Joao Seco

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Assessing the effect of electron density in photon dose calculations
    J Seco
    Francis H Burr Proton Therapy Center, Massachusetts Hospital, Harvard Medical School, 30 Fruit Street, Boston, Massachusetts 02114, USA
    Med Phys 33:540-52. 2006
  2. doi request reprint Characterizing the modulation transfer function (MTF) of proton/carbon radiography using Monte Carlo simulations
    Joao Seco
    Department of Radiation Oncology, Francis H Burr Proton Therapy Center, Massachusetts General Hospital MGH, Boston, Massachusetts 02114, USA
    Med Phys 40:091717. 2013
  3. doi request reprint Proton arc reduces range uncertainty effects and improves conformality compared with photon volumetric modulated arc therapy in stereotactic body radiation therapy for non-small cell lung cancer
    Joao Seco
    Francis H Burr Proton Therapy Center, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Int J Radiat Oncol Biol Phys 87:188-94. 2013
  4. doi request reprint Treatment of non-small cell lung cancer patients with proton beam-based stereotactic body radiotherapy: dosimetric comparison with photon plans highlights importance of range uncertainty
    Joao Seco
    Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 83:354-61. 2012
  5. ncbi request reprint Proof of principle study of the use of a CMOS active pixel sensor for proton radiography
    Joao Seco
    Francis H Burr Proton Therapy Center, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Med Phys 38:622-3. 2011
  6. doi request reprint Breathing interplay effects during proton beam scanning: simulation and statistical analysis
    Joao Seco
    Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA
    Phys Med Biol 54:N283-94. 2009
  7. pmc Golden beam data for proton pencil-beam scanning
    Benjamin Clasie
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Phys Med Biol 57:1147-58. 2012
  8. doi request reprint Extension of the NCAT phantom for the investigation of intra-fraction respiratory motion in IMRT using 4D Monte Carlo
    Ross McGurk
    Department of Radiation Oncology, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Phys Med Biol 55:1475-90. 2010
  9. doi request reprint Dosimetry robustness with stochastic optimization
    Omid Nohadani
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA Operations Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Phys Med Biol 54:3421-32. 2009
  10. doi request reprint Sensitivity study of proton radiography and comparison with kV and MV x-ray imaging using GEANT4 Monte Carlo simulations
    Nicolas Depauw
    Francis H Burr Proton Therapy Center, Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Phys Med Biol 56:2407-21. 2011

Detail Information

Publications32

  1. ncbi request reprint Assessing the effect of electron density in photon dose calculations
    J Seco
    Francis H Burr Proton Therapy Center, Massachusetts Hospital, Harvard Medical School, 30 Fruit Street, Boston, Massachusetts 02114, USA
    Med Phys 33:540-52. 2006
    ....
  2. doi request reprint Characterizing the modulation transfer function (MTF) of proton/carbon radiography using Monte Carlo simulations
    Joao Seco
    Department of Radiation Oncology, Francis H Burr Proton Therapy Center, Massachusetts General Hospital MGH, Boston, Massachusetts 02114, USA
    Med Phys 40:091717. 2013
    ..To characterize the modulation transfer function (MTF) of proton/carbon radiography using Monte Carlo simulations. To assess the spatial resolution of proton/carbon radiographic imaging...
  3. doi request reprint Proton arc reduces range uncertainty effects and improves conformality compared with photon volumetric modulated arc therapy in stereotactic body radiation therapy for non-small cell lung cancer
    Joao Seco
    Francis H Burr Proton Therapy Center, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Int J Radiat Oncol Biol Phys 87:188-94. 2013
    ....
  4. doi request reprint Treatment of non-small cell lung cancer patients with proton beam-based stereotactic body radiotherapy: dosimetric comparison with photon plans highlights importance of range uncertainty
    Joao Seco
    Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 83:354-61. 2012
    ..In the present study, we sought to analyze how the range uncertainties for protons might affect its therapeutic utility for SBRT...
  5. ncbi request reprint Proof of principle study of the use of a CMOS active pixel sensor for proton radiography
    Joao Seco
    Francis H Burr Proton Therapy Center, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Med Phys 38:622-3. 2011
    ..Proof of principle study of the use of a CMOS active pixel sensor (APS) in producing proton radiographic images using the proton beam at the Massachusetts General Hospital (MGH)...
  6. doi request reprint Breathing interplay effects during proton beam scanning: simulation and statistical analysis
    Joao Seco
    Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA
    Phys Med Biol 54:N283-94. 2009
    ..5 x 8.5 x 10 cm(3). For smaller tumor volumes more repaintings will be required, while for larger volumes five repaintings should be sufficient to achieve the required dose accuracy...
