Research Topics
| P E SaxSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
Strategies for management and treatment of dyslipidemia in HIV/AIDSP E Sax
Division of Infection, Diseases and HIV Program, Brigham and Women s Hospital, Boston, MA 02115, USA
AIDS Care 18:149-57. 2006..Each approach is associated with advantages and limitations and the need to maintain viral suppression must be balanced with the need to treat abnormal lipid levels...
Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus co-formulated efavirenz, emtricitabine, and tenofovir for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3 trial, analysis of results after 48 weeksPaul E Sax
Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Lancet 379:2439-48. 2012..We compared the efficacy and safety of EVG/COBI/FTC/TDF with standard of care-co-formulated efavirenz (EFV)/FTC/TDF-as initial treatment for HIV infection...
Abacavir-lamivudine versus tenofovir-emtricitabine for initial HIV-1 therapyPaul E Sax
Division of Infectious Diseases and the Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
N Engl J Med 361:2230-40. 2009....
Should resistance testing be performed for treatment-naive HIV-infected patients? A cost-effectiveness analysisPaul E Sax
Division of Infectious Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
Clin Infect Dis 41:1316-23. 2005..Our objective was to determine the clinical impact and cost-effectiveness of genotype resistance testing for treatment-naive patients with chronic HIV infection...
Cost-effectiveness of enfuvirtide in treatment-experienced patients with advanced HIV diseasePaul E Sax
Division of Infectious Disease and the Partners AIDS Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Acquir Immune Defic Syndr 39:69-77. 2005..Because of the high cost of ENF compared with other antiretroviral agents, our objectives were to determine the potential long-term clinical impact and cost-effectiveness of ENF in these patients...
Tolerability and safety of HIV protease inhibitors in adultsPaul E Sax
Brigham and Women s Hospital, Division of Infectious Disease, Boston, MA 02115, USA
J Acquir Immune Defic Syndr 37:1111-24. 2004....
Antiretroviral therapy for treatment-naïve patients: a review of recent literature and the updated guidelinesJennifer A Johnson
Division of Infectious Disease, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Curr Infect Dis Rep 11:311-8. 2009....
Early antiretroviral therapy for patients with acute aids-related opportunistic infections: a cost-effectiveness analysis of ACTG A5164Paul E Sax
Division of Infectious Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
HIV Clin Trials 11:248-59. 2010..We project the life expectancies, costs, and incremental cost-effectiveness ratios (ICERs) of these strategies...
Blood (1->3)-beta-D-glucan as a diagnostic test for HIV-related Pneumocystis jirovecii pneumoniaPaul E Sax
Division of Infectious Diseases, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Clin Infect Dis 53:197-202. 2011..See the editorial commentary by Morris and Masur, on pages 203-204.)..
Opportunistic infections in HIV disease: down but not outP E Sax
Division of Infectious Diseases, HIV Program, Brigham and Women s Hospital, Boston, Massachusetts, USA
Infect Dis Clin North Am 15:433-55. 2001....
Abacavir/lamivudine versus tenofovir DF/emtricitabine as part of combination regimens for initial treatment of HIV: final resultsPaul E Sax
Division of Infectious Diseases, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Infect Dis 204:1191-201. 2011..Due to higher virologic failure with ABC/3TC in the high HIV RNA stratum, blinded treatment was stopped in this group, but study follow-up continued for all patients...
Beyond efficacy: the impact of combination antiretroviral therapy on quality of lifePaul E Sax
Brigham and Women s Hospital, Division of Infectious Diseases, 75 Francis Street, PBB A 4, Boston, Massachusetts 02115, USA
AIDS Patient Care STDS 19:563-76. 2005..As long as the virologic activity of these newer PIs is comparable to that of existing options, differentiating features beyond efficacy are important in the choice of an appropriate treatment regimen for patients with HIV...
Antiretroviral resistance associated with supervised treatment interruptions in treated acute HIV infectionCecile L Tremblay
Massachusetts General Hospital and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
AIDS 17:1086-9. 2003..Resistance should be monitored in supervised treatment interruptions trials, because mutations may first be detected only after therapy is interrupted...
