Gary S Sachs

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi request reprint Psychosocial interventions as adjunctive therapy for bipolar disorder
    Gary S Sachs
    Bipolar Clinic and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Psychiatr Pract 14:39-44. 2008
  2. ncbi request reprint Effectiveness of adjunctive antidepressant treatment for bipolar depression
    Gary S Sachs
    Bipolar Clinic and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    N Engl J Med 356:1711-22. 2007
  3. ncbi request reprint Does recovery from substance use disorder matter in patients with bipolar disorder?
    Roger D Weiss
    Department of Psychiatry, Harvard Medical School, Boston, USA
    J Clin Psychiatry 66:730-5; quiz 808-9. 2005
  4. ncbi request reprint Predictors of recurrence in bipolar disorder: primary outcomes from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
    Roy H Perlis
    Bipolar Clinical and Research Program, Massachusetts General Hospital, ACC 812, 15 Parkman Street, Boston, MA 02114, USA
    Am J Psychiatry 163:217-24. 2006
  5. ncbi request reprint Anxiety disorder comorbidity in bipolar disorder patients: data from the first 500 participants in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Related Disorders, Wang ACC 815, Massachusetts General Hospital, 15 Parkman St, Boston, MA 02114, USA
    Am J Psychiatry 161:2222-9. 2004
  6. ncbi request reprint Treatment-resistant bipolar depression: a STEP-BD equipoise randomized effectiveness trial of antidepressant augmentation with lamotrigine, inositol, or risperidone
    Andrew A Nierenberg
    Massachusetts General Hospital Bipolar Clinic and Research Program, Suite 580, 50 Staniford Street, Boston, MA 02114, USA
    Am J Psychiatry 163:210-6. 2006
  7. doi request reprint Clinical features associated with poor pharmacologic adherence in bipolar disorder: results from the STEP-BD study
    Roy H Perlis
    Bipolar Clinic and Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 71:296-303. 2010
  8. doi request reprint Antidepressant discontinuation in bipolar depression: a Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) randomized clinical trial of long-term effectiveness and safety
    S Nassir Ghaemi
    Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, 800 Washington St, Box 1007, Boston, MA 02111, USA
    J Clin Psychiatry 71:372-80. 2010
  9. doi request reprint Adjunctive oral ziprasidone in patients with acute mania treated with lithium or divalproex, part 2: influence of protocol-specific eligibility criteria on signal detection
    Gary S Sachs
    Bipolar Clinic and Research Program, Massachusetts General Hospital, 50 Staniford St, 5th Floor, Boston, MA 02114, USA
    J Clin Psychiatry 73:1420-5. 2012
  10. ncbi request reprint Clinical and diagnostic implications of lifetime attention-deficit/hyperactivity disorder comorbidity in adults with bipolar disorder: data from the first 1000 STEP-BD participants
    Andrew A Nierenberg
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Depression and Clinical Research Program ACC 812, Boston, Massachusetts 02114, USA
    Biol Psychiatry 57:1467-73. 2005

Detail Information

Publications86

  1. doi request reprint Psychosocial interventions as adjunctive therapy for bipolar disorder
    Gary S Sachs
    Bipolar Clinic and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Psychiatr Pract 14:39-44. 2008
    ....
  2. ncbi request reprint Effectiveness of adjunctive antidepressant treatment for bipolar depression
    Gary S Sachs
    Bipolar Clinic and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    N Engl J Med 356:1711-22. 2007
    ..Our study was designed to determine whether adjunctive antidepressant therapy reduces symptoms of bipolar depression without increasing the risk of mania...
  3. ncbi request reprint Does recovery from substance use disorder matter in patients with bipolar disorder?
    Roger D Weiss
    Department of Psychiatry, Harvard Medical School, Boston, USA
    J Clin Psychiatry 66:730-5; quiz 808-9. 2005
    ..To examine the potential impact of recovery from substance use disorder (SUD) on the course of bipolar disorder among patients diagnosed with both bipolar and substance use disorders according to DSM-IV criteria...
  4. ncbi request reprint Predictors of recurrence in bipolar disorder: primary outcomes from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
    Roy H Perlis
    Bipolar Clinical and Research Program, Massachusetts General Hospital, ACC 812, 15 Parkman Street, Boston, MA 02114, USA
    Am J Psychiatry 163:217-24. 2006
    ..The authors looked for the features associated with risk of recurrence...