  7. pmc Golden beam data for proton pencil-beam scanning
    Benjamin Clasie
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Phys Med Biol 57:1147-58. 2012
    ..We used these Golden beam data on our PBS delivery systems and demonstrated that they yield absolute dosimetry well within clinical tolerance...
  8. doi request reprint Extension of the NCAT phantom for the investigation of intra-fraction respiratory motion in IMRT using 4D Monte Carlo
    Ross McGurk
    Department of Radiation Oncology, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Phys Med Biol 55:1475-90. 2010
    ..Our results indicate that the NCAT phantom, combined with 4D-MC simulations, is a useful tool in radiation therapy investigations and may allow the study of relative effects in many clinically relevant situations...
  9. doi request reprint Dosimetry robustness with stochastic optimization
    Omid Nohadani
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA Operations Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Phys Med Biol 54:3421-32. 2009
    ..The achieved speedup will allow computationally extensive multi-criteria or beam-angle optimization approaches to warrant for dosimetrically relevant plans...
  10. doi request reprint Sensitivity study of proton radiography and comparison with kV and MV x-ray imaging using GEANT4 Monte Carlo simulations
    Nicolas Depauw
    Francis H Burr Proton Therapy Center, Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Phys Med Biol 56:2407-21. 2011
    ..Furthermore, the use of daily proton radiography prior to proton therapy would ameliorate patient set-up while reducing the absorbed dose delivered through imaging...
  11. pmc Effects of Hounsfield number conversion on CT based proton Monte Carlo dose calculations
    Hongyu Jiang
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Med Phys 34:1439-49. 2007
    ..In addition, the significance of the elemental composition effect (dose to water vs. dose to tissue) is tissue-type dependent and is also affected by nuclear reactions...
  12. pmc Dosimetric accuracy of proton therapy for chordoma patients with titanium implants
    Joost M Verburg
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Med Phys 40:071727. 2013
    ..To investigate dosimetric errors in proton therapy treatment planning due to titanium implants, and to determine how these affect postoperative passively scattered proton therapy for chordoma patients with orthopedic hardware...
  13. doi request reprint Simulations using patient data to evaluate systematic errors that may occur in 4D treatment planning: a proof of concept study
    Sara St James
    Department of Radiation Oncology, Brigham and Women s Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Med Phys 40:091706. 2013
    ..The purpose of this work is to present a framework to evaluate the accuracy of four-dimensional treatment planning in external beam radiation therapy using measured patient data and digital phantoms...
  14. pmc A mass-conserving 4D XCAT phantom for dose calculation and accumulation
    Christopher L Williams
    Brigham and Women s Hospital, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    Med Phys 40:071728. 2013
    ..Dose calculations are performed to assess the implications of neglecting mass conservation, and to demonstrate an application of the phantom to calculate the accumulated delivered dose in an irregularly breathing patient...
  15. pmc Comparison of out-of-field photon doses in 6 MV IMRT and neutron doses in proton therapy for adult and pediatric patients
    Basit S Athar
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Phys Med Biol 55:2879-91. 2010
    ..At larger distances to the field (beyond approximately 25 cm), protons offer an advantage, resulting in doses that are roughly a factor of 2-3 lower...
  16. pmc Dosimetric impact of motion in free-breathing and gated lung radiotherapy: a 4D Monte Carlo study of intrafraction and interfraction effects
    Joao Seco
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Med Phys 35:356-66. 2008
    ..These differences are a consequence of the larger contribution of the inhale phase in the 3DCT data than in the 4DCT...
  17. doi request reprint Energy- and time-resolved detection of prompt gamma-rays for proton range verification
    Joost M Verburg
    Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA School of Medical Physics and Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Phys Med Biol 58:L37-49. 2013
    ..We conclude that the measurement of discrete prompt gamma-rays for in vivo range verification of clinical proton beams is feasible, and plan to further study methods and detector designs for clinical use...
  18. ncbi request reprint Use of a realistic breathing lung phantom to evaluate dose delivery errors
    Laurence E Court
    Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Med Phys 37:5850-7. 2010
    ..To compare the effect of respiration-induced motion on delivered dose (the interplay effect) for different treatment techniques under realistic clinical conditions...
  19. doi request reprint Proton radiography in three dimensions: a proof of principle of a new technique
    Milen Raytchev
    Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02114
    Med Phys 40:101917. 2013
    ..Monte Carlo simulations were used to investigate a range of phantom configurations to establish enabling three-dimensional proton radiographic techniques...
