J D Schmahmann

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc An fMRI study of intra-individual functional topography in the human cerebellum
    Catherine J Stoodley
    Cognitive Behavioral Neurology Unit, Massachusetts General Hospital and Harvard Medical School, 175 Cambridge Street, Boston, MA 02114, USA
    Behav Neurol 23:65-79. 2010
  2. doi request reprint Next generation sequencing with copy number variant detection expands the phenotypic spectrum of HSD17B4-deficiency
    Daniel S Lieber
    Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    BMC Med Genet 15:30. 2014
  3. pmc Atypical case of Wolfram syndrome revealed through targeted exome sequencing in a patient with suspected mitochondrial disease
    Daniel S Lieber
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    BMC Med Genet 13:3. 2012
  4. ncbi request reprint The neuropsychiatry of the cerebellum - insights from the clinic
    Jeremy D Schmahmann
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Cerebellum 6:254-67. 2007
  5. ncbi request reprint Association fibre pathways of the brain: parallel observations from diffusion spectrum imaging and autoradiography
    Jeremy D Schmahmann
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston MA 02114, USA
    Brain 130:630-53. 2007
  6. doi request reprint Evaluation of the assessment and grading of medical students on a neurology clerkship
    Jeremy D Schmahmann
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neurology 70:706-12. 2008
  7. pmc Disconnection syndromes of basal ganglia, thalamus, and cerebrocerebellar systems
    Jeremy D Schmahmann
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Cortex 44:1037-66. 2008
  8. pmc Cerebral white matter: neuroanatomy, clinical neurology, and neurobehavioral correlates
    Jeremy D Schmahmann
    Ataxia Unit, Cognitive Behavioral Neurology Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Ann N Y Acad Sci 1142:266-309. 2008
  9. pmc Cerebellar stroke without motor deficit: clinical evidence for motor and non-motor domains within the human cerebellum
    J D Schmahmann
    Ataxia Unit, Cognitive Behavioral Neurology Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Suite 340, Charles River Plaza South, 175 Cambridge Street, Boston, MA 02114, USA
    Neuroscience 162:852-61. 2009
  10. pmc Development of a brief ataxia rating scale (BARS) based on a modified form of the ICARS
    Jeremy D Schmahmann
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Mov Disord 24:1820-8. 2009

