Manish Sagar

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Transmembrane domain membrane proximal external region but not surface unit-directed broadly neutralizing HIV-1 antibodies can restrict dendritic cell-mediated HIV-1 trans-infection
    Manish Sagar
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
    J Infect Dis 205:1248-57. 2012
  2. pmc Selection of HIV variants with signature genotypic characteristics during heterosexual transmission
    Manish Sagar
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Infect Dis 199:580-9. 2009
  3. pmc HIV-1 transmission biology: selection and characteristics of infecting viruses
    Manish Sagar
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02139, USA
    J Infect Dis 202:S289-96. 2010
  4. ncbi Diversity in HIV-1 envelope V1-V3 sequences early in infection reflects sequence diversity throughout the HIV-1 genome but does not predict the extent of sequence diversity during chronic infection
    Manish Sagar
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    AIDS Res Hum Retroviruses 22:430-7. 2006
  5. pmc HIV-1 envelope replication and α4β7 utilization among newly infected subjects and their corresponding heterosexual partners
    Victor Pena-Cruz
    Department of Medicine, Division of Infectious Diseases, Boston University, Boston, MA, USA
    Retrovirology 10:162. 2013
  6. ncbi Effect of contraceptive methods on natural history of HIV: studies from the Mombasa cohort
    Jared M Baeten
    University of Washington, Seattle, WA, USA
    J Acquir Immune Defic Syndr 38:S18-21. 2005
  7. pmc Selection for human immunodeficiency virus type 1 envelope glycosylation variants with shorter V1-V2 loop sequences occurs during transmission of certain genetic subtypes and may impact viral RNA levels
    Bhavna Chohan
    Division of Human Biology, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, C3 168 Seattle, WA 98109 1024, USA
    J Virol 79:6528-31. 2005
  8. pmc Evolution of CCR5 antagonist resistance in an HIV-1 subtype C clinical isolate
    Timothy J Henrich
    Division of Infectious Diseases, Brigham and Women s Hospital, Boston, MA, USA
    J Acquir Immune Defic Syndr 55:420-7. 2010
  9. ncbi Identification of modifiable factors that affect the genetic diversity of the transmitted HIV-1 population
    Manish Sagar
    Division of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, 1100 Fairview Avenue, Seattle, WA 98109, USA
    AIDS 18:615-9. 2004
  10. pmc Env sequence determinants in CXCR4-using human immunodeficiency virus type-1 subtype C
    Nina H Lin
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA
    Virology 433:296-307. 2012