  5. ncbi request reprint Anxiety disorder comorbidity in bipolar disorder patients: data from the first 500 participants in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Related Disorders, Wang ACC 815, Massachusetts General Hospital, 15 Parkman St, Boston, MA 02114, USA
    Am J Psychiatry 161:2222-9. 2004
    ..The authors provide a detailed perspective on the correlates of comorbid anxiety in a large, well-characterized sample of bipolar disorder patients...
  6. ncbi request reprint Treatment-resistant bipolar depression: a STEP-BD equipoise randomized effectiveness trial of antidepressant augmentation with lamotrigine, inositol, or risperidone
    Andrew A Nierenberg
    Massachusetts General Hospital Bipolar Clinic and Research Program, Suite 580, 50 Staniford Street, Boston, MA 02114, USA
    Am J Psychiatry 163:210-6. 2006
    ..This study represents the first randomized trial of competing options for treatment-resistant bipolar depression and assesses the effectiveness and safety of antidepressant augmentation with lamotrigine, inositol, and risperidone...
  7. doi request reprint Clinical features associated with poor pharmacologic adherence in bipolar disorder: results from the STEP-BD study
    Roy H Perlis
    Bipolar Clinic and Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 71:296-303. 2010
    ..Poor medication adherence is common among bipolar patients...
  8. doi request reprint Antidepressant discontinuation in bipolar depression: a Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) randomized clinical trial of long-term effectiveness and safety
    S Nassir Ghaemi
    Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, 800 Washington St, Box 1007, Boston, MA 02111, USA
    J Clin Psychiatry 71:372-80. 2010
    ..To assess long-term effectiveness and safety of randomized antidepressant discontinuation after acute recovery from bipolar depression...
  9. doi request reprint Adjunctive oral ziprasidone in patients with acute mania treated with lithium or divalproex, part 2: influence of protocol-specific eligibility criteria on signal detection
    Gary S Sachs
    Bipolar Clinic and Research Program, Massachusetts General Hospital, 50 Staniford St, 5th Floor, Boston, MA 02114, USA
    J Clin Psychiatry 73:1420-5. 2012
    ..Data collected by computer interviews and by site-based raters were analyzed to examine the impact of eligibility criteria on signal detection...
  10. ncbi request reprint Clinical and diagnostic implications of lifetime attention-deficit/hyperactivity disorder comorbidity in adults with bipolar disorder: data from the first 1000 STEP-BD participants
    Andrew A Nierenberg
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Depression and Clinical Research Program ACC 812, Boston, Massachusetts 02114, USA
    Biol Psychiatry 57:1467-73. 2005
    ....
  11. ncbi request reprint Pharmacotherapy for bipolar disorder and comorbid conditions: baseline data from STEP-BD
    Naomi M Simon
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychopharmacol 24:512-20. 2004
    ..Our findings highlight the need for greater clinical guidance and treatment options for patients with bipolar disorder and comorbidity...
  12. doi request reprint Benzodiazepine use and risk of recurrence in bipolar disorder: a STEP-BD report
    Roy H Perlis
    Bipolar Clinic and Research Programs, 50 Staniford St, 5th Floor, Boston, MA 02114, USA
    J Clin Psychiatry 71:194-200. 2010
    ..Benzodiazepines are widely prescribed to patients with bipolar disorder, but their impact on relapse and recurrence has not been examined...
  13. pmc Impact of substance use disorders on recovery from episodes of depression in bipolar disorder patients: prospective data from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
    Michael J Ostacher
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Am J Psychiatry 167:289-97. 2010
    ..The authors hypothesized that comorbid drug and alcohol use disorders would be associated with longer time to recovery in patients with bipolar disorder...
  14. ncbi request reprint Menstrual dysfunction prior to onset of psychiatric illness is reported more commonly by women with bipolar disorder than by women with unipolar depression and healthy controls
    Hadine Joffe
    Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 67:297-304. 2006
    ..However, it is not always clear whether such abnormalities, reflecting disruption of the hypothalamic-pituitary-gonadal (HPG) axis, are caused by psychotropic treatments or associated with the disorder per se...
