Jason M Sheltzer

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Elite male faculty in the life sciences employ fewer women
    Jason M Sheltzer
    David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 and
    Proc Natl Acad Sci U S A 111:10107-12. 2014
  2. pmc Transcriptional consequences of aneuploidy
    Jason M Sheltzer
    David H Koch Institute for Integrative Cancer Research and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 109:12644-9. 2012
  3. doi request reprint Mitotic entry in the presence of DNA damage is a widespread property of aneuploidy in yeast
    Heidi M Blank
    Koch Institute for Integrative Cancer Research, Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139
    Mol Biol Cell 26:1440-51. 2015
  4. pmc A transcriptional and metabolic signature of primary aneuploidy is present in chromosomally unstable cancer cells and informs clinical prognosis
    Jason M Sheltzer
    Author s Affiliation David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts
    Cancer Res 73:6401-12. 2013
  5. pmc Aneuploidy drives genomic instability in yeast
    Jason M Sheltzer
    David H Koch Institute for Integrative Cancer Research and Howard Hughes Medical Institute HHMI, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 333:1026-30. 2011
  6. pmc The aneuploidy paradox: costs and benefits of an incorrect karyotype
    Jason M Sheltzer
    David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Trends Genet 27:446-53. 2011

Collaborators

Detail Information

Publications6

  1. pmc Elite male faculty in the life sciences employ fewer women
    Jason M Sheltzer
    David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 and
    Proc Natl Acad Sci U S A 111:10107-12. 2014
    ..Thus, one cause of the leaky pipeline in biomedical research may be the exclusion of women, or their self-selected absence, from certain high-achieving laboratories...
  2. pmc Transcriptional consequences of aneuploidy
    Jason M Sheltzer
    David H Koch Institute for Integrative Cancer Research and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 109:12644-9. 2012
    ....
  3. doi request reprint Mitotic entry in the presence of DNA damage is a widespread property of aneuploidy in yeast
    Heidi M Blank
    Koch Institute for Integrative Cancer Research, Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139
    Mol Biol Cell 26:1440-51. 2015
    ..Our results indicate that by causing low levels of DNA damage, whole-chromosome aneuploidies lead to DNA breaks that persist into mitosis. Such breaks provide the substrate for translocations and deletions that are a hallmark of cancer. ..
  4. pmc A transcriptional and metabolic signature of primary aneuploidy is present in chromosomally unstable cancer cells and informs clinical prognosis
    Jason M Sheltzer
    Author s Affiliation David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts
    Cancer Res 73:6401-12. 2013
    ....
  5. pmc Aneuploidy drives genomic instability in yeast
    Jason M Sheltzer
    David H Koch Institute for Integrative Cancer Research and Howard Hughes Medical Institute HHMI, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 333:1026-30. 2011
    ..Aneuploid fission yeast strains also exhibited defects in mitotic recombination. Aneuploidy-induced genomic instability could facilitate the development of genetic alterations that drive malignant growth in cancer...
  6. pmc The aneuploidy paradox: costs and benefits of an incorrect karyotype
    Jason M Sheltzer
    David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Trends Genet 27:446-53. 2011
    ....