Amanda M Shearman

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi request reprint Evidence for a gene influencing the TG/HDL-C ratio on chromosome 7q32.3-qter: a genome-wide scan in the Framingham study
    A M Shearman
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Hum Mol Genet 9:1315-20. 2000
  2. ncbi request reprint Estrogen receptor alpha gene variation is associated with risk of myocardial infarction in more than seven thousand men from five cohorts
    Amanda M Shearman
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Circ Res 98:590-2. 2006
  3. ncbi request reprint Oestrogen receptor genetics: a needle that cuts through many haystacks?
    Amanda M Shearman
    Eur Heart J 27:1519-20. 2006
  4. ncbi request reprint Association between estrogen receptor alpha gene variation and cardiovascular disease
    Amanda M Shearman
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Mass 02139, USA
    JAMA 290:2263-70. 2003
  5. ncbi request reprint Tobacco smoking, estrogen receptor alpha gene variation and small low density lipoprotein level
    Amanda M Shearman
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Hum Mol Genet 14:2405-13. 2005
  6. ncbi request reprint Estrogen receptor alpha gene variation and the risk of stroke
    Amanda M Shearman
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
    Stroke 36:2281-2. 2005
  7. ncbi request reprint Variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in the Framingham Heart Study
    Inga Peter
    Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Massachusetts Institute of Technology, Cambridge, MA, USA
    J Hypertens 23:2193-200. 2005
  8. ncbi request reprint Estrogen receptor beta polymorphisms are associated with bone mass in women and men: the Framingham Study
    Amanda M Shearman
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    J Bone Miner Res 19:773-81. 2004
  9. ncbi request reprint Association of estrogen receptor beta gene polymorphisms with left ventricular mass and wall thickness in women
    Inga Peter
    Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Am J Hypertens 18:1388-95. 2005
  10. ncbi request reprint Sex-specific association between estrogen receptor-alpha gene variation and measures of adiposity: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702, USA
    J Clin Endocrinol Metab 90:6257-62. 2005

Detail Information

Publications14

  1. ncbi request reprint Evidence for a gene influencing the TG/HDL-C ratio on chromosome 7q32.3-qter: a genome-wide scan in the Framingham study
    A M Shearman
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Hum Mol Genet 9:1315-20. 2000
    ..5 at 70 cM, LOD score for log(TG/HDL-C) = 1.1 at 75 cM] and chromosome 20 [LOD score for log(TG/HDL-C) = 1.7 at 35 cM, LOD score for log(TG) = 1.3 at 40 cM]. These results identify loci worthy of further study...
  2. ncbi request reprint Estrogen receptor alpha gene variation is associated with risk of myocardial infarction in more than seven thousand men from five cohorts
    Amanda M Shearman
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Circ Res 98:590-2. 2006
    ..44; P<0.0001), after adjustment for established cardiovascular risk factors. After exclusion of younger subjects from 2 cohorts, because of age interaction, the odds ratio increased (to 1.63)...
  3. ncbi request reprint Oestrogen receptor genetics: a needle that cuts through many haystacks?
    Amanda M Shearman
    Eur Heart J 27:1519-20. 2006
  4. ncbi request reprint Association between estrogen receptor alpha gene variation and cardiovascular disease
    Amanda M Shearman
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Mass 02139, USA
    JAMA 290:2263-70. 2003
    ..Relatively little is known, however, about the impact of genetic variation in estrogen receptor alpha (ESR1) on CVD risk...
  5. ncbi request reprint Tobacco smoking, estrogen receptor alpha gene variation and small low density lipoprotein level
    Amanda M Shearman
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Hum Mol Genet 14:2405-13. 2005
    ..454-397 T and c.454-351 A alleles with increased myocardial infarction and ischaemic heart disease, independent of the standard, established cardiovascular risk factors...
  6. ncbi request reprint Estrogen receptor alpha gene variation and the risk of stroke
    Amanda M Shearman
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
    Stroke 36:2281-2. 2005
    ..Given that there is a significantly higher risk of myocardial infarction among men with the CC genotype (PP of PvuII) of c.454-397T>C (rs2234693), we asked whether this genotype is associated with a higher risk of stroke...
  7. ncbi request reprint Variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in the Framingham Heart Study
    Inga Peter
    Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Massachusetts Institute of Technology, Cambridge, MA, USA
    J Hypertens 23:2193-200. 2005
    ..To examine the association between variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in men and women...
  8. ncbi request reprint Estrogen receptor beta polymorphisms are associated with bone mass in women and men: the Framingham Study
    Amanda M Shearman
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    J Bone Miner Res 19:773-81. 2004
    ..This was investigated in 723 men and 795 women from the Framingham study. Results show association of variation in this gene with BMD in both women and men...
  9. ncbi request reprint Association of estrogen receptor beta gene polymorphisms with left ventricular mass and wall thickness in women
    Inga Peter
    Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Am J Hypertens 18:1388-95. 2005
    ..Given sex-based differences in cardiac structure and remodeling, we hypothesized that variation in estrogen pathway genes might be associated with alteration of LV structure...
  10. ncbi request reprint Sex-specific association between estrogen receptor-alpha gene variation and measures of adiposity: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702, USA
    J Clin Endocrinol Metab 90:6257-62. 2005
    ..Polymorphisms in estrogen receptor-alpha (ESR1) may be associated with variation in body mass index and waist circumference. However, most prior studies have been limited by sample size and power...
  11. ncbi request reprint Estrogen receptor-alpha variants are associated with lipoprotein size distribution and particle levels in women: the Framingham Heart Study
    Serkalem Demissie
    Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, TE425 Boston, MA 02118, USA
    Atherosclerosis 185:210-8. 2006
    ..30T-c.454-397T-c.454-351A haplotype (frequency, 46%), where L and S are long and short TA repeats. Our results suggest that common ESR1 polymorphisms have a significant effect on lipoprotein metabolism in women...
  12. ncbi request reprint Age-related changes in echocardiographic measurements: association with variation in the estrogen receptor-alpha gene
    Inga Peter
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, MA 02111, USA
    Hypertension 49:1000-6. 2007
    ..Understanding the mechanisms predisposing to unfavorable LV remodeling of the heart with advancing age may aid in the discovery of new therapeutic targets for the prevention of heart failure...
  13. ncbi request reprint Genome-wide linkage analyses and candidate gene fine mapping for HDL3 cholesterol: the Framingham Study
    Qiong Yang
    Department of Biostatistics, Boston University, Boston, MA 02118, USA
    J Lipid Res 46:1416-25. 2005
    ..03). Further study of the linkage region and exploration of other variants in PLAGL1 are warranted to define the potential functional variants of HDL-C metabolism...
  14. ncbi request reprint Fine mapping of the Schnyder's crystalline corneal dystrophy locus
    Veena Theendakara
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Hum Genet 114:594-600. 2004
    ..32 Mbp between markers D1S1160 and D1S1635. Within this interval, identity-by-state was present in all 13 families for two markers D1S244 and D1S3153, further refining the candidate region to 1.58 Mbp...