-triggered interactions between AMPARs, GRIP and liprin-alphaBryony A Dickinson
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology LINE, Faculty of Medicine and Dentistry, University of Bristol, Whitson Street, Bristol BS1 3NY, UK
Mol Brain 2:18. 2009..However, we find a distinct mechanism of LTD involving GRIP and liprin-alpha... 
AMPA receptor trafficking and synaptic plasticity: major unanswered questionsMorgan Sheng
Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139, USA
Neurosci Res 46:127-34. 2003..In this update article, we try to highlight what we believe to be the major conceptual problems and unanswered questions in this rapidly moving field of neuroscience...- The postsynaptic architecture of excitatory synapses: a more quantitative viewMorgan Sheng
The Picower Institute for Learning and Memory, Howard Hughes Medical Institute, Departments of Brain and Cognitive Sciences, and Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Annu Rev Biochem 76:823-47. 2007..On the basis of such studies, a more quantitative and geometrically realistic view of PSD architecture is emerging... - 15 years of neuron cell biologyMorgan Sheng
The Picower Center for Learning and Memory, Howard Hughes Medical Institute, RIKEN-MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Neuron 40:193-7. 2003 - Postsynaptic signaling and plasticity mechanismsMorgan Sheng
Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Science 298:776-80. 2002..The complex molecular mechanisms that underlie postsynaptic signaling and plasticity are beginning to emerge... - Quaternary structure, protein dynamics, and synaptic function of SAP97 controlled by L27 domain interactionsTerunaga Nakagawa
The Picower Center for Learning and Memory, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Neuron 44:453-67. 2004..Thus SAP97 has a broader role than its close relative, PSD-95, in the maintenance of synaptic function... - Clathrin adaptor AP2 and NSF interact with overlapping sites of GluR2 and play distinct roles in AMPA receptor trafficking and hippocampal LTDSang Hyoung Lee
Picower Center for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Neuron 36:661-74. 2002..NSF function, on the other hand, is needed to maintain synaptic AMPA receptor responses, but is not directly required for NMDA receptor-mediated internalization and LTD... - Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroliginKensuke Futai
RIKEN MIT Neuroscience Research Center, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
Nat Neurosci 10:186-95. 2007..Presynaptic beta-neurexin serves as a likely presynaptic mediator of this effect. Our results indicate that trans-synaptic protein-protein interactions can link postsynaptic and presynaptic function... - Lipid rafts in the maintenance of synapses, dendritic spines, and surface AMPA receptor stabilityHeike Hering
Picower Center for Learning and Memory, Howard Hughes Medical Institute, and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Neurosci 23:3262-71. 2003..2001) and offers a potential link between disordered cholesterol metabolism and the synapse loss seen in neurodegenerative disease... - LAR receptor protein tyrosine phosphatases in the development and maintenance of excitatory synapsesAnthone W Dunah
The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Cambridge, Massachusetts 02139, USA
Nat Neurosci 8:458-67. 2005..We propose that the cadherin-beta-catenin complex is cotransported with AMPA receptors to synapses and dendritic spines by a mechanism that involves binding of liprin-alpha to LAR-RPTP and tyrosine dephosphorylation by LAR-RPTP... - Activity-dependent redistribution and essential role of cortactin in dendritic spine morphogenesisHeike Hering
The Picower Center for Learning and Memory, Howard Hughes Medical Institute, RIKEN-MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Neurosci 23:11759-69. 2003.... - GRIP1 controls dendrite morphogenesis by regulating EphB receptor traffickingCasper C Hoogenraad
The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Cambridge, Massachusetts 02139, USA
Nat Neurosci 8:906-15. 2005..These results indicate an important role for GRIP1 in dendrite morphogenesis by serving as an adaptor protein for kinesin-dependent transport of EphB receptors to dendrites... - The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapsesZheng Li
The Picower Center for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cell 119:873-87. 2004..Reciprocally, synaptic activity modulates the motility and fusion/fission balance of mitochondria and controls mitochondrial distribution in dendrites... - Subunit rules governing the sorting of internalized AMPA receptors in hippocampal neuronsSang Hyoung Lee
The Picower Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge 02139, USA
Neuron 43:221-36. 2004..Thus, GluR2 is a key subunit that controls recycling and degradation of AMPA receptors after internalization... 
