Morgan H Sheng

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1
    Albert Y Hung
    The Institute of Physical and Chemical Research RIKEN Massachusetts Institute of Technology Neuroscience Research Center, Cambridge, Massachusetts 02139, USA
    J Neurosci 28:1697-708. 2008
  2. pmc Degradation of postsynaptic scaffold GKAP and regulation of dendritic spine morphology by the TRIM3 ubiquitin ligase in rat hippocampal neurons
    Albert Y Hung
    Departments of Brain and Cognitive Sciences and Biology, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 5:e9842. 2010
  3. pmc Regulation of postsynaptic RapGAP SPAR by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neurons
    Xiaolu L Ang
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 283:29424-32. 2008
  4. pmc A novel mechanism of hippocampal LTD involving muscarinic receptor-triggered interactions between AMPARs, GRIP and liprin-alpha
    Bryony A Dickinson
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology LINE, Faculty of Medicine and Dentistry, University of Bristol, Whitson Street, Bristol BS1 3NY, UK
    Mol Brain 2:18. 2009
  5. ncbi request reprint The postsynaptic architecture of excitatory synapses: a more quantitative view
    Morgan Sheng
    The Picower Institute for Learning and Memory, Howard Hughes Medical Institute, Departments of Brain and Cognitive Sciences, and Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Biochem 76:823-47. 2007
  6. ncbi request reprint AMPA receptor trafficking and synaptic plasticity: major unanswered questions
    Morgan Sheng
    Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139, USA
    Neurosci Res 46:127-34. 2003
  7. ncbi request reprint 15 years of neuron cell biology
    Morgan Sheng
    The Picower Center for Learning and Memory, Howard Hughes Medical Institute, RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 40:193-7. 2003
  8. ncbi request reprint Postsynaptic signaling and plasticity mechanisms
    Morgan Sheng
    Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 298:776-80. 2002
  9. ncbi request reprint Quaternary structure, protein dynamics, and synaptic function of SAP97 controlled by L27 domain interactions
    Terunaga Nakagawa
    The Picower Center for Learning and Memory, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Neuron 44:453-67. 2004
  10. ncbi request reprint Clathrin adaptor AP2 and NSF interact with overlapping sites of GluR2 and play distinct roles in AMPA receptor trafficking and hippocampal LTD
    Sang Hyoung Lee
    Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 36:661-74. 2002

Research Grants

  1. MOLECULAR ORGANIZATION OF CNS SYNAPSES
    Morgan Sheng; Fiscal Year: 2001
  2. MOLECULAR ORGANIZATION OF CNS SYNAPSES
    Morgan Sheng; Fiscal Year: 2002
  3. MOLECULAR ORGANIZATION OF CNS SYNAPSES
    Morgan Sheng; Fiscal Year: 2003
  4. MOLECULAR ORGANIZATION OF CNS SYNAPSES
    Morgan Sheng; Fiscal Year: 2004
  5. MOLECULAR ORGANIZATION OF CNS SYNAPSES
    Morgan Sheng; Fiscal Year: 2005
  6. MOLECULAR ORGANIZATION OF CNS SYNAPSES
    Morgan Sheng; Fiscal Year: 2006
  7. MOLECULAR ORGANIZATION OF CNS SYNAPSES
    Morgan Sheng; Fiscal Year: 2007
  8. MOLECULAR ORGANIZATION OF CNS SYNAPSES
    Morgan Sheng; Fiscal Year: 2009