  20. doi request reprint Simulation of dosimetric consequences of 4D-CT-based motion margin estimation for proton radiotherapy using patient tumor motion data
    Ozhan Koybasi
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA Harvard Medical School, Boston, MA, USA
    Phys Med Biol 59:853-67. 2014
    ....
  21. pmc Numerical solutions of the γ-index in two and three dimensions
    Benjamin M Clasie
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Phys Med Biol 57:6981-97. 2012
    ..Furthermore, the difference between iterations can be used to determine the accuracy of the method...
  22. doi request reprint Simulation of prompt gamma-ray emission during proton radiotherapy
    Joost M Verburg
    Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA
    Phys Med Biol 57:5459-72. 2012
    ..These results indicate a need for additional theoretical and experimental study of proton-induced gamma emission in human tissue...
  23. pmc Proton SBRT for medically inoperable stage I NSCLC
    Kenneth D Westover
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Thorac Oncol 7:1021-5. 2012
    ..However, its utility for the treatment of medically inoperable stage I NSCLC patients with stereotactic body radiation therapy (SBRT) is unknown...
  24. doi request reprint Feasibility study of in vivo MRI based dosimetric verification of proton end-of-range for liver cancer patients
    Yading Yuan
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Radiother Oncol 106:378-82. 2013
    ..To investigate the feasibility of using MRI to verify proton beam distal range for liver tumor treatment in a retrospective study...
  25. doi request reprint CT metal artifact reduction method correcting for beam hardening and missing projections
    Joost M Verburg
    Harvard Medical School and Massachusetts General Hospital, Department of Radiation Oncology, Boston, MA 02114, USA
    Phys Med Biol 57:2803-18. 2012
    ..0001) and projection interpolation (p = 0.004). We conclude that effective reduction of CT metal artifacts can be achieved by combining algorithms tailored to specific types of implant materials...
  26. pmc Effects of organ motion on IMRT treatments with segments of few monitor units
    J Seco
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Med Phys 34:923-34. 2007
    ..In addition, dose averaging may not work well for hypo-fractionation, where fewer fractions are used. For hypo-fractionation, PDF modeling of the tumor motion in IMRT optimization may not be adequate...
  27. ncbi request reprint Electron dosimetry of angular fields
    G Davies
    Royal Marsden NHS Foundation Trust, Fulham Road, London SW3 6JJ, UK
    Br J Radiol 80:202-8. 2007
    ..5 mm at 9 MeV and +/-1.0 mm at 12 MeV, demonstrating the validity of using such calculations for this purpose. Graphs are presented which may help in the prospective assessment of the dose reductions likely to be incurred...
  28. ncbi request reprint A quantitative study of IMRT delivery effects in commercial planning systems for the case of oesophagus and prostate tumours
    J Seco
    Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT, UK
    Br J Radiol 79:401-8. 2006
    ..Currently, they must be taken into account during the optimization stage by altering the dose limits accepted during optimization so that the final (sequenced) dose is within the constraints...
  29. ncbi request reprint Head-and-neck IMRT treatments assessed with a Monte Carlo dose calculation engine
    J Seco
    Joint Department of Physics, Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Fulham Road, London SW3 6JJ, UK
    Phys Med Biol 50:817-30. 2005
    ..This is possibly due to the large air-cavity (the larynx of the patient) situated in the centre of the primary PTV and the approximations present in the dose calculation...
  30. ncbi request reprint An optimization algorithm that incorporates IMRT delivery constraints
    J Seco
    Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, Surrey, UK
    Phys Med Biol 47:899-915. 2002
    ..An optimum between 8 and 15 clusters of equal fluence 'intensity' was shown to establish the best compromise between the number of fluence levels and the PTV dose coverage...
  31. ncbi request reprint Amorphous silicon EPID calibration for dosimetric applications: comparison of a method based on Monte Carlo prediction of response with existing techniques
    L Parent
    Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Sutton, UK
    Phys Med Biol 52:3351-68. 2007
    ..MC, WS and MF methods all provided a major improvement on the FF method. Advantages and drawbacks of each method were reviewed...
  32. ncbi request reprint Analysis of the effects of the delivery technique on an IMRT plan: comparison for multiple static field, dynamic and NOMOS MIMiC collimation
    J Seco
    Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, Surrey, UK
    Phys Med Biol 46:3073-87. 2001
    ..13th Int. Conf. on Computers in Radiotherapy (Heidelberg, 2000)) such as to obtain 70 Gy at the isocentre. The IMRT techniques DMLC, MIMiC and MSF were compared for the organs at risk: rectum, bladder, and left and right femoral heads...