Joseph H Schwab

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi request reprint The surgical management of sacral chordomas
    Joseph H Schwab
    Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Spine (Phila Pa 1976) 34:2700-4. 2009
  2. ncbi request reprint Combination of PI3K/mTOR inhibition demonstrates efficacy in human chordoma
    Joseph Schwab
    Department of Orthopedic Surgery, Section of Orthopedic Oncology, Sarcoma Research Laboratory, Massachusetts General Hospital, Boston, MA 02114, U S A
    Anticancer Res 29:1867-71. 2009
  3. pmc Characterization and analysis of human chordoma cell lines
    Cao Yang
    Department of Orthopaedic Surgery, Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Spine (Phila Pa 1976) 35:1257-64. 2010
  4. doi request reprint Multidrug resistant osteosarcoma cell lines exhibit deficiency of GADD45alpha expression
    Cao Yang
    Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    Apoptosis 14:124-33. 2009
  5. doi request reprint Histone deacetylase inhibitor (HDACI) PCI-24781 potentiates cytotoxic effects of doxorubicin in bone sarcoma cells
    Cao Yang
    Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Cancer Chemother Pharmacol 67:439-46. 2011
  6. doi request reprint Chondrosarcoma of the mobile spine: a review of 21 cases treated at a single center
    Andrew J Schoenfeld
    Department of Orthopaedic Surgery, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Spine (Phila Pa 1976) 37:119-26. 2012
  7. doi request reprint A novel target for treatment of chordoma: signal transducers and activators of transcription 3
    Cao Yang
    Department of Orthopaedic Surgery, Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Mol Cancer Ther 8:2597-605. 2009
  8. doi request reprint Do histologic criteria predict biologic behavior of giant cell lesions?
    Zachary S Peacock
    Instructor of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, MA Electronic address
    J Oral Maxillofac Surg 70:2573-80. 2012
  9. pmc Chordoma and chondrosarcoma gene profile: implications for immunotherapy
    Joseph H Schwab
    Department of Surgery, Orthopedic Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Immunol Immunother 58:339-49. 2009
  10. doi request reprint Establishment and characterization of a novel chordoma cell line: CH22
    Xianzhe Liu
    Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Orthop Res 30:1666-73. 2012

Detail Information

Publications28

  1. doi request reprint The surgical management of sacral chordomas
    Joseph H Schwab
    Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Spine (Phila Pa 1976) 34:2700-4. 2009
    ..Retrospective case series...
  2. ncbi request reprint Combination of PI3K/mTOR inhibition demonstrates efficacy in human chordoma
    Joseph Schwab
    Department of Orthopedic Surgery, Section of Orthopedic Oncology, Sarcoma Research Laboratory, Massachusetts General Hospital, Boston, MA 02114, U S A
    Anticancer Res 29:1867-71. 2009
    ..PI-103 is a inhibitor of PI3K/AKT and mTOR activation. This study aims to determine whether the PI3K/mTOR pathway was active in chordomas and whether their inhibition could lead to decreased proliferation and increased apoptosis...
  3. pmc Characterization and analysis of human chordoma cell lines
    Cao Yang
    Department of Orthopaedic Surgery, Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Spine (Phila Pa 1976) 35:1257-64. 2010
    ..An experimental study to investigate the characterization of 3 chordoma cell lines...
  4. doi request reprint Multidrug resistant osteosarcoma cell lines exhibit deficiency of GADD45alpha expression
    Cao Yang
    Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    Apoptosis 14:124-33. 2009
    ..These results suggest that GADD45alpha may play a role in drug-induced apoptosis, as well as multidrug resistance in osteosarcoma cells...
  5. doi request reprint Histone deacetylase inhibitor (HDACI) PCI-24781 potentiates cytotoxic effects of doxorubicin in bone sarcoma cells
    Cao Yang
    Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Cancer Chemother Pharmacol 67:439-46. 2011
    ..To better understand the mechanisms of cytotoxicity and cell death induced by HDACI PCI-24781 in bone sarcoma cells...
