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Genomes and GenesSpecies | Nancy A ShadickSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
Low-dose aspirin in the primary prevention of rheumatoid arthritis: the Women's Health StudyNancy A Shadick
Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Arthritis Care Res (Hoboken) 62:545-50. 2010..Previous randomized trial data have demonstrated a beneficial effect of low-dose aspirin in reducing other inflammatory diseases, such as asthma and colorectal adenomas, but no trial has evaluated the role of aspirin in RA prevention...
C-reactive protein in the prediction of rheumatoid arthritis in womenNancy A Shadick
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Arch Intern Med 166:2490-4. 2006..The purpose of this study was to examine whether levels of C-reactive protein (CRP), a sensitive marker of disease activity in rheumatoid arthritis (RA), are associated with increased risk of subsequent RA...- Opposing effects of the D70 mutation and the shared epitope in HLA-DR4 on disease activity and certain disease phenotypes in rheumatoid arthritisN A Shadick
Division of Rheumatology, Immunology, Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Ann Rheum Dis 66:1497-502. 2007.... - Pain persists in DAS28 rheumatoid arthritis remission but not in ACR/EULAR remission: a longitudinal observational studyYvonne C Lee
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, 75 Francis Street, PBB B3, Boston, MA, USA
Arthritis Res Ther 13:R83. 2011..We assessed the prevalence of pain in RA patients in remission according to the Disease Activity Score (DAS28-CRP4) and the American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) remission criteria... - Biomarkers of inflammation and development of rheumatoid arthritis in women from two prospective cohort studiesElizabeth W Karlson
Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Arthritis Rheum 60:641-52. 2009..To examine the association of biomarkers of inflammation with preclinical rheumatoid arthritis (RA)... - Clinical predictors of erosion-free status in rheumatoid arthritis: a prospective cohort studyKatherine P Liao
Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
Rheumatology (Oxford) 50:1473-9. 2011..Our objective was to characterize the group of RA patients without erosions and identify its clinical predictors... 
Remission and radiographic outcome in rheumatoid arthritis: application of the 2011 ACR/EULAR remission criteria in an observational cohortSiri Lillegraven
Division of Rheumatology Section of Clinical Sciences, Alumnae Hall Room 305, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Ann Rheum Dis 71:681-6. 2012....- Using genetic and clinical data to understand response to disease-modifying anti-rheumatic drug therapy: data from the Brigham and Women's Hospital Rheumatoid Arthritis Sequential StudyChristine K Iannaccone
Department of Medicine, Brigham and Women s Hospital, PBB B3, 75 Francis Street, Boston, MA 02115, USA
Rheumatology (Oxford) 50:40-6. 2011.... - Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapyJing Cui
Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Arthritis Rheum 62:1849-61. 2010..The aim of the present study was to test established RA genetic risk factors to determine whether the same alleles also influence the response to anti-TNF therapy... - Predictors of discontinuation of tumor necrosis factor inhibitors in patients with rheumatoid arthritisSandeep K Agarwal
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Rheumatol 35:1737-44. 2008..Our goal was to determine the discontinuation rate of TNF inhibitors and identify predictors associated with discontinuation... - Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk lociEli A Stahl
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
Nat Genet 42:508-14. 2010..An additional 11 SNPs replicated at P < 0.05, many of which are validated autoimmune risk alleles, suggesting that most represent genuine rheumatoid arthritis risk alleles... - Genome-wide association study of determinants of anti-cyclic citrullinated peptide antibody titer in adults with rheumatoid arthritisJing Cui
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Med 15:136-43. 2009..We identified a SNP in moderate linkage disequilibrium (LD) with HLA-DR3, which may influence anti-CCP titer independently of the HLA-SE... - Investigation of candidate polymorphisms and disease activity in rheumatoid arthritis patients on methotrexateYvonne C Lee
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Rheumatology (Oxford) 48:613-7. 2009..We examined the association between candidate single nucleotide polymorphisms (SNPs) and disease activity in RA patients on MTX... - Performance of matrix-based risk models for rapid radiographic progression in a cohort of patients with established rheumatoid arthritisSiri Lillegraven
Brigham and Women s Hospital, Boston, Massachusetts Diakonhjemmet Hospital, Oslo, Norway
Arthritis Care Res (Hoboken) 65:526-33. 2013..We tested the performance of 3 risk models for RRP in an observational cohort... - Sustained rheumatoid arthritis remission is uncommon in clinical practiceFemke H M Prince
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Arthritis Res Ther 14:R68. 2012..Remission is an important goal of therapy in rheumatoid arthritis (RA), but data on duration of remission are lacking. Our objective was to describe the duration of remission in RA, assessed by different criteria... - Vitamin E in the primary prevention of rheumatoid arthritis: the Women's Health StudyElizabeth W Karlson
Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Arthritis Rheum 59:1589-95. 2008..Vitamin E supplements may reduce the risk of developing rheumatoid arthritis (RA) through antioxidant effects. Although previous observational studies have investigated this question, no randomized trial data are available... - Aberrant IgG galactosylation precedes disease onset, correlates with disease activity, and is prevalent in autoantibodies in rheumatoid arthritisAltan Ercan
Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Arthritis Rheum 62:2239-48. 2010..To examine the association between aberrant IgG galactosylation and disease parameters in rheumatoid arthritis (RA)... - Hand bone mineral density is associated with both total hip and lumbar spine bone mineral density in post-menopausal women with RASonali P Desai
Brigham and Women s Hospital, PBB B3, Boston, MA 02115, USA
