Nancy A Shadick

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Hypogalactosylation of serum N-glycans fails to predict clinical response to methotrexate and TNF inhibition in rheumatoid arthritis
    Altan Ercan
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, One Jimmy Fund Way, Smith 516C, Boston, MA 02115 USA
    Arthritis Res Ther 14:R43. 2012
  2. pmc Low-dose aspirin in the primary prevention of rheumatoid arthritis: the Women's Health Study
    Nancy A Shadick
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Care Res (Hoboken) 62:545-50. 2010
  3. ncbi request reprint C-reactive protein in the prediction of rheumatoid arthritis in women
    Nancy A Shadick
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 166:2490-4. 2006
  4. pmc Opposing effects of the D70 mutation and the shared epitope in HLA-DR4 on disease activity and certain disease phenotypes in rheumatoid arthritis
    N A Shadick
    Division of Rheumatology, Immunology, Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Ann Rheum Dis 66:1497-502. 2007
  5. pmc Pain persists in DAS28 rheumatoid arthritis remission but not in ACR/EULAR remission: a longitudinal observational study
    Yvonne C Lee
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, 75 Francis Street, PBB B3, Boston, MA, USA
    Arthritis Res Ther 13:R83. 2011
  6. pmc Biomarkers of inflammation and development of rheumatoid arthritis in women from two prospective cohort studies
    Elizabeth W Karlson
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Arthritis Rheum 60:641-52. 2009
  7. pmc Clinical predictors of erosion-free status in rheumatoid arthritis: a prospective cohort study
    Katherine P Liao
    Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    Rheumatology (Oxford) 50:1473-9. 2011
  8. doi request reprint Remission and radiographic outcome in rheumatoid arthritis: application of the 2011 ACR/EULAR remission criteria in an observational cohort
    Siri Lillegraven
    Division of Rheumatology Section of Clinical Sciences, Alumnae Hall Room 305, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Ann Rheum Dis 71:681-6. 2012
  9. doi request reprint Using genetic and clinical data to understand response to disease-modifying anti-rheumatic drug therapy: data from the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study
    Christine K Iannaccone
    Department of Medicine, Brigham and Women s Hospital, PBB B3, 75 Francis Street, Boston, MA 02115, USA
    Rheumatology (Oxford) 50:40-6. 2011
  10. pmc Sustained rheumatoid arthritis remission is uncommon in clinical practice
    Femke H M Prince
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Arthritis Res Ther 14:R68. 2012

Detail Information

Publications39

  1. pmc Hypogalactosylation of serum N-glycans fails to predict clinical response to methotrexate and TNF inhibition in rheumatoid arthritis
    Altan Ercan
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, One Jimmy Fund Way, Smith 516C, Boston, MA 02115 USA
    Arthritis Res Ther 14:R43. 2012
    ..We examined whether a proxy measure for galactosylation of IgG N-glycans could predict response to therapy or was differentially affected by methotrexate (MTX) or TNF blockade...
  2. pmc Low-dose aspirin in the primary prevention of rheumatoid arthritis: the Women's Health Study
    Nancy A Shadick
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Care Res (Hoboken) 62:545-50. 2010
    ..Previous randomized trial data have demonstrated a beneficial effect of low-dose aspirin in reducing other inflammatory diseases, such as asthma and colorectal adenomas, but no trial has evaluated the role of aspirin in RA prevention...
  3. ncbi request reprint C-reactive protein in the prediction of rheumatoid arthritis in women
    Nancy A Shadick
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 166:2490-4. 2006
    ..The purpose of this study was to examine whether levels of C-reactive protein (CRP), a sensitive marker of disease activity in rheumatoid arthritis (RA), are associated with increased risk of subsequent RA...
  4. pmc Opposing effects of the D70 mutation and the shared epitope in HLA-DR4 on disease activity and certain disease phenotypes in rheumatoid arthritis
    N A Shadick
    Division of Rheumatology, Immunology, Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Ann Rheum Dis 66:1497-502. 2007
    ....