Collaborators

Detail Information

Publications47

  1. pmc Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1
    Albert Y Hung
    The Institute of Physical and Chemical Research RIKEN Massachusetts Institute of Technology Neuroscience Research Center, Cambridge, Massachusetts 02139, USA
    J Neurosci 28:1697-708. 2008
    ....
  2. pmc Degradation of postsynaptic scaffold GKAP and regulation of dendritic spine morphology by the TRIM3 ubiquitin ligase in rat hippocampal neurons
    Albert Y Hung
    Departments of Brain and Cognitive Sciences and Biology, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 5:e9842. 2010
    ..RNAi of TRIM3 also prevented the loss of GKAP induced by synaptic activity. Thus, TRIM3 is a novel E3 ligase that mediates activity-dependent turnover of PSD scaffold proteins and is a negative regulator of dendritic spine morphology...
  3. pmc Regulation of postsynaptic RapGAP SPAR by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neurons
    Xiaolu L Ang
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 283:29424-32. 2008
    ..Our results identify a specific E3 ubiquitin ligase that mediates degradation of a key postsynaptic regulator of synaptic morphology and function...
  4. pmc A novel mechanism of hippocampal LTD involving muscarinic receptor-triggered interactions between AMPARs, GRIP and liprin-alpha
    Bryony A Dickinson
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology LINE, Faculty of Medicine and Dentistry, University of Bristol, Whitson Street, Bristol BS1 3NY, UK
    Mol Brain 2:18. 2009
    ..However, we find a distinct mechanism of LTD involving GRIP and liprin-alpha...
  5. ncbi request reprint The postsynaptic architecture of excitatory synapses: a more quantitative view
    Morgan Sheng
    The Picower Institute for Learning and Memory, Howard Hughes Medical Institute, Departments of Brain and Cognitive Sciences, and Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Biochem 76:823-47. 2007
    ..On the basis of such studies, a more quantitative and geometrically realistic view of PSD architecture is emerging...
  6. ncbi request reprint AMPA receptor trafficking and synaptic plasticity: major unanswered questions
    Morgan Sheng
    Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139, USA
    Neurosci Res 46:127-34. 2003
    ..In this update article, we try to highlight what we believe to be the major conceptual problems and unanswered questions in this rapidly moving field of neuroscience...
  7. ncbi request reprint 15 years of neuron cell biology
    Morgan Sheng
    The Picower Center for Learning and Memory, Howard Hughes Medical Institute, RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 40:193-7. 2003
  8. ncbi request reprint Postsynaptic signaling and plasticity mechanisms
    Morgan Sheng
    Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 298:776-80. 2002
    ..The complex molecular mechanisms that underlie postsynaptic signaling and plasticity are beginning to emerge...
  9. ncbi request reprint Quaternary structure, protein dynamics, and synaptic function of SAP97 controlled by L27 domain interactions
    Terunaga Nakagawa
    The Picower Center for Learning and Memory, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Neuron 44:453-67. 2004
    ..Thus SAP97 has a broader role than its close relative, PSD-95, in the maintenance of synaptic function...
  10. ncbi request reprint Clathrin adaptor AP2 and NSF interact with overlapping sites of GluR2 and play distinct roles in AMPA receptor trafficking and hippocampal LTD
    Sang Hyoung Lee
    Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 36:661-74. 2002
    ..NSF function, on the other hand, is needed to maintain synaptic AMPA receptor responses, but is not directly required for NMDA receptor-mediated internalization and LTD...
  11. ncbi request reprint Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroligin
    Kensuke Futai
    RIKEN MIT Neuroscience Research Center, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nat Neurosci 10:186-95. 2007
    ..Presynaptic beta-neurexin serves as a likely presynaptic mediator of this effect. Our results indicate that trans-synaptic protein-protein interactions can link postsynaptic and presynaptic function...
  12. ncbi request reprint LAR receptor protein tyrosine phosphatases in the development and maintenance of excitatory synapses
    Anthone W Dunah
    The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Cambridge, Massachusetts 02139, USA
    Nat Neurosci 8:458-67. 2005
    ..We propose that the cadherin-beta-catenin complex is cotransported with AMPA receptors to synapses and dendritic spines by a mechanism that involves binding of liprin-alpha to LAR-RPTP and tyrosine dephosphorylation by LAR-RPTP...
  13. ncbi request reprint Lipid rafts in the maintenance of synapses, dendritic spines, and surface AMPA receptor stability
    Heike Hering
    Picower Center for Learning and Memory, Howard Hughes Medical Institute, and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 23:3262-71. 2003
    ..2001) and offers a potential link between disordered cholesterol metabolism and the synapse loss seen in neurodegenerative disease...
  14. ncbi request reprint The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses
    Zheng Li
    The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 119:873-87. 2004
    ..Reciprocally, synaptic activity modulates the motility and fusion/fission balance of mitochondria and controls mitochondrial distribution in dendrites...
  15. ncbi request reprint Subunit rules governing the sorting of internalized AMPA receptors in hippocampal neurons
    Sang Hyoung Lee
    The Picower Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge 02139, USA
    Neuron 43:221-36. 2004
    ..Thus, GluR2 is a key subunit that controls recycling and degradation of AMPA receptors after internalization...
  16. ncbi request reprint Activity-dependent redistribution and essential role of cortactin in dendritic spine morphogenesis
    Heike Hering
    The Picower Center for Learning and Memory, Howard Hughes Medical Institute, RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 23:11759-69. 2003