  6. doi request reprint Chondrosarcoma of the mobile spine: a review of 21 cases treated at a single center
    Andrew J Schoenfeld
    Department of Orthopaedic Surgery, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Spine (Phila Pa 1976) 37:119-26. 2012
    ..Retrospective case series...
  7. doi request reprint A novel target for treatment of chordoma: signal transducers and activators of transcription 3
    Cao Yang
    Department of Orthopaedic Surgery, Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Mol Cancer Ther 8:2597-605. 2009
    ..In conclusion, the Stat3 pathway is constitutively activated in chordomas and the level of expression may serve as a predictor for prognosis. Blockade of the Stat3 pathway represents a potential strategy for future treatment...
  8. doi request reprint Do histologic criteria predict biologic behavior of giant cell lesions?
    Zachary S Peacock
    Instructor of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, MA Electronic address
    J Oral Maxillofac Surg 70:2573-80. 2012
    ..To determine whether the clinical behavior of giant cell lesions (GCLs) or their anatomic location can be differentiated by histologic criteria alone...
  9. pmc Chordoma and chondrosarcoma gene profile: implications for immunotherapy
    Joseph H Schwab
    Department of Surgery, Orthopedic Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Immunol Immunother 58:339-49. 2009
    ..In conclusion, chordomas and chondrosarcomas share a similar gene expression profile of up-regulated extracellular matrix genes. HMW-MAA represents a potential useful target to apply immunotherapy to these tumors...
  10. doi request reprint Establishment and characterization of a novel chordoma cell line: CH22
    Xianzhe Liu
    Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Orthop Res 30:1666-73. 2012
    ....
  11. doi request reprint Blockage of Stat3 with CDDO-Me inhibits tumor cell growth in chordoma
    Cao Yang
    Department of Orthopaedic Surgery, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Spine (Phila Pa 1976) 35:1668-75. 2010
    ..An experimental study to investigate the activation of Src/Stat3 pathways in chordomas and blockage of this pathway as a potential strategy for chordoma treatment...
  12. pmc A comparison of intramedullary and juxtacortical low-grade osteogenic sarcoma
    Joseph H Schwab
    Department of Surgery Section of Orthopedics, Memorial Sloan Kettering Cancer, Weill Cornell Medical School, 1275 York Avenue, New York, NY 10021, USA
    Clin Orthop Relat Res 466:1318-22. 2008
    ..LEVEL OF EVIDENCE: Level III, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence...
  13. doi request reprint Giant cell tumor of bone
    Kevin A Raskin
    Massachusetts General Hospital, Boston, MA, USA
    J Am Acad Orthop Surg 21:118-26. 2013
    ..Medical therapy and radiotherapy can alter the management of GCT of bone, especially in multifocal disease, local recurrences, and bulky central/axial disease...
  14. ncbi request reprint Imaging interpretation of oncologic musculoskeletal conditions
    Carol D Morris
    Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Instr Course Lect 61:541-51. 2012
    ....
  15. ncbi request reprint Skeletal metastases in myxoid liposarcoma: an unusual pattern of distant spread
    Joseph H Schwab
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Surg Oncol 14:1507-14. 2007
    ..Anecdotal evidence, mainly supported by isolated case reports, suggests that a subset of these patients also develop bone metastasis, especially within the spine, which was previously under-appreciated...
  16. ncbi request reprint Spinal metastases from myxoid liposarcoma warrant screening with magnetic resonance imaging
    Joseph H Schwab
    Department of Surgery, Orthopedic Service, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer 110:1815-22. 2007
    ..The objective of this study was to determine the prevalence of spinal metastasis, treatment outcomes, and optimal screening method for spinal metastasis in patients with MLS...
  17. doi request reprint Osteosarcoma of the spine: experience in 26 patients treated at the Massachusetts General Hospital
    Andrew J Schoenfeld
    Department of Orthopaedic Surgery, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Spine J 10:708-14. 2010
    ..Because of the low incidence, treatment recommendations for spinal osteosarcoma are guided by the results of small series and case reports. Many include patients who presented for treatment over the course of three to four decades...