Effectiveness of antiretroviral therapy after protease inhibitor failure: an analytic overviewElena Losina
Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
Clin Infect Dis 38:1613-22. 2004..The best response was seen in NNRTI-naive patients receiving NNRTI- and boosted PI-containing regimens. New approaches are needed to achieve better suppression in pretreated HIV-infected patients...
Cost-effectiveness implications of the timing of antiretroviral therapy in HIV-infected adultsBruce R Schackman
Department of Health Policy and Management, Harvard School of Public Health, Boston, MA, USA
Arch Intern Med 162:2478-86. 2002....
The impact of HIV/HCV co-infection on health care utilization and disability: results of the ACTG Longitudinal Linked Randomized Trials (ALLRT) CohortB P Linas
Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA
J Viral Hepat 18:506-12. 2011..5), 1.7 (95% CI: 1.4-2.1), and 1.6 (95% CI: 1.3-1.9) respectively. Programs serving HIV/HCV co-infected patients can expect approximately 70% higher rates of utilization than expected from a similar cohort of HIV mono-infected patients...
Quantifying the risks and benefits of efavirenz use in HIV-infected women of childbearing age in the USAH E Hsu
Harvard Medical School, Boston, MA, USA
HIV Med 12:97-108. 2011..The aim of the study was to quantify the benefits (life expectancy gains) and risks (efavirenz-related teratogenicity) associated with using efavirenz in HIV-infected women of childbearing age in the USA...
Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infectionM Altfeld
Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
J Exp Med 193:169-80. 2001..These data also provide rationale for therapeutic immunization aimed at broadening CTL responses in treated primary HIV infection...
Central nervous system aspergillosis in patients with human immunodeficiency virus infection. Report of 6 cases and reviewE Mylonakis
Infectious Disease Division, Massachusetts General Hospital, Boston 02114 2696, USA
Medicine (Baltimore) 79:269-80. 2000....
Access to medications and medical care after participation in HIV clinical trials: a systematic review of trial protocols and informed consent documentsAndrea L Ciaranello
Division of Infectious Disease, Massachusetts General Hospital, Boston, MA 02114, USA
HIV Clin Trials 10:13-24. 2009..We describe the frequency with which these posttrial services are described in the protocols and informed consent forms (ICFs) of antiretroviral drug (ARV) trials...
Longitudinal analysis of clinical markers following antiretroviral therapy initiated during acute or early HIV type 1 infectionSigall Kassutto
Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Clin Infect Dis 42:1024-31. 2006..Protease inhibitor-based and nonnucleoside reverse-transcriptase inhibitor-based regimens show comparable performance in tolerability, time to virological suppression, and CD4+ cell count when used as a first regimen...
Retroviral rebound syndrome with fatal outcome after discontinuation of antiretroviral therapyAmy B Garlin
Division of Infectious Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Clin Infect Dis 41:e83-5. 2005..Cases of retroviral rebound syndrome reported in the literature are briefly reviewed...
Predicting virologic failure in an HIV clinicGregory K Robbins
Harvard Medical School, Boston, Massachusetts, USA
Clin Infect Dis 50:779-86. 2010..We sought to use data captured in the electronic health record (EHR) to develop and validate a prediction rule for virologic failure among patients being treated for infection with human immunodeficiency virus (HIV)...
Treatment for primary HIV infection: projecting outcomes of immediate, interrupted, or delayed therapyRochelle P Walensky
Division of Infectious Disease and the Partners AIDS Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA
J Acquir Immune Defic Syndr 31:27-37. 2002..These results can assist decision makers and those planning clinical trials in defining evidence-based performance measures for primary HIV infection treatment and future trials...
Response to hepatitis B vaccine in HIV-1-positive subjects who test positive for isolated antibody to hepatitis B core antigen: implications for hepatitis B vaccine strategiesRajesh T Gandhi
Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Infect Dis 191:1435-41. 2005..Development of an anamnestic response after vaccination would suggest previous hepatitis B virus (HBV) infection, in which case vaccination is not necessary...