Activity-induced Polo-like kinase 2 is required for homeostatic plasticity of hippocampal neurons during epileptiform activityDaniel P Seeburg
The Picower Institute for Learning and Memory, RIKEN Massachusetts Institute of Technology Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Neurosci 28:6583-91. 2008..Thus, Plk2 function is required to prevent escalating potentiation and maintain synapses in a plastic state during epileptiform activity in hippocampal slice cultures...- Liprinalpha1 degradation by calcium/calmodulin-dependent protein kinase II regulates LAR receptor tyrosine phosphatase distribution and dendrite developmentCasper C Hoogenraad
The Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Dev Cell 12:587-602. 2007..Thus, regulated degradation of liprinalpha1 is important for proper LAR receptor distribution, and could provide a mechanism for localized control of dendrite and synapse morphogenesis by activity and CaMKII... - Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132Dieter Edbauer
The Picower Institute for Learning and Memory, Departments of Brain and Cognitive Sciences and Biology, Massachusetts Institute of Technology, Cambridge, MA 02319, USA
Neuron 65:373-84. 2010..Because NMDA receptor subunit composition profoundly affects synaptic plasticity, these observations have implications for the pathophysiology of fragile X syndrome, in which plasticity is altered... - Autophosphorylated CaMKIIalpha acts as a scaffold to recruit proteasomes to dendritic spinesBaris Bingol
The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences and Biology, Massachusetts Institute of Technology, Cambridge, 02139, USA
Cell 140:567-78. 2010..Our findings reveal a scaffolding role of postsynaptic CaMKIIalpha in activity-dependent proteasome redistribution, which is commensurate with the great abundance of CaMKIIalpha in synapses... - Critical role of CDK5 and Polo-like kinase 2 in homeostatic synaptic plasticity during elevated activityDaniel P Seeburg
The Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Neuron 58:571-83. 2008.... - Differential roles of NR2A- and NR2B-containing NMDA receptors in Ras-ERK signaling and AMPA receptor traffickingMyung Jong Kim
The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Neuron 46:745-60. 2005..Preferential coupling of NR2B to SynGAP could explain the subtype-specific function of NR2B-NMDARs in inhibition of Ras-ERK, removal of synaptic AMPARs, and weakening of synaptic transmission... - Neuroscience. Making synapses: a balancing actNatasha K Hussain
Picower Center for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Science 307:1207-8. 2005 - Targeted protein degradation and synapse remodeling by an inducible protein kinaseDaniel T S Pak
Picower Center for Learning and Memory, RIKEN Massachusetts Institute of Technology MIT Neuroscience Research Center, Howard Hughes Medical Institute, MIT, Cambridge, MA 02139, USA
Science 302:1368-73. 2003..These results implicate SNK as a mediator of activity-dependent change in the molecular composition and morphology of synapses... - Synaptic accumulation of PSD-95 and synaptic function regulated by phosphorylation of serine-295 of PSD-95Myung Jong Kim
The Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Neuron 56:488-502. 2007..The data suggest that synaptic strength can be regulated by phosphorylation-dephosphorylation of ser-295 of PSD-95 and that synaptic depression requires the dephosphorylation of ser-295... - Some assembly required: the development of neuronal synapsesZheng Li
The Picower Center for Learning and Memory, RIKEN-Massachusetts Institute of Technology Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, 02139, USA
Nat Rev Mol Cell Biol 4:833-41. 2003 - MINK and TNIK differentially act on Rap2-mediated signal transduction to regulate neuronal structure and AMPA receptor functionNatasha K Hussain
Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Neurosci 30:14786-94. 2010..MINK appears to antagonize Rap2 signal transduction by binding to activated Rap2. We suggest that MINK interaction with Rap2 plays a critical role in maintaining the morphological integrity of dendrites and synaptic transmission... - The dynamic turnover and functional roles of alpha-actinin in dendritic spinesTerunaga Nakagawa
The Picower Center for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room E18-215, Cambridge, MA 02139-4301, USA
Neuropharmacology 47:734-45. 2004..These results suggest that alpha-actinin regulates spine morphology and density... - Generation of lentiviral transgenic rats expressing glutamate receptor interacting protein 1 (GRIP1) in brain, spinal cord and testisTerunaga Nakagawa
The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, 77 Massachusetts Avenue E18 215, Cambridge, MA 02139, USA
J Neurosci Methods 152:1-9. 2006..Tissue specific lentiviral transgenic rats will be a powerful tool for various applications in modern neuroscience... - Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalizationZheng Li
The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cell 141:859-71. 2010..NMDA receptor stimulation that induces LTD transiently activates caspase-3 in dendrites, without causing cell death. These data indicate an unexpected causal link between the molecular mechanisms of apoptosis and LTD... - Eye opening induces a rapid dendritic localization of PSD-95 in central visual neuronsAkira Yoshii
Department of Biology, Center for Learning and Memory, McGovern Institute for Brain Research, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 4307, USA
Proc Natl Acad Sci U S A 100:1334-9. 2003.... - Proline-rich tyrosine kinase 2 regulates hippocampal long-term depressionHonor Hsin
Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Neurosci 30:11983-93. 2010..Overexpression of PYK2 depresses NMDA-induced ERK phosphorylation and inhibits LTP, but not LTD. Our data indicate that PYK2 is critical for the induction of LTD, possibly in part by antagonizing ERK signaling in hippocampal neurons... - Constitutively active Rap2 transgenic mice display fewer dendritic spines, reduced extracellular signal-regulated kinase signaling, enhanced long-term depression, and impaired spatial learning and fear extinctionJubin Ryu
The Picower Institute for Learning and Memory, RIKEN Massachusetts Institute of Technology Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Neurosci 28:8178-88. 2008..The findings also implicate Rap2 signaling in fear extinction mechanisms, which are thought to be aberrant in anxiety disorders and posttraumatic stress disorder... - Identification and characterization of neuronal mitogen-activated protein kinase substrates using a specific phosphomotif antibodyDieter Edbauer
The Picower Institute for Learning and Memory, Howard Hughes Medical Institute, RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Mol Cell Proteomics 8:681-95. 2009..Thus, phosphomotif-based affinity purification is a powerful approach to identify novel substrates of MAPKs in vivo and to reveal functionally significant phosphorylation events... - Role of Septin cytoskeleton in spine morphogenesis and dendrite development in neuronsTomoko Tada
The Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Curr Biol 17:1752-8. 2007..These data suggest that Sept7 is critical for spine morphogenesis and dendrite development during neuronal maturation... - Zinspy sensors with enhanced dynamic range for imaging neuronal cell zinc uptake and mobilizationElizabeth M Nolan
Department of Chemistry, Picower Institute of Learning and Memory, RIKEN-MIT Neuroscience Research Center, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Am Chem Soc 128:15517-28. 2006..ZS5 localizes to the mitochondria of HeLa cells and allows visualization of glutamate-mediated Zn(II) uptake in dendrites and Zn(II) release resulting from nitrosative stress in neurons... - Structure and different conformational states of native AMPA receptor complexesTerunaga Nakagawa
The Picower Center for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
Nature 433:545-9. 2005..These data provide a glimpse of the conformational changes of an important ligand-gated ion channel of the brain... - A critical role for myosin IIb in dendritic spine morphology and synaptic functionJubin Ryu
The Picower Institute for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Neuron 49:175-82. 2006..Thus, the structure and function of spines is regulated by an actin-based motor in addition to the polymerization state of actin... - ZP8, a neuronal zinc sensor with improved dynamic range; imaging zinc in hippocampal slices with two-photon microscopyChristopher J Chang
Department of Chemistry, Picower Center for Learning and Memory, RIKEN-MIT Neuroscience Research Center, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Inorg Chem 43:6774-9. 2004.... - Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95Heike Hering
Center for Learning and Memory, Howard Hughes Medical Institute, RIKEN MIT Neuroscience Research Center, and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue E18 215, Cambridge, MA 02139, USA
FEBS Lett 521:185-9. 2002.... - Molecular mechanisms of dendritic spine morphogenesisTomoko Tada
The Picower Institute for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA
Curr Opin Neurobiol 16:95-101. 2006..Numerous cell surface receptors, scaffold proteins and actin binding proteins are concentrated in spines and engaged in spine morphogenesis... - Bright fluorescent chemosensor platforms for imaging endogenous pools of neuronal zincChristopher J Chang
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Chem Biol 11:203-10. 2004..In addition to providing improved optical tools for Zn(2+) in the neurosciences, these results afford a rational starting point for creating superior fluorescent probes for biological applications... - Control of dendritic arborization by the phosphoinositide-3'-kinase-Akt-mammalian target of rapamycin pathwayJacek Jaworski
The Picower Institute for Learning and Memory, The Institute of Physical and Chemical Research (RIKEN, Massachusetts Institute of Technology Neuroscience Research Center, Cambridge, Massachusetts 02139, USA
J Neurosci 25:11300-12. 2005.... - Three-dimensional structure of an AMPA receptor without associated stargazin/TARP proteinsTerunaga Nakagawa
The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Biol Chem 387:179-87. 2006..In the absence of stargazin/TARP proteins, the density representing the transmembrane region of the AMPA-R particles is substantially smaller, corroborating our previous analysis that was based solely on projection images... - Polo-like kinases in the nervous systemDaniel P Seeburg
The Picower Center for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Oncogene 24:292-8. 2005.... - Midrange affinity fluorescent Zn(II) sensors of the Zinpyr family: syntheses, characterization, and biological imaging applicationsElizabeth M Nolan
Department of Chemistry, Picower Institute of Learning and Memory, RIKEN-MIT Neuroscience Research Center, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Inorg Chem 45:9748-57. 2006..Confocal microscopy studies indicate that such asymmetrical fluorescein-based probes are cell permeable and Zn(II) responsive in vivo...
Research Grants
- MOLECULAR ORGANIZATION OF CNS SYNAPSESMorgan Sheng; Fiscal Year: 2004..Because glutamate receptor function is intimately involved in brain synaptic function and excitotoxicity, this research may be relevant to human acute and chronic neurodegenerative disease and to psychiatric disorders. ..
- MOLECULAR ORGANIZATION OF CNS SYNAPSESMorgan Sheng; Fiscal Year: 2009..Together these aims will allow us to gain novel and fundamental insight into the molecular organization of NMDARs and their postsynaptic signaling pathways in central excitatory neurons. ..