  15. doi request reprint Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression
    Jie Huang
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, and Psychiatric Genetics Program in Mood and Anxiety Disorders, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 167:1254-63. 2010
    ..The purpose of this study was to apply genomewide association study (GWAS) analysis to address the specificity of genetic effects on these disorders...
  16. doi request reprint Longitudinal follow-up of bipolar disorder in women with premenstrual exacerbation: findings from STEP-BD
    Rodrigo S Dias
    Bipolar Clinic and Research Program, Massachusetts General Hospital, Boston, USA
    Am J Psychiatry 168:386-94. 2011
    ..The authors determined the course of illness and time to relapse of bipolar disorder in prospectively followed women with premenstrual exacerbation...
  17. ncbi request reprint Longitudinal follow-up of reproductive and metabolic features of valproate-associated polycystic ovarian syndrome features: A preliminary report
    Hadine Joffe
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Psychiatry 60:1378-81. 2006
    ..5% of 86 women. We now determine whether polycystic ovarian syndrome (PCOS) features reverse on valproate discontinutation...
  18. pmc Sleep disturbance in euthymic bipolar patients
    Louisa G Sylvia
    Bipolar Clinic and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    J Psychopharmacol 26:1108-12. 2012
    ..This suggests that sleep disturbance is an important prodromal symptom of bipolar disorder and should be considered a target for pharmacologic or psychosocial maintenance treatment...
  19. pmc Transition to mania during treatment of bipolar depression
    Roy H Perlis
    Department of Psychiatry, Bipolar Clinic and Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neuropsychopharmacology 35:2545-52. 2010
    ..These results indicate that certain clinical features may be associated with greater risk of transition from depression to manic or mixed states, but the majority of them are not specific to antidepressant-treated patients...
  20. ncbi request reprint The relationship between smoking and suicidal behavior, comorbidity, and course of illness in bipolar disorder
    Michael J Ostacher
    Massachusetts General Hospital, Bipolar Clinic and Research Program, Boston, MA 02114, USA
    J Clin Psychiatry 67:1907-11. 2006
    ..The purpose of this retrospective study was to examine the relationship between smoking, severity of bipolar disorder, suicidal behavior, and psychiatric and substance use disorder comorbidity...
  21. ncbi request reprint Update on bipolar disorder and substance abuse: recent findings and treatment strategies
    Michael J Ostacher
    Bipolar Clinic and Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    J Clin Psychiatry 67:e10. 2006
    ..Once treatment has begun, clinicians should ensure that medication and psychotherapy are administered appropriately and that treatment is modified when there is inadequate response...
  22. ncbi request reprint Inositol augmentation of lithium or valproate for bipolar depression
    A Eden Evins
    Harvard Bipolar Research Program and Department of Psychiatry of the Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 8:168-74. 2006
    ..Up to half of patients do not respond adequately to currently approved treatments. This study evaluated the efficacy of adjunctive inositol for bipolar depression...
  23. ncbi request reprint Revisiting depressive-prone bipolar disorder: polarity of initial mood episode and disease course among bipolar I systematic treatment enhancement program for bipolar disorder participants
    Roy H Perlis
    Bipolar Clinical and Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Psychiatry 58:549-53. 2005
    ..We examined the hypothesis that a first depressive rather than manic episode in bipolar disorder might herald a subsequent course notable for greater burden of depressive symptoms...
  24. doi request reprint Adjunctive oral ziprasidone in patients with acute mania treated with lithium or divalproex, part 1: results of a randomized, double-blind, placebo-controlled trial
    Gary S Sachs
    Bipolar Clinic and Research Program, Massachusetts General Hospital, 50 Staniford St, 5th Floor, Boston, MA 02114, USA
    J Clin Psychiatry 73:1412-9. 2012
    ..To assess the efficacy and safety of adjunctive ziprasidone in subjects with acute mania treated with lithium or divalproex, with an inadequate response to the mood stabilizer...
  25. ncbi request reprint Persistent posttraumatic stress disorder following September 11 in patients with bipolar disorder
    Mark H Pollack
    Department of Psychiatry, Massachusetts General Hospital, Boston, Mass, USA
    J Clin Psychiatry 67:394-9. 2006
    ....
  26. ncbi request reprint The integration of measurement and management for the treatment of bipolar disorder: a STEP-BD model of collaborative care in psychiatry
    Andrew A Nierenberg
    Bipolar Clinic and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 67:3-7. 2006
    ..This method was shown to be successful in the National Institute of Mental Health (NIMH) Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)...
