Elizabeth A Sailhamer

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Fulminant Clostridium difficile colitis: patterns of care and predictors of mortality
    Elizabeth A Sailhamer
    Department of Surgery, Division of Trauma, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Arch Surg 144:433-9; discussion 439-40. 2009
  2. ncbi Cell protective mechanism of valproic acid in lethal hemorrhagic shock
    Yongqing Li
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Surgery 144:217-24. 2008
  3. ncbi Hypoxic "second hit" in leukocytes from trauma patients: Modulation of the immune response by histone deacetylase inhibition
    Elizabeth A Sailhamer
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Cytokine 49:303-11. 2010
  4. ncbi Pharmacologic resuscitation: cell protective mechanisms of histone deacetylase inhibition in lethal hemorrhagic shock
    Muhammad U Butt
    Department of Surgery, Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    J Surg Res 156:290-6. 2009
  5. ncbi Protective effect of suberoylanilide hydroxamic acid against LPS-induced septic shock in rodents
    Yongqing Li
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Shock 32:517-23. 2009
  6. ncbi Putting life on hold-for how long? Profound hypothermic cardiopulmonary bypass in a Swine model of complex vascular injuries
    Hasan B Alam
    Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Trauma 64:912-22. 2008
  7. ncbi Acetylation: a novel method for modulation of the immune response following trauma/hemorrhage and inflammatory second hit in animals and humans
    Elizabeth A Sailhamer
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Surgery 144:204-16. 2008
  8. ncbi Prevention of hypoxia-induced neuronal apoptosis through histone deacetylase inhibition
    Yongqing Li
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA
    J Trauma 64:863-70; discussion 870-1. 2008
  9. ncbi Identification of a novel potential biomarker in a model of hemorrhagic shock and valproic acid treatment
    Yongqing Li
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Surg Res 159:474-81. 2010
  10. ncbi Histone deacetylase inhibitors prevent apoptosis following lethal hemorrhagic shock in rodent kidney cells
    Nikolaos Zacharias
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Resuscitation 82:105-9. 2011

Research Grants

  1. Histone deacetylase as a therapeutic target in rodent models of hemorrhagic shock
    Elizabeth Sailhamer; Fiscal Year: 2007

Collaborators

  • Hasan B Alam
  • George C Velmahos
  • Tareq Kheirbek
  • Peter Rhee
  • Hang Zhao
  • Elena Koustova
  • David R King
  • Yongqing Li
  • Baoling Liu
  • Marc Demoya
  • Christian Shults
  • Muhammad U Butt
  • Fahad Shuja
  • Huazhen Chen
  • Nikolaos Zacharias
  • Themistoklis Kourkoumpetis
  • Eugene Y Fukudome
  • Zengqiang Yuan
  • Tom Lin
  • Marc de Moya
  • Towia A Libermann
  • Dimitra Manolakaki
  • Simon T Dillon
  • Yuchiao Chang
  • Marc M De Moya
  • Eleftherios Mylonakis
  • Xiaobo Zhang
  • Charles A Hales
  • Robert A Finkelstein
  • Malek Tabbara
  • Muhammad Umar Butt
  • John Kirkpatrick

