Research Topics
| S SaidmanSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
| Collaborators
|
Detail Information
Publications
Significance of anti-HLA and donor-specific antibodies in long-term renal graft survivalS Saidman
Histocompatibility Laboratory, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Transplant Proc 39:744-6. 2007..Additional studies focusing on the mechanism behind the apparent protection from the detrimental effects of antibody in such patients are needed...
Histocompatibility testing for highly sensitized transplant candidatesS L Saidman
Histocompatibility Laboratory, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Transplant Proc 39:673-5. 2007..Assays used for detecting panel-reactive and donor-specific HLA antibodies, including cytotoxicity, flow cytometry, and solid phase assays, are described in this review...
Increasing the opportunity of live kidney donation by matching for two- and three-way exchangesSusan L Saidman
Department of Pathology, Massachusetts General Hospital, Boston, MA, USA
Transplantation 81:773-82. 2006....
Successful allogeneic stem cell transplantation with nonmyeloablative conditioning in patients with relapsed hematologic malignancy following autologous stem cell transplantationB R Dey
Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Biol Blood Marrow Transplant 7:604-12. 2001..Further follow-up and evaluation of additional patients are required to conclusively establish the role of this strategy in the treatment of hematologic malignancies after an autologous transplantation...
Chronic humoral rejection: identification of antibody-mediated chronic renal allograft rejection by C4d deposits in peritubular capillariesS Mauiyyedi
Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
J Am Soc Nephrol 12:574-82. 2001..C4d can be used to separate this group of CR from the nonspecific category of chronic allograft nephropathy and may have the potential to guide successful therapeutic intervention...
Comparison of outcomes after transplantation of peripheral blood stem cells versus bone marrow following an identical nonmyeloablative conditioning regimenB R Dey
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Bone Marrow Transplant 40:19-27. 2007..CD4 and CD8 T-cell recovery was faster in PBSC recipients. In PBSC recipients, a higher number of CD34+ cells was associated with increased rates of severe, grade III-IV acute GVHD...
The problem of late allograft loss in kidney transplantationF Cardarelli
Renal and Transplantation Units, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Minerva Urol Nefrol 55:1-11. 2003..Evidence is now accumulating that new immunosuppressive regimens must control not only T cell but also B cell responses (i.e. limit antidonor antibody production) in order to prevent CR/CAN and improve long-term allograft survival...
Acute renal endothelial injury during marrow recovery in a cohort of combined kidney and bone marrow allograftsA B Farris
Pathology Service, Massachusetts General Hospital MGH, Boston, MA, USA
Am J Transplant 11:1464-77. 2011..Graft endothelium is the primary target of this process, attributable to as yet obscure mechanisms, arising during leukocyte recovery...
Interferon-alpha therapy in liver transplant recipients: lack of association with increased production of anti-HLA antibodiesFrancesca Cardarelli
Renal and Transplantation Units, Departments of Medicine and Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Am J Transplant 4:1352-6. 2004..In this study, LTRs receiving IFN did not have an increased frequency of anti-HLA antibodies. This may partially explain the safety of IFN previously reported in LTRs requiring antiviral therapy...
Analysis of the cardiovascular risk profile in stable kidney transplant recipients after 50% cyclosporine reductionWaichi Wong
Transplantation Unit, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
Clin Transplant 18:341-8. 2004..Hence, a reduction in CsA dosage in kidney transplant recipients (KTR) may improve long-term outcomes. We analyzed the effects of 50% CsA dose reduction on the CVD risk profile in stable KTR...
Acute humoral rejection in kidney transplantation: II. Morphology, immunopathology, and pathologic classificationShamila Mauiyyedi
Pathology Service, Immunopathology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Am Soc Nephrol 13:779-87. 2002..Because AHR has a distinct therapy and prognosis, we propose that it should be classified separately from ACR, with further sub-classification into AHR 1 (neutrophilic capillary involvement) and AHR 2 (arterial fibrinoid necrosis)...
HLA-mismatched renal transplantation without maintenance immunosuppressionTatsuo Kawai
Transplantation Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, USA
N Engl J Med 358:353-61. 2008....
Prevalence and significance of anti-HLA and donor-specific antibodies long-term after renal transplantationFrancesca Cardarelli
Clinica Medica e Nefrologia, Universita degli Studi di Parma, Parma, Italy
Transpl Int 18:532-40. 2005..Anti-HLA antibodies were associated with a worse allograft function and in situ evidence of anti-donor humoral alloreactivity. Long-term RTR with an increase in creatinine could be screened for anti-HLA antibodies and C4d in biopsy...
Allosensitization does not increase the risk of xenoreactivity to alpha1,3-galactosyltransferase gene-knockout miniature swine in patients on transplantation waiting listsBanny S Wong
Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, 02129, USA
Transplantation 82:314-9. 2006..We have investigated this question using sera from such patients on GalT-KO target cells...
NK cell recovery, chimerism, function, and recognition in recipients of haploidentical hematopoietic cell transplantation following nonmyeloablative conditioning using a humanized anti-CD2 mAb, Medi-507Christian Koenecke
Department of Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts 02129, USA
Exp Hematol 31:911-23. 2003..Our data also raise questions about the applicability of observations made with NK cell clones to the bulk NK cell repertoire in humans...
Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal diseaseLeo H Buhler
Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
Transplantation 74:1405-9. 2002....