Detail Information

Publications20

  1. pmc Transmembrane domain membrane proximal external region but not surface unit-directed broadly neutralizing HIV-1 antibodies can restrict dendritic cell-mediated HIV-1 trans-infection
    Manish Sagar
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
    J Infect Dis 205:1248-57. 2012
    ....
  2. pmc Selection of HIV variants with signature genotypic characteristics during heterosexual transmission
    Manish Sagar
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Infect Dis 199:580-9. 2009
    ..Newly infected subjects acquire a limited number of human immunodeficiency virus type 1 (HIV-1) variants with specific genotypic and phenotypic features from the array of viruses present in a chronically infected transmitting partner...
  3. pmc HIV-1 transmission biology: selection and characteristics of infecting viruses
    Manish Sagar
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02139, USA
    J Infect Dis 202:S289-96. 2010
    ..Greater understanding of these issues may open promising new ways to effectively block HIV-1 transmission...
  4. ncbi Diversity in HIV-1 envelope V1-V3 sequences early in infection reflects sequence diversity throughout the HIV-1 genome but does not predict the extent of sequence diversity during chronic infection
    Manish Sagar
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    AIDS Res Hum Retroviruses 22:430-7. 2006
    ..Analysis of HIV-1 sequences from about 3 years after infection revealed that the level of diversity and diversification was similar between the women in the two groups...
  5. pmc HIV-1 envelope replication and α4β7 utilization among newly infected subjects and their corresponding heterosexual partners
    Victor Pena-Cruz
    Department of Medicine, Division of Infectious Diseases, Boston University, Boston, MA, USA
    Retrovirology 10:162. 2013
    ..We compared HIV-1 envelopes from 9 newly infected subjects and their linked transmitting partner to explore potential mechanisms for selection...
  6. ncbi Effect of contraceptive methods on natural history of HIV: studies from the Mombasa cohort
    Jared M Baeten
    University of Washington, Seattle, WA, USA
    J Acquir Immune Defic Syndr 38:S18-21. 2005
  7. pmc Selection for human immunodeficiency virus type 1 envelope glycosylation variants with shorter V1-V2 loop sequences occurs during transmission of certain genetic subtypes and may impact viral RNA levels
    Bhavna Chohan
    Division of Human Biology, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, C3 168 Seattle, WA 98109 1024, USA
    J Virol 79:6528-31. 2005
    ..Thus, our study also suggests that the extent of glycosylation in the infecting virus could impact disease progression...
  8. pmc Evolution of CCR5 antagonist resistance in an HIV-1 subtype C clinical isolate
    Timothy J Henrich
    Division of Infectious Diseases, Brigham and Women s Hospital, Boston, MA, USA
    J Acquir Immune Defic Syndr 55:420-7. 2010
    ..Here, we test the contribution of gp120 mutations to CCR5 antagonist resistance and investigate why certain minority V3 variants emerged as the dominant species under drug pressure...
  9. ncbi Identification of modifiable factors that affect the genetic diversity of the transmitted HIV-1 population
    Manish Sagar
    Division of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, 1100 Fairview Avenue, Seattle, WA 98109, USA
    AIDS 18:615-9. 2004
    ..Infection with multiple viral variants was associated with higher plasma HIV-1 RNA levels and faster CD4 T-cell decline...
  10. pmc Env sequence determinants in CXCR4-using human immunodeficiency virus type-1 subtype C
    Nina H Lin
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA
    Virology 433:296-307. 2012
    ..Chimeric env functional studies suggest that the V3 loop is necessary but often not sufficient to impart CXCR4 utilization. Our studies provide insights into the unique genotypic characteristics of X4 variants in HIV-1C...
  11. pmc Human immunodeficiency virus type 1 V1-V2 envelope loop sequences expand and add glycosylation sites over the course of infection, and these modifications affect antibody neutralization sensitivity
    Manish Sagar
    Department of Medicine, Brigham and Women s Hospital, Cambridge, Massachusetts 02139, USA
    J Virol 80:9586-98. 2006
    ..These studies suggest that changes within the V1-V2 envelope domains over the course of an infection influence sensitivity to autologous neutralizing antibodies and may also impact host receptor/coreceptor interactions...
  12. pmc Human immunodeficiency virus type 1 V1-to-V5 envelope variants from the chronic phase of infection use CCR5 and fuse more efficiently than those from early after infection
    Behzad Etemad
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, USA
    J Virol 83:9694-708. 2009
    ..Thus, envelope modifications over time within a host potentially enhance replication capacity...
  13. ncbi No evidence for rapid subtype C spread within an epidemic in which multiple subtypes and intersubtype recombinants circulate
    Stephanie Rainwater
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    AIDS Res Hum Retroviruses 21:1060-5. 2005
    ..This latter finding suggests that reinfection may have occurred in high-risk groups early in the epidemic, leading to intersubtype recombinant viruses that underwent secondary spread...
  14. pmc In vivo emergence of vicriviroc resistance in a human immunodeficiency virus type 1 subtype C-infected subject
    Athe M N Tsibris
    Massachusetts General Hospital, Boston, Massachusetts, USA
    J Virol 82:8210-4. 2008
    ..Pretreatment V3 loop sequences reemerged following VCV discontinuation, implying that VCV resistance has associated fitness costs...
  15. pmc Early infection HIV-1 envelope V1-V2 genotypes do not enhance binding or replication in cells expressing high levels of α4β7 integrin
    Behzad Etemad
    Department of Medicine, Division of Infectious Disease, Boston University School of Medicine, Boston, MA and Dana Farber Cancer Research Center, Boston, MA
    J Acquir Immune Defic Syndr 64:249-53. 2013
    ..Integrin α4β7 usage does not select for shorter less-glycosylated envelopes during transmission...
  16. pmc Human immunodeficiency virus type 1 (HIV-1) diversity at time of infection is not restricted to certain risk groups or specific HIV-1 subtypes
    Manish Sagar
    Division of Human Biology, Fred Hutchinson Cancer Research Center, and Department of Medicine, University of Washington, Seattle, USA
    J Virol 78:7279-83. 2004
    ..S. women, one U.S. man, and one Kenyan man near the time of seroconversion. These findings suggest that early HIV-1 genetic diversity is not exclusive to women from Africa or to infection with any particular HIV-1 subtype...
  17. pmc In vivo fitness cost of the M184V mutation in multidrug-resistant human immunodeficiency virus type 1 in the absence of lamivudine
    Roger Paredes
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 83:2038-43. 2009
    ..After a lag phase of variable duration, wild-type variants emerged due to continued evolution of pol and back mutation rather than through emergence of an archived wild-type variant...
  18. pmc Infection with multiple human immunodeficiency virus type 1 variants is associated with faster disease progression
    Manish Sagar
    Divisions of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington 98109, USA
    J Virol 77:12921-6. 2003
    ..01) 4 to 24 months after infection compared to women who were infected with a single viral genotype. These studies suggest that early HIV-1 genetic diversity is linked to faster disease progression...
  19. pmc Long-term reduction in peripheral blood HIV type 1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation
    Timothy J Henrich
    Divison of Infectious Diseases, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Infect Dis 207:1694-702. 2013
    ..The long-term impact of allogeneic hematopoietic stem cell transplantation (HSCT) on human immunodeficiency virus type 1 (HIV-1) reservoirs in patients receiving combination antiretroviral therapy (cART) is largely unknown...
  20. pmc Sensitivity changes over the course of infection increases the likelihood of resistance against fusion but not CCR5 receptor blockers
    Nikolaos Chatziandreou
    Brigham and Women s Hospital, Boston, MA 02139, USA
    AIDS Res Hum Retroviruses 28:1584-93. 2012
    ..Our in vitro passage studies suggest that these evolving phenotypes increase the likelihood of resistance against fusion but not CCR5 receptor blockers...

Research Grants4

  1. The role of viral diversity in HIV-1 drug resistance
    Manish Sagar; Fiscal Year: 2006
    ..With these studies, we will gain insight into the likelihood of success with ART in Africa and the possibility of the evolution of a 'new' epidemic with drug resistant HIV -1 viruses. ..
  2. Genotypic and Phenotypic Characterization of Heterosexually Transmitted HIV-1
    Manish Sagar; Fiscal Year: 2009
    ..We will explore the biological relevance of observed differences in these phenotypic properties to develop potential biological models for selection during HIV-1 transmission. ..
  3. Genotypic and Phenotypic Characterization of Heterosexually Transmitted HIV-1
    Manish Sagar; Fiscal Year: 2010
    ..We will explore the biological relevance of observed differences in these phenotypic properties to develop potential biological models for selection during HIV-1 transmission. ..