  5. pmc Pain persists in DAS28 rheumatoid arthritis remission but not in ACR/EULAR remission: a longitudinal observational study
    Yvonne C Lee
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, 75 Francis Street, PBB B3, Boston, MA, USA
    Arthritis Res Ther 13:R83. 2011
    ..We assessed the prevalence of pain in RA patients in remission according to the Disease Activity Score (DAS28-CRP4) and the American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) remission criteria...
  6. pmc Biomarkers of inflammation and development of rheumatoid arthritis in women from two prospective cohort studies
    Elizabeth W Karlson
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Arthritis Rheum 60:641-52. 2009
    ..To examine the association of biomarkers of inflammation with preclinical rheumatoid arthritis (RA)...
  7. pmc Clinical predictors of erosion-free status in rheumatoid arthritis: a prospective cohort study
    Katherine P Liao
    Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    Rheumatology (Oxford) 50:1473-9. 2011
    ..Our objective was to characterize the group of RA patients without erosions and identify its clinical predictors...
  8. doi request reprint Remission and radiographic outcome in rheumatoid arthritis: application of the 2011 ACR/EULAR remission criteria in an observational cohort
    Siri Lillegraven
    Division of Rheumatology Section of Clinical Sciences, Alumnae Hall Room 305, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Ann Rheum Dis 71:681-6. 2012
    ....
  9. doi request reprint Using genetic and clinical data to understand response to disease-modifying anti-rheumatic drug therapy: data from the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study
    Christine K Iannaccone
    Department of Medicine, Brigham and Women s Hospital, PBB B3, 75 Francis Street, Boston, MA 02115, USA
    Rheumatology (Oxford) 50:40-6. 2011
    ....
  10. pmc Sustained rheumatoid arthritis remission is uncommon in clinical practice
    Femke H M Prince
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Arthritis Res Ther 14:R68. 2012
    ..Remission is an important goal of therapy in rheumatoid arthritis (RA), but data on duration of remission are lacking. Our objective was to describe the duration of remission in RA, assessed by different criteria...
  11. pmc Performance of matrix-based risk models for rapid radiographic progression in a cohort of patients with established rheumatoid arthritis
    Siri Lillegraven
    Brigham and Women s Hospital, Boston, Massachusetts Diakonhjemmet Hospital, Oslo, Norway
    Arthritis Care Res (Hoboken) 65:526-33. 2013
    ..We tested the performance of 3 risk models for RRP in an observational cohort...
  12. pmc Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy
    Jing Cui
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Rheum 62:1849-61. 2010
    ..The aim of the present study was to test established RA genetic risk factors to determine whether the same alleles also influence the response to anti-TNF therapy...
  13. pmc Predictors of discontinuation of tumor necrosis factor inhibitors in patients with rheumatoid arthritis
    Sandeep K Agarwal
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Rheumatol 35:1737-44. 2008
    ..Our goal was to determine the discontinuation rate of TNF inhibitors and identify predictors associated with discontinuation...
  14. pmc Investigation of candidate polymorphisms and disease activity in rheumatoid arthritis patients on methotrexate
    Yvonne C Lee
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Rheumatology (Oxford) 48:613-7. 2009
    ..We examined the association between candidate single nucleotide polymorphisms (SNPs) and disease activity in RA patients on MTX...
  15. pmc Genome-wide association study of determinants of anti-cyclic citrullinated peptide antibody titer in adults with rheumatoid arthritis
    Jing Cui
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Med 15:136-43. 2009
    ..We identified a SNP in moderate linkage disequilibrium (LD) with HLA-DR3, which may influence anti-CCP titer independently of the HLA-SE...
  16. ncbi request reprint Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
    Eli A Stahl
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Nat Genet 42:508-14. 2010
    ..An additional 11 SNPs replicated at P < 0.05, many of which are validated autoimmune risk alleles, suggesting that most represent genuine rheumatoid arthritis risk alleles...
  17. pmc Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis
    Jing Cui
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 9:e1003394. 2013
    ..These findings support a model in which CD84 genotypes and/or expression may serve as a useful biomarker for response to etanercept treatment in RA patients of European ancestry...
