Mohammad Salajegheh

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Autoantibodies against a 43 KDa muscle protein in inclusion body myositis
    Mohammad Salajegheh
    Department of Neurology, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 6:e20266. 2011
  2. pmc Sarcoplasmic redistribution of nuclear TDP-43 in inclusion body myositis
    Mohammad Salajegheh
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, and Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
    Muscle Nerve 40:19-31. 2009
  3. doi request reprint Permissive environment for B-cell maturation in myositis muscle in the absence of B-cell follicles
    Mohammad Salajegheh
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
    Muscle Nerve 42:576-83. 2010
  4. doi request reprint Cytosolic 5'-nucleotidase 1A autoimmunity in sporadic inclusion body myositis
    H Benjamin Larman
    Department of Genetics, Harvard University Medical School, Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Ann Neurol 73:408-18. 2013
  5. pmc Interferon-stimulated gene 15 (ISG15) conjugates proteins in dermatomyositis muscle with perifascicular atrophy
    Mohammad Salajegheh
    Children s Hospital Informatics Program, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Neurol 67:53-63. 2010
  6. pmc Human plasmacytoid dendritic cell accumulation amplifies their type 1 interferon production
    Anne P Liao
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Boston, MA, USA
    Clin Immunol 136:130-8. 2010
  7. doi request reprint Nature of "Tau" immunoreactivity in normal myonuclei and inclusion body myositis
    Mohammad Salajegheh
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Muscle Nerve 40:520-8. 2009
  8. doi request reprint Interferon β is associated with type 1 interferon-inducible gene expression in dermatomyositis
    Anne P Liao
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital and Children s Hospital Informatics Program, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Ann Rheum Dis 70:831-6. 2011
  9. pmc Type 1 interferons inhibit myotube formation independently of upregulation of interferon-stimulated gene 15
    Sara Franzi
    Children s Hospital Informatics Program, Boston Children s Hospital, Boston, Massachusetts, USA
    PLoS ONE 8:e65362. 2013
  10. doi request reprint Etiology of limb girdle muscular dystrophy 1D/1E determined by laser capture microdissection proteomics
    Steven A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Neurol 71:141-5. 2012

Collaborators

Detail Information

Publications13

  1. pmc Autoantibodies against a 43 KDa muscle protein in inclusion body myositis
    Mohammad Salajegheh
    Department of Neurology, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 6:e20266. 2011
    ..Though widely believed to have no significant humoral autoimmunity, we sought to identify novel autoantibodies with high specificity for this disease...
  2. pmc Sarcoplasmic redistribution of nuclear TDP-43 in inclusion body myositis
    Mohammad Salajegheh
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, and Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
    Muscle Nerve 40:19-31. 2009
    ..TDP-43 could be one of many nucleic acid binding proteins that are abnormally present in IBM sarcoplasm. They could potentially interfere with the normal function of extranuclear RNAs that maintain myofiber protein production...
  3. doi request reprint Permissive environment for B-cell maturation in myositis muscle in the absence of B-cell follicles
    Mohammad Salajegheh
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
    Muscle Nerve 42:576-83. 2010
    ..An atypical lymphoid histology, lacking concentrated collections of germinal-center-like B-cell follicles, is capable of antigen-stimulated clonal maturation of antibody-producing plasma cells...
  4. doi request reprint Cytosolic 5'-nucleotidase 1A autoimmunity in sporadic inclusion body myositis
    H Benjamin Larman
    Department of Genetics, Harvard University Medical School, Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Ann Neurol 73:408-18. 2013
    ..Here, we sought to identify the molecular target of this IBM autoantibody, understand the relationship between IBM autoimmunity and muscle degeneration, and develop an IBM blood test with high diagnostic accuracy...
  5. pmc Interferon-stimulated gene 15 (ISG15) conjugates proteins in dermatomyositis muscle with perifascicular atrophy
    Mohammad Salajegheh
    Children s Hospital Informatics Program, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Neurol 67:53-63. 2010
    ..We investigated interferon-stimulated gene 15 (ISG15), a poorly understood ubiquitin-like modifier, and its enzymatic pathway in dermatomyositis (DM), an autoimmune disease primarily involving muscle and skin...
  6. pmc Human plasmacytoid dendritic cell accumulation amplifies their type 1 interferon production
    Anne P Liao
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Boston, MA, USA
    Clin Immunol 136:130-8. 2010
    ..The role of the IFNAR-dependent mechanism of interferon production by human pDCs is greater than previously suggested. IFNAR blockade has potential for diminishing type 1 interferon production by all human cells...
  7. doi request reprint Nature of "Tau" immunoreactivity in normal myonuclei and inclusion body myositis
    Mohammad Salajegheh
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Muscle Nerve 40:520-8. 2009
    ..Normal myonuclei contain neurofilament H or other unidentified 200 kDa proteins with similar phosphorylated motifs accounting for SMI-31 immunoreactivity...
  8. doi request reprint Interferon β is associated with type 1 interferon-inducible gene expression in dermatomyositis
    Anne P Liao
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital and Children s Hospital Informatics Program, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Ann Rheum Dis 70:831-6. 2011
    ..To determine whether type 1 interferon (IFN) proteins in blood are associated with downstream type 1 IFN-inducible gene expression in blood from patients with myositis...
  9. pmc Type 1 interferons inhibit myotube formation independently of upregulation of interferon-stimulated gene 15
    Sara Franzi
    Children s Hospital Informatics Program, Boston Children s Hospital, Boston, Massachusetts, USA
    PLoS ONE 8:e65362. 2013
    ..To test this postulate, we developed a model of type 1 IFN mediated myotube toxicity and assessed whether or not downregulation of ISG15 expression prevents this toxicity...
  10. doi request reprint Etiology of limb girdle muscular dystrophy 1D/1E determined by laser capture microdissection proteomics
    Steven A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Neurol 71:141-5. 2012
    ..Sequencing in this patient and family members identified the genetic basis of the previously reported 6q23 linked LGMD1D/1E to be due to an intron splice donor site mutation (IVS3+3A>G) of the desmin gene located on chromosome 2q35...
  11. ncbi request reprint A local antigen-driven humoral response is present in the inflammatory myopathies
    Elizabeth M Bradshaw
    Department of Neurology, Laboratory of Molecular Immunology, Center for Neurologic Diseases and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 178:547-56. 2007
    ..These findings highlight the need for a revision of the current paradigm of exclusively T cell-mediated intramuscular Ag-specific autoimmunity in inclusion body myositis and polymyositis...
  12. pmc Targeted mutation of mouse skeletal muscle sodium channel produces myotonia and potassium-sensitive weakness
    Lawrence J Hayward
    Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Clin Invest 118:1437-49. 2008
    ....
  13. ncbi request reprint Upregulation of thrombospondin-1(TSP-1) and its binding partners, CD36 and CD47, in sporadic inclusion body myositis
    Mohammad Salajegheh
    The Division of Neuromuscular Disease, Department of Neurology, Brigham and Women s Hospital, 75 Francis Street, Tower 5D, Boston, MA 02115, USA
    J Neuroimmunol 187:166-74. 2007
    ..The TSP-complex is another inflammatory mediator associated with chronic inflammation in IBM that may perpetuate the immune responses to local antigens in response to TNF-alpha...