  27. doi request reprint A genomewide association study of response to lithium for prevention of recurrence in bipolar disorder
    Roy H Perlis
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
    Am J Psychiatry 166:718-25. 2009
    ....
  28. doi request reprint Association between therapeutic alliance, care satisfaction, and pharmacological adherence in bipolar disorder
    Louisa G Sylvia
    Bipolar Clinical and Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychopharmacol 33:343-50. 2013
    ....
  29. pmc Stability of symptoms across major depressive episodes in bipolar disorder
    Roy H Perlis
    Bipolar Clinic and Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Bipolar Disord 11:867-75. 2009
    ..These studies make the implicit assumption of stability of symptoms across episodes in mood disorders, which has rarely been investigated...
  30. ncbi request reprint Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD)
    Roy H Perlis
    Partners Bipolar Treatment Center at Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 55:875-81. 2004
    ..Early onset of mood symptoms in bipolar disorder has been associated with poor outcome in many studies; however, the factors that might contribute to poor outcome have not been adequately investigated...
  31. doi request reprint Linkage disequilibrium mapping of the chromosome 6q21-22.31 bipolar I disorder susceptibility locus
    Jinbo Fan
    Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 153:29-37. 2010
    ..Further studies in larger samples are warranted to clarify which, if any, genes in the 6q region confer risk for bipolar disorder...
  32. doi request reprint Efficacy and safety of adjunctive oral ziprasidone for acute treatment of depression in patients with bipolar I disorder: a randomized, double-blind, placebo-controlled trial
    Gary S Sachs
    Bipolar Clinic and Research Program, Massachusetts General Hospital, Boston MA 02114, USA
    J Clin Psychiatry 72:1413-22. 2011
    ..To assess efficacy and safety of adjunctive ziprasidone in subjects with bipolar depression treated with lithium, lamotrigine, or valproate...
  33. ncbi request reprint Rationale, design, and methods of the systematic treatment enhancement program for bipolar disorder (STEP-BD)
    Gary S Sachs
    Partners Bipolar Treatment Center, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Psychiatry 53:1028-42. 2003
    ....
  34. ncbi request reprint Decision tree for the treatment of bipolar disorder
    Gary S Sachs
    Partners Bipolar Treatment Center, Massachusetts General Hospital, Boston, Mass, USA
    J Clin Psychiatry 64:35-40. 2003
    ....
  35. ncbi request reprint Implementing evidence-based treatment of manic and mixed episodes
    Gary S Sachs
    Partners Bipolar Treatment Center, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 67:12-7. 2006
    ....
  36. doi request reprint Galantamine-ER for cognitive dysfunction in bipolar disorder and correlation with hippocampal neuronal viability: a proof-of-concept study
    Dan V Iosifescu
    The Bipolar Clinic and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    CNS Neurosci Ther 15:309-19. 2009
    ..Many subjects with bipolar disorder experience significant cognitive dysfunction, even when euthymic, but few studies assess biological correlates of or treatment strategies for cognitive dysfunction...
  37. pmc Cigarette smoking is associated with suicidality in bipolar disorder
    Michael J Ostacher
    Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Bipolar Disord 11:766-71. 2009
    ..Cigarette smoking in individuals with bipolar disorder has been associated with suicidal behavior, although the precise relationship between the two remains unclear...
  38. ncbi request reprint Psychosocial strategies to improve concordance and adherence in bipolar disorder
    Noreen Reilly-Harrington
    Bipolar Clinic and Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    J Clin Psychiatry 67:e04. 2006
    ..Using a variety of psychosocial strategies, patients can train themselves and a support team to effectively deal with bipolar disorder...
  39. ncbi request reprint Valproate is associated with new-onset oligoamenorrhea with hyperandrogenism in women with bipolar disorder
    Hadine Joffe
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Psychiatry 59:1078-86. 2006
    ..The development of PCOS features after initiation of valproate was therefore examined in women with bipolar disorder using a standardized definition of PCOS...
  40. doi request reprint The pharmacologic treatment of bipolar disorder
    Gary S Sachs
    Bipolar Clinic and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 72:704-15. 2011
    ..A paradigm for implementing evidence-based treatment is offered along with consideration of patterns emerging across clinical trials...
