Genomes and Genes
Affiliation: Massachusetts General Hospital
- Alterations in brain-derived neurotrophic factor in the mouse hippocampus following acute but not repeated benzodiazepine treatmentStephanie C Licata
McLean Hospital, Belmont, Massachusetts, United States of America Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 8:e84806. 2013..Future work should examine the interaction between ZP and DNA as the cause for altered gene expression in the HIP, given that BZs can enter the nucleus and intercalate into DNA directly. ..
- Cocaine-induced chromatin remodeling increases brain-derived neurotrophic factor transcription in the rat medial prefrontal cortex, which alters the reinforcing efficacy of cocaineGhazaleh Sadri-Vakili
MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129 4404, USA
J Neurosci 30:11735-44. 2010....
- CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seekingSharon M Anderson
Department of Pharmacology, Boston University School of Medicine, 715 Albany Street, L603, Boston, Massachusetts 02118, USA
Nat Neurosci 11:344-53. 2008..Thus, CaMKII may be an essential link between accumbens shell dopamine and glutamate systems involved in the neuronal plasticity underlying cocaine craving and relapse...
- Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's diseaseKaren N McFarland
Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
PLoS ONE 7:e41423. 2012....
- Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's diseaseAlice S Chen-Plotkin
MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital B114 2000, 114 16th Street, Charlestown, MA 02129 4404, USA
Neurobiol Dis 22:233-41. 2006..Moreover, the altered binding seen with Sp1 is not found with another transcription factor, NF-Y. These findings suggest that mutant huntingtin dissociates Sp1 from target promoters, inhibiting transcription of specific genes...
- Altered histone monoubiquitylation mediated by mutant huntingtin induces transcriptional dysregulationMee Ohk Kim
MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
J Neurosci 28:3947-57. 2008..These findings also provide a rationale for targeting histone monoubiquitylation for therapy in HD...
- Environmental enrichment reduces neuronal intranuclear inclusion load but has no effect on messenger RNA expression in a mouse model of Huntington diseaseCaroline L Benn
Mass General Institute for Neurodegenerative Disease, Charlestown, Massachusetts, USA
J Neuropathol Exp Neurol 69:817-27. 2010..Thus, the therapeutic effects of environmental enrichment likely contribute to decreasing aggregated polyglutamine protein levels without exerting strong effects on gene expression...
- Phosphorylation-dependent trafficking of GluR2-containing AMPA receptors in the nucleus accumbens plays a critical role in the reinstatement of cocaine seekingKatie R Famous
Department of Pharmacology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Neurosci 28:11061-70. 2008..The present results also demonstrate that the reinstatement of cocaine seeking is associated with increases in the phosphorylation-dependent trafficking of GluR2-containing AMPA receptors in the nucleus accumbens...
- Increased brain-derived neurotrophic factor (BDNF) expression in the ventral tegmental area during cocaine abstinence is associated with increased histone acetylation at BDNF exon I-containing promotersHeath D Schmidt
Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania School, Philadelphia, Pennsylvania, USA
J Neurochem 120:202-9. 2012....
- Cocaine alters BDNF expression and neuronal migration in the embryonic mouse forebrainDeirdre M McCarthy
Department of Neurology and NeuroEpigenetcis Laboratory, MassGeneral Institute for Neurodegenerative Disease, Harvard Medical School and Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
J Neurosci 31:13400-11. 2011..Our data suggest that cocaine can alter tangential and radial neuronal migration as well as BDNF expression in the embryonic brain and that decreased BDNF may mediate cocaine's effects on neuronal migration...
- Synapse density and dendritic complexity are reduced in the prefrontal cortex following seven days of forced abstinence from cocaine self-administrationKhampaseuth Rasakham
MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, Massachusetts, United States of America
PLoS ONE 9:e102524. 2014..These findings indicate that dynamic structural changes occur during cocaine abstinence that may contribute to the observed hypo-activity of the PFC in cocaine-addicted individuals. ..
- Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent mannerCaroline L Benn
Department of Neurology and Center for Interdisciplinary Informatics, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts 02129 4404, USA
J Neurosci 28:10720-33. 2008..Together, these findings suggest mutant Htt modulates gene expression through abnormal interactions with genomic DNA, altering DNA conformation and transcription factor binding...
- Epigenetic Mechanisms Involved in Huntington's Disease PathogenesisKelly E Glajch
MassGeneral Institute for neurodegenrative Disease, Massachussetts General Hospital, Boston, MA, USA
J Huntingtons Dis 4:1-15. 2015..Here, we review a range of studies describing epigenetic changes in HD as well as several potential therapeutics that target aberrant epigenetic alterations in HD...
- Mechanisms of disease: Histone modifications in Huntington's diseaseGhazaleh Sadri-Vakili
MassGeneral Institute for Neurodegenerative Disease, Boston, MA, USA
Nat Clin Pract Neurol 2:330-8. 2006..In addition, we discuss how these histone modifications not only lead to pathogenesis, but might also provide a novel therapeutic strategy for treating this devastating disease...