Research Grants

Collaborators

Detail Information

Publications38

  1. pmc An fMRI study of intra-individual functional topography in the human cerebellum
    Catherine J Stoodley
    Cognitive Behavioral Neurology Unit, Massachusetts General Hospital and Harvard Medical School, 175 Cambridge Street, Boston, MA 02114, USA
    Behav Neurol 23:65-79. 2010
    ..Inter-subject variability of motor and non-motor topography remains to be determined...
  2. doi request reprint Next generation sequencing with copy number variant detection expands the phenotypic spectrum of HSD17B4-deficiency
    Daniel S Lieber
    Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    BMC Med Genet 15:30. 2014
    ..Compound heterozygous mutations in HSD17B4 have also been reported in two sisters diagnosed with Perrault syndrome (MIM # 233400), who presented in adolescence with ovarian dysgenesis, hearing loss, and ataxia...
  3. pmc Atypical case of Wolfram syndrome revealed through targeted exome sequencing in a patient with suspected mitochondrial disease
    Daniel S Lieber
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    BMC Med Genet 13:3. 2012
    ....
  4. ncbi request reprint The neuropsychiatry of the cerebellum - insights from the clinic
    Jeremy D Schmahmann
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Cerebellum 6:254-67. 2007
    ....
  5. ncbi request reprint Association fibre pathways of the brain: parallel observations from diffusion spectrum imaging and autoradiography
    Jeremy D Schmahmann
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston MA 02114, USA
    Brain 130:630-53. 2007
    ..By replicating the major features of these tracts identified by histological techniques in monkey, we show that DSI has the potential to cast new light on the organization of the human brain in the normal state and in clinical disorders...
  6. doi request reprint Evaluation of the assessment and grading of medical students on a neurology clerkship
    Jeremy D Schmahmann
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neurology 70:706-12. 2008
    ....
  7. pmc Disconnection syndromes of basal ganglia, thalamus, and cerebrocerebellar systems
    Jeremy D Schmahmann
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Cortex 44:1037-66. 2008
    ..This model enables the formulation and testing of future hypotheses in investigations using evolving magnetic resonance imaging techniques in humans, and in clinical studies in patients with cortical and subcortical lesions...
  8. pmc Cerebral white matter: neuroanatomy, clinical neurology, and neurobehavioral correlates
    Jeremy D Schmahmann
    Ataxia Unit, Cognitive Behavioral Neurology Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Ann N Y Acad Sci 1142:266-309. 2008
    ....
  9. pmc Cerebellar stroke without motor deficit: clinical evidence for motor and non-motor domains within the human cerebellum
    J D Schmahmann
    Ataxia Unit, Cognitive Behavioral Neurology Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Suite 340, Charles River Plaza South, 175 Cambridge Street, Boston, MA 02114, USA
    Neuroscience 162:852-61. 2009
    ..To determine whether there are non-motor regions of cerebellum in which sizeable infarcts have little or no impact on motor control...
  10. pmc Development of a brief ataxia rating scale (BARS) based on a modified form of the ICARS
    Jeremy D Schmahmann
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Mov Disord 24:1820-8. 2009
    ..90 and 0.92 respectively; and inter-rater reliability (intraclass correlation coefficient) was 0.91 and 0.93 respectively. BARS is valid, reliable, and sufficiently fast and accurate for clinical purposes...
  11. doi request reprint The role of the cerebellum in cognition and emotion: personal reflections since 1982 on the dysmetria of thought hypothesis, and its historical evolution from theory to therapy
    Jeremy D Schmahmann
    Ataxia Unit, Laboratory for Neuroanatomy and Cerebellar Neurobiology, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neuropsychol Rev 20:236-60. 2010
    ....
  12. ncbi request reprint Disorders of the cerebellum: ataxia, dysmetria of thought, and the cerebellar cognitive affective syndrome
    Jeremy D Schmahmann
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Neuropsychiatry Clin Neurosci 16:367-78. 2004
    ..Cognitive and emotional disorders may accompany cerebellar diseases or be their principal clinical presentation, and this has significance for the diagnosis and management of patients with cerebellar dysfunction...
  13. ncbi request reprint Motor projections to the basis pontis in rhesus monkey
    Jeremy D Schmahmann
    Department of Neurology VBK 915, Massachusetts General Hospital and Harvard Medical School, Fruit Street, Boston, Massachusetts 02114, USA
    J Comp Neurol 478:248-68. 2004
    ....
  14. ncbi request reprint The human basis pontis: motor syndromes and topographic organization
    Jeremy D Schmahmann
    Department of Neurology VBK 915, Massachusetts General Hospital, Fruit Street, Boston, MA 02114, USA
    Brain 127:1269-91. 2004
    ....
  15. ncbi request reprint Plasmapheresis improves outcome in postinfectious cerebellitis induced by Epstein-Barr virus
    Jeremy D Schmahmann
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neurology 62:1443. 2004
  16. ncbi request reprint Ataxia after pontine stroke: insights from pontocerebellar fibers in monkey
    Jeremy D Schmahmann
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Ann Neurol 55:585-9. 2004
    ....
  17. ncbi request reprint Vascular syndromes of the thalamus
    Jeremy D Schmahmann
    Department of Neurology, VBK 915, Massachusetts General Hospital, Fruit St, Boston, MA 02114, USA
    Stroke 34:2264-78. 2003
    ..This article reviews the anatomy, connections, and functions of the thalamic nuclei, their vascular supply, and the clinical syndromes that result from thalamic infarction...
  18. ncbi request reprint The complex history of the fronto-occipital fasciculus
    Jeremy D Schmahmann
    Ataxia Unit, Cognitive Behavioral Neurology Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Hist Neurosci 16:362-77. 2007
    ..Our analysis of brain fiber pathways using isotope anterograde tract tracers (Schmahmann & Pandya, 2006) resolves the earlier uncertainties and provides hypotheses regarding functions of these fiber pathways...
  19. ncbi request reprint Prefrontal cortex projections to the basilar pons in rhesus monkey: implications for the cerebellar contribution to higher function
    J D Schmahmann
    Department of Neurology, Massachusetts General Hospital, Boston 02114, USA
    Neurosci Lett 199:175-8. 1995
    ..These findings strengthen the observation that the cerebrocerebellar system incorporates associative cerebral regions, and they enhance the notion that the cerebellum participates in the organization of cognitive function...