  41. ncbi request reprint Psychopathology in the offspring of parents with bipolar disorder: a controlled study
    Aude Henin
    Pediatric Psychopharmacology Unit and Harvard Bipolar Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02138, USA
    Biol Psychiatry 58:554-61. 2005
    ..To examine the risk for psychopathology in offspring at risk for bipolar disorder and the course of psychiatric disorders in these youth...
  42. ncbi request reprint Antimanic response to aripiprazole in bipolar I disorder patients is independent of the agitation level at baseline
    Gary S Sachs
    Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 68:1377-83. 2007
    ..To examine the antimanic efficacy of the relatively nonsedating antipsychotic aripiprazole in patients with bipolar I disorder and high or low baseline levels of agitation...
  43. ncbi request reprint Demographic and diagnostic characteristics of the first 1000 patients enrolled in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
    Jane N Kogan
    Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Bipolar Disord 6:460-9. 2004
    ..The current report provides a context for interpreting studies resulting from STEP-BD by summarizing the baseline demographic and diagnostic characteristics of the first 1000 enrolled...
  44. doi request reprint Brain GABA levels in patients with bipolar disorder
    Rebecca E Kaufman
    Massachusetts General Hospital Department of Psychiatry, Boston, MA 02114, United States
    Prog Neuropsychopharmacol Biol Psychiatry 33:427-34. 2009
    ..GENERAL METHODS: We used magnetic resonance spectroscopy (MRS) to examine whole brain and regional GABA, glutamate and glutamine in 13 patients with bipolar disorder compared to a matched group of 11 healthy controls...
  45. ncbi request reprint The prevalence and clinical correlates of anger attacks during depressive episodes in bipolar disorder
    Roy H Perlis
    Massachusetts General Hospital Department of Psychiatry, Boston, MA, USA
    J Affect Disord 79:291-5. 2004
    ..This study compared the prevalence and clinical significance of anger attacks in unipolar versus bipolar depression...
  46. ncbi request reprint Psychoeducational and cognitive-behavioral strategies in the management of bipolar disorder
    Michael W Otto
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Affect Disord 73:171-81. 2003
    ....
  47. ncbi request reprint Response, remission, and recovery in bipolar disorders: what are the realistic treatment goals?
    Gary S Sachs
    Harvard Bipolar Research Program, Massachusetts General Hospital, Boston 02114, USA
    J Clin Psychiatry 64:18-22; discussion 28. 2003
    ..Despite effective treatment, relapse is common. Realistic treatment goals should strive for sustained symptom abatement while maximizing patient quality of life from visit to visit...
  48. ncbi request reprint Effect of abrupt change from standard to low serum levels of lithium: a reanalysis of double-blind lithium maintenance data
    Roy H Perlis
    Department of Psychiatry, Massachusetts General Hospital, 50 Staniford Street, Boston, MA 02114, USA
    Am J Psychiatry 159:1155-9. 2002
    ..To assess the effect of abrupt change in lithium dose, the authors reanalyzed data from a previously reported, randomized, double-blind trial of standard- versus low-dose lithium for maintenance therapy in bipolar disorder...
  49. ncbi request reprint Combination of a mood stabilizer with risperidone or haloperidol for treatment of acute mania: a double-blind, placebo-controlled comparison of efficacy and safety
    Gary S Sachs
    Bipolar Research Program, Department of Psychiatry, Massachusetts General Hospital, 50 Staniford Street, Suite 580, Boston, MA 02114, USA
    Am J Psychiatry 159:1146-54. 2002
    ..The study assessed the efficacy and safety of risperidone as an adjunctive agent to mood stabilizers in the treatment of acute mania...
  50. ncbi request reprint Childhood antecedent disorders to bipolar disorder in adults: a controlled study
    Aude Henin
    Pediatric Psychopharmacology Unit and Bipolar Clinic and Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02138, United States
    J Affect Disord 99:51-7. 2007
    ..The aim of the study was to examine antecedent childhood psychiatric disorders in adult patients with bipolar disorder...
  51. ncbi request reprint Presence of irritability during depressive episodes in bipolar disorder
    Thilo Deckersbach
    Department of Psychiatry, Psychiatric Neuroscience Program and Bipolar Research Program, Harvard Medical School 149 2611, Massachusetts General Hospital Bldg 149, 13th Street, Charlestown, MA 02129, USA
    CNS Spectr 9:227-31. 2004
    ....