    ....
  17. ncbi request reprint GRIP1 controls dendrite morphogenesis by regulating EphB receptor trafficking
    Casper C Hoogenraad
    The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Cambridge, Massachusetts 02139, USA
    Nat Neurosci 8:906-15. 2005
    ..These results indicate an important role for GRIP1 in dendrite morphogenesis by serving as an adaptor protein for kinesin-dependent transport of EphB receptors to dendrites...
  18. ncbi request reprint Liprinalpha1 degradation by calcium/calmodulin-dependent protein kinase II regulates LAR receptor tyrosine phosphatase distribution and dendrite development
    Casper C Hoogenraad
    The Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Dev Cell 12:587-602. 2007
    ..Thus, regulated degradation of liprinalpha1 is important for proper LAR receptor distribution, and could provide a mechanism for localized control of dendrite and synapse morphogenesis by activity and CaMKII...
  19. pmc Activity-induced Polo-like kinase 2 is required for homeostatic plasticity of hippocampal neurons during epileptiform activity
    Daniel P Seeburg
    The Picower Institute for Learning and Memory, RIKEN Massachusetts Institute of Technology Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 28:6583-91. 2008
    ..Thus, Plk2 function is required to prevent escalating potentiation and maintain synapses in a plastic state during epileptiform activity in hippocampal slice cultures...
  20. pmc Critical role of CDK5 and Polo-like kinase 2 in homeostatic synaptic plasticity during elevated activity
    Daniel P Seeburg
    The Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 58:571-83. 2008
    ....
  21. ncbi request reprint Synaptic accumulation of PSD-95 and synaptic function regulated by phosphorylation of serine-295 of PSD-95
    Myung Jong Kim
    The Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 56:488-502. 2007
    ..The data suggest that synaptic strength can be regulated by phosphorylation-dephosphorylation of ser-295 of PSD-95 and that synaptic depression requires the dephosphorylation of ser-295...
  22. doi request reprint Autophosphorylated CaMKIIalpha acts as a scaffold to recruit proteasomes to dendritic spines
    Baris Bingol
    The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences and Biology, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Cell 140:567-78. 2010
    ..Our findings reveal a scaffolding role of postsynaptic CaMKIIalpha in activity-dependent proteasome redistribution, which is commensurate with the great abundance of CaMKIIalpha in synapses...
  23. doi request reprint Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132
    Dieter Edbauer
    The Picower Institute for Learning and Memory, Departments of Brain and Cognitive Sciences and Biology, Massachusetts Institute of Technology, Cambridge, MA 02319, USA
    Neuron 65:373-84. 2010
    ..Because NMDA receptor subunit composition profoundly affects synaptic plasticity, these observations have implications for the pathophysiology of fragile X syndrome, in which plasticity is altered...
  24. ncbi request reprint Differential roles of NR2A- and NR2B-containing NMDA receptors in Ras-ERK signaling and AMPA receptor trafficking
    Myung Jong Kim
    The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Neuron 46:745-60. 2005
    ..Preferential coupling of NR2B to SynGAP could explain the subtype-specific function of NR2B-NMDARs in inhibition of Ras-ERK, removal of synaptic AMPARs, and weakening of synaptic transmission...
  25. ncbi request reprint Targeted protein degradation and synapse remodeling by an inducible protein kinase
    Daniel T S Pak
    Picower Center for Learning and Memory, RIKEN Massachusetts Institute of Technology MIT Neuroscience Research Center, Howard Hughes Medical Institute, MIT, Cambridge, MA 02139, USA
    Science 302:1368-73. 2003
    ..These results implicate SNK as a mediator of activity-dependent change in the molecular composition and morphology of synapses...
  26. ncbi request reprint Some assembly required: the development of neuronal synapses
    Zheng Li
    The Picower Center for Learning and Memory, RIKEN Massachusetts Institute of Technology Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Nat Rev Mol Cell Biol 4:833-41. 2003
  27. ncbi request reprint Neuroscience. Making synapses: a balancing act
    Natasha K Hussain
    Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 307:1207-8. 2005
  28. pmc MINK and TNIK differentially act on Rap2-mediated signal transduction to regulate neuronal structure and AMPA receptor function
    Natasha K Hussain
    Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 30:14786-94. 2010
    ..MINK appears to antagonize Rap2 signal transduction by binding to activated Rap2. We suggest that MINK interaction with Rap2 plays a critical role in maintaining the morphological integrity of dendrites and synaptic transmission...
  29. ncbi request reprint The dynamic turnover and functional roles of alpha-actinin in dendritic spines
    Terunaga Nakagawa
    The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room E18 215, Cambridge, MA 02139 4301, USA
    Neuropharmacology 47:734-45. 2004
    ..These results suggest that alpha-actinin regulates spine morphology and density...
  30. pmc Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization
    Zheng Li
    The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 141:859-71. 2010
    ..NMDA receptor stimulation that induces LTD transiently activates caspase-3 in dendrites, without causing cell death. These data indicate an unexpected causal link between the molecular mechanisms of apoptosis and LTD...
  31. ncbi request reprint Generation of lentiviral transgenic rats expressing glutamate receptor interacting protein 1 (GRIP1) in brain, spinal cord and testis
    Terunaga Nakagawa
    The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, 77 Massachusetts Avenue E18 215, Cambridge, MA 02139, USA
    J Neurosci Methods 152:1-9. 2006
    ..Tissue specific lentiviral transgenic rats will be a powerful tool for various applications in modern neuroscience...
  32. pmc Eye opening induces a rapid dendritic localization of PSD-95 in central visual neurons
