Sandro Santagata

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Intramedullary neuroma of the cervicomedullary junction. Case report
    Sandro Santagata
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02130, USA
    J Neurosurg Spine 5:362-6. 2006
  2. pmc BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications
    Dora Dias-Santagata
    Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e17948. 2011
  3. pmc Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state
    Sandro Santagata
    Department of Pathology, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02215, USA
    Science 341:1238303. 2013
  4. pmc MALDI mass spectrometry imaging analysis of pituitary adenomas for near-real-time tumor delineation
    David Calligaris
    Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 112:9978-83. 2015
  5. doi request reprint ARID1A and TERT promoter mutations in dedifferentiated meningioma
    Malak S Abedalthagafi
    Division of Neuropathology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Cancer Genet 208:345-50. 2015
  6. pmc Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery
    Sandro Santagata
    Departments of Pathology, Department of Pathology, Boston Children s Hospital and Harvard Medical School, Boston, MA 02115 Department of Cancer Biology, Harvard Medical School and Dana Farber Cancer Institute, Boston, MA 02115
    Proc Natl Acad Sci U S A 111:11121-6. 2014
  7. pmc Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1
    Lori A Ramkissoon
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 110:8188-93. 2013
  8. doi request reprint Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets
    Priscilla K Brastianos
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts Broad Institute, Boston, Massachusetts
    Cancer Discov 5:1164-77. 2015
  9. pmc CRX is a diagnostic marker of retinal and pineal lineage tumors
    Sandro Santagata
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 4:e7932. 2009
  10. doi request reprint MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism
    Pratiti Bandopadhayay
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Nat Genet 48:273-82. 2016

Detail Information

Publications35

  1. ncbi request reprint Intramedullary neuroma of the cervicomedullary junction. Case report
    Sandro Santagata
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02130, USA
    J Neurosurg Spine 5:362-6. 2006
    ..This case may represent the first true traumatic intramedullary neuroma of the CMJ diagnosed in a living patient and treated surgically...
  2. pmc BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications
    Dora Dias-Santagata
    Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e17948. 2011
    ..1%) giant cell GBM (gcGBM). The finding that BRAF V600E mutations are common in the majority of PXA has important therapeutic implications and may help in differentiating less aggressive PXAs from lethal gcGBMs and GBMs...
  3. pmc Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state
    Sandro Santagata
    Department of Pathology, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02215, USA
    Science 341:1238303. 2013
    ....
  4. pmc MALDI mass spectrometry imaging analysis of pituitary adenomas for near-real-time tumor delineation
    David Calligaris
    Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 112:9978-83. 2015
    ..The tissue characterization can be completed in fewer than 30 min and could therefore be applied for the near-real-time detection and delineation of pituitary tumors for intraoperative surgical decision-making. ..
  5. doi request reprint ARID1A and TERT promoter mutations in dedifferentiated meningioma
    Malak S Abedalthagafi
    Division of Neuropathology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Cancer Genet 208:345-50. 2015
    ..These findings provide new insights into intratumoral heterogeneity in the evolution of malignant phenotypes in anaplastic meningiomas and potential pathways of malignant progression. ..
  6. pmc Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery
    Sandro Santagata
    Departments of Pathology, Department of Pathology, Boston Children s Hospital and Harvard Medical School, Boston, MA 02115 Department of Cancer Biology, Harvard Medical School and Dana Farber Cancer Institute, Boston, MA 02115
    Proc Natl Acad Sci U S A 111:11121-6. 2014
    ..This work indicates that metabolite-imaging MS could transform many aspects of surgical care. ..
  7. pmc Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1
    Lori A Ramkissoon
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 110:8188-93. 2013
    ..Our results define clinically relevant molecular subclasses of diffuse PLGGs and highlight a potential role for the MYB family in the biology of low-grade gliomas...
  8. doi request reprint Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets
    Priscilla K Brastianos
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts Broad Institute, Boston, Massachusetts
    Cancer Discov 5:1164-77. 2015
    ..Genomic analysis of brain metastases provides an opportunity to identify potentially clinically informative alterations not detected in clinically sampled primary tumors, regional lymph nodes, or extracranial metastases...
  9. pmc CRX is a diagnostic marker of retinal and pineal lineage tumors
    Sandro Santagata
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 4:e7932. 2009
    ..To determine the biologic and diagnostic potential of CRX in human tumors of the retina and pineal, we examined its expression in multiple settings...
  10. doi request reprint MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism
    Pratiti Bandopadhayay
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Nat Genet 48:273-82. 2016
    ..To our knowledge, this represents the first example of a single driver rearrangement simultaneously transforming cells via three genetic and epigenetic mechanisms in a tumor. ..