Rheumatology (Oxford) 49:513-9. 2010..RA is associated with localized bone loss in the hands, as well as generalized osteoporosis. We evaluated the relationship between hand digital X-ray radiogrammetry BMD (DXR-BMD) and total hip and lumbar spine BMD... - Dietary caffeine intake does not affect methotrexate efficacy in patients with rheumatoid arthritisElizabeth Benito-Garcia
Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Rheumatol 33:1275-81. 2006..CONCLUSION: Caffeine intake among patients taking high doses of MTX for RA did not affect MTX efficacy and RA disease activity over time... - Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexateAlex Parker
Millennium Pharmaceuticals Inc, Cambridge, Massachusetts, USA
J Rheumatol 34:1817-22. 2007..We analyzed association of gene expression with disease activity, rheumatoid factor (RF), age, sex, disease duration, treatment modality, and clinical response... - Erroneous augmentation of multiplex assay measurements in patients with rheumatoid arthritis due to heterophilic binding by serum rheumatoid factorDerrick J Todd
Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Arthritis Rheum 63:894-903. 2011..The purpose of this study was to assess whether these factors confound multiplex-based immunoassays, which are used with increasing frequency to measure cytokine and chemokine analytes in patients with rheumatoid arthritis (RA)... - Behavioral and attitudes survey about Lyme disease among a Brazilian population in the endemic area of Martha's Vineyard, MassachusettsJenny E Heller
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
J Immigr Minor Health 12:377-83. 2010..Forty-one percent did not think LD posed a risk, while 79% were not sure they could recognize symptoms. Accordingly, the population as a whole reported taking few precautions... - Validity of self-report of infections in a longitudinal cohort of patients with rheumatoid arthritis differs by source of report and infection severityJulia F Simard
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
J Clin Epidemiol 63:1358-62. 2010..We evaluated and compared the validity of patients' and rheumatologists' reports of infection with those confirmed by medical record review... - Prospective cohort study of breast implants and the risk of connective-tissue diseasesI Min Lee
Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
Int J Epidemiol 40:230-8. 2011..Because of limitations inherent to the retrospective cohort study design, we sought clarification by conducting a prospective cohort study of the association of breast implants with CTD risk... - Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis riskSoumya Raychaudhuri
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
Nat Genet 41:1313-8. 2009..0008 replication, P = 4 x 10(-6) overall) and FCGR2A (rs12746613, P = 0.0022 replication, P = 2 x 10(-5) overall). Many of these loci are also associated to other immunologic diseases... - Two independent alleles at 6q23 associated with risk of rheumatoid arthritisRobert M Plenge
Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
Nat Genet 39:1477-82. 2007..We show that these two SNP associations are statistically independent, are each reproducible in the comparison of our data and WTCCC data, and define risk and protective haplotypes for rheumatoid arthritis at 6q23... - Associations between human leukocyte antigen, PTPN22, CTLA4 genotypes and rheumatoid arthritis phenotypes of autoantibody status, age at diagnosis and erosions in a large cohort studyE W Karlson
Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Ann Rheum Dis 67:358-63. 2008..HLA-DRB1 shared epitope (HLA-SE), PTPN22 and CTLA4 alleles are associated with cyclic citrullinated peptide (CCP) and rheumatoid arthritis (RA)... - Outcomes in rheumatoid arthritis: incorporating the patient perspectiveJenny E Heller
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
Curr Opin Rheumatol 19:101-5. 2007..This review aims first to highlight some of the recent research in more traditional outcomes and then to focus on the rapid development of patient-centered outcomes over the last several years... - Principal components analysis corrects for stratification in genome-wide association studiesAlkes L Price
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Genet 38:904-9. 2006..Our simple, efficient approach can easily be applied to disease studies with hundreds of thousands of markers... - Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid ArthritisJing Cui
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Genet 9:e1003394. 2013..These findings support a model in which CD84 genotypes and/or expression may serve as a useful biomarker for response to etanercept treatment in RA patients of European ancestry... - Evaluation of selected rheumatoid arthritis activity scores for office-based assessmentMary Beth Sullivan
Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
J Rheumatol 37:2466-8. 2010..The goal of our study was to establish the validity of patient-reported indices compared to the C-reactive protein-based Disease Activity Score (DAS28-CRP4)... - The validity of a rheumatoid arthritis medical records-based index of severity compared with the DAS28Masayo Sato
Division of Pharmacoepidemiology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
Arthritis Res Ther 8:R57. 2006..The RARBIS has both face and convergent validity for patients with RA and relevant subgroups and may have application for medical records studies in patients with RA... - De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of FallotSteven C Greenway
Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
Nat Genet 41:931-5. 2009..Our findings predict that at least 10% (4.5-15.5%, 95% confidence interval) of sporadic nonsyndromic TOF cases result from de novo CNVs and suggest that mutations within these loci might be etiologic in other cases of TOF... - Common variants at CD40 and other loci confer risk of rheumatoid arthritisSoumya Raychaudhuri
Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
Nat Genet 40:1216-23. 2008..1 x 10(-7) overall), CDK6 (rs42041, P = 0.010 replication, P = 4.0 x 10(-6) overall), PRKCQ (rs4750316, P = 0.0078 replication, P = 4.4 x 10(-6) overall), and KIF5A-PIP4K2C (rs1678542, P = 0.0026 replication, P = 8.8 x 10(-8) overall)... - HPLC-based analysis of serum N-glycans on a 96-well plate platform with dedicated database softwareLouise Royle
Department of Biochemistry, Glycobiology Institute, University of Oxford, Oxford OX1 3QU, UK
Anal Biochem 376:1-12. 2008..This technology is also suitable for preparing released glycans for other analytical techniques. Here we demonstrate its application to rheumatoid arthritis using 5 microl of patient serum...