    Akira Yoshii
    Department of Biology, Center for Learning and Memory, McGovern Institute for Brain Research, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 4307, USA
    Proc Natl Acad Sci U S A 100:1334-9. 2003
    ....
  33. ncbi request reprint Proline-rich tyrosine kinase 2 regulates hippocampal long-term depression
    Honor Hsin
    Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 30:11983-93. 2010
    ..Overexpression of PYK2 depresses NMDA-induced ERK phosphorylation and inhibits LTP, but not LTD. Our data indicate that PYK2 is critical for the induction of LTD, possibly in part by antagonizing ERK signaling in hippocampal neurons...
  34. pmc Constitutively active Rap2 transgenic mice display fewer dendritic spines, reduced extracellular signal-regulated kinase signaling, enhanced long-term depression, and impaired spatial learning and fear extinction
    Jubin Ryu
    The Picower Institute for Learning and Memory, RIKEN Massachusetts Institute of Technology Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 28:8178-88. 2008
    ..The findings also implicate Rap2 signaling in fear extinction mechanisms, which are thought to be aberrant in anxiety disorders and posttraumatic stress disorder...
  35. pmc Identification and characterization of neuronal mitogen-activated protein kinase substrates using a specific phosphomotif antibody
    Dieter Edbauer
    The Picower Institute for Learning and Memory, Howard Hughes Medical Institute, RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Mol Cell Proteomics 8:681-95. 2009
    ..Thus, phosphomotif-based affinity purification is a powerful approach to identify novel substrates of MAPKs in vivo and to reveal functionally significant phosphorylation events...
  36. pmc Role of Septin cytoskeleton in spine morphogenesis and dendrite development in neurons
    Tomoko Tada
    The Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Curr Biol 17:1752-8. 2007
    ..These data suggest that Sept7 is critical for spine morphogenesis and dendrite development during neuronal maturation...
  37. ncbi request reprint Structure and different conformational states of native AMPA receptor complexes
    Terunaga Nakagawa
    The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nature 433:545-9. 2005
    ..These data provide a glimpse of the conformational changes of an important ligand-gated ion channel of the brain...
  38. pmc Zinspy sensors with enhanced dynamic range for imaging neuronal cell zinc uptake and mobilization
    Elizabeth M Nolan
    Department of Chemistry, Picower Institute of Learning and Memory, RIKEN MIT Neuroscience Research Center, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 128:15517-28. 2006
    ..ZS5 localizes to the mitochondria of HeLa cells and allows visualization of glutamate-mediated Zn(II) uptake in dendrites and Zn(II) release resulting from nitrosative stress in neurons...
  39. ncbi request reprint A critical role for myosin IIb in dendritic spine morphology and synaptic function
    Jubin Ryu
    The Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Neuron 49:175-82. 2006
    ..Thus, the structure and function of spines is regulated by an actin-based motor in addition to the polymerization state of actin...
  40. ncbi request reprint ZP8, a neuronal zinc sensor with improved dynamic range; imaging zinc in hippocampal slices with two-photon microscopy
    Christopher J Chang
    Department of Chemistry, Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Inorg Chem 43:6774-9. 2004
    ....
  41. ncbi request reprint Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95
    Heike Hering
    Center for Learning and Memory, Howard Hughes Medical Institute, RIKEN MIT Neuroscience Research Center, and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue E18 215, Cambridge, MA 02139, USA
    FEBS Lett 521:185-9. 2002
    ....
  42. ncbi request reprint Molecular mechanisms of dendritic spine morphogenesis
    Tomoko Tada
    The Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA
    Curr Opin Neurobiol 16:95-101. 2006
    ..Numerous cell surface receptors, scaffold proteins and actin binding proteins are concentrated in spines and engaged in spine morphogenesis...
  43. ncbi request reprint Bright fluorescent chemosensor platforms for imaging endogenous pools of neuronal zinc
    Christopher J Chang
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Chem Biol 11:203-10. 2004
    ..In addition to providing improved optical tools for Zn(2+) in the neurosciences, these results afford a rational starting point for creating superior fluorescent probes for biological applications...
  44. ncbi request reprint Three-dimensional structure of an AMPA receptor without associated stargazin/TARP proteins
    Terunaga Nakagawa
    The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Biol Chem 387:179-87. 2006
    ..In the absence of stargazin/TARP proteins, the density representing the transmembrane region of the AMPA-R particles is substantially smaller, corroborating our previous analysis that was based solely on projection images...
  45. pmc Midrange affinity fluorescent Zn(II) sensors of the Zinpyr family: syntheses, characterization, and biological imaging applications
    Elizabeth M Nolan
    Department of Chemistry, Picower Institute of Learning and Memory, RIKEN MIT Neuroscience Research Center, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Inorg Chem 45:9748-57. 2006
    ..Confocal microscopy studies indicate that such asymmetrical fluorescein-based probes are cell permeable and Zn(II) responsive in vivo...
  46. ncbi request reprint Polo-like kinases in the nervous system
    Daniel P Seeburg
    The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Oncogene 24:292-8. 2005
    ....
  47. ncbi request reprint Control of dendritic arborization by the phosphoinositide-3'-kinase-Akt-mammalian target of rapamycin pathway
    Jacek Jaworski
    The Picower Institute for Learning and Memory, The Institute of Physical and Chemical Research RIKEN, Massachusetts Institute of Technology Neuroscience Research Center, Cambridge, Massachusetts 02139, USA
    J Neurosci 25:11300-12. 2005
    ....