  52. ncbi request reprint Unmet clinical needs in bipolar disorder
    Gary S Sachs
    Harvard Bipolar Research Program, Massachusetts General Hospital, Boston, 02114, USA
    J Clin Psychopharmacol 23:S2-8. 2003
    ..The role of atypical antipsychotics in maintenance therapy for bipolar disorder is currently being evaluated in a number of large clinical trials...
  53. pmc The interactive computer interview for mania
    Noreen A Reilly-Harrington
    Concordant Rater Systems, Boston, MA, USA
    Bipolar Disord 12:521-7. 2010
    ..The current study examines the acceptability, feasibility, and reliability of the ICI-M as a potential method for evaluating the performance of human raters...
  54. ncbi request reprint A clinical monitoring form for mood disorders
    Gary S Sachs
    Department of Psychiatry, Harvard Bipolar Research Program, Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Bipolar Disord 4:323-7. 2002
    ..This report presents preliminary data evaluating the correlation between the CMF's dimensional subscales for depression and mood elevation and formal mood rating scales across a wide spectrum of mood states...
  55. pmc Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
    Manuel A R Ferreira
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 40:1056-8. 2008
    ..0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder...
  56. ncbi request reprint Characteristics of rapid cycling bipolar-I patients in a bipolar speciality clinic
    Aysegul Yildiz
    Bipolar Program, Harvard Medical School, Massachussets General Hospital, Boston, MA, USA
    J Affect Disord 79:247-51. 2004
    ..To investigate the characteristics of patients with rapid cycling bipolar illness...
  57. ncbi request reprint Treatment of bipolar depression: current status, continued challenges, and the STEP-BD approach
    Michael E Thase
    Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Psychiatr Clin North Am 26:495-518. 2003
    ....
  58. ncbi request reprint The Texas implementation of medication algorithms: update to the algorithms for treatment of bipolar I disorder
    Trisha Suppes
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9121, USA
    J Clin Psychiatry 66:870-86. 2005
    ..The guidelines for evaluating possible medications, the criteria for selection and ranking, and the updated algorithms are described...
  59. ncbi request reprint Olanzapine versus lithium in the maintenance treatment of bipolar disorder: a 12-month, randomized, double-blind, controlled clinical trial
    Mauricio Tohen
    Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Am J Psychiatry 162:1281-90. 2005
    ..The authors compared the efficacy of olanzapine and lithium in the prevention of mood episode relapse/recurrence...
  60. ncbi request reprint Phenomenology of rapid-cycling bipolar disorder: data from the first 500 participants in the Systematic Treatment Enhancement Program
    Christopher D Schneck
    Department of Psychiatry, University of Colorado Health Sciences Center, 4455 East 12th Ave, Box A011 15, Denver, CO 80220, USA
    Am J Psychiatry 161:1902-8. 2004
    ..This study compared demographic and phenomenological variables between bipolar patients with and without rapid cycling as a function of bipolar I versus bipolar II status...
  61. ncbi request reprint Efficacy of olanzapine in combination with valproate or lithium in the treatment of mania in patients partially nonresponsive to valproate or lithium monotherapy
    Mauricio Tohen
    Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, IN 46285, USA
    Arch Gen Psychiatry 59:62-9. 2002
    ....
  62. ncbi request reprint Relapse prevention in bipolar I disorder: 18-month comparison of olanzapine plus mood stabiliser v. mood stabiliser alone
    Mauricio Tohen
    Lilly Research Laboratories, Indianapolis, Indiana 46285, USA
    Br J Psychiatry 184:337-45. 2004
    ..Aims To evaluate whether olanzapine plus either lithium or valproate reduces the rate of relapse, compared with lithium or valproate alone...
  63. ncbi request reprint Validity of the distinction between primary and secondary substance use disorder in patients with bipolar disorder: data from the first 1000 STEP-BD participants
    Mark D Fossey
    Department of Psychiatry, University of Oklahoma College of Medicine Tulsa, Tulsa, Oklahoma 74135, USA
    Am J Addict 15:138-43. 2006
    ..The primary/secondary distinction for SUD is not valid when variations in the age of onset of the non-SUD are linked to course characteristics...