Routine human immunodeficiency virus testing: an economic evaluation of current guidelinesRochelle P Walensky
Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, and the Partners AIDS Research Center, Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Med 118:292-300. 2005..Our objective was to evaluate the clinical effect and cost-effectiveness of current guidelines and of alternate HIV prevalence thresholds...
The survival benefits of AIDS treatment in the United StatesRochelle P Walensky
Division of Infectious Disease and General Medicine, Massachusetts General Hospital, Boston 02114, USA
J Infect Dis 194:11-9. 2006..As widespread adoption of potent combination antiretroviral therapy (ART) reaches its tenth year, our objective was to quantify the cumulative survival benefits of acquired immunodeficiency syndrome (AIDS) care in the United States...
Projecting the cost-effectiveness of adherence interventions in persons with human immunodeficiency virus infectionSue J Goldie
Center for Risk Analysis, Harvard School of Public Health, Boston, Massachusetts 02115 5924, USA
Am J Med 115:632-41. 2003..To explore the cost-effectiveness of interventions to improve adherence to combination antiretroviral therapy in patients with human immunodeficiency virus (HIV) infection...
Metabolic effects of rosiglitazone in HIV lipodystrophy: a randomized, controlled trialColleen Hadigan
Massachusetts General Hospital and Brigham and Women s Hospital, Boston, Massachusetts 02114, USA
Ann Intern Med 140:786-94. 2004....
Isolated antibody to hepatitis B core antigen in human immunodeficiency virus type-1-infected individualsRajesh T Gandhi
Infectious Diseases Unit, Massachusetts General Hospital, Boston, MA 02114, USA
Clin Infect Dis 36:1602-5. 2003..A screening strategy that tests only for HBsAg and anti-HBs in HIV-1-infected patients will miss a large number of individuals with isolated anti-HBc...
Predictive value of polymerase chain reaction of cerebrospinal fluid for detection of Epstein-Barr virus to establish the diagnosis of HIV-related primary central nervous system lymphomaLouise C Ivers
Division of Infectious Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Clin Infect Dis 38:1629-32. 2004..Of 7 patients with CSF PCR positive for EBV, 2 had PCNSL, and 5 received alternative diagnoses (specificity, 79.1%)...
Safety and immunogenicity of therapeutic DNA vaccination in individuals treated with antiretroviral therapy during acute/early HIV-1 infectionEric S Rosenberg
Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 5:e10555. 2010..clinicaltrials.gov NCT00125099)..
Therapeutic options for treatment experienced patients: a focus on resistance testing and optimizing background therapyPaul E Sax
Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
AIDS Read 16:265-75, 277-8. 2006..The development of new agents will be necessary to create highly effective regimens for patients with complicated resistance patterns...
Test and treat DC: forecasting the impact of a comprehensive HIV strategy in Washington DCRochelle P Walensky
Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Clin Infect Dis 51:392-400. 2010..We forecast outcomes of this approach if implemented in Washington DC...
Prediction of coronary heart disease risk in HIV-infected patients with fat redistributionColleen Hadigan
Program in Nutritional Metabolism, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
Clin Infect Dis 36:909-16. 2003..Therefore, although CHD risk is increased in HIV-infected patients with fat redistribution, the pattern of fat distribution and sex are potential important components in determining the risk in this population...
Positive Epstein-Barr virus heterophile antibody tests in patients with primary human immunodeficiency virus infectionJ A Vidrih
Department of Medicine, Section of General Internal Medicine and Clinical AIDS Program, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts, USA
Am J Med 111:192-4. 2001..Patients presenting with nonspecific viral syndromes should be assessed for HIV risk behaviors and tested for primary HIV infection when appropriate...
Pharmacokinetic interactions between ritonavir-boosted darunavir and NNRTIs: a report of 3 casesHolly E Rawizza
Division of Infectious Diseases, Brigham and Women s Hospital, Boston, Massachusetts, USA
AIDS Read 18:466-72, 478-9. 2008..Understanding these pharmacokinetic changes might allow clinicians to predict which patients may be more vulnerable to adverse effects or inadequate antiviral activity caused by this drug interaction...