  18. ncbi request reprint Evaluation of the patient presenting with a malignant spinal tumor
    Peter S Rose
    Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA
    Instr Course Lect 61:553-65. 2012
    ..Equally important is the ability to recognize the rare patient who presents with a primary spinal malignancy, which requires a significantly different treatment protocol...
  19. ncbi request reprint Patellar complications following distal femoral replacement after bone tumor resection
    Joseph H Schwab
    Department of Orthopaedic Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Suite A342, New York, NY 10021, USA
    J Bone Joint Surg Am 88:2225-30. 2006
    ..The purpose of our study was to determine the prevalence and type of patellar complications following distal femoral replacements after excisions of bone tumors...
  20. ncbi request reprint Does local recurrence impact survival in low-grade chondrosarcoma of the long bones?
    Joseph H Schwab
    Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN 55901, USA
    Clin Orthop Relat Res 462:175-80. 2007
    ..The difference in survival was not apparent until after 5 years and was more pronounced after 10 years. Recurrence may be regarded as a declaration of an aggressive phenotype and should be treated as such...
  21. doi request reprint RAIDD expression is impaired in multidrug resistant osteosarcoma cell lines
    Cao Yang
    Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    Cancer Chemother Pharmacol 64:607-14. 2009
    ..To identify the apoptosis genes involved in the multidrug resistant phenotype of osteosarcoma...
  22. doi request reprint Maxillofacial and axial/appendicular giant cell lesions: unique tumors or variants of the same disease?--A comparison of phenotypic, clinical, and radiographic characteristics
    Cory M Resnick
    Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    J Oral Maxillofac Surg 68:130-7. 2010
    ..The present study compared the clinical and radiographic characteristics of subjects with MF and AA GCLs...
  23. doi request reprint An effective preoperative three-dimensional radiotherapy target volume for extremity soft tissue sarcoma and the effect of margin width on local control
    Bokyong Kim
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 77:843-50. 2010
    ..We retrospectively analyzed the pattern of local failure (LF) to help elucidate optimal field design...
  24. pmc Intraosseous synovial sarcoma of the proximal tibia
    Sarah E Beck
    Department of Orthopaedics, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Surg Oncol 2011:184891. 2011
    ..The current recommended treatment for synovial sarcoma is wide surgical resection followed by chemotherapy as well as long-term followup. Despite improved surgical techniques, long-term survival rates remain low...
  25. pmc FDG-PET Lacks Sufficient Sensitivity to Detect Myxoid Liposarcoma Spinal Metastases Detected by MRI
    Joseph H Schwab
    Section of Orthopedic Surgery, Department of Surgery, Memorial Sloan Kettering Cancer Center, Weill Cornell University Medical School, New York, NY 10021, USA
    Sarcoma 2007:36785. 2007
    ..Our report demonstrates that FDG-PET may also lack the sensitivity needed to detect these lesions. We advocate total spine MRI when screening for metastases in this population when they present with back pain...
  26. doi request reprint Optimal fixation for the extended trochanteric osteotomy: a pilot study comparing 3 cables vs 2 cables
    Joseph H Schwab
    Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Arthroplasty 23:534-8. 2008
    ..Peak force and stiffness were both greater in the 3-cable group, whereas angular and transverse displacement were less in the 2-cable construct...
  27. pmc Case reports: splenic rupture after anterior thoracolumbar spinal fusion through a thoracoabdominal approach
    Benton E Heyworth
    Department of Orthopaedic Surgery, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA
    Clin Orthop Relat Res 466:2271-5. 2008
    ..Splenic rupture should be considered as part of the differential diagnosis for patients with hemodynamic instability after anterior approaches to the thoracolumbar spine...
  28. ncbi request reprint Function correlates with deltoid preservation in patients having scapular replacement
    Joseph H Schwab
    Orthopaedic Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Orthop Relat Res 452:225-30. 2006
    ..We favor using a scapular prosthesis if there is a functioning deltoid; however resection of the deltoid should not be considered an absolute contraindication for scapular replacement...