Genomes and Genes
Jeremiah M Scharf
Affiliation: Massachusetts General Hospital
- Genome-wide association study of Tourette's syndromeJ M Scharf
Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Boston, MA, USA
Mol Psychiatry 18:721-8. 2013..This study lays the groundwork for the eventual identification of common TS susceptibility variants in larger cohorts and helps to provide a more complete understanding of the full genetic architecture of this disorder...
- Prevalence of Tourette syndrome and chronic tics in the population-based Avon longitudinal study of parents and children cohortJeremiah M Scharf
Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, UK
J Am Acad Child Adolesc Psychiatry 51:192-201.e5. 2012..We evaluated the prevalence of TS, CT, and their overlap with OCD and ADHD in the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort...
- The familial association of tourette's disorder and ADHD: the impact of OCD symptomsJulia A O'Rourke
Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, USA
Am J Med Genet B Neuropsychiatr Genet 156:553-60. 2011..The current results suggest that TD, ADHD, and OCD symptoms have overlapping neurobiology when occurring in families of TD and/or ADHD probands...
- Family-based genetic association study of DLGAP3 in Tourette SyndromeJacquelyn Crane
Center for Human Genetics Research, Massachusetts General Hospital, Boston, USA
Am J Med Genet B Neuropsychiatr Genet 156:108-14. 2011..Although none of these results remained significant after correction for multiple hypothesis testing, DLGAP3 remains a promising candidate gene for TS...
- The genetics of Tourette syndrome: a reviewJulia A O'Rourke
Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Psychosom Res 67:533-45. 2009..This article summarizes and evaluates recent advances in the genetics of Gilles de la Tourette syndrome (GTS)...
- Four-factor structure of obsessive-compulsive disorder symptoms in children, adolescents, and adultsS Evelyn Stewart
Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Am Acad Child Adolesc Psychiatry 47:763-72. 2008..Identification of a category-based OCD symptom dimension structure that is validated for use across child, adolescent, and adult age groups is necessary to guide ongoing translational research...
- Association between pre- and perinatal exposures and Tourette syndrome or chronic tic disorder in the ALSPAC cohortCarol A Mathews
Carol A Mathews, MD, Program for Genetics and Epidemiology of Neuropsychiatric Symptoms, Department of Psychiatry, University of California San Francisco, San Francisco, California, USA Jeremiah M Scharf, MD, PhD, Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston, Massachusetts Departments of Psychiatry and Neurology, Massachusetts General Hospital, Boston, Massachusetts Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women s Hospital, Boston, Massachusetts, USA Laura L Miller, MSc, School of Social and Community Medicine, University of Bristol, UK Corrie Macdonald Wallis, PhD, Debbie A Lawlor, PhD, School of Social and Community Medicine, and MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, UK Yoav Ben Shlomo, MD, PhD, School of Social and Community Medicine, University of Bristol, UK
Br J Psychiatry 204:40-5. 2014..Tourette syndrome and chronic tic disorder are heritable but aetiologically complex. Although environment plays a role in their development, existing studies of non-genetic risk factors are inconsistent...
- Association of the SLC1A1 glutamate transporter gene and obsessive-compulsive disorderS Evelyn Stewart
Psychiatric Neurodevelopmental and Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Med Genet B Neuropsychiatr Genet 144:1027-33. 2007..Two separate proximal haplotypes in the glutamate transporter gene, SLC1A1, were recently reported to be associated with OCD among males, but replication is required...