  64. ncbi request reprint Report of the Texas Consensus Conference Panel on medication treatment of bipolar disorder 2000
    Trisha Suppes
    Department of Psychiatry The University of Texas Southwestern Medical Center Dallas, 75390 9070, USA
    J Clin Psychiatry 63:288-99. 2002
    ....
  65. ncbi request reprint Rash in multicenter trials of lamotrigine in mood disorders: clinical relevance and management
    Joseph R Calabrese
    Department of Psychiatry, Case Western Reserve University University Hospitals of Cleveland, Cleveland, Ohio, USA
    J Clin Psychiatry 63:1012-9. 2002
    ..The objective of this report was to determine rash rates in clinical trials of lamotrigine in DSM-IV unipolar depression or bipolar disorder...
  66. ncbi request reprint Lamotrigine treatment of bipolar disorder: data from the first 500 patients in STEP-BD
    Lauren B Marangell
    Mood Disorders Program, Department of Psychiatry, Baylor College of Medicine, Houston, TX 77030, USA
    Bipolar Disord 6:139-43. 2004
    ..To describe the frequency and correlates of lamotrigine therapy among the first 500 patients enrolled into the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) study...
  67. ncbi request reprint Rates of study completion with single versus split daily dosing of antidepressants: a meta-analysis
    Aysegul Yildiz
    Dokuz Eylul Medical School, Department of Psychiatry, Izmir, Turkey
    J Affect Disord 78:157-62. 2004
    ..To examine the tolerability of single versus multiple daily dosing (SDD vs. MDD) of antidepressant drugs in clinical practice...
  68. ncbi request reprint Do antidepressants induce rapid cycling? A gender-specific association
    Aysegul Yildiz
    Dokuz Eylul Medical School, Department of Psychiatry, Izmir, Turkey
    J Clin Psychiatry 64:814-8. 2003
    ..To investigate the influence of antidepressant use and gender in the genesis of rapid-cycling bipolar illness...
  69. ncbi request reprint Gender differences in bipolar disorder: retrospective data from the first 500 STEP-BD participants
    Claudia F Baldassano
    Bipolar Disorders Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Bipolar Disord 7:465-70. 2005
    ..To examine gender differences in a large sample of patients with bipolar illness...
  70. ncbi request reprint Suicidal ideation and pharmacotherapy among STEP-BD patients
    Joseph F Goldberg
    Affective Disorders Program, Silver Hill Hospital, 208 Valley Road, New Canaan, Connecticut 06840, and Department of Psychiatry, University of Colorado School of Medicine, Denver, USA
    Psychiatr Serv 56:1534-40. 2005
    ..Little is known about the effects of lithium on suicidal ideation or about the possible antisuicidal effects of divalproex, second-generation antipsychotics, or antidepressants among persons with bipolar disorder...
  71. ncbi request reprint Impact of lamotrigine and lithium on weight in obese and nonobese patients with bipolar I disorder
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Am J Psychiatry 163:1199-201. 2006
    ..This study assessed weight changes in a large cohort of patients with bipolar disorder who were treated with randomly assigned maintenance monotherapies...
  72. ncbi request reprint Focus on bipolar disorder treatment
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, TX, USA
    J Clin Psychiatry 66:1598-609. 2005
  73. ncbi request reprint Influence of sub-syndromal symptoms after remission from manic or mixed episodes
    Mauricio Tohen
    Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Br J Psychiatry 189:515-9. 2006
    ..Sub-syndromal symptoms in bipolar disorder impair functioning and diminish quality of life...
  74. ncbi request reprint Comparisons of perceived quality of life across clinical states in bipolar disorder: data from the first 2000 Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) participants
    Hongwei Zhang
    Epidemiology Data Center, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Compr Psychiatry 47:161-8. 2006
    ..However, the pattern of specific deficits has not been well studied, and the role of potential confounders has received no attention...
  75. pmc Psychosocial treatments for bipolar depression: a 1-year randomized trial from the Systematic Treatment Enhancement Program
    David J Miklowitz
    Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
    Arch Gen Psychiatry 64:419-26. 2007
    ..Psychosocial interventions have been shown to enhance pharmacotherapy outcomes in bipolar disorder...