  18. pmc Vitamin E in the primary prevention of rheumatoid arthritis: the Women's Health Study
    Elizabeth W Karlson
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arthritis Rheum 59:1589-95. 2008
    ..Vitamin E supplements may reduce the risk of developing rheumatoid arthritis (RA) through antioxidant effects. Although previous observational studies have investigated this question, no randomized trial data are available...
  19. ncbi request reprint Aberrant IgG galactosylation precedes disease onset, correlates with disease activity, and is prevalent in autoantibodies in rheumatoid arthritis
    Altan Ercan
    Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Rheum 62:2239-48. 2010
    ..To examine the association between aberrant IgG galactosylation and disease parameters in rheumatoid arthritis (RA)...
  20. pmc Hand bone mineral density is associated with both total hip and lumbar spine bone mineral density in post-menopausal women with RA
    Sonali P Desai
    Brigham and Women s Hospital, PBB B3, Boston, MA 02115, USA
    Rheumatology (Oxford) 49:513-9. 2010
    ..RA is associated with localized bone loss in the hands, as well as generalized osteoporosis. We evaluated the relationship between hand digital X-ray radiogrammetry BMD (DXR-BMD) and total hip and lumbar spine BMD...
  21. pmc Automatic prediction of rheumatoid arthritis disease activity from the electronic medical records
    Chen Lin
    Informatics Program, Boston Children s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 8:e69932. 2013
    ..We cast the problem as a document classification task where the feature space includes concepts from the clinical narrative and lab values as stored in the Electronic Medical Record...
  22. pmc Associations of smoking and alcohol consumption with disease activity and functional status in rheumatoid arthritis
    Bing Lu
    From the Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital Harvard Medical School Division of Rheumatology, Boston University Medical Center, Boston, Massachusetts, USA
    J Rheumatol 41:24-30. 2014
    ..To investigate the associations of smoking and alcohol consumption with disease activity and functional status in rheumatoid arthritis (RA)...
  23. ncbi request reprint Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate
    Alex Parker
    Millennium Pharmaceuticals Inc, Cambridge, Massachusetts, USA
    J Rheumatol 34:1817-22. 2007
    ..We analyzed association of gene expression with disease activity, rheumatoid factor (RF), age, sex, disease duration, treatment modality, and clinical response...
  24. doi request reprint Behavioral and attitudes survey about Lyme disease among a Brazilian population in the endemic area of Martha's Vineyard, Massachusetts
    Jenny E Heller
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    J Immigr Minor Health 12:377-83. 2010
    ..Forty-one percent did not think LD posed a risk, while 79% were not sure they could recognize symptoms. Accordingly, the population as a whole reported taking few precautions...
  25. doi request reprint Erroneous augmentation of multiplex assay measurements in patients with rheumatoid arthritis due to heterophilic binding by serum rheumatoid factor
    Derrick J Todd
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Arthritis Rheum 63:894-903. 2011
    ..The purpose of this study was to assess whether these factors confound multiplex-based immunoassays, which are used with increasing frequency to measure cytokine and chemokine analytes in patients with rheumatoid arthritis (RA)...
  26. ncbi request reprint Dietary caffeine intake does not affect methotrexate efficacy in patients with rheumatoid arthritis
    Elizabeth Benito-Garcia
    Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Rheumatol 33:1275-81. 2006
    ..We investigated whether patients with RA taking MTX with a higher dietary caffeine intake have a worse clinical response to MTX than those with a lower intake...
  27. pmc Prospective cohort study of breast implants and the risk of connective-tissue diseases
    I Min Lee
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Int J Epidemiol 40:230-8. 2011
    ..Because of limitations inherent to the retrospective cohort study design, we sought clarification by conducting a prospective cohort study of the association of breast implants with CTD risk...
  28. pmc Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk
    Soumya Raychaudhuri
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Nat Genet 41:1313-8. 2009
    ..0008 replication, P = 4 x 10(-6) overall) and FCGR2A (rs12746613, P = 0.0022 replication, P = 2 x 10(-5) overall). Many of these loci are also associated to other immunologic diseases...
  29. pmc Validity of self-report of infections in a longitudinal cohort of patients with rheumatoid arthritis differs by source of report and infection severity
    Julia F Simard
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    J Clin Epidemiol 63:1358-62. 2010
    ..We evaluated and compared the validity of patients' and rheumatologists' reports of infection with those confirmed by medical record review...