  11. doi request reprint Decreased FOXJ1 expression and its ciliogenesis programme in aggressive ependymoma and choroid plexus tumours
    Malak S Abedalthagafi
    Department of Pathology, Division of Neuropathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Pathol 238:584-97. 2016
    ..Copyright © 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. ..
  12. pmc Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas
    Priscilla K Brastianos
    1 Division of Hematology Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA 2 Division of Neuro Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA 3 Harvard Medical School, Boston, Massachusetts, USA 4 Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA 5 Broad Institute of MIT and Harvard, Boston, Massachusetts, USA 6
    Nat Genet 46:161-5. 2014
    ..Adamantinomatous and papillary craniopharyngiomas harbor mutations that are mutually exclusive and clonal. These findings have important implications for the diagnosis and treatment of these neoplasms. ..
  13. pmc Using the heat-shock response to discover anticancer compounds that target protein homeostasis
    Sandro Santagata
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, United States
    ACS Chem Biol 7:340-9. 2012
    ..From a chemical biology perspective, they define a robust approach for discovering candidate compounds that target the malignant phenotype by disrupting protein homeostasis...
  14. pmc DNA fragmentation simulation method (FSM) and fragment size matching improve aCGH performance of FFPE tissues
    Justin M Craig
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
    PLoS ONE 7:e38881. 2012
    ..This study demonstrates that rigorous control of DNA fragment size improves aCGH performance. This methodological advance will permit the routine analysis of FFPE tumor samples for clinical trials and in daily clinical practice...
  15. pmc Detection of KIAA1549-BRAF fusion transcripts in formalin-fixed paraffin-embedded pediatric low-grade gliomas
    Yongji Tian
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02215, USA
    J Mol Diagn 13:669-77. 2011
    ..These results show that fusion transcripts and mutations can be detected reliably in standard FFPE specimens and may be useful for incorporation into future studies of pediatric gliomas in basic science or clinical trials...
  16. doi request reprint Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype
    Guillaume Bergthold
    Department of Cancer Biology, Dana Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts G B, P B, B R P, S E S, B T, R F L, C S, R S, R B Broad Institute, Cambridge, Massachusetts G B, P B, B R P, S E S, B T, R F L, T G, R B Pediatric Neuro Oncology Program, Dana Farber Boston Children s Cancer and Blood Disorders Center, Dana Farber Cancer Institute and Boston Children s Hospital, and Harvard Medical School, Boston, Massachusetts P B, L C G, M W K Liver Cancer Program, Tisch Cancer Institute, Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York Y H Department of Pathology, Brigham and Women s Hospital, Boston
    Neuro Oncol 17:1486-96. 2015
    ..However, little is known about the molecular characteristics inherent to their clinical and histological heterogeneity...
  17. doi request reprint A prognostic cytogenetic scoring system to guide the adjuvant management of patients with atypical meningioma
    Ayal A Aizer
    Department of Radiation Oncology, Dana Farber Brigham and Women s Cancer Center, Boston, Massachusetts A A A, M C H, N D A, B M A Department of Pathology, Dana Farber Brigham and Women s Cancer Center, Boston, Massachusetts M A, K L L, A H L, S S Department of Neurosurgery, Dana Farber Brigham and Women s Cancer Center, Boston, Massachusetts W L B, O A M, I F D Center for Neuro Oncology, Dana Farber Brigham and Women s Cancer Center, Boston, Massachusetts E Q L, L N, M L R, A D N, D A R, P Y W, R B
    Neuro Oncol 18:269-74. 2016
    ..We sought to determine whether cytogenetic/genetic characterization may facilitate better estimation of the probability of recurrence...
  18. doi request reprint Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma
    Shakti H Ramkissoon
    Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Boston, Massachusetts S H R, L A R, S H, D K, Y J K, K L L Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts S E S, L B, M B, D A R, E Q L, M L R, A D N, L N, S R, L M D, D C L, P K, B J R, P Y W, R B, K L L Department of Neurosurgery, Brigham and Women s Hospital, Boston, Massachusetts W L B, E B C, O A M, M D J, A J G
    Neuro Oncol 17:1344-55. 2015
    ..We report our experience with implementing a multiplexed copy number and mutation-testing program in a diagnostic laboratory certified by the Clinical Laboratory Improvement Amendments...
  19. pmc Angiomatous meningiomas have a distinct genetic profile with multiple chromosomal polysomies including polysomy of chromosome 5
    Malak S Abedalthagafi
    Department of Pathology, Division of Neuropathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Oncotarget 5:10596-606. 2014
    ..Our study demonstrates that angiomatous meningiomas have distinct genomic features that may be clinically useful for their diagnosis...
  20. doi request reprint Cross-reactivity of the BRAF VE1 antibody with epitopes in axonemal dyneins leads to staining of cilia
    Robert T Jones
    Division of Neuropathology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Mod Pathol 28:596-606. 2015
    ..A familiarity with the cross-reactivity of the VE1 antibody with epitopes of proteins in cilia is of value when evaluating tissues stained with this important clinical antibody. ..