Male sexual dysfunction associated with antiretroviral therapyAmy E Colson
Channing Laboratory, Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
J Acquir Immune Defic Syndr 30:27-32. 2002..69; 95% CI, 0.84-3.37; p =.14), nelfinavir (HR, 1.53; 95% CI, 0.66-3.54; p =.32) and saquinavir (HR, 1.25; 95% CI, 0.53-2.96; p =.60). We conclude that PIs, especially ritonavir, appear to increase the risk of sexual dysfunction...
The major genetic determinants of HIV-1 control affect HLA class I peptide presentationFlorencia Pereyra
Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology MIT and Harvard, Boston, MA, USA
Science 330:1551-7. 2010..These results implicate the nature of the HLA-viral peptide interaction as the major factor modulating durable control of HIV infection...
HSV-1 encephalitis complicated by cerebral hemorrhage in an HIV-positive personJonathan Z Li
Division of Infectious Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
AIDS Read 19:153-5. 2009..He ultimately improved after surgical decompression, treatment with acyclovir, and a switch from a protease inhibitor-based antiretroviral regimen to one including an integrase inhibitor...
Top stories of 2007Paul E Sax
AIDS Clin Care 20:1-3. 2008
Report from the 47th Interscience Conference on Antimicrobial Agents and ChemotherapyPaul E Sax
AIDS Clin Care 19:99-100. 2007
Updated DHHS treatment guidelinesPaul E Sax
AIDS Clin Care 18:105. 2006
Potential risks and benefits of HIV treatment simplification: a simulation model of a proposed clinical trialBruce R Schackman
Department of Public Health, Weill Cornell Medical College, New York, NY 10021, USA
Clin Infect Dis 45:1062-70. 2007..We projected the long-term outcomes of this treatment simplification strategy to inform the design of a proposed multicenter, randomized clinical trial...
FDA approval: etravirinePaul E Sax
AIDS Clin Care 20:17-8. 2008
Epidemiological evidence for cardiovascular disease in HIV-infected patients and relationship to highly active antiretroviral therapyJudith S Currier
Circulation 118:e29-35. 2008
Lower dose of ritonavir approved for use with fosamprenavirPaul E Sax
AIDS Clin Care 19:106. 2007
XVI International AIDS Conference: Part 1Brian A Boyle
Department of International Medicine and Infectious Diseases, New York Presbyterian Hospital-Weill Medical College of Cornell University, New York, USA
AIDS Read 16:517-21. 2006
Report from the 14th Retrovirus Conference. Treatment options for antiretroviral-naive patientsPaul E Sax
AIDS Clin Care 19:38-9. 2007
Safety and antiviral activity at 48 weeks of lopinavir/ritonavir plus nevirapine and 2 nucleoside reverse-transcriptase inhibitors in human immunodeficiency virus type 1-infected protease inhibitor-experienced patientsConstance A Benson
Department of Medicine, University of Colorado Health Sciences Center, 4200 E 9th Avenue, B 168, Denver, CO 80262, USA
J Infect Dis 185:599-607. 2002..Mean CD4 cell counts increased by 125 cells/muL. Three patients discontinued therapy for drug-related adverse events...
Report from the XVI International AIDS Conference. Preexposure prophylaxis studies move forwardPaul E Sax
AIDS Clin Care 18:101-2. 2006
XVI International AIDS Conference: Part 2Brian A Boyle
Department of International Medicine and Infectious Diseases, New York Presbyterian Hospital-Weill Medical College of Cornell University, New York, USA
AIDS Read 16:581-4, 591-2. 2006
Low prevalence of ongoing hepatitis B viremia in HIV-positive individuals with isolated antibody to hepatitis B core antigenRajesh T Gandhi
J Acquir Immune Defic Syndr 34:439-41. 2003
Report from the 11th conference on retroviruses and opportunistic infections. New drugsPaul E Sax
AIDS Clin Care 16:29. 2004
Report from the 12th Retrovirus Conference. ResistancePaul E Sax
AIDS Clin Care 17:36-7. 2005
Meeting notes from ICAAC. Tenofovir + ddI: a combination to avoidPaul E Sax
AIDS Clin Care 17:6-7. 2005
Report from the Tenth Retrovirus Conference. New drugsPaul E Sax
AIDS Clin Care 15:32-3. 2003
Report from the 12th Retrovirus Conference. New drugsPaul E Sax
AIDS Clin Care 17:37. 2005
Treating morphologic and metabolic complications in HIV-infected patients on antiretroviral therapy. A consensus statement of an advisory committee of the International Association of Physicians in AIDS CareCarl J Fichtenbaum
IAPAC Mon 11:38-46. 2005..Scientific and clinical research, and other data in published literature and abstracts from scientific conferences were considered by strength of evidence. This document represents the consensus agreement of the Advisory Committee...