  30. pmc Two independent alleles at 6q23 associated with risk of rheumatoid arthritis
    Robert M Plenge
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 39:1477-82. 2007
    ..We show that these two SNP associations are statistically independent, are each reproducible in the comparison of our data and WTCCC data, and define risk and protective haplotypes for rheumatoid arthritis at 6q23...
  31. pmc Associations between human leukocyte antigen, PTPN22, CTLA4 genotypes and rheumatoid arthritis phenotypes of autoantibody status, age at diagnosis and erosions in a large cohort study
    E W Karlson
    Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Ann Rheum Dis 67:358-63. 2008
    ..HLA-DRB1 shared epitope (HLA-SE), PTPN22 and CTLA4 alleles are associated with cyclic citrullinated peptide (CCP) and rheumatoid arthritis (RA)...
  32. ncbi request reprint A randomized controlled trial of an internal family systems-based psychotherapeutic intervention on outcomes in rheumatoid arthritis: a proof-of-concept study
    Nancy A Shadick
    From the Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School Department of Psychiatry, Cambridge Health Alliance, Boston, Massachusetts Center for Self Leadership, Oak Park, Illinois and Department of Psychology, Massachusetts School of Professional Psychology, Boston, Massachusetts, USA
    J Rheumatol 40:1831-41. 2013
    ..To conduct a proof-of-concept randomized trial of an Internal Family Systems (IFS) psychotherapeutic intervention on rheumatoid arthritis (RA) disease activity and psychological status...
  33. ncbi request reprint Outcomes in rheumatoid arthritis: incorporating the patient perspective
    Jenny E Heller
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Rheumatol 19:101-5. 2007
    ..This review aims first to highlight some of the recent research in more traditional outcomes and then to focus on the rapid development of patient-centered outcomes over the last several years...
  34. ncbi request reprint Principal components analysis corrects for stratification in genome-wide association studies
    Alkes L Price
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 38:904-9. 2006
    ..Our simple, efficient approach can easily be applied to disease studies with hundreds of thousands of markers...
  35. doi request reprint Evaluation of selected rheumatoid arthritis activity scores for office-based assessment
    Mary Beth Sullivan
    Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Rheumatol 37:2466-8. 2010
    ..The goal of our study was to establish the validity of patient-reported indices compared to the C-reactive protein-based Disease Activity Score (DAS28-CRP4)...
  36. pmc The validity of a rheumatoid arthritis medical records-based index of severity compared with the DAS28
    Masayo Sato
    Division of Pharmacoepidemiology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    Arthritis Res Ther 8:R57. 2006
    ..The RARBIS has both face and convergent validity for patients with RA and relevant subgroups and may have application for medical records studies in patients with RA...
  37. pmc De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot
    Steven C Greenway
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Nat Genet 41:931-5. 2009
    ..Our findings predict that at least 10% (4.5-15.5%, 95% confidence interval) of sporadic nonsyndromic TOF cases result from de novo CNVs and suggest that mutations within these loci might be etiologic in other cases of TOF...
  38. pmc Common variants at CD40 and other loci confer risk of rheumatoid arthritis
    Soumya Raychaudhuri
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 40:1216-23. 2008
    ..1 x 10(-7) overall), CDK6 (rs42041, P = 0.010 replication, P = 4.0 x 10(-6) overall), PRKCQ (rs4750316, P = 0.0078 replication, P = 4.4 x 10(-6) overall), and KIF5A-PIP4K2C (rs1678542, P = 0.0026 replication, P = 8.8 x 10(-8) overall)...
  39. doi request reprint HPLC-based analysis of serum N-glycans on a 96-well plate platform with dedicated database software
    Louise Royle
    Department of Biochemistry, Glycobiology Institute, University of Oxford, Oxford OX1 3QU, UK
    Anal Biochem 376:1-12. 2008
    ..This technology is also suitable for preparing released glycans for other analytical techniques. Here we demonstrate its application to rheumatoid arthritis using 5 microl of patient serum...