  21. pmc Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells
    Mikko Taipale
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Nat Biotechnol 31:630-7. 2013
    ....
  22. pmc Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations
    Priscilla K Brastianos
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Nat Genet 45:285-9. 2013
    ..These mutations were present in therapeutically challenging tumors of the skull base and higher grade. These results begin to define the spectrum of genetic alterations in meningiomas and identify potential therapeutic targets...
  23. pmc Multiplex amplification coupled with COLD-PCR and high resolution melting enables identification of low-abundance mutations in cancer samples with low DNA content
    Coren A Milbury
    Department of Radiation Oncology, Dana Farber Brigham and Women s Cancer Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Mol Diagn 13:220-32. 2011
    ..In summary, we demonstrate an efficient approach to increase screening capabilities from limited DNA material via multiplex-PCR and improve mutation detection sensitivity via COLD-PCR amplification...
  24. pmc The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection
    Claire Marie Filone
    Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts, United States of America United States Army Medical Research Institute of Infectious Diseases, Virology Division, Fort Detrick, Maryland, United States of America
    PLoS Pathog 10:e1003904. 2014
    ..The dependence on HSF1 and its chaperone network offers multiple opportunities for antiviral drug development. ..
  25. pmc Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome
    Yoon Jae Cho
    Children s Hospital Boston, Boston, MA 02115, USA
    J Clin Oncol 29:1424-30. 2011
    ....
  26. doi request reprint Phase II study of protracted daily temozolomide for low-grade gliomas in adults
    Santosh Kesari
    Dana Farber Brigham and Women s Cancer Center, Center for Neuro Oncology, Boston, MA 02115, USA
    Clin Cancer Res 15:330-7. 2009
    ..Protracted treatment with temozolomide potentially overcomes MGMT resistance and improves outcome. We conducted a phase II study of protracted daily temozolomide in adults with low-grade gliomas...
  27. pmc Profiling critical cancer gene mutations in clinical tumor samples
    Laura E MacConaill
    Center for Cancer Genome Discovery, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 4:e7887. 2009
    ..We report the implementation of a genotyping and validation algorithm that enables robust tumor mutation profiling in the clinical setting...
  28. doi request reprint ENDOCRINE TUMORS: BRAF V600E mutations in papillary craniopharyngioma
    Priscilla K Brastianos
    Division of Neuro OncologyMassachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USADepartment of Cancer BiologyDana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USADepartment of PathologyBrigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USADepartment of PathologyBoston Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Eur J Endocrinol 174:R139-44. 2016
    ..Further advances in the non-invasive diagnosis of PCP by radiologic criteria and by cell-free DNA testing could someday allow neo-adjuvant therapy for this disease in select patient populations. ..
  29. pmc Intraoperative Magnetic Resonance Imaging in Intracranial Glioma Resection: A Single-Center, Retrospective Blinded Volumetric Study
    Olutayo Ibukunolu Olubiyi
    Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA Electronic address
    World Neurosurg 84:528-36. 2015
    ..Intraoperative magnetic resonance imaging (IoMRI) was devised to overcome brain shifts during craniotomies. Yet, the acceptance of IoMRI is limited...
  30. pmc Increased expression of the immune modulatory molecule PD-L1 (CD274) in anaplastic meningioma
    Ziming Du
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Oncotarget 6:4704-16. 2015
    ..This work indicates that high-grade meningioma harbor an immunosuppressive tumor microenviroment and that increased Treg cells and elevated PD-L1 may contribute to the aggressive phenotype of these tumors. ..
  31. pmc Sporadic hemangioblastomas are characterized by cryptic VHL inactivation
    Ganesh M Shankar
    Departments of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA
    Acta Neuropathol Commun 2:167. 2014
    ..Our findings support the central role of VHL inactivation in the molecular pathogenesis of both familial and sporadic hemangioblastomas...
  32. pmc Mass spectrometry imaging as a tool for surgical decision-making
    David Calligaris
    Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, 02115, USA
    J Mass Spectrom 48:1178-87. 2013
    ....
  33. pmc High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer
    Sandro Santagata
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:18378-83. 2011
    ..The findings indicate that HSF1 should be evaluated prospectively as an independent prognostic indicator in ER-positive breast cancer. HSF1 may ultimately be a useful therapeutic target in cancer...
  34. ncbi request reprint Embryonic stem cell transcription factor signatures in the diagnosis of primary and metastatic germ cell tumors
    Sandro Santagata
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 31:836-45. 2007
    ....
  35. ncbi request reprint Anaplastic variant of medulloblastoma mimicking a vestibular schwannoma
    Sandro Santagata
    Division of Neuropathology, Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    J Neurooncol 81:49-51. 2007