Esperance A K Schaefer
Affiliation: Massachusetts General Hospital
- Anti-hepatitis C virus drugs in developmentEsperance A K Schaefer
Massachusetts General Hospital, Department of Medicine, Gastrointestinal Unit, Boston, USA
Gastroenterology 142:1340-1350.e1. 2012..These new reagents against hepatitis C virus should lead to highly effective, well-tolerated, and likely interferon-sparing therapies in the next several years...
- The impact of human gene polymorphisms on HCV infection and disease outcomeEsperance A K Schaefer
GI Unit, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
Semin Liver Dis 31:375-86. 2011..Finally, PNPLA3 polymorphisms were initially described as predictors of nonalcoholic fatty liver disease, but have recently been associated with disease progression in HCV...
- HCV and host lipids: an intimate connectionEsperance A K Schaefer
Massachusetts General Hospital, Harvard Medical School, GI Unit, Boston, Massachusetts
Semin Liver Dis 33:358-68. 2013..The virus is then packaged alongside the cellular machinery for VLDL production. The complex interplay highlights pathways of hepatic steatosis and unveils drug targets for the treatment of HCV. ..
- The AMPK-related kinase SNARK regulates hepatitis C virus replication and pathogenesis through enhancement of TGF-β signalingKaku Goto
Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan Japan Society for the Promotion of Science, Tokyo 102 8472, Japan
J Hepatol 59:942-8. 2013..The biological and therapeutic importance of host cellular cofactors for viral replication has been recently appreciated. Here we examined the roles of SNF1/AMP kinase-related kinase (SNARK) in HCV replication and pathogenesis...
- Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A synthaseLee F Peng
Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Infect Dis 204:609-16. 2011..The identification of more effective and better-tolerated agents for treating HCV is a high priority. We have reported elsewhere the discovery of the anti-HCV compound ceestatin using a high-throughput screen of a small molecule library...