  76. pmc Predictors of bipolar disorder risk among patients currently treated for major depression
    Joseph R Calabrese
    Mood Disorders Program, Department of Psychiatry, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio, USA
    MedGenMed 8:38. 2006
    ..PATIENTS, DESIGN, AND SETTING: Psychiatrists from community and private practice settings sequentially selected patients with unipolar depression who exhibited nonresponse to at least 1 antidepressant (AD) trial...
  77. pmc Intensive psychosocial intervention enhances functioning in patients with bipolar depression: results from a 9-month randomized controlled trial
    David J Miklowitz
    Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
    Am J Psychiatry 164:1340-7. 2007
    ..In a randomized trial, the authors examined the impact of intensive psychosocial treatment plus pharmacotherapy on the functional outcomes of patients with bipolar disorder over the 9 months following a depressive episode...
  78. ncbi request reprint Adjunctive antidepressant use and symptomatic recovery among bipolar depressed patients with concomitant manic symptoms: findings from the STEP-BD
    Joseph F Goldberg
    Affective Disorders Program, Silver Hill Hospital, New Canaan, Connecticut, USA
    Am J Psychiatry 164:1348-55. 2007
    ..However, few studies have examined the outcomes of patients with co-occurring manic and depressive symptoms who are treated with antidepressants plus mood stabilizing drugs...
  79. ncbi request reprint Contributors to suicidal ideation among bipolar patients with and without a history of suicide attempts
    Michael H Allen
    University of Colorado Health Science Center, University North Pavilion, 4455 East 12th Avenue, Denver, CO, USA
    Suicide Life Threat Behav 35:671-80. 2005
    ..Bipolar patients with suicidal ideation may benefit from different treatment strategies depending on their prior attempt status...
  80. ncbi request reprint Self-reported history of manic/hypomanic switch associated with antidepressant use: data from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
    Christine J Truman
    Finney Psychotherapy Associates, Norfolk, VA, USA
    J Clin Psychiatry 68:1472-9. 2007
    ....
  81. doi request reprint The prospective course of rapid-cycling bipolar disorder: findings from the STEP-BD
    Christopher D Schneck
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO 80220, USA
    Am J Psychiatry 165:370-7; quiz 410. 2008
    ..In a naturalistic follow-up of adult bipolar patients, the authors examined the contributions of demographic, phenomenological, and clinical variables, including antidepressant use, to prospectively observed mood episode frequency...
  82. ncbi request reprint Overweight and obesity in bipolar disorders
    Po W Wang
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Room 2117, CA 94305 5723, USA
    J Psychiatr Res 40:762-4. 2006
  83. ncbi request reprint Randomized, placebo-controlled trial of olanzapine as maintenance therapy in patients with bipolar I disorder responding to acute treatment with olanzapine
    Mauricio Tohen
    Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Am J Psychiatry 163:247-56. 2006
    ..In a placebo-controlled, double-blind study, the authors investigated the efficacy and safety of olanzapine as monotherapy in relapse prevention in bipolar I disorder...
  84. ncbi request reprint Are antidepressants associated with new-onset suicidality in bipolar disorder? A prospective study of participants in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
    Mark S Bauer
    Providence Veterans Affairs Medical Center and the Department of Psychiatry and Human Behavior, Brown University, VAMC 116R, 830 Chalkstone Avenue, Providence, R I 02908 4799, USA
    J Clin Psychiatry 67:48-55. 2006
    ..However, few data are available to inform the suicidality risk assessment of antidepressant use specifically in bipolar disorder...
  85. ncbi request reprint Baseline predictors of serious adverse events at one year among patients with bipolar disorder in STEP-BD
    James M Martinez
    Mood Disorders Center, Menninger Department of Psychiatry, Baylor College of Medicine, Ben Taub Hospital, Houston, TX 77030, USA
    Psychiatr Serv 56:1541-8. 2005
    ..Little is known about serious adverse events that occur in the context of clinical care for bipolar disorder. This study examined predictors of serious adverse events in a large cohort of patients with bipolar disorder...
  86. ncbi request reprint Psychotherapy, symptom outcomes, and role functioning over one year among patients with bipolar disorder
    David J Miklowitz
    Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
    Psychiatr Serv 57:959-65. 2006
    ..A one-year naturalistic-prospective design was used to examine the association between psychotherapy use and the symptomatic and functional outcomes of patients with bipolar disorder...