FDA approval: tipranavirPaul E Sax
AIDS Clin Care 17:78. 2005
Report from the 45th Interscience Conference on Antimicrobial Agents and ChemotherapyPaul E Sax
AIDS Clin Care 18:25-6. 2006
Report from the 13th retrovirus conference. Should we be starting treatment earlier?Paul E Sax
AIDS Clin Care 18:36. 2006
The lifetime cost of current human immunodeficiency virus care in the United StatesBruce R Schackman
Department of Public Health, Weill Medical College of Cornell University, New York, New York 10021, USA
Med Care 44:990-7. 2006..We sought to project the lifetime cost of medical care for human immunodefiency virus (HIV)-infected adults using current antiretroviral therapy (ART) standards...
Hepatic steatosis is associated with fibrosis, nucleoside analogue use, and hepatitis C virus genotype 3 infection in HIV-seropositive patientsBarbara H McGovern
HIV HCV Co infection Clinic, Lemuel Shattuck Hospital, Jamaica Plain, Jamaica Plain, MA 02494, USA
Clin Infect Dis 43:365-72. 2006....
Renal safety of tenofovir disoproxil fumaratePaul E Sax
AIDS Read 17:90-2, 99-104, C3. 2007..We present a review of the renal safety of tenofovir and provide a brief summary of the clinical implications of these data...
Revised package insert for atazanavirPaul E Sax
AIDS Clin Care 20:23. 2008
Meeting notes from ICAAC. D-D4FC (Reverset): further data on treatment-experienced patientsPaul E Sax
AIDS Clin Care 17:8. 2005
FDA approval: darunavirPaul E Sax
AIDS Clin Care 18:71. 2006
Top stories of 2004. Back to the future: lopinavir/ritonavir as "monotherapy"Paul E Sax
AIDS Clin Care 17:4. 2005
Meeting report. Report from ICAACPaul E Sax
AIDS Clin Care 18:111-2. 2006
Meeting report from the XV International AIDS Conference. New drugsPaul E Sax
AIDS Clin Care 16:71-2. 2004
Meeting notes from ICAAC. NRTI-only regimens: making a comeback?Paul E Sax
AIDS Clin Care 17:8-9. 2005
One pill, once daily: now an option for HIV patientsPaul E Sax
AIDS Clin Care 18:77. 2006
Meeting report from the XV International AIDS Conference. Structured treatment interruption and other novel treatment strategiesPaul E Sax
AIDS Clin Care 16:72-3. 2004
FDA approval: maravirocPaul E Sax
AIDS Clin Care 19:75. 2007
Report from the Tenth Retrovirus Conference. Comparing efavirenz and nevirapine: the 2NN studyPaul E Sax
AIDS Clin Care 15:32. 2003
Report on the XIV International AIDS ConferenceSalim S Abdool Karim
AIDS Clin Care 14:77-85. 2002
Meeting notes from the 3rd IAS Conference. Advances in the treatment of hepatitis/HIV coinfectionPaul E Sax
AIDS Clin Care 17:97-8. 2005..New studies address the optimal duration of HCV treatment, early predictors of treatment response, and risk factors for liver-related mortality...
Report from the 13th retrovirus conference. Vicriviroc less effective than efavirenz in treatment-naive patientsPaul E Sax
AIDS Clin Care 18:34-5. 2006
Roundtable. Who should be providing HIV care?Jonathan S Appelbaum
AIDS Clin Care 18:21-4. 2006