Research Grants9

  1. MOLECULAR ORGANIZATION OF CNS SYNAPSES
    Morgan Sheng; Fiscal Year: 2001
    ..Because glutamate receptor function is intimately involved in brain synaptic function and excitotoxicity, this research may be relevant to human acute and chronic neurodegenerative disease and to psychiatric disorders. ..
  2. MOLECULAR ORGANIZATION OF CNS SYNAPSES
    Morgan Sheng; Fiscal Year: 2002
    ..Because glutamate receptor function is intimately involved in brain synaptic function and excitotoxicity, this research may be relevant to human acute and chronic neurodegenerative disease and to psychiatric disorders. ..
  3. MOLECULAR ORGANIZATION OF CNS SYNAPSES
    Morgan Sheng; Fiscal Year: 2003
    ..Because glutamate receptor function is intimately involved in brain synaptic function and excitotoxicity, this research may be relevant to human acute and chronic neurodegenerative disease and to psychiatric disorders. ..
  4. MOLECULAR ORGANIZATION OF CNS SYNAPSES
    Morgan Sheng; Fiscal Year: 2004
    ..Because glutamate receptor function is intimately involved in brain synaptic function and excitotoxicity, this research may be relevant to human acute and chronic neurodegenerative disease and to psychiatric disorders. ..
  5. MOLECULAR ORGANIZATION OF CNS SYNAPSES
    Morgan Sheng; Fiscal Year: 2005
    ..Together these aims will allow us to gain novel and fundamental insight into the molecular organization of NMDARs and their postsynaptic signaling pathways in central excitatory neurons. ..
  6. MOLECULAR ORGANIZATION OF CNS SYNAPSES
    Morgan Sheng; Fiscal Year: 2006
    ..Together these aims will allow us to gain novel and fundamental insight into the molecular organization of NMDARs and their postsynaptic signaling pathways in central excitatory neurons. ..
  7. MOLECULAR ORGANIZATION OF CNS SYNAPSES
    Morgan Sheng; Fiscal Year: 2007
    ..Together these aims will allow us to gain novel and fundamental insight into the molecular organization of NMDARs and their postsynaptic signaling pathways in central excitatory neurons. ..
  8. MOLECULAR ORGANIZATION OF CNS SYNAPSES
    Morgan Sheng; Fiscal Year: 2009
    ..Together these aims will allow us to gain novel and fundamental insight into the molecular organization of NMDARs and their postsynaptic signaling pathways in central excitatory neurons. ..