Ghazaleh Sadri-Vakili

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Alterations in brain-derived neurotrophic factor in the mouse hippocampus following acute but not repeated benzodiazepine treatment
    Stephanie C Licata
    McLean Hospital, Belmont, Massachusetts, United States of America Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e84806. 2013
  2. pmc Cocaine-induced chromatin remodeling increases brain-derived neurotrophic factor transcription in the rat medial prefrontal cortex, which alters the reinforcing efficacy of cocaine
    Ghazaleh Sadri-Vakili
    MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129 4404, USA
    J Neurosci 30:11735-44. 2010
  3. doi request reprint CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking
    Sharon M Anderson
    Department of Pharmacology, Boston University School of Medicine, 715 Albany Street, L603, Boston, Massachusetts 02118, USA
    Nat Neurosci 11:344-53. 2008
  4. pmc Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's disease
    Karen N McFarland
    Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
    PLoS ONE 7:e41423. 2012
  5. ncbi request reprint Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease
    Alice S Chen-Plotkin
    MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital B114 2000, 114 16th Street, Charlestown, MA 02129 4404, USA
    Neurobiol Dis 22:233-41. 2006
  6. pmc Altered histone monoubiquitylation mediated by mutant huntingtin induces transcriptional dysregulation
    Mee Ohk Kim
    MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurosci 28:3947-57. 2008
  7. pmc Cocaine alters BDNF expression and neuronal migration in the embryonic mouse forebrain
    Deirdre M McCarthy
    Department of Neurology and NeuroEpigenetcis Laboratory, MassGeneral Institute for Neurodegenerative Disease, Harvard Medical School and Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurosci 31:13400-11. 2011
  8. doi request reprint Environmental enrichment reduces neuronal intranuclear inclusion load but has no effect on messenger RNA expression in a mouse model of Huntington disease
    Caroline L Benn
    Mass General Institute for Neurodegenerative Disease, Charlestown, Massachusetts, USA
    J Neuropathol Exp Neurol 69:817-27. 2010
  9. pmc Phosphorylation-dependent trafficking of GluR2-containing AMPA receptors in the nucleus accumbens plays a critical role in the reinstatement of cocaine seeking
    Katie R Famous
    Department of Pharmacology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurosci 28:11061-70. 2008
  10. pmc Increased brain-derived neurotrophic factor (BDNF) expression in the ventral tegmental area during cocaine abstinence is associated with increased histone acetylation at BDNF exon I-containing promoters
    Heath D Schmidt
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania School, Philadelphia, Pennsylvania, USA
    J Neurochem 120:202-9. 2012

Collaborators

Detail Information

Publications12

  1. pmc Alterations in brain-derived neurotrophic factor in the mouse hippocampus following acute but not repeated benzodiazepine treatment
    Stephanie C Licata
    McLean Hospital, Belmont, Massachusetts, United States of America Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e84806. 2013
    ..Future work should examine the interaction between ZP and DNA as the cause for altered gene expression in the HIP, given that BZs can enter the nucleus and intercalate into DNA directly. ..
  2. pmc Cocaine-induced chromatin remodeling increases brain-derived neurotrophic factor transcription in the rat medial prefrontal cortex, which alters the reinforcing efficacy of cocaine
    Ghazaleh Sadri-Vakili
    MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129 4404, USA
    J Neurosci 30:11735-44. 2010
    ....
  3. doi request reprint CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking
    Sharon M Anderson
    Department of Pharmacology, Boston University School of Medicine, 715 Albany Street, L603, Boston, Massachusetts 02118, USA
    Nat Neurosci 11:344-53. 2008
    ..Thus, CaMKII may be an essential link between accumbens shell dopamine and glutamate systems involved in the neuronal plasticity underlying cocaine craving and relapse...
  4. pmc Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's disease
    Karen N McFarland
    Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
    PLoS ONE 7:e41423. 2012
    ....
  5. ncbi request reprint Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease
    Alice S Chen-Plotkin
    MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital B114 2000, 114 16th Street, Charlestown, MA 02129 4404, USA
    Neurobiol Dis 22:233-41. 2006
    ..Moreover, the altered binding seen with Sp1 is not found with another transcription factor, NF-Y. These findings suggest that mutant huntingtin dissociates Sp1 from target promoters, inhibiting transcription of specific genes...
  6. pmc Altered histone monoubiquitylation mediated by mutant huntingtin induces transcriptional dysregulation
    Mee Ohk Kim
    MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurosci 28:3947-57. 2008
    ..These findings also provide a rationale for targeting histone monoubiquitylation for therapy in HD...
  7. pmc Cocaine alters BDNF expression and neuronal migration in the embryonic mouse forebrain
    Deirdre M McCarthy
    Department of Neurology and NeuroEpigenetcis Laboratory, MassGeneral Institute for Neurodegenerative Disease, Harvard Medical School and Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurosci 31:13400-11. 2011
    ..Our data suggest that cocaine can alter tangential and radial neuronal migration as well as BDNF expression in the embryonic brain and that decreased BDNF may mediate cocaine's effects on neuronal migration...
  8. doi request reprint Environmental enrichment reduces neuronal intranuclear inclusion load but has no effect on messenger RNA expression in a mouse model of Huntington disease
    Caroline L Benn
    Mass General Institute for Neurodegenerative Disease, Charlestown, Massachusetts, USA
    J Neuropathol Exp Neurol 69:817-27. 2010
    ..Thus, the therapeutic effects of environmental enrichment likely contribute to decreasing aggregated polyglutamine protein levels without exerting strong effects on gene expression...
  9. pmc Phosphorylation-dependent trafficking of GluR2-containing AMPA receptors in the nucleus accumbens plays a critical role in the reinstatement of cocaine seeking
    Katie R Famous
    Department of Pharmacology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurosci 28:11061-70. 2008
    ..The present results also demonstrate that the reinstatement of cocaine seeking is associated with increases in the phosphorylation-dependent trafficking of GluR2-containing AMPA receptors in the nucleus accumbens...
  10. pmc Increased brain-derived neurotrophic factor (BDNF) expression in the ventral tegmental area during cocaine abstinence is associated with increased histone acetylation at BDNF exon I-containing promoters
    Heath D Schmidt
    Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania School, Philadelphia, Pennsylvania, USA
    J Neurochem 120:202-9. 2012
    ....
  11. pmc Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner
    Caroline L Benn
    Department of Neurology and Center for Interdisciplinary Informatics, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts 02129 4404, USA
    J Neurosci 28:10720-33. 2008
    ..Together, these findings suggest mutant Htt modulates gene expression through abnormal interactions with genomic DNA, altering DNA conformation and transcription factor binding...
  12. ncbi request reprint Mechanisms of disease: Histone modifications in Huntington's disease
    Ghazaleh Sadri-Vakili
    MassGeneral Institute for Neurodegenerative Disease, Boston, MA, USA
    Nat Clin Pract Neurol 2:330-8. 2006
    ..In addition, we discuss how these histone modifications not only lead to pathogenesis, but might also provide a novel therapeutic strategy for treating this devastating disease...