  20. ncbi request reprint Cognition, emotion and the cerebellum
    Jeremy D Schmahmann
    Ataxia Unit, Massachusetts General Hospital Boston, MA, USA
    Brain 129:290-2. 2006
  21. ncbi request reprint Cerebral white matter--historical evolution of facts and notions concerning the organization of the fiber pathways of the brain
    Jeremy D Schmahmann
    Department of Neurology, Cognitive Behavioral Neurology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Hist Neurosci 16:237-67. 2007
    ....
  22. doi request reprint The cerebellum and language: evidence from patients with cerebellar degeneration
    Catherine J Stoodley
    Ataxia Unit, Cognitive Behavioral Neurology Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United States
    Brain Lang 110:149-53. 2009
    ....
  23. pmc Hypertrophic pachymeningitis and cerebral venous sinus thrombosis in inflammatory bowel disease
    Zongqi Xia
    Department of Neurology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Clin Neurosci 17:1454-6. 2010
    ..This report highlights the challenges of the diagnosis and management of hypertrophic pachymeningitis from an unusual primary cause...
  24. ncbi request reprint Evidence for reduced cerebellar volumes in trichotillomania
    Nancy J Keuthen
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 61:374-81. 2007
    ..Limited knowledge exists regarding the neurobiology of trichotillomania (TTM). Cerebellum (CBM) volumes were explored, given its role in complex, coordinated motor sequences...
  25. doi request reprint Functional topography in the human cerebellum: a meta-analysis of neuroimaging studies
    Catherine J Stoodley
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neuroimage 44:489-501. 2009
    ..Prospective studies of multiple domains within single individuals are necessary to better elucidate neurobehavioral structure-function correlations in the cerebellar posterior lobe...
  26. pmc Evidence for topographic organization in the cerebellum of motor control versus cognitive and affective processing
    Catherine J Stoodley
    Ataxia Unit, Cognitive Behavioral Neurology Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 175 Cambridge Street, Boston, MA 02114, USA
    Cortex 46:831-44. 2010
    ..These observations provide testable hypotheses for future investigations...
  27. pmc Adult onset leukodystrophy with neuroaxonal spheroids: clinical, neuroimaging and neuropathologic observations
    Stefanie H Freeman
    C S Kubik Laboratory for Neuropathology, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Brain Pathol 19:39-47. 2009
    ..These observations lend further support to the notion that white matter disease alone can account for dementia...
  28. doi request reprint Diffusion spectrum magnetic resonance imaging (DSI) tractography of crossing fibers
    V J Wedeen
    Department of Radiology, MGH Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 41:1267-77. 2008
    ..These findings indicate that DSI tractography is able to image crossing fibers in neural tissue, an essential step toward non-invasive imaging of connectional neuroanatomy...
  29. doi request reprint Human cerebellar responses to brush and heat stimuli in healthy and neuropathic pain subjects
    D Borsook
    PAIN Group, Brain Imaging Center, McLean Hospital, Harvard Medical School, Massachusetts, USA
    Cerebellum 7:252-72. 2008
    ..These results lead us to propose that the cerebellum may modulate the emotional and cognitive experience that distinguishes the perception of pain from the appreciation of innocuous sensory stimulation...
  30. ncbi request reprint Human cerebellum: surface-assisted cortical parcellation and volumetry with magnetic resonance imaging
    Nikos Makris
    Massachusetts General Hospital, USA
    J Cogn Neurosci 15:584-99. 2003
    ..The SAP technique makes it possible to represent multimodal structural and functional imaging data on the flattened surface of the cerebellar cortex as illustrated in one functional MRI experiment...
  31. ncbi request reprint Pathological laughter and crying in patients with multiple system atrophy-cerebellar type
    Josef Parvizi
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Mov Disord 22:798-803. 2007
    ..Our findings are consistent with the view that the cerebellum and its interconnected structures may be involved in the regulation of emotional expression...
  32. doi request reprint Delayed leukoencephalopathy after hypoxic-ischemic injury
    Alice S Chen-Plotkin
    Department of Neurology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Arch Neurol 65:144-5. 2008
  33. doi request reprint Arginine test is not reliable for diagnosing cerebellar multiple system atrophy
    Raquel C Gardner
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Ann Neurol 67:404-8. 2010
    ..Thirty-six percent of ILOCA subjects and 40 percent of healthy controls mounted responses <4 microg/l GH. Arginine thus appears to be unreliable for the diagnosis of MSAc...
  34. ncbi request reprint Compressive myelopathy presenting as cervical cord neurapraxia: a differential diagnosis of TIA
    Thomas Cochrane
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neurology 65:1140-1. 2005
  35. ncbi request reprint Myotonic dystrophy type 1 presenting with ventilatory failure
    Nizar Souayah
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Clin Neuromuscul Dis 9:252-5. 2007
    ..To report a series of patients with adult onset myotonic dystrophy type 1 (DM1) in whom the presenting symptom was ventilatory failure...
  36. ncbi request reprint Diagnosis and management of pathological laughter and crying
    Josef Parvizi
    Department of Neurology, University of California Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Mayo Clin Proc 81:1482-6. 2006
    ..This article focuses on the clinical presentation, diagnosis, prevalence, and proposed pathophysiological mechanisms of and available treatment options for this clinical phenomenon...
  37. ncbi request reprint MRI-based surface-assisted parcellation of human cerebellar cortex: an anatomically specified method with estimate of reliability
    Nikos Makris
    Center for Morphometric Analysis, MGH East, 149 13th Street, Charlestown, MA 02129, USA
    Neuroimage 25:1146-60. 2005
    ..933. Whereas the individual units provide a high level of detail and anatomical specificity, the clusters add flexibility to the analysis by providing higher reliability...
  38. ncbi request reprint Ataxia and cerebellar atrophy--a novel manifestation of neuro-Beh├žet disease?
    Raquel C Gardner
    Mov Disord 23:307-8. 2008

Research Grants5

  1. Cognitive Effects of Cerebellar Lesions in Humans
    JEREMY SCHMAHMANN; Fiscal Year: 2006
    ..This study has implications for the recognition and treatment of disorders of higher order function in cerebellar patients. ..
  2. Diffusion MRI of Complex White Matter and Connectivity
    Van J Wedeen; Fiscal Year: 2010
    ....