Detail Information

Publications17

  1. ncbi Fulminant Clostridium difficile colitis: patterns of care and predictors of mortality
    Elizabeth A Sailhamer
    Department of Surgery, Division of Trauma, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Arch Surg 144:433-9; discussion 439-40. 2009
    ..There exist predictors of mortality and the need for colectomy among patients with fulminant Clostridium difficile colitis...
  2. ncbi Cell protective mechanism of valproic acid in lethal hemorrhagic shock
    Yongqing Li
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Surgery 144:217-24. 2008
    ..This study investigated whether VPA treatment works through the beta-catenin survival pathways...
  3. ncbi Hypoxic "second hit" in leukocytes from trauma patients: Modulation of the immune response by histone deacetylase inhibition
    Elizabeth A Sailhamer
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Cytokine 49:303-11. 2010
    ..The current experiments were designed to study the effects of HDACI after hemorrhage and severe hypoxia...
  4. ncbi Pharmacologic resuscitation: cell protective mechanisms of histone deacetylase inhibition in lethal hemorrhagic shock
    Muhammad U Butt
    Department of Surgery, Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    J Surg Res 156:290-6. 2009
    ..This study investigated whether VPA treatment works through the c-Jun N-terminal kinase (JNK)/Caspase-3 survival pathways...
  5. ncbi Protective effect of suberoylanilide hydroxamic acid against LPS-induced septic shock in rodents
    Yongqing Li
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Shock 32:517-23. 2009
    ..We report for the first time that administration of SAHA (50 mg/kg) significantly attenuates a variety of inflammatory markers and improves long-term survival after a lethal LPS insult...
  6. ncbi Putting life on hold-for how long? Profound hypothermic cardiopulmonary bypass in a Swine model of complex vascular injuries
    Hasan B Alam
    Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Trauma 64:912-22. 2008
    ..5 degrees C/min) for best results. However, the maximum duration of hypothermic arrest in a clinically relevant trauma model remains unknown...
  7. ncbi Acetylation: a novel method for modulation of the immune response following trauma/hemorrhage and inflammatory second hit in animals and humans
    Elizabeth A Sailhamer
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Surgery 144:204-16. 2008
    ..Correction of this imbalance with histone deacetylase inhibitors (HDACI) improves survival. We aimed to identify whether this was due to modulation of the post-shock immune response...
  8. ncbi Prevention of hypoxia-induced neuronal apoptosis through histone deacetylase inhibition
    Yongqing Li
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA
    J Trauma 64:863-70; discussion 870-1. 2008
    ..In the present study, neurons were subjected to severe hypoxic condition in vitro to test whether VPA would prevent hypoxia-induced apoptosis, and to explore the possible mechanisms...
  9. ncbi Identification of a novel potential biomarker in a model of hemorrhagic shock and valproic acid treatment
    Yongqing Li
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Surg Res 159:474-81. 2010
    ..Treatment with valproic acid (VPA) has been shown to up-regulate various survival pathways and improve outcome. Here we determine whether these changes would result in altered serum biomarkers...
  10. ncbi Histone deacetylase inhibitors prevent apoptosis following lethal hemorrhagic shock in rodent kidney cells
    Nikolaos Zacharias
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Resuscitation 82:105-9. 2011
    ..These agents are known to acetylate insulin receptor substrate-I (IRS-I), which in turn activates the Akt survival pathway. This study investigated whether HDACI exert their beneficial effects through the Akt survival pathway...
  11. ncbi Surviving blood loss without fluid resuscitation
    Christian Shults
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA
    J Trauma 64:629-38; discussion 638-40. 2008
    ..The current experiment was done to test whether administration of HDACI after lethal hemorrhage, without fluid resuscitation, would improve outcome by creating a pro-survival phenotype...
  12. ncbi Candida infection and colonization among non-trauma emergency surgery patients
    Themistoklis Kourkoumpetis
    Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Virulence 1:359-66. 2010
    ..Herein we describe the incidence of both colonization and infection from Candida and risk factors for invasive disease in this population...
  13. ncbi Histone deacetylase as therapeutic target in a rodent model of hemorrhagic shock: effect of different resuscitation strategies on lung and liver
    Tom Lin
    Department of Surgery, Washington Hospital Center, Washington, DC, USA
    Surgery 141:784-94. 2007
    ....
  14. ncbi Environmental impact of accelerated clinical care in a high-volume center
    Elizabeth A Sailhamer
    Department of Surgery, Massachusetts General Hospital, Boston, MA, USA
    Surgery 142:343-9. 2007
    ..The sustainability of the benefits and the "drag" effect on non-participating surgeons through changed nursing and resident practice is undetermined...
  15. ncbi Profound hypothermic cardiopulmonary bypass facilitates survival without a high complication rate in a swine model of complex vascular, splenic, and colon injuries
    Elizabeth A Sailhamer
    Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    J Am Coll Surg 204:642-53. 2007
    ....
  16. ncbi Impact of resuscitation strategies on the acetylation status of cardiac histones in a swine model of hemorrhage
    Hasan B Alam
    Trauma Research and Readiness Institute for Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
    Resuscitation 76:299-310. 2008
    ....
  17. ncbi Differential effect of resuscitation on Toll-like receptors in a model of hemorrhagic shock without a septic challenge
    Huazhen Chen
    Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
    Resuscitation 74:526-37. 2007
    ..This study was conducted to measure the impact of different resuscitation strategies on TLR expression and downstream signaling in key organs...

Research Grants2

  1. Histone deacetylase as a therapeutic target in rodent models of hemorrhagic shock
    Elizabeth Sailhamer; Fiscal Year: 2007
    ..Development of novel strategies, such as the use of drugs to improve the chances of survival, is an area of exciting new research and may lead to improved outcome in hemorrhagic shock. ..